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1. Phenotypic clustering of patients hospitalized in intensive cardiac care units: Insights from the ADDICT-ICCU study

Author

Hamzi, Kenza, Gall, Emmanuel, Roubille, François, Trimaille, Antonin, Elbaz, Meyer, El Ouahidi, Amine, Noirclerc, Nathalie, Fard, Damien, Lattuca, Benoit, Fauvel, Charles, Goralski, Marc, Alvain, Sean, Chaib, Aures, Piliero, Nicolas, Schurtz, Guillaume, Pommier, Thibaut, Bouleti, Claire, Tron, Christophe, Bonnet, Guillaume, Nhan, Pascal, Auvray, Simon, Léquipar, Antoine, Dillinger, Jean-Guillaume, Vicaut, Eric, Henry, Patrick, Toupin, Solenn, and Pezel, Théo

Published
2024
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3. Profile of patients hospitalized in intensive cardiac care units in France: ADDICT-ICCU registry

Author

Gall, Emmanuel, Pezel, Théo, Lattuca, Benoît, Hamzi, Kenza, Puymirat, Etienne, Piliero, Nicolas, Deney, Antoine, Fauvel, Charles, Aboyans, Victor, Schurtz, Guillaume, Bouleti, Claire, Fabre, Julien, El Ouahidi, Amine, Thuaire, Christophe, Millischer, Damien, Noirclerc, Nathalie, Delmas, Clément, Roubille, François, Dillinger, Jean-Guillaume, and Henry, Patrick

Published
2024
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4. Carbon monoxide and prognosis in smokers hospitalised with acute cardiac events: a multicentre, prospective cohort study

Author

Aboyans, Victor, Albert, Emeric, Albert, Franck, Alvain, Sean, Amri, Nabil, Andrieu, Stéphane, Attou, Sabir, Auvray, Simon, Azzakani, Sonia, Azencot, Ruben, Bedossa, Marc, Boccara, Franck, Boccara, Albert, Bochaton, Thomas, Bonnefoy-Cudraz, Eric, Bonnet, Guillaume, Bouali, Nabil, Bouchot, Océane, Bouleti, Claire, Boukertouta, Tanissia, Brette, Jean-Baptiste, Canu, Marjorie, Chaib, Aures, Charbonnel, Clement, Chaussade, Anne-Solene, Coppens, Alexandre, Cottin, Yves, Darmon, Arthur, de Angelis, Elena, Delmas, Clément, Delsarte, Laura, Deney, Antoine, Dib, Jean-Claude, Dillinger, Jean-Guillaume, Docq, Clemence, Dupasquier, Valentin, Elbaz, Meyer, El Hadad, Antony, El Ouahidi, Amine, Ezzouhairi, Nacim, Fabre, Julien, Fard, Damien, Fauvel, Charles, Gerbaud, Édouard, Gilard, Martine, Goralski, Marc, Grinberg, Nissim, Grentzinger, Alain, Hauguel-Moreau, Marie, Henry, Patrick, Huet, Fabien, Landemaine, Thomas, Lattuca, Benoit, Lemarchand, Léo, Levasseur, Thomas, Lim, Pascal, Maitre Ballesteros, Laura, Mansencal, Nicolas, Marie, Benjamin, Martinez, David, Merat, Benoit, Meune, Christophe, Millischer, Damien, Moine, Thomas, Nhan, Pascal, Noirclerc, Nathalie, Ohlmann, Patrick, Pezel, Théo, Picard, Fabien, Piliero, Nicolas, Pommier, Thibaut, Puymirat, Etienne, Ramonatxo, Arthur, Rossanaly Vasram, Reza, Roubille, François, Roule, Vincent, Schurtz, Guillaume, Stevenard, Mathilde, Sulman, David, Swedsky, Fédérico, Tea, Victoria, Thevenet, Eugénie, Thuaire, Christophe, Trimaille, Antonin, Tron, Christophe, Viboud, Guillaume, Yomi, Dominique, Zakine, Cyril, Roubille, Francois, Gerbaud, Edouard, Toupin, Solenn, and Vicaut, Eric

Published
2024
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5. In-hospital prognostic value of TAPSE/sPAP in patients hospitalized for acute heart failure.

