42 results on '"Murenzi, Gad"'
Search Results
2. Comparison of AmpFire and MY09/11 assays for HPV genotyping in anogenital specimen of Rwandan men who have sex with men
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Kanyabwisha, Faustin, Kim, Hae-Young, Shi, Qiuhu, Murenzi, Gad, Tuyisenge, Patrick, Kubwimana, Gallican, Munyaneza, Athanase, Murangwa, Anthère, Turizigiye, Onesphore, Da Costa, Maria, Nsengiyumva, Boniface, Chen, Xin, Mutesa, Leon, Anastos, Kathryn M, and Palefsky, Joel M
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Sexually Transmitted Infections ,Infectious Diseases ,HIV/AIDS ,Clinical Research ,MSM ,MY09 ,11 ,AmpFire ,Anal hrHPV ,Penile hrHPV ,MY09/11 - Abstract
IntroductionThe AmpFire HPV genotyping Assay (Atila Biosystems, Mountain View, CA, USA) is a new test for which there are few data regarding its analytic performance and reliability. Using anal and penile swab specimens from a cohort study of men who have sex with men (MSM) in Rwanda, we compared high-risk HPV (hrHPV) detection by AmpFire done at two laboratories, one at University of California San Francisco (UCSF) and the other Rwanda Military Hospital, and well-validated MY09/11-based assay done at UCSF.MethodsAnal and penile specimens collected from 338 MSM from March 2016 to September 2016 were tested for high-risk HPV genotypes (hrHPV) by MY09/11, AmpFire UCSF and AmpFire RMH. Cohen's kappa coefficient was used to test for reproducibility.ResultsThe hrHPV positivity by MY09/11 and AmpFire UCSF was 13% and 20.7% (k = 0.73) for anal specimens and was 26.3% and 32.6% (k = 0.67) for penile specimens. Specifically, good reproducibility was for types 16 and 18 (k = 0.69 and k = 0.71) for anal specimens and (k = 0.50 and k = 0.72) for penile specimens. The hrHPV positivity by AmpFire at UCSF and RMH was 20.7% for both laboratories (k = 0.87) for anal specimens and was 34.9% and 31.9% (k = 0.89) for penile specimens. Specifically, excellent reproducibility was for types 16 and 18 for anal specimens (k = 0.80 and k = 1.00) and penile specimens (k = 0.85 and k = 0.91).ConclusionResults show that MY09/11 and AmpFire assays have good reproducibility while the AmpFire UCSF and RMH assays have excellent reproducibility. These results show that AmpFire is a promising HPV genotyping test.
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- 2023
3. Cervical cancer prevention and care in HIV clinics across sub‐Saharan Africa: results of a facility‐based survey
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Asangbeh‐Kerman, Serra Lem, Davidović, Maša, Taghavi, Katayoun, Dhokotera, Tafadzwa, Manasyan, Albert, Sharma, Anjali, Jaquet, Antoine, Musick, Beverly, Twizere, Christella, Chimbetete, Cleophas, Murenzi, Gad, Tweya, Hannock, Muhairwe, Josephine, Wools‐Kaloustian, Kara, Technau, Karl‐Gunter, Anastos, Kathryn, Yotebieng, Marcel, Jousse, Marielle, Ezechi, Oliver, Orang'O, Omenge, Bosomprah, Samuel, Boni, Simon Pierre, Basu, Partha, and Bohlius, Julia
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HIV (Viruses) -- Prevention ,Women -- Health aspects ,World health ,Vaccination ,Medical informatics ,Cancer -- Prevention ,Cervical cancer -- Prevention ,Health ,World Health Organization - Abstract
: INTRODUCTION: To eliminate cervical cancer (CC), access to and quality of prevention and care services must be monitored, particularly for women living with HIV (WLHIV). We assessed implementation practices in HIV clinics across sub‐Saharan Africa (SSA) to identify gaps in the care cascade and used aggregated patient data to populate cascades for WLHIV attending HIV clinics. METHODS: Our facility‐based survey was administered between November 2020 and July 2021 in 30 HIV clinics across SSA that participate in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. We performed a qualitative site‐level assessment of CC prevention and care services and analysed data from routine care of WLHIV in SSA. RESULTS: Human papillomavirus (HPV) vaccination was offered in 33% of sites. Referral for CC diagnosis (42%) and treatment (70%) was common, but not free at about 50% of sites. Most sites had electronic health information systems (90%), but data to inform indicators to monitor global targets for CC elimination in WLHIV were not routinely collected in these sites. Data were collected routinely in only 36% of sites that offered HPV vaccination, 33% of sites that offered cervical screening and 20% of sites that offered pre‐cancer and CC treatment. CONCLUSIONS: Though CC prevention and care services have long been available in some HIV clinics across SSA, patient and programme monitoring need to be improved. Countries should consider leveraging their existing health information systems and use monitoring tools provided by the World Health Organization to improve CC prevention programmes and access, and to track their progress towards the goal of eliminating CC., INTRODUCTION The World Health Organization (WHO) seeks to eliminate cervical cancer (CC) within this century, and has defined the “90‐70‐90” targets it expects countries to reach by 2030: 90% of [...]
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- 2024
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4. Experiences of stigma and HIV care engagement in the context of Treat All in Rwanda: a qualitative study
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Ingabire, Charles, Watnick, Dana, Gasana, Josephine, Umwiza, Francine, Munyaneza, Athanase, Kubwimana, Gallican, Murenzi, Gad, Anastos, Kathryn, Adedimeji, Adebola, and Ross, Jonathan
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- 2023
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5. Metabolic causes of liver disease among adults living with HIV from low‐ and middle‐income countries: a cross‐sectional study
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Plaisy, Marie Kerbie, Minga, Albert K., Wandeler, Gilles, Murenzi, Gad, Samala, Niharika, Ross, Jeremy, Lopez, Alvaro, Mensah, Ephrem, Waal, Renée, Kuniholm, Mark H., Diero, Lameck, Salvi, Sonali, Moreira, Rodrigo, Attia, Alain, Mandiriri, Ardele, Shumbusho, Fabienne, Goodrich, Suzanne, Rupasinghe, Dhanushi, Alarcon, Paola, Maruri, Fernanda, Perrazo, Hugo, and Jaquet, Antoine
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Medical research -- Analysis ,Diseases -- Risk factors ,Hepatitis C virus -- Analysis ,Stavudine -- Analysis ,Hypertension -- Risk factors ,HIV (Viruses) -- Risk factors ,Medicine, Experimental -- Analysis ,Hepatitis -- Risk factors ,Mortality -- India -- Mexico -- Brazil -- Zambia ,Efavirenz -- Analysis ,Highly active antiretroviral therapy -- Analysis ,HIV patients -- Analysis ,Atazanavir -- Analysis ,Type 2 diabetes -- Risk factors ,Health - Abstract
: Introduction: Liver disease is a leading cause of morbidity and mortality among persons living with HIV (PLHIV). While chronic viral hepatitis has been extensively studied in low‐ and middle‐income countries (LMICs), there is limited information about the burden of metabolic disorders on liver disease in PLHIV. Methods: We conducted a cross‐sectional analysis of baseline data collected between October 2020 and July 2022 from the IeDEA‐Sentinel Research Network, a prospective cohort enrolling PLHIV ≥40 years on antiretroviral treatment (ART) for ≥6 months from eight clinics in Asia, Americas, and central, East, southern and West Africa. Clinical assessments, laboratory testing on fasting blood samples and liver stiffness measurement (LSM)/controlled attenuation parameter (CAP) by vibration‐controlled transient elastography were performed. Multivariable logistic regression models assessed factors associated with liver fibrosis (LSM ≥7.1 kPa) and steatosis (CAP ≥248 dB/m). Population attributable fraction (PAF) of each variable associated with significant liver fibrosis was estimated using Levin's formula. Results: Overall, 2120 PLHIV (56% female, median age 50 [interquartile range: 45−56] years) were included. The prevalence of obesity was 19%, 12% had type 2 diabetes mellitus (T2DM), 29% had hypertension and 53% had dyslipidaemia. The overall prevalence of liver fibrosis and steatosis was 7.6% (95% confidence interval [CI] 6.1−8.4) and 28.4% (95% CI 26.5−30.7), respectively, with regional variability. Male sex at birth (odds ratio [OR] 1.62, CI 1.10−2.40), overweight/obesity (OR = 2.50, 95% CI 1.69−3.75), T2DM (OR 2.26, 95% CI 1.46−3.47) and prolonged exposure to didanosine (OR 3.13, 95% CI 1.46−6.49) were associated with liver fibrosis. Overweight/obesity and T2DM accounted for 42% and 11% of the PAF for liver fibrosis, while HBsAg and anti‐HCV accounted for 3% and 1%, respectively. Factors associated with steatosis included overweight/obesity (OR 4.25, 95% CI 3.29−5.51), T2DM (OR 2.06, 95% CI 1.47−2.88), prolonged exposure to stavudine (OR 1.69, 95% CI 1.27−2.26) and dyslipidaemia (OR 1.68, 95% CI 1.31−2.16). Conclusions: Metabolic disorders were significant risk factors for liver disease among PLHIV in LMICs. Early recognition of metabolic disorders risk factors might be helpful to guide clinical and lifestyle interventions. Further prospective studies are needed to determine the causative natures of these findings., INTRODUCTION With the expanded coverage of antiretroviral treatment (ART), AIDS‐related mortality among persons living with HIV (PLHIV) has substantially decreased, resulting in a growing burden of non‐AIDS comorbidities, including liver [...]
