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Your search keyword '"Munderi, Paula"' showing total 5 results
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5 results on '"Munderi, Paula"'

1. Switch to long-acting cabotegravir and rilpivirine in virologically suppressed adults with HIV in Africa (CARES): week 48 results from a randomised, multicentre, open-label, non-inferiority trial

Author

Kityo, Cissy, primary, Mambule, Ivan K, additional, Musaazi, Joseph, additional, Sokhela, Simiso, additional, Mugerwa, Henry, additional, Ategeka, Gilbert, additional, Cresswell, Fiona, additional, Siika, Abraham, additional, Kosgei, Josphat, additional, Shah, Reena, additional, Naidoo, Logashvari, additional, Opiyo, Kimton, additional, Otike, Caroline, additional, Möller, Karlien, additional, Kaimal, Arvind, additional, Wambui, Charity, additional, Van Eygen, Veerle, additional, Mohammed, Perry, additional, Addo Boateng, Fafa, additional, Paton, Nicholas I, additional, Tamale, William, additional, Yiga, Joshua, additional, Asaasira, Susan Esther, additional, Kinyera, Nigel, additional, Nambi, Christine, additional, Nakiboneka, Dridah Luyirika, additional, Kabatana, Rose, additional, Kiyimba, Winfred, additional, Yawe, Ibrahim, additional, Alinaitwe, Adolf, additional, Zawedde, Aidah, additional, Wasswa, George, additional, Arinda, Allan, additional, Rweyora, Angela, additional, Kangah, Mary Goretti, additional, Castelnuovo, Barbara, additional, Ogwal, Patience, additional, Muhumuza, Neville, additional, Okwero, Max, additional, Ayebare, Peruth, additional, Nakate, Vivian, additional, Asienzo, Jesca, additional, Mayanja, Hamza, additional, Laker, Eva, additional, Riunga, Felix, additional, Onyango, Peter Odhiambo, additional, Wanja, Josephine, additional, Sayed, Shaheen, additional, Gohil, Jaimini, additional, Mungathia, Isaiah, additional, Githuka, Alfred Mburu, additional, Kibwage, Haron, additional, Siika, Abraham Mosigisi, additional, Wambui, Charity Kanyoro, additional, Kirui, Viola Cherotich, additional, Kipyego, Jairus, additional, Sang, Natalie, additional, Mokaya, Martha Mokeira Bisieri, additional, Chepkorir, Consolata, additional, Mboya, Chris Sande, additional, Tonui, Ronald, additional, Njulu, Florence, additional, Kaziga, Hilda, additional, Sawe, Fredrick, additional, Omol, Magdaline Adhiambo, additional, Riziki, Faith, additional, Daud, Ibrahim, additional, Kimetto, Leelgo, additional, Okumu, Billy Omalla, additional, Lipuku, Francis, additional, Venter, Francois, additional, Moller, Karlien, additional, Nzuza, Nompumelelo, additional, Ramela, Gontse, additional, Tom, Noxolo, additional, Nyamuzihwa, Tsitsi, additional, Macholo, Philadelphia, additional, Macebele, Hlamulani, additional, Akpomiemie, Godspower, additional, Jeenarain, Nitesha, additional, Hurbans, Nivriti, additional, Reddy, Mayuri, additional, Mphisa, Gerald Thsepo, additional, Kityo, Cissy, additional, Paton, Nicholas, additional, Mambule, Ivan Kiggundu, additional, Kabanyoro, Ritah, additional, Sekajja, Francis, additional, Nantumbwe, Sandra, additional, Sekabira, Harriet, additional, Ocitti, Paul, additional, Ouma, Benson, additional, Nankya, Immaculate, additional, Ainembabazi, Pamela, additional, Lötter, Melissa, additional, Mohamed, Saeeda, additional, Herbst, Madel, additional, Peters, Tarryn, additional, Mehta, Heena, additional, Khan, Shaguftha, additional, Kruger, Marlien, additional, van Rein-van der Horst, Willemijn, additional, Van Solingen, Rodica, additional, Vandermeulen, Kati, additional, Crauwels, Herta, additional, Luo, Donghan, additional, Votto, Donna, additional, Idahosa, Awhonukeh, additional, Mwendia, Fridah, additional, Klasko-Foster, Lynne, additional, Bondal, Malavika, additional, Eshun-Wilsonova, Ingrid, additional, Spreen, William, additional, D'Amico, Ronald, additional, Kaleebu, Pontiano, additional, Ojoo, Sylvia, additional, Katana, Milly, additional, Moosa, Yunus, additional, Phiri, Sam, additional, Munderi, Paula, additional, and Hill, Andrew, additional

Published
2024
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2. Antiretroviral initiation at ≥800 CD4+ cells/ mm 3 associated with lower HIV reservoir size

Author

Rasmussen, Thomas A, Ahuja, Sunil K, Kuwanda, Locadiah, Vjecha, Michael J, Hudson, Fleur, Lal, Luxshimi, Rhodes, Ajantha, Chang, Judy, Palmer, Sarah, Auberson-Munderi, Paula, Mugerwa, Henry, Wood, Robin, Badal-Faesen, Sharlaa, Pillay, Sandy, Mngqibisa, Rosie, LaRosa, Alberto, Hildago, Jose, Petoumenos, Kathy, Chiu, Chris, Lutaakome, Joseph, Kitonsa, Jonathan, Kabaswaga, Esther, Pala, Pietro, Ganoza, Carmela, Fisher, Katie, Chang, Christina, Lewin, Sharon R, and Wright, Edwina J