Author

Fauvel, Charles, Dillinger, Jean-Guillaume, Vasram, Reza Rossanaly, Bouleti, Claire, Logeart, Damien, Roubille, François, Meune, Christophe, Ohlmann, Patrick, Bonnefoy-Coudraz, Eric, Albert, Franck, Attou, Sabir, Boukhris, Marouane, Pommier, Thibaut, Merat, Benoit, Noirclerc, Nathalie, Bouali, Nabil, Aghezzaf, Samy, Schurtz, Guillaume, Mansencal, Nicolas, and Andrieu, Stéphane

Subjects
TRICUSPID valve, LEFT heart ventricle, CARDIOGENIC shock, VENTRICULAR ejection fraction, RECEIVER operating characteristic curves, GRAPHIC arts, T-test (Statistics), PULMONARY artery, MAJOR adverse cardiovascular events, FISHER exact test, HEART failure, HEART physiology, CHI-squared test, MANN Whitney U Test, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, SYSTOLIC blood pressure, RIGHT ventricular dysfunction, CARDIAC arrest, CONFIDENCE intervals, ECHOCARDIOGRAPHY, COMORBIDITY
Abstract

Aims Tricuspid annular plane systolic excursion over systolic pulmonary artery pressure (TAPSE/sPAP) assessed by echocardiography appears to be a good non-invasive approach for right ventricular to pulmonary artery coupling assessment. We aimed to assess the in-hospital prognostic value of TAPSE/sPAP among patients hospitalized for acute heart failure (AHF). Methods and results In total, 333 consecutive patients (mean age 68 ± 14 years, 70% of male, mean left ventricular ejection fraction 44 ± 16%) were hospitalized for AHF across 39 French cardiology departments, with TAPSE/sPAP measured by echocardiography within the first 24 h of hospitalization were included in this prospective study. The primary outcome was in-hospital major adverse cardiovascular events (MACEs) defined as all-cause death, resuscitated cardiac arrest or cardiogenic shock and occurred in 50 (15%) patients. Using receiver operating characteristic curve analysis, the best TAPSE/sPAP threshold for in-hospital MACEs was 0.40 mm/mmHg. TAPSE/sPAP < 0.40 mm/mmHg was independently associated with in-hospital MACEs, even after adjustment with comorbidities [odds ratio (OR): 3.75, 95% CI (1.87–7.93), P < 0.001], clinical severity [OR: 2.80, 95% CI (1.36–5.95), P = 0.006]. Using a 1:1 propensity-matched population, TAPSE/sPAP ratio < 0.40 was associated with a higher rate of in-hospital MACEs [OR: 2.98, 95% CI (1.53–6.12), P = 0.002]. After adjustment, TAPSE/sPAP < 0.40 showed the best improvement in model discrimination and reclassification above traditional prognostic factors (C-statistic improvement: 0.05; χ 2 improvement: 14.4; likelihood-ratio test P < 0.001). These results were consistent in an external validation cohort of 133 patients. Conclusion TAPSE/sPAP < 0.40 mm/mmHg assessed by an early echocardiography during an AHF episode is independently associated with in-hospital MACEs suggesting enhanced close monitoring and strengthened heart failure-specific care in these patients. Trial Registration ClinicalTrials.gov Identifier: NCT05063097 [ABSTRACT FROM AUTHOR]

Published
2024
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6. A study of ChatGPT in facilitating Heart Team decisions on severe aortic stenosis

Author

Salihu, Adil, primary, Meier, David, additional, Noirclerc, Nathalie, additional, Skalidis, Ioannis, additional, Mauler-Wittwer, Sarah, additional, Recordon, Frederique, additional, Kirsch, Matthias, additional, Roguelov, Christan, additional, Berger, Alexandre, additional, Sun, Xiaowu, additional, Abbe, Emmanuel, additional, Marcucci, Carlo, additional, Rancati, Valentina, additional, Rosner, Lorenzo, additional, Scala, Emanuelle, additional, Rotzinger, David C., additional, Humbert, Marc, additional, Muller, Olivier, additional, Lu, Henri, additional, and Fournier, Stephane, additional

Published
2024
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7. Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease

