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24 results on '"Noguchi, Kazuma"'

4. Incidence of antiresorptive agent-related osteonecrosis of the jaw: A multicenter retrospective epidemiological study in Hyogo Prefecture, Japan

Author

Nashi, Masanori, Kishimoto, Hiromitsu, Kobayashi, Masaki, Tachibana, Akira, Suematsu, Motoo, Fujiwara, Shigeyoshi, Ota, Yoshiyuki, Hashitani, Susumu, Shibatsuji, Takeshi, Nishida, Tetsuya, Fujimura, Kazuma, Furudoi, Shungo, Ishida, Yoshiki, Ishii, Shoichiro, Fujita, Tsuyoshi, Iwai, Soichi, Shigeta, Takashi, Harada, Takeshi, Miyai, Daisuke, Takeda, Daisuke, Akashi, Masaya, Noguchi, Kazuma, and Takenobu, Toshihiko

Published
2023
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8. Shotgun metagenomic analysis of saliva microbiome suggests Mogibacterium as a factor associated with chronic bacterial osteomyelitis.

Author

Yahara, Hiroko, Yanamoto, Souichi, Takahashi, Miho, Hamada, Yuji, Asaka, Takuya, Kitagawa, Yoshimasa, Moridera, Kuniyasu, Noguchi, Kazuma, Maruoka, Yutaka, and Yahara, Koji

Subjects
SALIVA analysis, OSTEOMYELITIS, SALIVA, METAGENOMICS, GUT microbiome, SHOTGUN sequencing, SHOTGUNS
Abstract

Osteomyelitis of the jaw is a severe inflammatory disorder that affects bones, and it is categorized into two main types: chronic bacterial and nonbacterial osteomyelitis. Although previous studies have investigated the association between these diseases and the oral microbiome, the specific taxa associated with each disease remain unknown. In this study, we conducted shotgun metagenome sequencing (≥10 Gb from ≥66,395,670 reads per sample) of bulk DNA extracted from saliva obtained from patients with chronic bacterial osteomyelitis (N = 5) and chronic nonbacterial osteomyelitis (N = 10). We then compared the taxonomic composition of the metagenome in terms of both taxonomic and sequence abundances with that of healthy controls (N = 5). Taxonomic profiling revealed a statistically significant increase in both the taxonomic and sequence abundance of Mogibacterium in cases of chronic bacterial osteomyelitis; however, such enrichment was not observed in chronic nonbacterial osteomyelitis. We also compared a previously reported core saliva microbiome (59 genera) with our data and found that out of the 74 genera detected in this study, 47 (including Mogibacterium) were not included in the previous meta-analysis. Additionally, we analyzed a core-genome tree of Mogibacterium from chronic bacterial osteomyelitis and healthy control samples along with a reference complete genome and found that Mogibacterium from both groups was indistinguishable at the core-genome and pan-genome levels. Although limited by the small sample size, our study provides novel evidence of a significant increase in Mogibacterium abundance in the chronic bacterial osteomyelitis group. Moreover, our study presents a comparative analysis of the taxonomic and sequence abundances of all genera detected using deep salivary shotgun metagenome data. The distinct enrichment of Mogibacterium suggests its potential as a marker to distinguish between patients with chronic nonbacterial osteomyelitis and chronic bacterial osteomyelitis, particularly at the early stages when differences are unclear. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Management of odontogenic foci of infection (dental caries, periodontal disease and odontogenic infections) in the oral functional management of patients receiving cancer treatments: Guidelines based on a systematic review: A secondary publication...

Author

Kurita, Hiroshi, Umeda, Masahiro, Ueno, Takaaki, Uzawa, Narikazu, Shibuya, Yasuyuki, Nakamura, Norifumi, Nagatsuka, Hitoshi, Hayashi, Takafumi, Mizoguch, Itaru, Tomihara, Kei, Ikegami, Yumiko, Noguchi, Kazuma, Takiguchi, Yuichi, Yamamoto, Nobuyuki, and Sakai, Hironori

