7 results on '"Nihal Demirel"'
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2. Intravenous Immunoglobulin Use in Hemolytic Disease Due to ABO Incompatibility to Prevent Exchange Transfusion
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Emel Okulu, Omer Erdeve, Ilknur Kilic, Ozgur Olukman, Sebnem Calkavur, Gokhan Buyukkale, Merih Cetinkaya, Dilek Ulubas, Nihal Demirel, Deniz Hanta, Sabahattin Ertugrul, Nazli Dilay Gultekin, Oguz Tuncer, Nihat Demir, Leyla Bilgin, Nejat Narli, Duran Yildiz, Demet Terek, Ozge Altun Koroglu, Canan Seren, Elif Ozyazici, Ramazan Ozdemir, Hatice Turgut, Fatma Narter, Yasemin Akin, Ahmet Ozyazici, Aysegul Zenciroglu, Huseyin Selim Asker, Zeynel Gokmen, Musa Salihli, Ali Bulbul, Umut Zubarioglu, Begum Atasay, Esin Koc, Turkish Neonatal Society IVIG Study Group, Kurthan Mert, Akan Yaman, Evrim Alyamac Dizdar, Nurdan Uras, Berna Hekimoglu, Ayse Engin Arisoy, Yasemin Senel, Eren Ozek, Hulya Ozdemir, Kadir Tekgunduz, Ibrahim Caner, Sema Tanriverdi, Dilek Sarici, F. Mehmet Kislali, Didem Aliefendioglu, Nilufer Guzoglu, Cumhur Aydemir, Muhittin Celik, Belma Saygili Karagol, Bilge Bayraktar, Suzan Sahin, Ibrahim Murat Hirfanoglu, Betul Acunas, Ferda Ozlu, Ayse Ecevit, Cengiz Arcagok, Neslihan Tekin, Hacer Ergin, Selda Arslan, and Asuman Coban
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hemolytic disease of the newborn ,ABO incompatibility ,intravenous immunoglobulin ,exchange transfusion ,light-emitting diode ,phototherapy ,Pediatrics ,RJ1-570 - Abstract
IntroductionIntravenous immunoglobulin (IVIG) has been widely used to treat the hemolytic disease of the newborn (HDN). Although it has been shown that IVIG treatment reduces the duration of phototherapy and hospitalization, the use of IVIG in hemolytic disease due to ABO incompatibility has been controversial in recent years. This study aimed to investigate the role of IVIG in the prevention of exchange transfusion in infants with ABO HDN who presented with bilirubin levels at or above the level of exchange transfusion.Materials and MethodsThis study evaluated the data of infants with ABO HDN in the Turkish Neonatal Jaundice Online Registry. The infants with ABO HDN who met the total serum bilirubin level inclusion criteria (within 2–3 mg/dL of exchange transfusion or even above exchange transfusion level) were included in the study according to the guidelines from the American Academy of Pediatrics and the Turkish Neonatal Society. All patients were managed according to the unit protocols recommended by these guidelines and received light-emitting diode (LED) phototherapy. Infants who only received LED phototherapy, and who received one dose of IVIG with LED phototherapy were compared.ResultsDuring the study period, 531 term infants were included in the study according to inclusion criteria. There were 408 cases in the phototherapy-only group, and 123 cases in the IVIG group. The demographic findings and the mean bilirubin and reticulocyte levels at admission were similar between the groups (p > 0.05), whereas the mean hemoglobin level was slightly lower in the IVIG group (p = 0.037). The mean age at admission was earlier, the need for exchange transfusion was higher, and the duration of phototherapy was longer in the IVIG group (p < 0.001, p = 0.001, and p < 0.001, respectively). The rate of re-hospitalization and acute bilirubin encephalopathy (ABE) was higher in the IVIG group (p < 0.001 and p = 0.01, respectively).ConclusionIn this study, we determined that one dose of IVIG did not prevent an exchange transfusion nor decrease the duration of phototherapy in infants, who had bilirubin levels near or at exchange transfusion level, with hemolytic disease due to ABO incompatibility.