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- 2024
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6. Incidence, Clearance, and Persistence of Penile High-Risk Human Papillomavirus Among Rwandan Men Who Have Sex With Men.
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Murenzi, Gad, Kim, Hae-Young, Mivumbi, Jean Paul, Gasana, Josephine, Munyaneza, Athanase, Tuyisenge, Patrick, Kanyabwisha, Faustin, Zawadi, Thierry, Muhoza, Benjamin, Kubwimana, Gallican, Adedimeji, Adebola, Yotebieng, Marcel, Mutesa, Leon, Shi, Qiuhu, Anastos, Kathryn, and Palefsky, Joel M
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HUMAN papillomavirus , *MEN who have sex with men , *DIAGNOSIS of HIV infections , *MIDDLE-income countries , *HIV status - Abstract
Background Little is known about penile high-risk human papillomavirus (hrHPV) among men who have sex with men (MSM) in low- and middle-income countries. We aimed to determine the incidence, clearance, and persistence of penile hrHPV among Rwandan MSM. Methods We enrolled 350 MSM (345 with valid human papillomavirus [HPV] results) aged ≥18 years. At each visit (6–12 months apart), we collected penile PreservCyt specimens and blood for HPV and HIV testing, as well as sociodemographic and behavioral variables. HPV testing was performed with the Ampfire assay. Penile hrHPV incidence and clearance per 1000 person-months of follow-up, as well as prevalent and incident persistence, were computed and compared by HIV status. Results The mean (SD) age was 27.7 (6.7) years and 19.4% were living with HIV. Penile hrHPV incidence was 34.8 (95% CI, 29.1–41.8) per 1000 person-months of follow-up. HPV-16 (11.7; 95% CI, 9.26–14.9) and HPV-59 (6.1; 95% CI, 4.52–8.39) had the highest incidence rates. Prevalent and incident persistence was 47.5% and 46.6%, respectively. HPV-66 (33.3%), HPV-52 (30.8%), and HPV-16 (29.2%) had the highest prevalent persistence and HPV-33 (53.8%), HPV-31 (46.7%), and HPV-16 (42.6%) the highest incident persistence. No differences were found by HIV status except for HPV-45 (higher in MSM with HIV). Conclusions We found high incidence and prevalent/incident persistence of penile hrHPV among Rwandan MSM. This highlights the importance of preventive strategies for HPV-associated anogenital cancers. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Prevalence and co‐occurrence of symptoms of mental and substance use disorders among people with HIV age 40 and older in low‐ and middle‐income countries: a cross‐sectional study.
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Parcesepe, Angela M., Stockton, Melissa, Bernard, Charlotte, Kanguya, Tukiya, Kwobah, Edith Kamaru, Lopez, Alvaro, Murenzi, Gad, Ross, Jeremy, Minga, Albert, Maruri, Fernanda, Tlali, Mpho, Goodrich, Suzanne, Perazzo, Hugo, Musabyimana, Françoise, Nimkar, Smita, Lancaster, Kathryn, and Consortium, IeDEA
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MENTAL health services ,MENTAL depression ,ALCOHOL drinking ,SUBSTANCE abuse ,MENTAL health ,POST-traumatic stress disorder - Abstract
Introduction: Due to the increased effectiveness of and access to antiretroviral therapy (ART), people with HIV (PWH) are living longer. As a result, the population of older PWH has increased. Mental and substance use disorders (MSDs) are common and frequently co‐occurring among PWH and are associated with poor HIV care outcomes. Research into the prevalence and co‐occurrence of MSDs among ageing PWH remains limited, particularly in low‐ and middle‐income countries (LMICs). Methods: We analysed data collected between 2020 and 2022 from the International epidemiology Databases to Evaluate AIDS (IeDEA) Sentinel Research Network cohort of PWH aged 40 years or older on ART at 11 HIV clinics in Brazil, Côte d'Ivoire, India, Kenya, Mexico, Uganda, Rwanda, Togo, Vietnam, Zambia and Zimbabwe. We estimated the prevalence and co‐occurrence of unhealthy alcohol use (AUDIT‐C ≥3 for women, ≥4 for men), unhealthy drug use (ASSIST >3 for cannabis, cocaine, amphetamines, inhalants, sedatives, hallucinogens and/or opioids), and moderate to severe symptoms of depression (PHQ‐9 ≥10), anxiety (GAD‐7 ≥10) and post‐traumatic stress disorder (PTSD) (PCL‐5 ≥33). Psychiatric multimorbidity was defined as having symptoms of two or more disorders assessed. Log binomial models assessed the association between socio‐demographic and HIV care characteristics and symptoms of anxiety, depression, PTSD or unhealthy substance use. Results: Of 2821 participants, the prevalence of unhealthy alcohol and drug use was 21% and 5%, respectively. The prevalence of moderate to severe symptoms of depression, anxiety and PTSD was 14%, 9% and 6%, respectively. Overall, the prevalence of psychiatric multimorbidity was 11%. Among those with symptoms of at least one mental health or substance use outcome assessed (n = 1036), the prevalence of psychiatric multimorbidity was 31%. In binomial models, the prevalence of symptoms of depression and anxiety was higher, while the prevalence of unhealthy alcohol and drug use was lower among women than men. Conclusions: Unhealthy alcohol use and symptoms of depression were most commonly reported, among this cohort of PWH aged 40 or older across 11 LMICs. Integration of MSD screening and treatment into HIV care should be prioritized. The effectiveness and implementation of transdiagnostic or multi‐focus mental health treatment approaches in HIV care settings should be examined. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Stage at diagnosis and survival among adult patients with cancer in Rwanda: A population‐based study.
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Hagenimana, Marc, Motlhale, Melitah, Parkin, Donald Maxwell, Businge, Lydia, Bardot, Aude, Liu, Biying, Anastos, Kathryn, Castle, Philip E., Murenzi, Gad, Claire, Kimilu, Sabushimike, Daniel, Cyuzuzo, Callixte, Kubwiana, Gallican, Maniragaba, Theoneste, Uwinkindi, Francois, Paczkowski, Maggie, and Soerjomataram, Isabelle
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CANCER patients ,METASTATIC breast cancer ,PROSTATE cancer ,LOW-income countries ,HIGH-income countries ,GRANULOSA cell tumors ,RECTAL cancer - Abstract
There are marked disparities in cancer survival in low‐income countries compared to high‐income countries, yet population‐based data in the first is largely lacking. In this study, data from the national cancer registry of Rwanda were examined for 542 patients diagnosed with eight of the most common cancers of adults stomach (C16), colorectum (C18‐20), liver (C22), breast (female) (C50), cervix (C53), ovary (C56), prostate (C61), and non‐Hodgkin lymphomas (C82‐85) between 2014 and 2017. Subjects were randomly selected for active followed‐up to calculate 1‐, 3‐, and 5‐year observed and relative survival (RS) by cancer type and stage. Overall, 53.7% of cases had died within 5 years of diagnosis. Five‐year RS varied by malignancy and ranged from 17.6% (95% confidence interval [CI]: 6.7%–32.6%) for liver cancer to 68% (CI: 51.6%–79.8%) for cancers of the prostate. Stage was assigned for 71.6% of patients (n = 388 of 542), with over half (58%) having advanced stage (III/IV) at diagnosis. For all except liver and ovary, stage was a strong predictor of survival; for example, three‐year observed survival was 90.9% and 44.8% (p‐value:.002) for early and advanced breast cancer, respectively. This study demonstrates that stage specific survival can be obtained from population based cancer registries in sub Saharan Africa, data that are invaluable for international benchmarking, and for local planning and evaluation of cancer control programs. [ABSTRACT FROM AUTHOR]
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- 2024
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9. High-risk human papillomavirus genotyping in cervical cancers in Tanzania.
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Murenzi, Gad, Vuhahula, Edda, Kimambo, Asteria, Matiku, Subira, Tuyishime, Obed, Liwa, Edwin, Habanabakize, Thomas, Rugengamanzi, Eulade, Malango, Atuganile, Kubwimana, Gallican, Anastos, Kathryn, and Castle, Philip E.