Abstract

BACKGROUND: Identifying factors that determine the frequency of latently infected CD4+ T-cells on antiretroviral therapy (ART) may inform strategies for HIV cure. We investigated the role of CD4 count at ART initiation for HIV persistence on ART. METHODS: Among participants of the Strategic Timing of Antiretroviral Treatment (START) Study, we enrolled people with HIV (PWH) who initiated ART with CD4+ T-cell counts of 500-599, 600-799 or ≥800 cells/mm 3. After 36-44 months on ART, we quantified levels of total HIV-DNA, cell-associated unspliced HIV-RNA (CA-US HIV-RNA) and 2-long terminal repeat HIV-DNA in CD4+ T-cells and measured plasma HIV-RNA by single-copy assay. We measured T-cell expression of HLA-DR, programmed death-1, phosphorylated signal transducer and activator of transcription-5 (pSTAT5). Virological and immunological measures were compared across CD4+ strata. RESULTS: We enrolled 146 PWH, 36 in the 500-599, 60 in the 600-799 and 50 in the ≥800 CD4 strata. After 36-44 months of ART, total HIV-DNA, plasma HIV-RNA and HLA-DR expression were significantly lower in PWH with CD4+ T-cell count ≥800 cells/mm 3 at ART initiation compared to 600-799 or 500-599 cells/mm 3. The median level of HIV-DNA after 36-44 months of ART was lower by 75% in participants initiating ART with ≥800 vs. 500-599 cells/mm 3 [median (IQR): 16.3 (7.0-117.6) vs. 68.4 (13.7-213.1) copies/million cells, respectively). Higher pSTAT5 expression significantly correlated with lower levels of HIV-DNA and CA-US HIV-RNA. Virological measures were significantly lower in females.. CONCLUSION: Initiating ART with a CD4+ count ≥800 cells/mm 3 compared to 600-799 or 500-599 cells/mm 3 was associated with achieving a substantially smaller HIV reservoir on ART.

Published
2022

3. Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size

Author

Rasmussen, Thomas A, primary, Ahuja, Sunil K, additional, Kuwanda, Locadiah, additional, Vjecha, Michael J, additional, Hudson, Fleur, additional, Lal, Luxshimi, additional, Rhodes, Ajantha, additional, Chang, Judy, additional, Palmer, Sarah, additional, Auberson-Munderi, Paula, additional, Mugerwa, Henry, additional, Wood, Robin, additional, Badal-Faesen, Sharlaa, additional, Pillay, Sandy, additional, Mngqibisa, Rosie, additional, LaRosa, Alberto, additional, Hildago, Jose, additional, Petoumenos, Kathy, additional, Chiu, Chris, additional, Lutaakome, Joseph, additional, Kitonsa, Jonathan, additional, Kabaswaga, Esther, additional, Pala, Pietro, additional, Ganoza, Carmela, additional, Fisher, Katie, additional, Chang, Christina, additional, Lewin, Sharon R, additional, and Wright, Edwina J, additional

Published
2022
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4. Phylogenetic analysis of HIV-1 shows frequent cross-country transmission and local population expansions.

Author

Bennedbæk, Marc, Zhukova, Anna, Tang, Man-Hung Eric, Bennet, Jaclyn, Munderi, Paula, Ruxrungtham, Kiat, Gisslen, Magnus, Worobey, Michael, Lundgren, Jens D, and Marvig, Rasmus L

Subjects
HIV, TRANSMISSION of texts, GENETIC variation
Abstract

Understanding of pandemics depends on the characterization of pathogen collections from well-defined and demographically diverse cohorts. Since its emergence in Congo almost a century ago, Human Immunodeficiency Virus Type 1 (HIV-1) has geographically spread and genetically diversified into distinct viral subtypes. Phylogenetic analysis can be used to reconstruct the ancestry of the virus to better understand the origin and distribution of subtypes. We sequenced two 3.6-kb amplicons of HIV-1 genomes from 3,197 participants in a clinical trial with consistent and uniform sampling at sites across 35 countries and analyzed our data with another 2,632 genomes that comprehensively reflect the HIV-1 genetic diversity. We used maximum likelihood phylogenetic analysis coupled with geographical information to infer the state of ancestors. The majority of our sequenced genomes (n  = 2,501) were either pure subtypes (A–D, F, and G) or CRF01_AE. The diversity and distribution of subtypes across geographical regions differed; USA showed the most homogenous subtype population, whereas African samples were most diverse. We delineated transmission of the four most prevalent subtypes in our dataset (A, B, C, and CRF01_AE), and our results suggest both continuous and frequent transmission of HIV-1 over country borders, as well as single transmission events being the seed of endemic population expansions. Overall, we show that coupling of genetic and geographical information of HIV-1 can be used to understand the origin and spread of pandemic pathogens. [ABSTRACT FROM AUTHOR]

Published
2021
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5. The impact of viraemia on inflammatory biomarkers and CD4+ cell subpopulations in HIV-infected children in sub-Saharan Africa.

Author

Prendergast, Andrew J., Szubert, Alexander J., Pimundu, Godfrey, Berejena, Chipo, Pala, Pietro, Shonhai, Annie, Hunter, Patricia, Arrigoni, Francesca I. F., Musiime, Victor, Bwakura-Dangarembizi, Mutsa, Musoke, Philippa, Poulsom, Hannah, Kihembo, Macklyn, Munderi, Paula, Gibb, Diana M., Spyer, Moira J., Sarah Walker, A., Klein, Nigel, Walker, A Sarah, and and the ARROW Trial Team

Published
2021
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