Author

Leborgne, Laurent, Fournier, Alexandre, Jarry, Geneviève, Leleu, François, Malaquin, Dorothée, Mirode, Anfani, Belle, Loïc, Mangin, Lionel, Noirclerc, Nathalie, Barnay, Pierre, Hirsch, Jean-Lou, Metge, Marc, Pansiery, Michel, Soto, FrançoisXavier, Boge, Antoine, HadjHamou, Kamel, Miliani, Ichem, Molins, Guillaume, Mourot, Stéphane, Pelletier, Marion, Ressencourt, Olivier, Schaad, Frédéric, Coste, Pierre, Chasseriaud, Warren, Cetran, Laura, Poustis, Pierre, Morelle, Jean-Francois, Albert, Franck, Demicheli, Thibaud, Range, Grégroire, Thuaire, Christophe, Motreff, Pascal, Barber-Chamoux, Nicolas, Combaret, Nicolas, Malclès, Guilhem, Souteyrand, Géraud, Cottin, Yves, Buffet, Philippe, Gudjonvick, Aurélie, L’Huillier, Isabelle, Lorgis, Luc, Richard, Carole, Bertrand, Bernard, Baronne-Rochette, Gilles, Bouvaist, Hélène, Marlière, Stéphanie, Ormezzano, Olivier, Vanzetto, Gérald, Meunier, Ludovic, Trouillet, Charlotte, Valy, Yann, Lesault, Pierre-François, VanBelle, Eric, Bauters, Christophe, Delhaye, Cédric, Lemesle, Gilles, Rihani, Riadh, Graux, Pierre, Lemahieu, Jean-Michel, Harbaoui, Brahim, Besnard, Cyril, Courand, Pierre-Yves, Dauphin, Raphaël, Lantelme, Pierre, Perret, Thibault, Caignault, Jean-Raymond, Dubreuil, Olivier, Ranc, Sylvain, Ritz, Bernard, Rioufol, Gilles, Bergerot, Cyrille, Bochaton, Thomas, Bonnefoy-Cudraz, Eric, Bresson, Didier, Dementhon, Julie, Derimay, François, Finet, Gérard, Green, Lisa, Prieur, Cyril, Sanchez, Ingrid, Zouaghi, Oualid, Arméro, Sébastien, Lefèvre, Thierry, Ben-Amer, Hakim, Chevalier, Bernard, Garot, Philippe, Hovasse, Thomas, Louvard, Yves, Morice, Marie-Claude, Tavolaro, Oscar, Unterseeh, Thierry, Dupouy, Patrick, Roubille, François, Cung, DinhThienTri, Macia, Jean-Christophe, Piot, Christophe, Levy, Gilles, Roth, Olivier, Jacquemin, Laurent, Wiedemann, Jean-Yves, Cayla, Guillaume, Cornillet, Luc, Ledermann, Bertrand, Schmutz, Laurent, Lafont, Antoine, Karam, Nicole, Rahal, Saliha, Caussin, Christophe, Amabile, Nicolas, Girard, Philippe, Veugeois, Aurélie, Barthélémy, Olivier, Collet, Jean-Philippe, Montalescot, Gilles, Koning, René, Berland, Jacques, Godin, Matthieu, Landolff, Quentin, Zoghlami, Bilel, Pouillot, Christophe, Bougrini, Karim, Geyer, Christophe, Glanenapp, Jens, Mascarel, Patrick, Rambaud, Geoffray, ViFane, Richard, Angoulvant, Denis, Desveaux, Bernard, Ivanes, Fabrice, Pacouret, Gérard, Quilliet, Laurent-Emmanuel, SaintEtienne, Christophe, Chapon, Philippe, Bretelle, Christophe, Champin, Stanislas, Dérimay, François, Van Belle, Éric, Morelle, Jean-François, Soto, François-Xavier, Barthelemy, Olivier, Armero, Sébastien, Amaz, Camille, Vaz, Bernadette, Benyahya, Lakhdar, Varillon, Yvonne, Ovize, Michel, and Mewton, Nathan

Published
2021
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9. Psychoactive Substance Use in Elderly Patients: Insights from the Addict-Iccu Study