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PAPILLOMAVIRUS diseases , *RISK assessment , *CROSS-sectional method , *WOMEN , *RESEARCH funding , *HIV-positive persons , *EARLY detection of cancer , *HOSPITALS , *CANCER patients , *AGE distribution , *DESCRIPTIVE statistics , *HUMAN papillomavirus vaccines , *BIOLOGICAL assay , *WOMEN'S health , *GENOTYPES , *GENETIC profile , *HISTOLOGY , *DISEASE risk factors , *DISEASE complications ,CERVIX uteri tumors - Abstract
Background: High-risk human papillomavirus (hrHPV) infection causes almost all cervical cancer. Women living with human immunodeficiency virus (Women living with HIV: WLWHIV) are at a six-fold increased risk of developing cervical cancer. This study assessed hrHPV types in cervical cancer by HIV status and histologic subtypes at Muhimbili National Hospital (MNH) in Tanzania. Methods: This cross-sectional study used formalin-fixed paraffin-embedded (FFPE) archived tissue blocks of cervical carcinomas diagnosed in the Department of Anatomical Pathology at MNH from January to December 2020. Tissue sections were tested for 15 HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, and 68) using the Ampfire assay. The distribution of HPV genotypes was assessed and compared by HIV status and histologic subtypes. Results: The mean age ± standard deviation (N = 227, with valid HPV results) was 55 ± 12.9 years, 28.6% (n = 65) were WLWHIV, and squamous cell carcinoma (SCC) was the most common histologic subtype (91.2%). Most cervical carcinomas (81.1%, n = 184) tested positive for hrHPV with HPV16 (44.1%), HPV18 (15.9%), HPV35 (8.4%) and HPV45 (5.7%) being the most common HPV types. hrHPV was higher among older women with 64.5%, 85.1% and 81.3% among 30–40, 41–60 and ≥ 61-year-old women, respectively (p = 0.033). HPV16 was more commonly detected in SCC (47.8%) than in adenocarcinomas (5%) (p < 0.0001). There was no difference in hrHPV positivity by HIV status. Conclusions: We found a high proportion of hrHPV among cervical carcinomas diagnosed in Tanzania. Rolling out HPV vaccines that target more hrHPV types than HPV16/18, especially HPV35 and HPV45, could optimize protection against cervical cancer in Tanzania. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Stage at diagnosis and survival by stage for the leading childhood cancers in Rwanda
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Businge, Lydia, primary, Hagenimana, Marc, additional, Motlhale, Melitah, additional, Bardot, Aude, additional, Liu, Biying, additional, Anastos, Kathryn, additional, Castle, Philip E., additional, Murenzi, Gad, additional, Claire, Kimilu, additional, Sabushimike, Daniel, additional, Cyuzuzo, Callixte, additional, Kubwimana, Gallican, additional, Maniragaba, Theoneste, additional, Uwinkindi, Francois, additional, Paczkowski, Maggie, additional, Soerjomataram, Isabelle, additional, and Parkin, Donald Maxwell, additional
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- 2024
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11. Mucormycosis: a rare forgotten but fatal disease—a case report and literature review
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Matiku, Subira Bhoke, primary, Murenzi, Gad, additional, Shaban, Idd, additional, Msonge, Augustine Muhiza, additional, Kamafa, Ajuna Enock, additional, Kitua, Daniel W., additional, Kimambo, Asteria, additional, Mwakigonja, Amos Rodger, additional, and Massawe, Enica Richard, additional
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- 2024
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12. Awareness and willingness to use pre-exposure prophylaxis for HIV prevention among men who have sex with men in Rwanda: findings from a web-based survey
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Munyaneza, Athanase, primary, Patel, Viraj V., additional, Gutierrez, Nataly Rios, additional, Shi, Qiuhu, additional, Muhoza, Benjamin, additional, Kubwimana, Gallican, additional, Ross, Jonathan, additional, Nsereko, Etienne, additional, Murenzi, Gad, additional, Nyirazinyoye, Laetitia, additional, Mutesa, Leon, additional, Anastos, Kathryn, additional, and Adedimeji, Adebola, additional
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- 2024
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13. Service delivery challenges in HIV care during the first year of the COVID‐19 pandemic: results from a site assessment survey across the global IeDEA consortium
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Brazier, Ellen, Ajeh, Rogers, Maruri, Fernanda, Musick, Beverly, Freeman, Aimee, Wester, C. William, Lee, Man?Po, Shamu, Tinei, Ramírez, Brenda Crabtree, D' Almeida, Marcelline, Wools?Kaloustian, Kara, Kumarasamy, N., Althoff, Keri N., Twizere, Christella, Grinsztejn, Beatriz, Tanser, Frank, Messou, Eugène, Byakwaga, Helen, Duda, Stephany N., Nash, Denis, Chansilpa, Chidchon, Dougherty, Trevor, Karminia, Azar, Law, Matthew, Ross, Jeremy, Sohn, Annette, Aguirre, Ivette, Baker, David, Bloch, Mark, Cabot, Safaa, Carr, Andrew, Couldwell, Deborah, Edwards, Sian, Eu, Beng, Farlow, Heather, Finlayson, Robert, Gunathilake, Manoji, Hazlewood, Cherie, Hoy, Jennifer, Langton?Lockton, Julian, Le, Jacqueline, Leprince, Elizabeth, Minc, Ariane, Moore, Richard, O'Sullivan, Maree, Roth, Norm, Rowling, Dianne, Russell, Darren, Ryder, Nathan, Saunders, Craig, Silvers, Julie, Smith, David J., Sowden, David, Sweeney, Grant, Tan, Lynn, Teague, Ricard, Templeton, David, Thng, Caroline, Woolley, Ian, Khol, Vohith, Ly, Penh Sun, Li, Tsz Hei, Po, Lee Man, Kinikar, Aarti, Kumarasamy, Nagalingeswaran, Mundhe, Sanjay, Pujari, Sanjay, Sangle, Shashikala, Nimkar, Smita, Jassin, Madelein, Kurniati, Nia, Merati, Tuti Parwati, Muktiarti, Dina, Amalia, Rizqi, Sukmawati, Ni Made Dewi Dian, Wati, Ketut Dewi Kumara, Yunihastuti, Evy, Tanuma, Junko, Choi, Jun Yong, Azwa, Raja Iskandar Shah Raja, Cheng, Chan Kwai, Gani, Yasmin Mohamed, Mohamed, Thahira Jamal, Moy, Fong Siew, Nallusamy, Revathy, Nor, Mohamad Zulfahami Mohd, Rudi, Nuraini, Shyan, Wong Peng, Yusoff, Nik Khairulddin Nik, Ditangco, Rossana, Chan, Yu?Jiun, Wu, Pei?Chieh, Wu, Ping?Feng, Avihingsanon, Anchalee, Chaiwarith, Romanee, Chokephaibulkit, Kulkanya, Khusuwan, Suwimon, Kiertiburanakul, Sasisopin, Kosalaraksa, Pope, Lumbiganon, Pagakrong, Ounchanam, Pradtana, Puthanakit, Thanyawee, Rungmaitree, Supattra, Solai, Nuttarika, Sudjaritruk, Tavitiya, An, Vu Thien, Cuong, Do Duy, Do, Chau Viet, Huy, Bui Vu, Quy, Tuan, Van Nguyen, Kinh, Nguyen, Luan, Nguyen, Van Lam, Nguyen, Yen Thi, Nong, Vuong Minh, Truong, Huu Khanh, Tuyen, Ngo Thi Thu, Mcgowan, Catherine C., Duda, Stephany, Cahn, Florencia, Cahn, Pedro, Cesar, Carina, Fink, Valeria, Sued, Omar, Coelho, Lara, Machado, Daisy Maria, Pinto, Jorge, Wolff, Marcelo, Rouzier, Vanessa, Padgett, Denis, Gotuzzo, Eduardo, Biziragusenyuka, Jérémie, Gateretse, Patrick, Nimbona, Pelagie, Niyonkuru, Olive, Twizere, Christelle, Anicetus, Surreng, Djenabou, Amadou, Enow, Priscilla, Mbu, Eyongetah, Manga, Martin, Ndobe, Mercy, Nasah, Judith, Ekossono, Elle Nathalie Syntyche, Bouseko, Mireille Teno, Kitetele, Faustin, Lelo, Patricia, Diafouka, Merlin Isidore Justin, Mafoua, Adolphe, Nsonde, Dominique Mahambou, Bihira, Uitonze Aime Maurice, Dusabe, Marie Chantal, Feza, Rosine, Habanabashaka, Jean Claude, Habumuremyi, Viateur, Igizeneza, Ernestine, Kamigisha, Anne Marie, Kubwimana, Gallican, Maniriho, Gilbert, Mbaraga, Gilbert, Muhoza, Benjamin, Mukakarangwa, Jeanne, Mukamana, Joyce, Mukanyirigira, Patricie, Mukeshimana, Yvone Claude, Munyaneza, Athanase, Murenzi, Gad, Musaninyange, Jacqueline, Nyiraneza, Jules Ndumuhire, Ntarambirwa, Fidele, Nyiraneza, Marie Louise, Tuyishime, Josette, Tuyishimire, Yvonne, Ubandutira, Alexis, Umugiraneza, Florance, Umugwaneza, Rosine, Uwamahoro, Olive, Uwamahoro, Pauline, Uwambaje, Marie Victoire, Uwimpuhwe, Clarisse, Uwiragiye, Siphora, Kuhn, Yee Yee, Adera, Felix, Adhiambo, Beatricec, Aggrey, Khaemba, Akadikor, Daniel, Ambulla, Felix, Apiyo, Dorah, Ariya, Patrick, Atemba, Naftal, Ayodi, Fridah, Benard, Chirchir, Bett, Maureen, Birgen, Serafine, Bwalei, Rael, Chebon, Nancy, Chebor, Valentine Jirry, Chebuiywo, Philip, Chemutai, Jacline, Chepkorir, Emily, Chepseba, Carolyne, Chirchir, John, Diero, Lameck, Dukwa, Benard, Elphas, Alice, Etyang, Tom, Idiama, Agnes, Jebichuko, Ann, Jepchumba, Delvine, Juma, Churchill, Juma, Maureen, Juma, Sheila, Kadima, Julie, Karani, Rose, Keitany, Christopher, Keter, Pricilla, Kiavoga, Lucy, Kibet, Harrison, Kimutai, Ruth, Kiplagat, Mutai, Kiprono, Wilfred, Kipruto, Nicholas