Abstract

In cancer treatment, perioperative oral functional management is used as a part of supportive care. Its main objectives are as follows: (1) preventing and reducing adverse events, (2) maintaining or improving nutritional status, (3) improving cancer treatment outcomes, (4) maintaining or improving quality of life, (5) providing high quality medical care through comprehensive oral care, (6) controlling odontogenic foci of infection, and (7) maintaining or improving oral function. A literature search was conducted using the electronic databases of Medical Journal and PubMed. Electronic database searches were performed using various combinations of the following key words: cancer, surgery, treatment, chemotherapy, radiotherapy and dental disease, oral care, oral management, dental intervention, oral health, dental care, and dental management. The selection of literature for inclusion in the review was restricted to dental management of patients receiving cancer treatment. In the course of the literature review, hand searches were also added as needed. The guideline was developed by summarizing the results of the review. Based on a review of the literature on the management of dental foci of infection in the oral functional management of patients undergoing cancer treatment, a guideline was developed by summarizing the results of the review. This report is a secondary publication of our previous review report "J. Stomatol. Soc. 70(4): 279–289. Dec 2021." [ABSTRACT FROM AUTHOR]

Published
2024
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10. Huge glandular odontogenic cyst: Report of a case and use of CRTC1/3-MAML2 fusion gene analysis for diagnosis.

Author

Ohmae, Takayuki, Noguchi, Kazuma, Yamanegi, Koji, Omori, Yuji, Makihara, Yuna, Yoshikawa, Kyohei, Takaoka, Kazuki, Nakano, Yoshiro, and Kishimoto, Hiromitsu

Abstract

Glandular odontogenic cyst (GOC) is a rare odontogenic cyst with aggressive behavior. A 50-year-old Japanese man presented with pain and swelling of the mental region of the mandible. Panoramic radiography showed a clearly bordered radiolucent lesion extending from the alveolar to cortical bone of the mandible. The clinical diagnosis was an odontogenic tumor (e.g., ameloblastoma), and an incisional biopsy was performed. The histopathological diagnosis was GOC, and extirpation and tooth extraction were performed under general anesthesia. Because bone destruction is evident in patients with a huge GOC, it is important to differentiate these cysts from intraosseous mucoepidermoid carcinoma. Therefore, we analyzed the GOC for the presence of the CRTC1/3-MAML2 fusion gene and found it to be negative. The patient had developed no recurrence of the GOC at the time of following. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Management of odontogenic foci of infection (dental caries, periodontal disease and odontogenic infections) in the oral functional management of patients receiving cancer treatments: Guidelines based on a systematic review

Author

Kurita, Hiroshi, primary, Umeda, Masahiro, additional, Ueno, Takaaki, additional, Uzawa, Narikazu, additional, Shibuya, Yasuyuki, additional, Nakamura, Norifumi, additional, Nagatsuka, Hitoshi, additional, Hayashi, Takafumi, additional, Mizoguch, Itaru, additional, Tomihara, Kei, additional, Ikegami, Yumiko, additional, Noguchi, Kazuma, additional, Takiguchi, Yuichi, additional, Yamamoto, Nobuyuki, additional, and Sakai, Hironori, additional

Published
2023
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13. Huge glandular odontogenic cyst: Report of a case and use of CRTC1/3-MAML2fusion gene analysis for diagnosis

Author

Ohmae, Takayuki, Noguchi, Kazuma, Yamanegi, Koji, Omori, Yuji, Makihara, Yuna, Yoshikawa, Kyohei, Takaoka, Kazuki, Nakano, Yoshiro, and Kishimoto, Hiromitsu

Abstract

Glandular odontogenic cyst (GOC) is a rare odontogenic cyst with aggressive behavior. A 50-year-old Japanese man presented with pain and swelling of the mental region of the mandible. Panoramic radiography showed a clearly bordered radiolucent lesion extending from the alveolar to cortical bone of the mandible. The clinical diagnosis was an odontogenic tumor (e.g., ameloblastoma), and an incisional biopsy was performed. The histopathological diagnosis was GOC, and extirpation and tooth extraction were performed under general anesthesia. Because bone destruction is evident in patients with a huge GOC, it is important to differentiate these cysts from intraosseous mucoepidermoid carcinoma. Therefore, we analyzed the GOC for the presence of the CRTC1/3-MAML2fusion gene and found it to be negative. The patient had developed no recurrence of the GOC at the time of following.

