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Your search keyword '"Nakagawa, Yasuaki"' showing total 27 results
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27 results on '"Nakagawa, Yasuaki"'

4. Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors

Author

Oda, Sayaka, Nishiyama, Kazuhiro, Furumoto, Yuka, Yamaguchi, Yohei, Nishimura, Akiyuki, Tang, Xiaokang, Kato, Yuri, Numaga-Tomita, Takuro, Kaneko, Toshiyuki, Mangmool, Supachoke, Kuroda, Takuya, Okubo, Reishin, Sanbo, Makoto, Hirabayashi, Masumi, Sato, Yoji, Nakagawa, Yasuaki, Kuwahara, Koichiro, Nagata, Ryu, Iribe, Gentaro, Mori, Yasuo, and Nishida, Motohiro

Published
2022
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7. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis

Author

Inazumi, Hideaki, Kuwahara, Koichiro, Nakagawa, Yasuaki, Kuwabara, Yoshihiro, Numaga-Tomita, Takuro, Kashihara, Toshihide, Nakada, Tsutomu, Kurebayashi, Nagomi, Oya, Miku, Nonaka, Miki, Sugihara, Masami, Kinoshita, Hideyuki, Moriuchi, Kenji, Yanagisawa, Hiromu, Nishikimi, Toshio, Motoki, Hirohiko, Yamada, Mitsuhiko, Morimoto, Sachio, Otsu, Kinya, Mortensen, Richard M., Nakao, Kazuwa, and Kimura, Takeshi

Published
2021
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9. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis

Author

Inazumi, Hideaki, Kuwahara, Koichiro, Nakagawa, Yasuaki, Kuwabara, Yoshihiro, Numaga-Tomita, Takuro, Kashihara, Toshihide, Nakada, Tsutomu, Kurebayashi, Nagomi, Oya, Miku, Nonaka, Miki, Sugihara, Masami, Kinoshita, Hideyuki, Moriuchi, Kenji, Yanagisawa, Hiromu, Nishikimi, Toshio, Motoki, Hirohiko, Yamada, Mitsuhiko, Morimoto, Sachio, Otsu, Kinya, Mortensen, Richard M., Nakao, Kazuwa, and Kimura, Takeshi

Published
2022
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10. Abstract P2163: The Genetic And Pharmacological Inhibition Of Classic Transient Receptor Potential Channels 3 And 6 (trpc3/c6) Improve Pulmonary Arterial Hypertension.

Author

Moriuchi, Kenji, primary, Nakagawa, Yasuaki, additional, Kinoshita, Hideyuki, additional, Inazumi, Hideaki, additional, Yanagisawa, Hiromu, additional, Kanamori, Takahiko, additional, Nishikimi, Toshio, additional, Oya, Miku, additional, Nishida, Motohiro, additional, Mori, Yasuo, additional, Nagata, Ryu, additional, Nakamura, Kazufumi, additional, Kuwahara, Koichiro, additional, Nakao, Kazuwa, additional, and Kimura, Takeshi, additional

Published
2023
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14. Study on Advanced Maintenance Strategies and Asset Management for Substation Equipment in Japan: Analysis of the Degradation Mechanisms and Investigation of Maintenance Strategy

Author

Kamatani, Kosho, primary, Aihara, Yuji, additional, Ichihara, Satoshi, additional, Miyajima, Isao, additional, Tainaka, Yoshito, additional, Ito, Ken, additional, Nakagawa, Yasuaki, additional, Sasaki, Yusuke, additional, Miyamoto, Yasushi, additional, Ogata, Hideki, additional, and Sato, Koma, additional

Published
2022
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18. Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure

Author

Shiba, Masayuki, primary, Kato, Takao, additional, Morimoto, Takeshi, additional, Yaku, Hidenori, additional, Inuzuka, Yasutaka, additional, Tamaki, Yodo, additional, Ozasa, Neiko, additional, Seko, Yuta, additional, Yamamoto, Erika, additional, Yoshikawa, Yusuke, additional, Kitai, Takeshi, additional, Yamashita, Yugo, additional, Iguchi, Moritake, additional, Nagao, Kazuya, additional, Kawase, Yuichi, additional, Morinaga, Takashi, additional, Toyofuku, Mamoru, additional, Furukawa, Yutaka, additional, Ando, Kenji, additional, Kadota, Kazushige, additional, Sato, Yukihito, additional, Nakagawa, Yasuaki, additional, Kuwahara, Koichiro, additional, and Kimura, Takeshi, additional

Published
2022
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19. NRSF- GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis

Author

Inazumi, Hideaki, primary, Kuwahara, Koichiro, additional, Nakagawa, Yasuaki, additional, Kuwabara, Yoshihiro, additional, Numaga-Tomita, Takuro, additional, Kashihara, Toshihide, additional, Nakada, Tsutomu, additional, Kurebayashi, Nagomi, additional, Oya, Miku, additional, Nonaka, Miki, additional, Sugihara, Masami, additional, Kinoshita, Hideyuki, additional, Moriuchi, Kenji, additional, Yanagisawa, Hiromu, additional, Nishikimi, Toshio, additional, Motoki, Hirohiko, additional, Yamada, Mitsuhiko, additional, Morimoto, Sachio, additional, Otsu, Kinya, additional, Mortensen, Richard M., additional, Nakao, Kazuwa, additional, and Kimura, Takeshi, additional