Kogei, Kirimi, Asenath, Koech, Zeddy, Kosgei, Carolyne, Kutto, Karen, Kweyu, Mildred, Liech, Ephraim Kenneth, Limo, Milka, Maina, Rose, Marumbu, Priscah, Masese, Agnes, Mochotto, Patricia, Molly, Omudeck, Momanyi, Tom, Murutu, John W., Mwanda, Praxidis, Ndakalu, Lillian, Nderitu, Rose N., Obatsa, Sarah, Obiga, Fredrick, Oboya, Moses, Odhiambo, Joseph, Olaya, George, Omanyala, Oscar, Oray, Christine, Otieno, Molly, Otwane, Modesta Toto, Ouma, Paul, Owuor, Charles, Pepela, Doris Tutu, Pessah, Collins, Rotich, Evans, Rotich, Edwin K., Rutto, Titus C., Shikuku, Monica, Sibweche, Rose Naliaka, Simiyu, Robert Wanyonyi, Siria, Hellen, Some, Michael, Songok, Winnie Cherotich, Tanui, Immaculate, Wafula, Grace, Wambura, Rebecca, Wanjala, Ellah, Wanyama, Carolyne, Wanyonyi, Hellen, Woyakapel, Emmanuel, Zelbabel, Wandera, Gwimo, Dikengela, Kinyota, Ester, Lwali, Jerome, Lyamuya, Rita, Machemba, Richard, Mathias, Julia, Mkombachepa, Lilian, Mokiwa, Athuman, Mushi, Ombeni, Ndunguru, Charles, Ngonyani, Kapella, Nyaga, Charles, Ruta, Happiness, Urassa, Mark, Akanyihayo, James, Arinaitwe, Arnold, Batuuka, Jesca, Birungi, Walusimbi, Bugembe, John Nyanzi, Ddungu, Ahmed, Francis, Kato, Imran, Bangira, Kafuuma, George William, Kalulue, John Bosco, Kanaabi, Grace, Kanyesigye, Michale, Karuhanga, Godfery, Kasozi, Charles, Kasule, Godfrey, Katusime, Assumpta, Kibalama, Donozio, Kimera, Simon Peter, Kulusumu, Namatovu, Lule, Yusuf, Lwanga, Isaac, Mluindwa, Margaret, Moses, Jemba, Mubarak, Sseremba, Muggaga, Daniel, Mukalazi, Evelyn, Muleebwa, Joseph, Mulema, Derick, Musisi, Ivan, Muwawu, John, Muyindike, Winnie, Mwaka, Dick, Naava, Milly, Nabiyki, Immaculate, Nabusulwa, Agnes, Nakabugo, Dorah, Nakamya, Esther, Nakanwagi, Daisy, Nakato, Oliver, Nakayi, Lydian, Nakigozi, Patience, Nakku, Juliet, Nakuya, Juliet, Nakyomu, Justine, Namayanja, Joan, Namirembe, Sarah, Namugumya, Juliet, Namukasa, Ezereth, Namulindwa, Viola, Nankya, Irene, Nannyondo, Grace Mugagga, Nansamba, Harriet, Nansera, Denis, Nanyanzi, Brenda, Nanyonjo, Esther Celina, Nayiga, Irene, Opira, Isaac, Owarwo, Noela C., Resty, Sserunkuma, Semuwemba, Haruna, Senoga, Julius, Sseguya, Gerald, Ssekyewa, John Paul, Ssemakadde, Matthew, Tebajjwa, Jonah, Tugumisirize, Doreen, Tushemerirwe, Robinah, Waliyi, Kawuki, Althoff, Keri, Bishop, Jennifer, Gill, M J., Loutfy, Mona, Smith, Graham, Bamford, Laura, Black, Anthony, Brice, Asia, Brown, Sheldon, Colasanti, Jonathan, Duarte, Piper, Firnhaber, Cynthia, Goetz, Matthew, Grasso, Chris, Gripshover, Barbara, Horberg, Michael, Kelly, Rita, Levine, Ken, Luu, Mitchell, Marconi, Vincent, Maroney, Karen, Mayer, Kenneth, Mayor, Angel, Mcgowan, Catherine, Multani, Ami, Napravnik, Sonia, Nijhawan, Ank, Novak, Richard, Palella, Frank, Rodriguez, Maria C., Scott, Mia, Tedaldi, Ellen, Willig, James, Cornell, Morna, Davies, Mary?Ann, Egger, Matthias, Haas, Andreas, Bereng, Monkoe, Kalake, Maleshoane, Lenela, Keketso, Seretse, Relebohile, Chintenga, Matthews, Chiwoko, Jane, Gumulira, Joe, Huwa, Jacqueline, Maluwa, Rafique, Matanje, Beatrice, Mbewe, Ronald, Mfungwe, Sunshine, Mphande, Zakaliah, Tweya, Hannock, Rafael, Idiovino, Apolles, Patti, Beneke, Eunice, Dlamini, Siphephelo, Edson, Claire, Eley, Brian, Euvrard, Jonathan, Fatti, Geoffrey, Goeieman, Bridgette, Grimwood, Ashraf, Huang, David, Hugo, Susan, Ismail, Zahiera, Jennings, Lauren, Mathenjwa, Thulile, Monteith, Lizette, Mshweshwe, Zamuxolo, Ntuli, Mfundi, Ndlovu, En, Ndlozi, Hloniphile, Noyakaza, Sylvia, Prozesky, Hans, Rabie, Helena, Sipambo, Nosisa, Technau, Karl?Günter, Tembe, Thokozani, Xaba, Nontando, Njobvu, Thandiwe, Munthaly, Mary, Mwetwa, Elly, Kabeba, Gillian, Mwendafilumba, Derrick, Maanguka, Ethel, Manyika, Nelly, Mwansa, Chalwe, Banda, Future, Mwenda, Dickson, Bwalya, Abel, Shapi, Leah, Syame, Kasapo, Sashi, Rita, Mulenga, Chisha, Nanyangwe, Ruth, Chimbetete, Cleophas, Chinofunga, A., Mhike, J., Mubvigwi, E., Nyika, F., Quarter, Kumbirai Pise, Arikawa, Shino Chassagne, Becquet, Renaud, Bernard, Charlotte, Dabis, François, Desmonde, Sophie, Dahourou, Désiré, Ekouevi, Didier Koumavi, Jaquet, Antoine, Jesson, Julie, Leroy, Valeriane, Malateste, Karen, Rabourdin, Elodie, Tiendrebeogo, Thierry, Assogba, Michée, Zannou, Djimon Marcel, Hounhoui, Ghislaine, Bere, Denise, Poda, Armel, Pooda, Gbolo, Traore, Richard, Abauble, Yao, Abby, Ouattara, Acquah, Patrick, Andoble, Valérie, Aude, Yobo N'Dzama, Azani, Jean?Claude, Berete, Oka, Beugre, Jacques Daple, Bohoussou, Caroline Yao, Brou, Simon Boni Emmanuel, Chenal, Henri, Cissé, Abdoulaye, Coulibaly, Nambate, Dainguy, Marie Evelyne, Daligou, Marcelle, D' Aquin, Toni Thomas, Dasse, Claude Desire, Folquet, Madeleine Amorissani, Gnepa, Guy, Gobe, Olivier, Guira, Salif, Hawerlander, Denise, Horo, Apollinaire, Kanga, Guillaume, Messou, Zobo Konan Eugène, Minga, Kla Albert, Moh, Raoul, N'Gbeche, Mariesylvie, Ogbo, Patricia, Oulai, Mathieu, Stéphanie, Se, Eboua, Tanoh, Valère, Itchy Max, Afrane, Adwoa Kumiwa Asare, Akrofi, Esther, Andoh, John Christian, Renner, Lorna, Bagayoko, Awa, Bagayoko, Kadidiatou, Bah, Abdou Salam, Berthe, Alima, Coulibaly, Boureïma, Coulibaly, Fatimata, Coulibaly, Yacouba Aba, Diakité, Aïssata, Bocoum, Fatoumata, Boré, Fatoumata, Dicko, Fatoumata, Koné, Odile, Sylla, Mariam, Tangara, Assitan, Traoré, Mamadou, Seydi, Moussa, Amegatse, Edmond, Djossou, Julienne, Takassi, Elom, and Palanga, Sénam
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HIV (Viruses) -- Care and treatment -- Patient outcomes ,Public health administration -- Evaluation ,Health - Abstract
: Introduction: Interruptions in treatment pose risks for people with HIV (PWH) and threaten progress in ending the HIV epidemic; however, the COVID‐19 pandemic's impact on HIV service delivery across diverse settings is not broadly documented. Methods: From September 2020 to March 2021, the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium surveyed 238 HIV care sites across seven geographic regions to document constraints in HIV service delivery during the first year of the pandemic and strategies for ensuring care continuity for PWH. Descriptive statistics were stratified by national HIV prevalence ( Results: Questions about pandemic‐related consequences for HIV care were completed by 225 (95%) sites in 42 countries with low (n = 82), medium (n = 86) and high (n = 57) HIV prevalence, including low‐ (n = 57), lower‐middle (n = 79), upper‐middle (n = 39) and high‐ (n = 50) income countries. Most sites reported being subject to pandemic‐related restrictions on travel, service provision or other operations (75%), and experiencing negative impacts (76%) on clinic operations, including decreased hours/days, reduced provider availability, clinic reconfiguration for COVID‐19 services, record‐keeping interruptions and suspension of partner support. Almost all sites in low‐prevalence and high‐income countries reported increased use of telemedicine (85% and 100%, respectively), compared with less than half of sites in high‐prevalence and lower‐income settings. Few sites in high‐prevalence settings (2%) reported suspending antiretroviral therapy (ART) clinic services, and many reported adopting mitigation strategies to support adherence, including multi‐month dispensing of ART (95%) and designating community ART pick‐up points (44%). While few sites (5%) reported stockouts of first‐line ART regimens, 10–11% reported stockouts of second‐ and third‐line regimens, respectively, primarily in high‐prevalence and lower‐income settings. Interruptions in HIV viral load (VL) testing included suspension of testing (22%), longer turnaround times (41%) and supply/reagent stockouts (22%), but did not differ across settings. Conclusions: While many sites in high HIV prevalence settings and lower‐income countries reported introducing or expanding measures to support treatment adherence and continuity of care, the COVID‐19 pandemic resulted in disruptions to VL testing and ART supply chains that may negatively affect the quality of HIV care in these settings., INTRODUCTION The COVID‐19 pandemic has had major direct and indirect impacts on population health globally, through disruptions in the accessibility and quality of basic health services [1], in supply chains [...]