Author

Bouali, Nabil, primary, Benmansour, Othmane, additional, El Bèze, Nathan, additional, Trimaille, Antonin, additional, Bouleti, Claire, additional, Brette, Jean-Baptiste, additional, Schurtz, Guillaume, additional, Lim, Pascal, additional, Millischer, Damien, additional, El Ouahidi, Amine, additional, Gonçalves, Trecy, additional, Gall, Emmanuel, additional, Léquipar, Antoine, additional, Singh, Manveer, additional, Thuaire, Christophe, additional, Piliero, Nicolas, additional, Noirclerc, Nathalie, additional, Andrieu, Stéphane, additional, Fauvel, Charles, additional, Florence, Jeremy, additional, Delmas, Clément, additional, Toupin, Solenn, additional, Dillinger, Jean-Guillaume, additional, Henry, Patrick, additional, and Pezel, Theo, additional

Published
2024
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10. Carbon monoxide and prognosis in smokers hospitalised with acute cardiac events: a multicentre, prospective cohort study

Author

Dillinger, Jean-Guillaume, primary, Pezel, Théo, additional, Delmas, Clément, additional, Schurtz, Guillaume, additional, Trimaille, Antonin, additional, Piliero, Nicolas, additional, Bouleti, Claire, additional, Lattuca, Benoit, additional, Andrieu, Stéphane, additional, Fabre, Julien, additional, Rossanaly Vasram, Reza, additional, Dib, Jean-Claude, additional, Aboyans, Victor, additional, Fauvel, Charles, additional, Roubille, Francois, additional, Gerbaud, Edouard, additional, Boccara, Albert, additional, Puymirat, Etienne, additional, Toupin, Solenn, additional, Vicaut, Eric, additional, Henry, Patrick, additional, Albert, Emeric, additional, Albert, Franck, additional, Alvain, Sean, additional, Amri, Nabil, additional, Attou, Sabir, additional, Auvray, Simon, additional, Azzakani, Sonia, additional, Azencot, Ruben, additional, Bedossa, Marc, additional, Boccara, Franck, additional, Bochaton, Thomas, additional, Bonnefoy-Cudraz, Eric, additional, Bonnet, Guillaume, additional, Bouali, Nabil, additional, Bouchot, Océane, additional, Boukertouta, Tanissia, additional, Brette, Jean-Baptiste, additional, Canu, Marjorie, additional, Chaib, Aures, additional, Charbonnel, Clement, additional, Chaussade, Anne-Solene, additional, Coppens, Alexandre, additional, Cottin, Yves, additional, Darmon, Arthur, additional, de Angelis, Elena, additional, Delsarte, Laura, additional, Deney, Antoine, additional, Dillinger, Jean-Guillaume, additional, Docq, Clemence, additional, Dupasquier, Valentin, additional, Elbaz, Meyer, additional, El Hadad, Antony, additional, El Ouahidi, Amine, additional, Ezzouhairi, Nacim, additional, Fard, Damien, additional, Gerbaud, Édouard, additional, Gilard, Martine, additional, Goralski, Marc, additional, Grinberg, Nissim, additional, Grentzinger, Alain, additional, Hauguel-Moreau, Marie, additional, Huet, Fabien, additional, Landemaine, Thomas, additional, Lemarchand, Léo, additional, Levasseur, Thomas, additional, Lim, Pascal, additional, Maitre Ballesteros, Laura, additional, Mansencal, Nicolas, additional, Marie, Benjamin, additional, Martinez, David, additional, Merat, Benoit, additional, Meune, Christophe, additional, Millischer, Damien, additional, Moine, Thomas, additional, Nhan, Pascal, additional, Noirclerc, Nathalie, additional, Ohlmann, Patrick, additional, Picard, Fabien, additional, Pommier, Thibaut, additional, Ramonatxo, Arthur, additional, Roubille, François, additional, Roule, Vincent, additional, Stevenard, Mathilde, additional, Sulman, David, additional, Swedsky, Fédérico, additional, Tea, Victoria, additional, Thevenet, Eugénie, additional, Thuaire, Christophe, additional, Tron, Christophe, additional, Viboud, Guillaume, additional, Yomi, Dominique, additional, and Zakine, Cyril, additional

Published
2024
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11. Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome: A multicenter prospective study

Author

Skalidis, Ioannis, primary, Noirclerc, Nathalie, additional, Meier, David, additional, Luangphiphat, Wongsakorn, additional, Cagnina, Aurelien, additional, Mauler-Wittwer, Sarah, additional, Mahendiran, Thabo, additional, De Bruyne, Bernard, additional, Candreva, Alessandro, additional, Collet, Carlos, additional, Sonck, Jeroen, additional, Muller, Olivier, additional, and Fournier, Stephane, additional