Published
2022
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20. The Contribution of Deleterious Rare Alleles in ENPP1 and Osteomalacia Causative Genes to Atypical Femoral Fracture

Author

Furukawa, Hiroshi, primary, Oka, Shomi, additional, Kondo, Naoki, additional, Nakagawa, Yasuaki, additional, Shiota, Naofumi, additional, Kumagai, Kenji, additional, Ando, Keiji, additional, Takeshita, Tsutao, additional, Oda, Takenori, additional, Takahashi, Yoshinori, additional, Izawa, Kazutaka, additional, Iwasaki, Yoichi, additional, Hasegawa, Kazuhiro, additional, Arino, Hiroshi, additional, Minamizaki, Takeshi, additional, Yoshikawa, Norie, additional, Takata, Shinjiro, additional, Yoshihara, Yasuo, additional, and Tohma, Shigeto, additional

Published
2022
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21. Molecular ratio of mature B‐type natriuretic peptide in acute heart failure: an indicator for ventricular contractile recovery

Author

Kimura, Akihisa, primary, Takahama, Hiroyuki, additional, Nishikimi, Toshio, additional, Takashio, Seiji, additional, Hayashi, Tomohiro, additional, Nagai‐Okatani, Chiaki, additional, Nakagawa, Yasuaki, additional, Yasuda, Satoshi, additional, Anzai, Toshihisa, additional, Minamino, Naoto, additional, and Izumi, Chisato, additional

Published
2021
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24. Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.

Author

Oda, Sayaka, Nishiyama, Kazuhiro, Furumoto, Yuka, Yamaguchi, Yohei, Nishimura, Akiyuki, Tang, Xiaokang, Kato, Yuri, Numaga-Tomita, Takuro, Kaneko, Toshiyuki, Mangmool, Supachoke, Kuroda, Takuya, Okubo, Reishin, Sanbo, Makoto, Hirabayashi, Masumi, Sato, Yoji, Nakagawa, Yasuaki, Kuwahara, Koichiro, Nagata, Ryu, Iribe, Gentaro, and Mori, Yasuo

Subjects
TRP channels, CARDIAC contraction, BAROREFLEXES, HEART failure, AMINO acids, HOMEOSTASIS
Abstract

Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve activation is important for cardiocirculatory homeostasis. Transient receptor potential canonical subfamily (TRPC) channels are responsible for α1-adrenoceptor (α1AR)-stimulated cation entry and their upregulation is associated with pathological cardiac remodeling. Whether TRPC channels participate in physiological pump functions remains unclear. We demonstrate that TRPC6-specific Zn2+ influx potentiates β-adrenoceptor (βAR)-stimulated positive inotropy in rodent cardiomyocytes. Deletion of trpc6 impairs sympathetic nerve–activated positive inotropy but not chronotropy in mice. TRPC6-mediated Zn2+ influx boosts α1AR-stimulated βAR/Gs-dependent signaling in rat cardiomyocytes by inhibiting β-arrestin-mediated βAR internalization. Replacing two TRPC6-specific amino acids in the pore region with TRPC3 residues diminishes the α1AR-stimulated Zn2+ influx and positive inotropic response. Pharmacological enhancement of TRPC6-mediated Zn2+ influx prevents chronic heart failure progression in mice. Our data demonstrate that TRPC6-mediated Zn2+ influx with α1AR stimulation enhances baroreflex-induced positive inotropy, which may be a new therapeutic strategy for chronic heart failure. Baroreflex control of cardiac contractility is essential to maintain cardiocirculatory homeostasis. Here, Oda et al show that α1 adrenoceptor-stimulated Zn2+ entry through TRPC6 channels boosts β adrenoceptor-dependent myocardial positive inotropy. [ABSTRACT FROM AUTHOR]

Published
2022
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25. The effects of alendronate on the suppression of bone resorption and the promotion of cartilage formation in the human mosaicplasty donor site: A randomized, double-blind, placebo-controlled prospective study.

Author

Nakagawa, Yasuaki, Mukai, Shogo, Mori, Koji, Yabumoto, Hiromitsu, Nakamura, Ryota, and Shinya, Yuki

Subjects
*BONE resorption, *PATELLOFEMORAL joint, *BONE grafting, *CARTILAGE, *ALENDRONATE, *MAGNETIC resonance imaging, *BONE growth, *KNEE joint, *RESEARCH, *CHONDROGENESIS, *ANIMAL experimentation, *RESEARCH methodology, *RABBITS, *EVALUATION research, *AUTOGRAFTS, *COMPARATIVE studies, *RANDOMIZED controlled trials, *ARTICULAR cartilage, *LONGITUDINAL method, *PHARMACODYNAMICS
Abstract