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- 2022
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14. HPV vaccination in Africa in the COVID-19 era: a cross-sectional survey of healthcare providers’ knowledge, training, and recommendation practices
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Fokom Domgue, Joel, primary, Dille, Issimouha, additional, Kapambwe, Sharon, additional, Yu, Robert, additional, Gnangnon, Freddy, additional, Chinula, Lameck, additional, Murenzi, Gad, additional, Mbatani, Nomonde, additional, Pande, Mala, additional, Sidibe, Fatoumata, additional, Kamgno, Joseph, additional, Traore, Bangaly, additional, Fazazi, Hicham El, additional, Diop, Mamadou, additional, Tebeu, Pierre-Marie, additional, Diomande, Mohenou Isidore, additional, Lecuru, Fabrice, additional, Adewole, Isaac, additional, Plante, Marie, additional, Basu, Partha, additional, Dangou, Jean-Marie, additional, and Shete, Sanjay, additional
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- 2024
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15. Awareness and Willingness to Use HIV Infection Pre-Exposure Prophylaxis among Rwandan Men Who Have Sex with Men: Findings from a Web-based Survey
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Munyaneza, Athanase, primary, Patel, Viraj V., additional, Gutierrez, Nataly Rios, additional, Shi, Qiuhu, additional, Muhoza, Benjamin, additional, Kubwimana, Gallican, additional, Ross, Jonathan, additional, Nsereko, Etienne, additional, Murenzi, Gad, additional, Nyirazinyoye, Laetitia, additional, Mutesa, Leon, additional, Anastos, Kathryn, additional, and Adedimeji, Adebola, additional
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- 2023
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16. Type-specific persistence, clearance and incidence of high-risk HPV among screen-positive Rwandan women living with HIV
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Murenzi, Gad, Tuyisenge, Patrick, Kanyabwisha, Faustin, Munyaneza, Athanase, Muhoza, Benjamin, Kubwimana, Gallican, Murangwa, Anthere, Mutesa, Leon, Anastos, Kathryn, and Castle, Philip E.
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- 2021
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17. Awareness and Willingness to Use HIV Pre-exposure Prophylaxis Among Men Who Have Sex With Men in Rwanda: A Cross-Sectional Descriptive Survey
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Munyaneza, Athanase, Adedimeji, Adebola, Kim, Hae-Young, Shi, Qiuhu, Hoover, Donald R, Ross, Jonathan, Murchison, Lynn, Murenzi, Gad, Kabahizi, Jules, Gasana, Josephine, Nsengiyumva, Boniface, Kubwimana, Gallican, Kanyabwisha, Faustin, Muhoza, Benjamin, Ingabire, Charles, Mutesa, Leon, Castle, Philip E, Palefsky, Joel M., Anastos, Kathryn, and Patel, Viraj V.
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- 2021
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18. Real‐world use and outcomes of dolutegravir‐containing antiretroviral therapy in HIV and tuberculosis co‐infection: a site survey and cohort study in sub‐Saharan Africa
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Romo, Matthew L., Brazier, Ellen, Mahambou?Nsondé, Dominique, De Waal, Reneé, Sekaggya?Wiltshire, Christine, Chimbetete, Cleophas, Muyindike, Winnie R., Murenzi, Gad, Kunzekwenyika, Cordelia, Tiendrebeogo, Thierry, Muhairwe, Josephine A., Lelo, Patricia, Dzudie, Anastase, Twizere, Christelle, Rafael, Idiovino, Ezechi, Oliver C., Diero, Lameck, Yotebieng, Marcel, Fenner, Lukas, Wools?Kaloustian, Kara K., Shah, N. Sarita, and Nash, Denis
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HIV (Viruses) -- Drug therapy -- Patient outcomes ,Tuberculosis -- Care and treatment -- Patient outcomes ,Highly active antiretroviral therapy -- Complications and side effects -- Patient outcomes ,Health - Abstract
: Introduction: Dolutegravir is being scaled up globally as part of antiretroviral therapy (ART), but for people with HIV and tuberculosis co‐infection, its use is complicated by a drug–drug interaction with rifampicin requiring an additional daily dose of dolutegravir. This represents a disadvantage over efavirenz, which does not have a major drug–drug interaction with rifampicin. We sought to describe HIV clinic practices for prescribing concomitant dolutegravir and rifampicin, and characterize virologic outcomes among patients with tuberculosis co‐infection receiving dolutegravir or efavirenz. Methods: Within the four sub‐Saharan Africa regions of the International epidemiology Databases to Evaluate AIDS consortium, we conducted a site survey (2021) and a cohort study (2015–2021). The cohort study used routine clinical data and included patients newly initiating or already receiving dolutegravir or efavirenz at the time of tuberculosis diagnosis. Patients were followed from tuberculosis diagnosis until viral suppression ( Results: In the survey, 86 of 90 (96%) HIV clinics in 18 countries reported prescribing dolutegravir to patients who were receiving rifampicin as part of tuberculosis treatment, with 77 (90%) reporting that they use twice‐daily dosing of dolutegravir, of which 74 (96%) reported having 50 mg tablets available to accommodate twice‐daily dosing. The cohort study included 3563 patients in 11 countries, with 67% newly or recently initiating ART. Among patients receiving dolutegravir (n = 465), the cumulative incidence of viral suppression was 58.9% (95% confidence interval [CI]: 54.3–63.3%), switching ART regimen was 4.1% (95% CI: 2.6–6.2%) and loss to program/death was 23.4% (95% CI: 19.7–27.4%). Patients receiving dolutegravir had improved viral suppression compared with patients receiving efavirenz who had a tuberculosis diagnosis before site dolutegravir availability (adjusted subdistribution hazard ratio [aSHR]: 1.47, 95% CI: 1.28–1.68) and after site dolutegravir availability (aSHR 1.28, 95% CI: 1.08–1.51). Conclusions: At a programmatic level, dolutegravir was being widely prescribed in sub‐Saharan Africa for people with HIV and tuberculosis co‐infection with a dose adjustment for the drug–drug interaction with rifampicin. Despite this more complex regimen, our cohort study revealed that dolutegravir did not negatively impact viral suppression., INTRODUCTION Dolutegravir, an integrase strand transfer inhibitor (InSTI), is recommended as part of preferred antiretroviral therapy (ART) regimens for people with HIV (PWH) [1, 2]. Globally, HIV treatment programs are [...]
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- 2022
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19. Reducing time to differentiated service delivery for newly-diagnosed people living with HIV in Kigali, Rwanda: a pilot, unblinded, randomized controlled trial.
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Ross, Jonathan, Anastos, Kathryn, Hill, Sarah, Remera, Eric, Rwibasira, Gallican N, Ingabire, Charles, Umwiza, Francine, Munyaneza, Athanase, Muhoza, Benjamin, Zhang, Chenshu, Nash, Denis, Yotebieng, Marcel, and Murenzi, Gad
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HIV-positive persons ,VIRAL load ,ANTIRETROVIRAL agents ,HEALTH facilities - Abstract
Background: Differentiated service delivery (DSD) programs for people living with HIV (PWH) limit eligibility to patients established on antiretroviral therapy (ART), yet uncertainty exists regarding the duration on ART necessary for newly-diagnosed PWH to be considered established. We aimed to determine the feasibility, acceptability, and preliminary impact of entry into DSD at six months after ART initiation for newly-diagnosed PWH. Methods: We conducted a pilot randomized controlled trial in three health facilities in Rwanda. Participants were randomized to: (1) entry into DSD at six months after ART initiation after one suppressed viral load (DSD-1VL); (2) entry into DSD at six months after ART initiation after two consecutive suppressed viral loads (DSD-2VL); (3) treatment as usual (TAU). We examined feasibility by examining the proportion of participants assigned to intervention arms who entered DSD, assessed acceptability through patient surveys and by examining instances when clinical staff overrode the study assignment, and evaluated preliminary effectiveness by comparing study arms with respect to 12-month viral suppression. Results: Among 90 participants, 31 were randomized to DSD-1VL, 31 to DSD-2VL, and 28 to TAU. Among 62 participants randomized to DSD-1VL or DSD-2VL, 37 (60%) entered DSD at 6 months while 21 (34%) did not enter DSD because they were not virally suppressed. Patient-level acceptability was high for both clinical (mean score: 3.8 out of 5) and non-clinical (mean score: 4.1) elements of care and did not differ significantly across study arms. Viral suppression at 12 months was 81%, 81% and 68% in DSD-1VL, DSD-2VL, and TAU, respectively (p = 0.41). Conclusions: The majority of participants randomized to intervention arms entered DSD and had similar rates of viral suppression compared to TAU. Results suggest that early DSD at six months after ART initiation is feasible for newly-diagnosed PWH, and support current WHO guidelines on DSD. Trial registration: Clinicaltrials.gov NCT04567693; first registered on September 28, 2020. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Facility-Based Indicators to Manage and Scale Up Cervical Cancer Prevention and Care Services for Women Living With HIV in Sub-Saharan Africa: a Three-Round Online Delphi Consensus Method.
