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Your search keyword '"Nathalia Zak"' showing total 4 results
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4 results on '"Nathalia Zak"'

1. Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation

Author

Irene Voldsbekk, Atle Bjørnerud, Inge Groote, Nathalia Zak, Daniel Roelfs, Ivan I. Maximov, Oliver Geier, Paulina Due-Tønnessen, Erlend Bøen, Yvonne S. Kuiper, Lise-Linn Løkken, Marie Strømstad, Taran Y. Blakstvedt, Bjørn Bjorvatn, Ulrik F. Malt, Lars T. Westlye, Torbjørn Elvsåshagen, and Håkon Grydeland

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Cortical microstructure is influenced by circadian rhythm and sleep deprivation, yet the precise underpinnings of these effects remain unclear. The ratio between T1-weighted and T2-weighted magnetic resonance images (T1w/T2w ratio) has been linked to myelin levels and dendrite density and may offer novel insight into the intracortical microstructure of the sleep deprived brain. Here, we examined intracortical T1w/T2w ratio in 41 healthy young adults (26 women) before and after 32 h of either sleep deprivation (n = 18) or a normal sleep-wake cycle (n = 23). Linear models revealed significant group differences in T1w/T2w ratio change after 32 h in four clusters, including bilateral effects in the insular, cingulate, and superior temporal cortices, comprising regions involved in attentional, auditory and pain processing. Across clusters, the sleep deprived group showed an increased T1w/T2w ratio, while the normal sleep-wake group exhibited a reduced ratio. These changes were not explained by in-scanner head movement, and 95% of the effects across clusters remained significant after adjusting for cortical thickness and hydration. Compared with a normal sleep-wake cycle, 32 h of sleep deprivation yields intracortical T1w/T2w ratio increases. While the intracortical changes detected by this study could reflect alterations in myelin or dendritic density, or both, histological analyses are needed to clarify the precise underlying cortical processes.

Published
2022
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2. Corrigendum to 'Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling'

Author

Irene Voldsbekk, Inge Groote, Nathalia Zak, Daniël Roelfs, Oliver Geier, Paulina Due-Tønnessen, Lise-Linn Løkken, Marie Strømstad, Taran Y. Blakstvedt, Yvonne S. Kuiper, Torbjørn Elvsåshagen, Lars T. Westlye, Atle Bjørnerud, and Ivan I. Maximov

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2023
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4. Longitudinal structural brain changes in bipolar disorder: A multicenter neuroimaging study of 1232 individuals by the ENIGMA Bipolar Disorder Working Group

Author

Theophilus N. Akudjedu, Frederike Stein, Edith Pomarol-Clotet, Lars T. Westlye, Ulrik Fredrik Malt, Erlend Bøen, Fabian Breuer, Chao Suo, Tina Meller, Tim Hahn, Francesco Benedetti, Jose Manuel Goikolea, Silvia Alonso-Lana, Adam George White, Dag Alnæs, Julia-Katharina Pfarr, Beathe Haatveit, Sara Poletti, Kai Ringwald, Nathalia Zak, Benny Liberg, Kelvin Sarink, Giulia Tronchin, Yann Chye, Janice M. Fullerton, Orwa Dandash, Igor Nenadic, Caterina del Mar Bonnín, Elisa M T Melloni, Udo Dannlowski, Michael Berk, Dominik Grotegerd, Christopher R.K. Ching, Lukas Fisch, Torbjørn Elvsåshagen, Andreas Dahl, Martin Alda, Francesco Panicalli, Ingrid Agartz, Martin Ingvar, Bronwyn Overs, Joaquim Radua, Katharina Brosch, Alexander V. Lebedev, Kang Sim, Tilo Kircher, Leila Nabulsi, Dara M. Cannon, Erick J. Canales-Rodríguez, Paul M. Thompson, Nils Opel, Jonathan Repple, R. Salvador, Katharina Dohm, Philip B. Mitchell, Colm McDonald, Salvador Sarró, Rachel M. Brouwer, Ole A. Andreassen, Tomas Hajek, Mikael Landén, Simon Schmitt, Sophia I. Thomopoulos, Elena Rodriguez-Cano, Eduard Vieta, Ingrid Melle, Rhoshel K. Lenroot, Lakshmi N. Yatham, Sean R. McWhinney, Gloria Roberts, Christoph Abé, Walter Heindel, Abe, C., Ching, C. R. K., Liberg, B., Lebedev, A. V., Agartz, I., Akudjedu, T. N., Alda, M., Alnaes, D., Alonso-Lana, S., Benedetti, F., Berk, M., Boen, E., Bonnin, C. D. M., Breuer, F., Brosch, K., Brouwer, R. M., Canales-Rodriguez, E. J., Cannon, D. M., Chye, Y., Dahl, A., Dandash, O., Dannlowski, U., Dohm, K., Elvsashagen, T., Fisch, L., Fullerton, J. M., Goikolea, J. M., Grotegerd, D., Haatveit, B., Hahn, T., Hajek, T., Heindel, W., Ingvar, M., Sim, K., Kircher, T. T. J., Lenroot, R. K., Malt, U. F., Mcdonald, C., Mcwhinney, S. R., Melle, I., Meller, T., Melloni, E. M. T., Mitchell, P. B., Nabulsi, L., Nenadic, I., Opel, N., Overs, B. J., Panicalli, F., Pfarr, J. -K., Poletti, S., Pomarol-Clotet, E., Radua, J., Repple, J., Ringwald, K. G., Roberts, G., Rodriguez-Cano, E., Salvador, R., Sarink, K., Sarro, S., Schmitt, S., Stein, F., Suo, C., Thomopoulos, S. I., Tronchin, G., Vieta, E., Westlye, L. T., White, A. G., Yatham, L. N., Zak, N., Thompson, P. M., Andreassen, O. A., Landen, M., Complex Trait Genetics, and Amsterdam Neuroscience - Complex Trait Genetics

Subjects
Adult, Male, Longitudinal study, medicine.medical_specialty, Bipolar disorder, Neuroimaging, volume changes, surface-based analysis, Young Adult, gray-matter, Cortex (anatomy), Internal medicine, medicine, Humans, Multicenter Studies as Topic, Biological Psychiatry, mri, human cerebral-cortex, Psychiatry, medicine.diagnostic_test, business.industry, ENIGMA, Brain, Magnetic resonance imaging, Cerebral Cortical Thinning, Middle Aged, cortical thickness, medicine.disease, Magnetic Resonance Imaging, Neuroprogression, Mania, genetic influences, medicine.anatomical_structure, Mood, Meta-analysis, Cardiology, lithium treatment, Female, medicine.symptom, i disorder, business, metaanalysis
Abstract

Background: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD. Methods: Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables. Results: Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18 < d < 0.22). More (hypo)manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex. Conclusions: In the hitherto largest longitudinal MRI study on BD, we did not detect accelerated cortical thinning but noted faster ventricular enlargements in BD. However, abnormal frontocortical thinning was observed in association with frequent manic episodes. Our study yields insights into disease progression in BD and highlights the importance of mania prevention in BD treatment.

Published
2022
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