Background: We previously reported that early alendronate administration accelerated bone formation and improved the quality of repaired cartilage in the donor site in rabbits. To investigate whether alendronate administration has effects in humans similar to those observed in rabbits.Methods: The study cohort included 35 patients over the age of 12-years old who underwent mosaicplasty without osteoporotic therapy from March 2011 to October 2012. The donor sites were medial or lateral in the patellofemoral joint. Placebo (P) or Bonalon containing 35 mg of alendronate (A) was administered orally every week for 8 weeks. The cohort comprised 15 male and 20 female, including 14 right and 21 left knees. The mean age at the time of surgery was 57.1 years. Bone formation was examined using computer tomography and lateral knee radiography, and cartilage formation was examined using magnetic resonance imaging (MRI), second-look assessment, and intraoperative acoustic evaluation. The clinical outcomes were assessed using the Japanese Orthopaedic Association knee score and visual analog scale (VAS). Bone and cartilage formation in the donor site and clinical outcomes were assessed at 3, 6, and 12 months after mosaicplasty.Results: The ratio of TRAP-5b in group A was significantly smaller than that in group P at 2 and 8 weeks after mosaicplasty. The extent of bone formation in the donor sites in group A was significantly greater than that in group P at 3 and 6 months after mosaicplasty. Cartilage formation did not differ significantly between the two groups as determined by MRI, macroscopic assessment, and intraoperative acoustic evaluation. Clinical outcomes did not differ significantly between the two groups, and no negative clinical outcomes were observed.Conclusion: Early alendronate administration accelerated bone formation but not cartilage formation in the mosaicplasty donor site in humans. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Midterm Outcomes of Autologous Osteochondral Graft Transplantation Only in the Femoral Condyle without Treating the Tibial Plateau with Subchondral Bone Exposed

Author

Nakagawa, Yasuaki, Mukai, Shogo, Maeda, Takahiro, Akamatsu, Shota, Satomi, Kentaro, and Nakamura, Ryota

Abstract

Objective This study aimed to examine the midterm clinical outcomes of autologous osteochondral grafts (AOG) that were performed in the femoral condyle without treating the tibial plateau with subchondral bone exposed, and to compare these outcomes with those of AOG used in patients with osteoarthritis (lateral type or medial type) or osteonecrosis.Design The study included 6 men and 16 women and 11 right knees and 11 left knees. The mean operative age was 56.0 years (range, 21-76 years), and the mean follow-up period was 98.4 months (range, 60-164 months). Six patients had lateral type osteoarthritis (OAL), 7 had medial type osteoarthritis (OAM), and 9 had osteonecrosis (ON). The patients’ knee symptoms as their clinical outcome were evaluated using the knee scoring system of the Japanese Orthopedic Association (JOA), and the International Knee Documentation Committee (IKDC) subjective score.Results The postoperative clinical outcomes of the OAL and ON group were significantly better than their preoperative clinical scores and remained the same until the final follow-up. However, the clinical outcomes of OAM improved 2 years after AOG, but eventually decreased thereafter. The number of worse cases in the OAM group was significantly larger than those in the OAL and ON groups.Conclusion In these procedures, the postoperative clinical outcomes of the OAL and ON groups were significantly better than their preoperative clinical scores and were maintained for about 8 years. However, the clinical outcomes of OAM improved until 2 years after AOG, but eventually decreased thereafter.

Published
2021
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27. Long-Term Survivorship and Clinical Outcomes of Osteochondral Autologous Transplantation for Steroid-Induced Osteonecrosis of the Knee

Author

Nishitani, Kohei, Nakagawa, Yasuaki, Kobayashi, Masahiko, Nakamura, Shinichiro, Mukai, Shogo, Kuriyama, Shinichi, and Matsuda, Shuichi

Abstract

Objective Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee.Design This retrospective case series included patients who underwent OAT for steroid-induced osteonecrosis of the knee from 1998 to 2008. The survivorship and need for secondary surgery were evaluated, and the clinical outcome was evaluated with the International Knee Documentation Committee (IKDC) subjective score. Preoperative and final Kellgren-Lawrence (KL) grade of the femorotibial and patellofemoral joints were individually evaluated.Results Fourteen knees of 10 patients whose mean age was 32.5 (95%CI 26.4-38.6) years were included and followed for 14.0 (12.4-15.7) years. The mean lesion size of 6.9 (5.3-8.5) cm2was repaired using 4 median (minimum 2, maximum 5) osteochondral plugs. No revision surgeries were performed for transplanted osteochondral plugs. The IKDC subjective score improved from 32.9 (24.5-41.3) to 74.2 (61.9-88.5) (P< 0.001). Knee flexion was improved at the final follow-up, and Seiza sitting was finally possible in 9 knees in 7 patients. Although the osteoarthritic change did not progress in femorotibial joint, patellofemoral joint showed early osteoarthritic changes at the final follow-up (mean KL grade: 0.8 [0.5-1.1]).Conclusions Prosthetic joint replacement was successfully avoided for at least the first decade by OAT in young patients with steroid-induced osteonecrosis of the knee. The progression of KL grade of the patellofemoral joint is of concern.

Published
2021
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