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Davidović, Maša, Asangbeh, Serra Lem, Taghavi, Katayoun, Dhokotera, Tafadzwa, Jaquet, Antoine, Musick, Beverly, Van Schalkwyk, Cari, Schwappach, David, Rohner, Eliane, Murenzi, Gad, Wools-Kaloustian, Kara, Anastos, Kathryn, Omenge, Orang'o Elkanah, Boni, Simon Pierre, Duda, Stephany N., von Groote, Per, and Bohlius, Julia
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- 2024
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21. Low birth weight among infants and pregnancy outcomes among women living with HIV and HIV-negative women in Rwanda
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Zotova, Natalia, primary, Munyaneza, Athanase, additional, Murenzi, Gad, additional, Kubwimana, Gallican, additional, Adedimeji, Adebola, additional, Anastos, Kathryn, additional, Yotebieng, Marcel, additional, and CA-IeDEA, CA-IeDEA, additional
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- 2023
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22. Toward 70% cervical cancer screening coverage: Technical challenges and opportunities to increase access to human papillomavirus (HPV) testing
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Kundrod, Kathryn A., primary, Jeronimo, Jose, additional, Vetter, Beatrice, additional, Maza, Mauricio, additional, Murenzi, Gad, additional, Phoolcharoen, Natacha, additional, and Castle, Philip E., additional
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- 2023
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23. Association Between Time to Antiretroviral Therapy and Loss to Care Among Newly Diagnosed Rwandan People Living with Human Immunodeficiency Virus
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Murenzi, Gad, primary, Kim, Hae-Young, additional, Shi, Qiuhu, additional, Muhoza, Benjamin, additional, Munyaneza, Athanase, additional, Kubwimana, Gallican, additional, Remera, Eric, additional, Nsanzimana, Sabin, additional, Yotebieng, Marcel, additional, Nash, Denis, additional, Anastos, Kathryn, additional, and Ross, Jonathan, additional
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- 2023
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24. Impact of the human papillomavirus vaccine in low-resource settings
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Murenzi, Gad, primary and Mungo, Chemtai, additional
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- 2023
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25. HPV vaccination in Africa in the COVID-19 era: a cross-sectional survey of healthcare providers' knowledge, training, and recommendation practices.
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Domgue, Joel Fokom, Dille, Issimouha, Kapambwe, Sharon, Yu, Robert, Gnangnon, Freddy, Chinula, Lameck, Murenzi, Gad, Mbatani, Nomonde, Pande, Mala, Sidibe, Fatoumata, Kamgno, Joseph, Traore, Bangaly, El Fazazi, Hicham, Diop, Mamadou, Tebeu, Pierre-Marie, Diomande, Mohenou Isidore, Lecuru, Fabrice, Adewole, Isaac, Plante, Marie, and Basu, Partha
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- 2024
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26. Review of: "Histopathological Patterns of Cervical Cancer Among Females Presenting to Makerere University Pathology Core Reference Laboratory. A 5-Year Review"
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Murenzi, Gad, primary
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- 2023
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27. The first Choosing Wisely Africa conference: a roadmap to value-based cancer care in Africa (16th December 2022, Senegal)
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Mushonga, Melinda, primary, Abdhamid, Omar, additional, Ntizimira, Christian, additional, Murenzi, Gad, additional, Ka, Sidy, additional, Hammad, Nazik, additional, and Rubagumya, Fidel, additional
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- 2023
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28. An analysis of the African cancer research ecosystem: tackling disparities
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Rubagumya, Fidel, primary, Carson, Laura, additional, Mushonga, Melinda, additional, Manirakiza, Achillle, additional, Murenzi, Gad, additional, Abdihamid, Omar, additional, Athman, Abeid, additional, Mungo, Chemtai, additional, Booth, Christopher, additional, and Hammad, Nazik, additional
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- 2023
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29. The Impact of WHO’s Treat All Guideline on Disease Progression Among People Enrolled in HIV Care in Central Africa: An Observational Cohort Data by Target Trial Design with Multistate Modeling
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Zhu, Jiaqi, primary, Zhang, Hongbin, additional, Brazier, Ellen, additional, Tymejczyk, Olga, additional, Yotebieng, Marcel, additional, Kimmel, April D., additional, Anastos, Kathryn, additional, Ross, Jonathan, additional, Hoover, Donald R., additional, Shi, Qiuhu, additional, Murenzi, Gad, additional, Nsonde, Dominique Mahambu, additional, Dzudie, A, additional, Lelo, Patricia, additional, Christella, Christella, additional, and Nash, Denis, additional
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- 2023
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30. COVID-19 associated changes in HIV service delivery over time in Central Africa: Results from facility surveys during the first and second waves of the pandemic
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Rogers, Ajeh, primary, Brazier, Ellen, additional, Dzudie, Anastase, additional, Adedimeji, Adebola, additional, Yotebieng, Marcel, additional, Muhoza, Benjamin, additional, Twizere, Christella, additional, Lelo, Patricia, additional, Nsonde, Dominique, additional, Mafoua, Adolphe, additional, Munyaneza, Athanase, additional, Gateretse, Patrick, additional, Diafouka, Merlin, additional, Murenzi, Gad, additional, Niyongabo, Théodore, additional, Anastos, Kathryn, additional, and Nash, Denis, additional
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- 2022
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31. Agreement between Xpert and AmpFire tests for high-risk human papillomavirus among HIV-positive women in Rwanda
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Murangwa, Anthere, primary, Desai, Kanan T., additional, Gage, Julia C., additional, Murenzi, Gad, additional, Tuyisenge, Patrick, additional, Kanyabwisha, Faustin, additional, Musafili, Aimable, additional, Kubwimana, Gallican, additional, Mutesa, Leon, additional, Anastos, Kathryn, additional, Kim, Hae-Young, additional, and Castle, Philip E., additional
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- 2022
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32. The impact of WHO’s Treat All guideline on disease progression among people enrolled in HIV care in Central Africa: an observational cohort data by target trial design with multistate modeling
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Zhu, Jiaqi, primary, Zhang, Hongbin, additional, Brazier, Ellen, additional, Tymejczyk, Olga, additional, Yotebieng, Marcel, additional, Kimmel, April D., additional, Anastos, Kathryn, additional, Ross, Jonathan, additional, Hoover, Donald R, additional, Shi, Qiuhu, additional, Murenzi, Gad, additional, Nsonde, Dominique, additional, Dzudie, Anastase, additional, Lelo, Patricia, additional, Twizere, Christella, additional, and Nash, Denis, additional
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- 2022
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33. Long-term human papillomavirus vaccination effectiveness and immunity in Rwandan women living with and without HIV: a study protocol
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Murenzi, Gad, primary, Shumbusho, Fabienne, additional, Hansen, Natasha, additional, Munyaneza, Athanase, additional, Gage, Julia C, additional, Muhoza, Benjamin, additional, Kanyabwisha, Faustin, additional, Pierz, Amanda, additional, Tuyisenge, Patrick, additional, Anastos, Kathryn, additional, and Castle, Philip E, additional
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- 2022
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34. Comparison of AmpFire and MY09/11 Assays for HPV Genotyping in Anogenital Specimen of Rwandan Men Who Have Sex with Men
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Kanyabwisha, Faustin, primary, Kim, Hae-Young, additional, Shi, Qiuhu, additional, Murenzi, Gad, additional, Tuyisenge, Patrick, additional, Kubwimana, Gallican, additional, Munyaneza, Athanase, additional, Murangwa, Anthere, additional, Turizigiye, Onesphore, additional, Costa, Maria Da, additional, Nsengiyumva, Boniface, additional, Chen, Xin, additional, Mutesa, Leon, additional, Anastos, Kathryn, additional, and Palefsky, Joel, additional
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- 2022
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35. Viral Load Status Before Switching to Dolutegravir-Containing Antiretroviral Therapy and Associations With Human Immunodeficiency Virus Treatment Outcomes in Sub-Saharan Africa.