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- 2022
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3. In-Hospital Newborn Falls and Near Miss Events: A Need to Report
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Sezin Unal, Nihal Demirel, Betül Tokgoz-Cuni, Fatma İyigün, Ozlem Moraloglu Tekin, and Ahmet Y. Baş
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Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology - Abstract
Objective This study aimed to evaluate the clinical characteristics of the neonates who fell in the maternity ward and identify the incidence of near miss events during the immediate postpartum period. Study Design The study consisted of two steps. The retrospective part included the evaluation of admissions due to the in-hospital newborn fall for 6 years. The prospective part included the assessment of the near miss events (any probability of falling of the newborn; either cosleeping or an incident with a possible consequence of falling of the newborn) in the postpartum clinic ( Results Seventeen in-hospital newborn falls were recorded: 1.8 to 2.4/10,000 live births. The median age of the neonates when the fall occurred was 22 (16–34) postnatal hours. Fourteen events (82%) occurred between 10 p.m. and 6 a.m. All neonates who experienced a fall were discharged without any known adverse outcomes. Twelve mothers (71%) had experienced a near miss event before. In the prospective arm of the study, 67 out of 804 mothers (8.3%) were found to experience a near miss event (44/1,000 days of postpartum hospitalization). Thirty-two events (49%) occurred in the first postpartum day. Fifty-two events (78%) occurred between 10 p.m. and 6 a.m. Fifty-eight mothers (86%) had no companion. Sixty-three percent of the mothers expressed intense fatigue after delivery. Conclusion In-hospital newborn fall may occur in the postpartum period, and near miss events should warn clinicians for a probable fall event. The nighttime shift requires more attention regarding the prevention of both the fall and the near miss events. Immediate postpartum mothers are needed to be observed carefully. Key Points
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- 2023
4. Can the triglyceride-glucose index predict insulin resistance in LGA newborns?
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Sumru Kavurt, Safiye Elif Uzlu, Ahmet Yagmur Bas, Mehtap Tosun, Şevki Çelen, Yaprak Engin Üstün, and Nihal Demirel
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Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology - Abstract
The aim of this study is to investigate the TyG index and TG/HDL-C ratio and their relationships with insulin resistance in LGA infants.A prospective controlled study was conducted including 65 LGA and gestational age, gender-matched appropriate for gestational age (AGA) neonates. Serum TG, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), insulin and glucose levels were measured within two hours after birth, TyG index and HOMA-IR values were calculated.TyG index and TG/HDL- C ratio were higher in LGA neonates compared to AGA ones (p = 0.03; p = 0.00, respectively). Compared with AGA newborns, LGA newborns had higher levels of insulin and HOMA-IR (p = 0.00; p = 0.00, respectively). TyG index and TG/HDL-C ratio showed moderate correlation with HOMA-IR (r = 0.59 R
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- 2022
5. Multi-organ dysfunction in infants with acidosis at birth in the absence of moderate to severe hypoxic ischemic encephalopathy
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Nihal Demirel, Sezin Unal, Mehtap Durukan, İstemi Han Celik, and Ahmet Yagmur Bas
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Pediatrics, Perinatology and Child Health ,Obstetrics and Gynecology - Published
- 2023
6. Yenidoğanda İzole Laküner Kafa Deformitesi
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Ayşen Sumru KAVURT, Nihal DEMİREL, Betül CUNİ, Yasemin TASCI YILDIZ, and Ahmet Yağmur BAŞ
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General Mathematics - Abstract
The lacunar skull is a fetal ossification disorder first defined in the early 19th century, commonly associated with spina bifida and meningocele, and rarely seen as an isolated defect. It is characterized by defects on the inner table of the skull, in the form of shallow depressions or deep cavitations causes the skull to appear fenestrated because of mesenchymal dysplasia during intramembranous ossification. These bone defects may be present in any part of the calvarium but most frequently occur in the parietal and frontal bones. Clinically, lacunar skull may be suspected, but the diagnosis usually depends on the roentgenographic appearance. We report a newborn diagnosed with severe lacunar skull defect without any congenital malformations however accompanying severe vitamin D deficiency of maternal origin.