Published
2024
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17. Whole blood transcriptome profiling identifies gene expression subnetworks and a key gene characteristic of the rare type of osteomyelitis

Author

Yahara, Hiroko, primary, Yanamoto, Souichi, additional, Takahashi, Miho, additional, Hamada, Yuji, additional, Sakamoto, Haruo, additional, Asaka, Takuya, additional, Kitagawa, Yoshimasa, additional, Moridera, Kuniyasu, additional, Noguchi, Kazuma, additional, Sugiyama, Masaya, additional, Maruoka, Yutaka, additional, and Yahara, Koji, additional

Published
2022
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18. Incidence of antiresorptive agent-related osteonecrosis of the jaw: A multicenter retrospective epidemiological study in Hyogo Prefecture, Japan

Author

Nashi, Masanori, primary, Kishimoto, Hiromitsu, additional, Kobayashi, Masaki, additional, Tachibana, Akira, additional, Suematsu, Motoo, additional, Fujiwara, Shigeyoshi, additional, Ota, Yoshiyuki, additional, Hashitani, Susumu, additional, Shibatsuji, Takeshi, additional, Nishida, Tetsuya, additional, Fujimura, Kazuma, additional, Furudoi, Shungo, additional, Ishida, Yoshiki, additional, Ishii, Shoichiro, additional, Fujita, Tsuyoshi, additional, Iwai, Soichi, additional, Shigeta, Takashi, additional, Harada, Takeshi, additional, Miyai, Daisuke, additional, Takeda, Daisuke, additional, Akashi, Masaya, additional, Noguchi, Kazuma, additional, and Takenobu, Toshihiko, additional

Published
2022
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19. Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study)

Author

Yanamoto, Souichi, primary, Michi, Yasuyuki, additional, Otsuru, Mitsunobu, additional, Inomata, Toru, additional, Nakayama, Hideki, additional, Nomura, Takeshi, additional, Hasegawa, Takumi, additional, Yamamura, Yoshiko, additional, Yamada, Shin-ichi, additional, Kusukawa, Jingo, additional, Yamakawa, Nobuhiro, additional, Hasegawa, On, additional, Ueda, Michihiro, additional, Kitagawa, Yoshimasa, additional, Hiraki, Akimitsu, additional, Hasegawa, Toshihiro, additional, Ohiro, Yoichi, additional, Kobayashi, Wataru, additional, Asoda, Seiji, additional, Kobayashi, Takanori, additional, Iino, Mitsuyoshi, additional, Fukuda, Masayuki, additional, Ishibashi-Kanno, Naomi, additional, Kawaguchi, Koji, additional, Aijima, Reona, additional, Noguchi, Kazuma, additional, Okura, Masaya, additional, Tanaka, Akira, additional, Sugiura, Tsuyoshi, additional, Shintani, Yukari, additional, Yagihara, Kazuhiro, additional, Yamashiro, Masashi, additional, Ota, Yoshihide, additional, Miyazaki, Akihiro, additional, Takeshita, Akinori, additional, Kawamata, Hitoshi, additional, Hiroshi, Iwabuchi, additional, Uchida, Kenichiro, additional, Umeda, Masahiro, additional, Kurita, Hiroshi, additional, and Kirita, Tadaaki, additional

Published
2022
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20. Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study)

Author

Yanamoto, Souichi, Michi, Yasuyuki, Otsuru, Mitsunobu, Inomata, Toru, Nakayama, Hideki, Nomura, Takeshi, Hasegawa, Takumi, Yamamura, Yoshiko, Yamada, Shin-ichi, Kusukawa, Jingo, Yamakawa, Nobuhiro, Hasegawa, On, Ueda, Michihiro, Kitagawa, Yoshimasa, Hiraki, Akimitsu, Hasegawa, Toshihiro, Ohiro, Yoichi, Kobayashi, Wataru, Asoda, Seiji, Kobayashi, Takanori, Iino, Mitsuyoshi, Fukuda, Masayuki, Ishibashi-Kanno, Naomi, Kawaguchi, Koji, Aijima, Reona, Noguchi, Kazuma, Okura, Masaya, Tanaka, Akira, Sugiura, Tsuyoshi, Shintani, Yukari, Yagihara, Kazuhiro, Yamashiro, Masashi, Ota, Yoshihide, Miyazaki, Akihiro, Takeshita, Akinori, Kawamata, Hitoshi, Hiroshi, Iwabuchi, Uchida, Kenichiro, Umeda, Masahiro, Kurita, Hiroshi, Kirita, Tadaaki, Yanamoto, Souichi, Michi, Yasuyuki, Otsuru, Mitsunobu, Inomata, Toru, Nakayama, Hideki, Nomura, Takeshi, Hasegawa, Takumi, Yamamura, Yoshiko, Yamada, Shin-ichi, Kusukawa, Jingo, Yamakawa, Nobuhiro, Hasegawa, On, Ueda, Michihiro, Kitagawa, Yoshimasa, Hiraki, Akimitsu, Hasegawa, Toshihiro, Ohiro, Yoichi, Kobayashi, Wataru, Asoda, Seiji, Kobayashi, Takanori, Iino, Mitsuyoshi, Fukuda, Masayuki, Ishibashi-Kanno, Naomi, Kawaguchi, Koji, Aijima, Reona, Noguchi, Kazuma, Okura, Masaya, Tanaka, Akira, Sugiura, Tsuyoshi, Shintani, Yukari, Yagihara, Kazuhiro, Yamashiro, Masashi, Ota, Yoshihide, Miyazaki, Akihiro, Takeshita, Akinori, Kawamata, Hitoshi, Hiroshi, Iwabuchi, Uchida, Kenichiro, Umeda, Masahiro, Kurita, Hiroshi, and Kirita, Tadaaki