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Romo, Matthew L, Edwards, Jessie K, Semeere, Aggrey S, Musick, Beverly S, Urassa, Mark, Odhiambo, Francesca, Diero, Lameck, Kasozi, Charles, Murenzi, Gad, Lelo, Patricia, Wyka, Katarzyna, Kelvin, Elizabeth A, Sohn, Annette H, Wools-Kaloustian, Kara K, Nash, Denis, and (IeDEA), International epidemiology Databases to Evaluate AIDS
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HIV infection prognosis ,HIV infections ,PUBLIC health surveillance ,CONFIDENCE intervals ,HIV integrase inhibitors ,VIRAL load ,MULTIVARIATE analysis ,REGRESSION analysis ,HIGHLY active antiretroviral therapy ,TREATMENT effectiveness ,PATIENT monitoring ,TUBERCULOSIS ,DESCRIPTIVE statistics ,DECISION making in clinical medicine ,DATA analysis software ,PROPORTIONAL hazards models - Abstract
Background Dolutegravir is being rolled out globally as part of preferred antiretroviral therapy (ART) regimens, including among treatment-experienced patients. The role of viral load (VL) testing before switching patients already on ART to a dolutegravir-containing regimen is less clear in real-world settings. Methods We included patients from the International epidemiology Databases to Evaluate AIDS consortium who switched from a nevirapine- or efavirenz-containing regimen to one with dolutegravir. We used multivariable cause-specific hazards regression to estimate the association of the most recent VL test in the 12 months before switching with subsequent outcomes. Results We included 36 393 patients at 37 sites in 5 countries (Democratic Republic of the Congo, Kenya, Rwanda, Tanzania, Uganda) who switched to dolutegravir from July 2017 through February 2020, with a median follow-up of approximately 11 months. Compared with those who switched with a VL <200 copies/mL, patients without a recent VL test or with a preswitch VL ≥1000 copies/mL had significantly increased hazards of an incident VL ≥1000 copies/mL (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.99–4.19 and aHR, 6.60; 95% CI, 4.36–9.99, respectively) and pulmonary tuberculosis or a World Health Organization clinical stage 4 event (aHR, 4.78; 95% CI, 2.77–8.24 and aHR, 13.97; 95% CI, 6.62–29.50, respectively). Conclusions A VL test before switching to dolutegravir may help identify patients who need additional clinical monitoring and/or adherence support. Further surveillance of patients who switched to dolutegravir with an unknown or unsuppressed VL is needed. [ABSTRACT FROM AUTHOR]
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- 2022
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36. Association of cardiovascular disease risk with liver steatosis and fibrosis in people living with hiv in low- and middle-income countries.
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Kuniholm MH, Murenzi G, Shumbusho F, Brazier E, Plaisy MK, Mensah E, Wandeler G, Riebensahm C, Chihota BV, Samala N, Diero L, Semeere AS, Chanyachukul T, Borse R, Nguyen DTH, Perazzo H, Lopez-Iniguez A, Castilho JL, Maruri F, and Jaquet A
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Objective: To understand the relationship between cardiovascular disease (CVD) risk and liver steatosis and fibrosis among people living with HIV (PLWH) ≥40 years on antiretroviral therapy (ART) in low- and middle-income countries (LMIC)., Design: We used cross-sectional behavioral and clinical data collected during study enrollment visits in 2020-2022 for the Sentinel Research Network of International epidemiology Databases to Evaluate AIDS (SRN of IeDEA)., Methods: Ten-year CVD risk was calculated using 2019 World Health Organization non-laboratory and laboratory models. Transient elastography (TE) was used to assess liver disease. Presence of steatosis and significant fibrosis were defined by Controlled Attenuation Parameter (CAP) ≥248 dB/m and liver stiffness measurement (LSM) ≥7.1 kPa, respectively. Participants with viral hepatitis, hazardous alcohol consumption and unsuppressed HIV viral load were excluded from the analysis. Logistic regression was used to estimate odds ratios, adjusting for study site, CD4 T cell count, stavudine and didanosine exposure, and in models stratified by sex and geographic region., Results: There were 1,750 participants from nine LMIC. Median CVD risk was 3% for both non-laboratory and laboratory-based models. Adjusted odds ratios (ORs) for steatosis and significant fibrosis associated with laboratory CVD risk (≥10% vs. <5%) were OR = 1.83 (95% confidence interval:(CI) = 1.21-2.76; P = 0.004) and OR = 1.62 (95% CI = 0.85-3.07; P = 0.14), respectively. Associations of CVD risk with steatosis were stronger in males and among participants at study sites outside Africa., Conclusions: Higher CVD risk was associated with steatosis but not with significant fibrosis in PLWH in our LMIC cohort., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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37. Development and calibration of a mathematical model of HIV outcomes among Rwandan adults: informing equitable achievement of targets in Rwanda.
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Kimmel AD, Pan Z, Brazier E, Murenzi G, Muhoza B, Yotebieng M, Anastos K, and Nash D
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Background: We developed and calibrated the Central Africa-International epidemiology Databases to Evaluate AIDS (CA-IeDEA) HIV policy model to inform equitable achievement of global goals, overall and across sub-populations, in Rwanda., Methods: We created a deterministic dynamic model to project adult HIV epidemic and care continuum outcomes, overall and for 25 subpopulations (age group, sex, HIV acquisition risk, urbanicity). Data came from the Rwanda cohort of CA-IeDEA, 2004-2020; Rwanda Demographic and Health Surveys, 2005, 2010, 2015; Rwanda Population-based HIV Impact Assessment, 2019; and the literature and reports. We calibrated the model to 47 targets by selecting the 50 best-fitting parameter sets among 20,000 simulations. Calibration targets reflected epidemic (HIV prevalence, incidence), global goals (percentage on antiretroviral therapy (ART) among diagnosed, percentage virally suppressed among on ART) and other (number on ART, percentage virally suppressed) indicators, overall and by sex. Best-fitting sets minimized the summed absolute value of the percentage deviation (AVPD) between model projections and calibration targets. Good model performance was mean AVPD ≤5% across the 50 best-fitting sets and/or projections within the target confidence intervals; acceptable was mean AVPD >5% and ≤15%., Results: Across indicators, 1,841 of 2,350 (78.3%) model projections were a good or acceptable fit to calibration targets. For HIV epidemic indicators, 256 of 300 (85.3%) projections were a good fit to targets, with the model performing better for women (83.3% a good fit) than for men (71.7% a good fit). For global goals indicators, 96 of 100 (96.0%) projections were a good fit; model performance was similar for women and men. For other indicators, 653 of 950 (68.7%) projections were a good or acceptable fit. Fit was better for women than for men (percentage virally suppressed only) and when restricting targets for number on ART to 2013 and beyond., Conclusions: The CA-IeDEA HIV policy model fits historical data and can inform policy solutions for equitably achieving global goals to end the HIV epidemic in Rwanda. High-quality, unbiased population-based data, as well as novel approaches that account for calibration target quality, are critical to ongoing use of mathematical models for programmatic planning.
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- 2024
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38. Transition to dolutegravir-based ART in 35 low- and middle-income countries: a global survey of HIV care clinics.
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Zaniewski E, Skrivankova VW, Brazier E, Avihingsanon A, Cardoso SW, Cesar C, Chenal H, Crabtree-Ramírez BE, Ditangco RA, Ebasone PV, Eley B, Euvrard JG, Fatti G, Huwa JM, Lelo P, Machado DM, Messou EK, Minga AK, Muleebwa J, Mundhe S, Murenzi G, Muyindike WR, Nsonde DM, Obatsa SM, Odhiambo J, Prozesky HW, Rungmaitree S, Semeere AS, Seydi M, Sipambo N, Sudjaritruk T, Technau KG, Tiendrebeogo T, Twizere C, and Ballif M
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Objective: We studied the transition to dolutegravir-containing antiretroviral therapy (ART) at HIV treatment clinics within the International epidemiology Databases to Evaluate AIDS (IeDEA)., Design: Site-level survey conducted in 2020-2021 among HIV clinics in low- and middle-income countries (LMICs)., Methods: We assessed the status of dolutegravir rollout and viral load and drug resistance testing practices for patients on ART switching to dolutegravir-based regimens. We used generalized estimating equations to assess associations between clinic rollout of both first- and second-line dolutegravir-based ART regimens (dual rollout) and site-level factors., Results: Of 179 surveyed clinics, 175 (98%) participated; 137 (78%) from Africa, 30 (17%) from the Asia-Pacific, and 8 (5%) from Latin America. Most clinics (80%) were in low- or lower-middle-income countries, and there were a mix of primary-, secondary- and tertiary-level clinics. Ninety percent reported rollout of first-line dolutegravir, 59% of second-line, 94% of first- or second-line and 55% of dual rollout. The adjusted odds of dual rollout were higher among tertiary-level (aOR 4.00; 95% CI 1.39 to 11.47) and secondary-level clinics (aOR 3.66; 95% CI 2.19 to 6.11) than in primary-level clinics. Over half (59%) of clinics that introduced first- or second-line dolutegravir-based ART required recent viral load testing before switching to dolutegravir, and 15% performed genotypic resistance testing at switch., Conclusions: Dolutegravir-based ART was rolled out at nearly all IeDEA clinics in LMICs, yet many switched patients to dolutegravir without recent viral load testing and drug resistance testing was rarely performed. Without such testing, drug resistance among patient switching to dolutegravir may go undetected., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2024
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39. PrEP in the key population community: a qualitative study of perspectives on pre-exposure prophylaxis by men who have sex with men and female sex workers in Kigali, Rwanda.