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- 2022
7. Evaluation of cord blood ischemia modified albumin and mean platelet volume in infants of preeclamptic mothers
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Ayşen Sumru KAVURT, Fatma İYİGÜN, Nihal DEMİREL, Dilek ULUBAS ISİK, Şafak ÖZDEMİRCİ, and Ahmet Yağmur BAŞ
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oksidatif stres,iskemi modifiye albümin,yenidoğan,preeklampsi ,Pediatri ,General Mathematics ,Pediatrics ,oxidative stress,ischemia modified albumin,newborn,preeclampcia - Abstract
Amaç: Oksidatif stres (OS), plasental disfonksiyonun bilinen bir nedenidir, bu nedenle preeklampsi ve gestasyon haftasınagöre düşük doğum ağırlığı ile nedensel olarak ilişkili olabilir. Preeklampsili annelerden doğan yenidoğanlarda kordonkanı iskemi modifiye albumin (İMA) ve ortalama trombosit hacmi (MPV) düzeylerini araştırmayı ve belirlenen düzeyleringestasyon haftasına göre düşük doğum ağırlığı ile ilişkisini değerlendirmeyi amaçladık.Gereç ve Yöntem: Prospektif kontrollü olan bu çalışmaya annesinde preeklampsi olan 50 bebek ve sağlıklı annelerin 40sağlıklı yenidoğanı dahil edildi. Preeklampsili annelerin bebeklerinde kordon kanı İMA ve MPV düzeyleri ölçüldü. Kordonkanı İMA düzeylerinin gestasyon haftasına göre düşük doğum ağırlığı olma durumunu öngörmedeki rolü de araştırıldı.Bulgular: Preeklamptik annelerin bebeklerinin kordon kanı İMA ve MPV düzeyleri kontrollere göre anlamlı derecede yüksekti.Serum İMA düzeyleri gestasyon haftasına göre düşük doğum ağırlığı olan bebeklerde, doğum ağırlığı gestasyonel yaşa uygun(AGA) bebeklere göre anlamlı olarak yüksekti (p=0,018), ancak MPV düzeyleri her iki grupta da benzerdi (p=0,735).Sonuç: Bu çalışmaya göre, preeklamptik annelerin bebeklerinde kord kanı İMA ve MPV düzeylerinin OS durumunun basitbir ölçümü olarak yararlı olduğu düşünülebilir. Bununla birlikte, bu belirteçlerin klinik pratikteki yararlılığını belirlemek içindaha büyük örneklemli daha ileri çalışmalar gerekli olacaktır., Aim: Oxidative stress (OS) is a known cause of placental dysfunction, thus may be causally related to preeclampsia andsmall for gestational age infant (SGA). We aimed to investigate cord blood ischemia-modified albumin (IMA) and meanplatelet volüme (MPV) levels in neonates born to mothers with preeclampsia and correlate the determined levels withbeeing SGA.Material and Method: A prospective controlled study was conducted. Fifty infants of mothers with preeclampsia, 40healthy neonates of healthy mothers were included. Cord blood IMA and MPV levels were measured in infants ofmothers with preeclampsia. The role of cord blood IMA levels to predict beeing SGA was also investigated.Results: Cord blood IMA and MPV levels of infants of preeclamptic mothers were significantly higher compared tocontrols. Serum IMA levels were significantly higher in SGA infants compared to appropirate for gestational age (AGA)infants (p=0.018), however MPV levels were similar in both groups (p=0.735).Conclusion: According to this study cord blood IMA and MPV levels may be considered useful as a simple measure ofOS status in infants of mothers with preeclampsia. However, further studies with larger samples will be necessary todetermine usefulness of these markers in clinical practice.
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- 2021
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