Abstract

Introduction In early-stage oral tongue squamous cell carcinoma (OTSCC), elective neck dissection (END) is recommended when occult lymph node metastasis is suspected; however, there is no unanimous consensus on the risks and benefits of END in such cases. The management of clinically node-negative (cN0) OTSCC remains controversial. This study, therefore, aimed to evaluate the efficacy of END and its impact on the quality of life (QoL) of patients with cN0 OTSCC. Methods and analysis This is a prospective, multicentre, nonrandomised observational study. The choice of whether to perform END at the same time as resection of the primary tumour is based on institutional policy and patient preference. The primary endpoint of this study is 3-year overall survival. The secondary endpoints are 3-year disease-specific survival, 3-year relapse-free survival and the impact on patient QoL. Propensity score-matching analysis will be performed to reduce selection bias. Ethics and dissemination This study was approved by the Clinical Research Review Board of the Nagasaki University. The protocol of this study was registered at the University Hospital Medical Information Network Clinical Trials Registry. The datasets generated during the current study will be available from the corresponding author on reasonable request. The results will be disseminated internationally, through scientific and professional conferences and in peer-reviewed medical journals., BMJ open, 12 (9), art. no. e059615; 2022

Published
2022

24. LAMB3and TACSTD2, both highly expressed in salivary gland mucoepidermoid carcinoma, represent potential diagnostic biomarkers and therapeutic targets

Author

Yoshida, Kazunari, Noguchi, Kazuma, Yamanegi, Koji, Yoshikawa, Kyohei, Kanda, Shuji, Omori, Yuji, Omae, Takayuki, Takaoka, Kazuki, Terada, Tomonori, Nakano, Yoshiro, and Kishimoto, Hiromitsu

Abstract

Salivary mucoepidermoid carcinoma (MEC) is the most common malignant tumor in major and minor salivary glands. The CRTC1-MAML2or CRTC3-MAML2gene arrangements, which occur in up to 80% of primary salivary glands with MEC, are the major oncogenic drivers of MEC carcinogenesis. However, the molecular consequences of these fusions remain unknown. We sought to identify the key functional genes involved in MEC, then characterize biomarkers with potential therapeutic relevance. We analyzed the gene expression profiles of two primary tumors (fusion-positive HCM-MEC020T and fusion-negative HCM-MEC030T); we compared them with the profiles of the established cell line HCM-MEC010 (derived from CRTC1-MAML2 fusion-positive MEC) and fibroblast cells derived from an HCM-MEC010 patient (non-tumor control cells). Fifty-three genes were identified as commonly expressed genes among the top 500 highly expressed genes in MEC but not in fibroblasts. Among these 53 genes, we focused on LAMB3and TACSTD2, which are not predicted to be CRTC1/CRTC3-MAML2target genes. LAMB3(laminin subunit beta-3) is the basement membrane protein in normal salivary glands. TACSTD2encodes a membrane protein associated with calcium signaling. To investigate the relationship between gene expression patterns and MEC pathological grade, we performed immunohistochemical staining of 13 MEC samples. LAMB3 and TACSTD2 proteins were expressed in the tumor cells of MEC samples (LAMB3, 12/13; TACSTD2, 13/13) but not in surrounding stromal cells. Although there were no statistically significant differences in LAMB3 or TACSTD2 expression among pathological grades, further studies are needed to elucidate the value of LAMB3and TACSTD2in clinical applications.

Published
2023
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