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Ross J, Gasana J, Zotova N, Ndabakuranye G, Mabano F, Ingabire C, Adedimeji A, Murenzi G, and Patel VV
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Background: Men who have sex with men (MSM) and female sex workers (FSW) are increasingly and disproportionately impacted by HIV in sub-Saharan Africa, yet current PrEP care models in this region are not optimized for these communities. Limited data exist describing experiences and preferences of MSM and FSW with respect to accessing and using PrEP., Methods: We conducted qualitative, semi-structured interviews with MSM and FSW recruited from three health centers and seven community organizations in Kigali, Rwanda. Data were analyzed using a mixed deductive and inductive approach to describe key themes related to initiating and adhering to PrEP., Results: Participants included 18 MSM and 14 FSW; 12 were using PrEP at the time of interview, 9 had previously used PrEP, and 11 had never used it. Participants highlighted the central role of their social networks as key sources of information about and support for PrEP use, and described a strong motivation to use PrEP as a way to protect both themselves and their communities from HIV. While stigma and discrimination were pervasive, these were experienced differently by MSM and FSW. Participants suggested community access points that allowed more discreet and less frequent contact with health care workers as important and desired strategies to improve engagement., Conclusions: These findings suggest that leveraging community resources for disseminating information about HIV prevention and delivering PrEP could contribute to successful implementation of PrEP for MSM and FSW in Rwanda and other settings in SSA., Competing Interests: Competing interests: The authors have no conflicts of interest or competing interests to declare.
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- 2024
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40. Facility-Based Indicators to Manage and Scale Up Cervical Cancer Prevention and Care Services for Women Living With HIV in Sub-Saharan Africa: a Three-Round Online Delphi Consensus Method.
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Davidović M, Asangbeh SL, Taghavi K, Dhokotera T, Jaquet A, Musick B, Van Schalkwyk C, Schwappach D, Rohner E, Murenzi G, Wools-Kaloustian K, Anastos K, Omenge OE, Boni SP, Duda SN, von Groote P, and Bohlius J
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- Humans, Female, Consensus, Delphi Technique, Africa South of the Sahara epidemiology, HIV Infections diagnosis, HIV Infections drug therapy, HIV Infections prevention & control, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Neoplasms prevention & control
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Background: Of women with cervical cancer (CC) and HIV, 85% live in sub-Saharan Africa, where 21% of all CC cases are attributable to HIV infection. We aimed to generate internationally acceptable facility-based indicators to monitor and guide scale up of CC prevention and care services offered on-site or off-site by HIV clinics., Methods: We reviewed the literature and extracted relevant indicators, grouping them into domains along the CC control continuum. From February 2021 to March 2022, we conducted a three-round, online Delphi process to reach consensus on indicators. We invited 106 experts to participate. Through an anonymous, iterative process, participants adapted the indicators to their context (round 1), then rated them for 5 criteria on a 5-point Likert-type scale (rounds 2 and 3) and then ranked their importance (round 3)., Results: We reviewed 39 policies from 21 African countries and 7 from international organizations; 72 experts from 15 sub-Saharan Africa countries or international organizations participated in our Delphi process. Response rates were 34% in round 1, 40% in round 2, and 44% in round 3. Experts reached consensus for 17 indicators in the following domains: primary prevention (human papillomavirus prevention, n = 2), secondary prevention (screening, triage, treatment of precancerous lesions, n = 11), tertiary prevention (CC diagnosis and care, n = 2), and long-term impact of the program and linkage to HIV service (n = 2)., Conclusion: We recommend that HIV clinics that offer CC control services in sub-Saharan Africa implement the 17 indicators stepwise and adapt them to context to improve monitoring along the CC control cascade., Competing Interests: S.L.A. received the Swiss Government Excellence Scholarship, No 2019.0741. The remaining authors have no funding or conflicts of interest to disclose., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2024
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41. Awareness and Willingness to Use HIV Infection Pre-Exposure Prophylaxis among Rwandan Men Who Have Sex with Men: Findings from a Web-based Survey.
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Munyaneza A, Patel VV, Gutierrez NR, Shi Q, Muhoza B, Kubwimana G, Ross J, Nsereko E, Murenzi G, Nyirazinyoye L, Mutesa L, Anastos K, and Adedimeji A
- Abstract
Introduction: Pre-exposure Prophylaxis (PrEP) is a daily pill intended to reduce the risk of acquiring Human Immunodeficiency Virus (HIV) when taken as prescribed. It is strongly recommended for Men who have sex with Men (MSM) at high risk of HIV transmission to minimize infection risk. Despite its proven effectiveness, there is a lack of information about awareness and willingness to use PrEP among Rwandan MSM. In the context of HIV acquisition, the purpose of this study was to ascertain the awareness and willingness to use PrEP among high-risk Rwandan MSM. The findings of this research will provide valuable perspectives to mold policy and direct the effective execution of PrEP within the country., Method: This is a cross-sectional study design that utilized a web-based survey conducted between April and June 2019 to assess awareness and willingness to use PrEP among sexually active MSM in Rwanda. A snowball sampling technique was used to recruit participants who were contacted via social medial such as WhatsApp and e-mail. To be eligible, participants were supposed to be sexually active, aged ≥18 years, self-identify as MSM, residence in Rwanda, self-reported engagement in receptive or insertive anal sex in the last 12 months, and self-reported HIV-negative sero-status. We assessed two primary outcomes: PrEP awareness (having ever heard of PrEP) and willingness to use PrEP within one month of completing the survey. Multivariable logistic regression was performed to identify participant characteristics associated with PrEP awareness and willingness to use it., Results: Among the 521 participants included in the analysis, 63% were aged below 24 years. The majority (73%) demonstrated awareness of PrEP. Factors associated with PrEP awareness included residing outside of the capital, Kigali, as opposed to living in Kigali (adjusted odds ratio [aOR] 2.35, 95% confidence interval [CI] 1.40-3.97), being in the age groups 18-24 years (aOR 2.28, 95% CI: 1.03-5.01) or 25-29 years (aOR 3.06, 95% CI 1.35-6.93) compared to those aged 30 or older, having higher education levels, such as completing secondary education (aOR 1.76, 95% CI 1.01-3.06) or university education (aOR 2.65, 95% CI 1.18-5.96) in contrast to having no education. Lastly, perceiving a benefit from PrEP (aOR 9.52, 95% CI 4.27-21.22), and engaging in vaginal sex with a woman using a condom in the last 12 months (aOR 1.82, 95% CI 1.14-2.91) versus not. Impressively, 96% of participants expressed a strong willingness to use PrEP., Conclusion: Among Rwandan MSM, there is a high level of awareness of PrEP, notably associated with factors such as residing outside Kigali, younger age, higher education, perceived benefits of PrEP and condom use during vaginal sex in the past year. Furthermore, a significant portion of participants demonstrated an intense desire to use PrEP, suggesting promising possibilities for its extensive implementation among this group of people. The findings from this study emphasize the importance of implementing highly focused awareness campaigns, personalized intervention, and comprehensive sexual health education programs in order to enhance the adoption of PrEP and bolster HIV prevention initiatives among the Rwandan population of MSM., Competing Interests: Conflict of Interest Authors declared of no conflict of interest.
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- 2023
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42. Low birth weight among infants and pregnancy outcomes among women living with HIV and HIV-negative women in Rwanda.
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Zotova N, Munyaneza A, Murenzi G, Kubwimana G, Adedimeji A, Anastos K, Yotebieng M, and Ca-IeDEA CI
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Introduction: In utero exposure to HIV and/or triple antiretroviral therapy (ART) have been shown to be associated with preterm births and low birth weight (LBW), but data from low-resources settings with high burden of HIV remain limited. This study utilized retrospective data to describe pregnancy outcomes among Rwandan women living with HIV (WLHIV) and HIV-negative women and to assess the association of HIV and ART with LBW., Methods: This study used data from a large cohort of WLHIV and HIV-negative women in Rwanda for a cross-sectional analysis. Retrospective data were collected from antenatal care (ANC), delivery, and Prevention of Mother to Child Transmission (PMTCT) registries within the Central Africa International Epidemiology Databases to Evaluate AIDS (CA-IeDEA) in Rwanda. Data from women with documented HIV test results and known pregnancy outcomes were included in the analysis. Analyses for predictors of LBW (< 2,500 g) were restricted to singleton live births. Logistic models were used to identify independent predictors and estimate the odd ratios (OR) and 95% confidence intervals (CI) measuring the strength of their association with LBW., Results and Discussion: Out of 10,608 women with known HIV status and with documented pregnancy outcomes, 9.7% (n = 1,024) were WLHIV. We restricted the sample to 10,483 women who had singleton live births for the analysis of the primary outcome, LBW. Compared with HIV-negative women, WLHIV had higher rates of stillbirth, preterm births, and LBW babies. Multivariable model showed that WLHIV and primigravidae had higher odds of LBW. Lower maternal weight and primigravidae status were associated with greater odds of LBW. Among WLHIV, the use of ART was associated with significantly lower odds of LBW in a bivariate analysis. Even in a sample of relatively healthier uncomplicated pregnancies and women who delivered in low-risk settings, WLHIV still had higher rates of poor pregnancy outcomes and to have LBW infants compared to women without HIV. Lower maternal weight and primigravidae status were independently associated with LBW. Given that supplementary nutrition to malnourished pregnant women is known to decrease the incidence of LBW, providing such supplements to lower-weight WLHIV, especially primigravidae women, might help reduce LBW., Competing Interests: Declarations COMPETING INTERESTS No author had a competing interest to declare.
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- 2023
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