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Despite increasing antibiotic resistance, vancomycin remains the first choice to treat severe infections due to drug-resistant gram-positive bacteria. This study aimed to summarise the clinical, microbiological, and vancomycin treatment outcomes in bacteremia patients. From July to December 2019, a retrospective cohort analysis was conducted on patients with bacteremia treated with vancomycin at a tertiary hospital in Hanoi, Vietnam. Patients without vancomycin concentrations were excluded from the study. Patients had a median age of 54 years (IQR, 41.8 - 63.3), with a male/female ratio of 1.86. Renal complication was markedly different; Clcr < 60, 60 - 130, and > 130 mL/min was 29%, 60%, and 11%, respectively. The median Charlson score was 3.0 (2-4.3), the qSOFA score was 1 (1-2), and the NEWS score was 76%, with a median of 6 (5-8). Twenty-one cases had positive blood culture where85.7% were gram-positive. 93% of patients with sepsis were treated with vancomycin as the first antimicrobial, of which 72% used vancomycin in combination with other antibiotics. Renal complications occurred in 12% of all patients, with grades R, I, and F accounting for 4%, 5%, and 3%, respectively. The median duration of treatment was 12 days (IQR, 7-17), with a success rate of 82 % and a failure rate of 18%, respectively. Conclusions: In most patients with bacteremia, microbiological tests reveal no detectable bacteria. When sepsis is suspected, a vancomycin regimen should be initiated.

The coastal erosion due to storm surge and unsustainable urban development in the central region of Vietnam has become increasingly in the last decade. It requires accurate coastal vulnerability assessments (CVI). The aim of this study is to propose (1) a new approach to classify the coasts and (2) the selection of appropriate criteria to assess the CVI index at the regional scale. Accordingly, the study has calculated the CVI index for the coastal area of Son Tra - Cua Dai region based on 5 coastal characteristic variables, 3 coastal dynamics and 4 socio-economic variables. The results show that more than 15% of the coastline of the study area has very high CVI values, especially in the coastal area of Hoi An. The coastal landscape with residential and tourist sites near beaches without protection forests has been strongly affected by storm erosion.