Published
2023
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12. Prevalence and impact of recreational drug use in patients with acute cardiovascular events

Author

Pezel, Théo, primary, Dillinger, Jean-Guillaume, additional, Trimaille, Antonin, additional, Delmas, Clément, additional, Piliero, Nicolas, additional, Bouleti, Claire, additional, Pommier, Thibaut, additional, El Ouahidi, Amine, additional, Andrieu, Stéphane, additional, Lattuca, Benoit, additional, Rossanaly Vasram, Reza, additional, Fard, Damien, additional, Noirclerc, Nathalie, additional, Bonnet, Guillaume, additional, Goralski, Marc, additional, Elbaz, Meyer, additional, Deney, Antoine, additional, Schurtz, Guillaume, additional, Docq, Clemence, additional, Roubille, Francois, additional, Fauvel, Charles, additional, Bochaton, Thomas, additional, Aboyans, Victor, additional, Boccara, Franck, additional, Puymirat, Etienne, additional, Batisse, Anne, additional, Steg, Gabriel, additional, Vicaut, Eric, additional, and Henry, Patrick, additional

Published
2023
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13. Machine learning-based scoring system to predict in-hospital outcomes in patients hospitalized with COVID-19

Author

Weizman, Orianne, primary, Duceau, Baptiste, additional, Trimaille, Antonin, additional, Pommier, Thibaut, additional, Cellier, Joffrey, additional, Geneste, Laura, additional, Panagides, Vassili, additional, Marsou, Wassima, additional, Deney, Antoine, additional, Attou, Sabir, additional, Delmotte, Thomas, additional, Ribeyrolles, Sophie, additional, Chemaly, Pascale, additional, Karsenty, Clément, additional, Giordano, Gauthier, additional, Gautier, Alexandre, additional, Chaumont, Corentin, additional, Guilleminot, Pierre, additional, Sagnard, Audrey, additional, Pastier, Julie, additional, Ezzouhairi, Nacim, additional, Perin, Benjamin, additional, Zakine, Cyril, additional, Levasseur, Thomas, additional, Ma, Iris, additional, Chavignier, Diane, additional, Noirclerc, Nathalie, additional, Darmon, Arthur, additional, Mevelec, Marine, additional, Sutter, Willy, additional, Mika, Delphine, additional, Fauvel, Charles, additional, Pezel, Théo, additional, Waldmann, Victor, additional, Cohen, Ariel, additional, and Bonnet, Guillaume, additional

Published
2022
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16. Fractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease

Author

Rioufol, Gilles, primary, Dérimay, François, additional, Roubille, François, additional, Perret, Thibault, additional, Motreff, Pascal, additional, Angoulvant, Denis, additional, Cottin, Yves, additional, Meunier, Ludovic, additional, Cetran, Laura, additional, Cayla, Guillaume, additional, Harbaoui, Brahim, additional, Wiedemann, Jean-Yves, additional, Van Belle, Éric, additional, Pouillot, Christophe, additional, Noirclerc, Nathalie, additional, Morelle, Jean-François, additional, Soto, François-Xavier, additional, Caussin, Christophe, additional, Bertrand, Bernard, additional, Lefèvre, Thierry, additional, Dupouy, Patrick, additional, Lesault, Pierre-François, additional, Albert, Franck, additional, Barthelemy, Olivier, additional, Koning, René, additional, Leborgne, Laurent, additional, Barnay, Pierre, additional, Chapon, Philippe, additional, Armero, Sébastien, additional, Lafont, Antoine, additional, Piot, Christophe, additional, Amaz, Camille, additional, Vaz, Bernadette, additional, Benyahya, Lakhdar, additional, Varillon, Yvonne, additional, Ovize, Michel, additional, Mewton, Nathan, additional, Finet, Gérard, additional, Fournier, Alexandre, additional, Jarry, Geneviève, additional, Leleu, François, additional, Malaquin, Dorothée, additional, Mirode, Anfani, additional, Belle, Loïc, additional, Mangin, Lionel, additional, Hirsch, Jean-Lou, additional, Metge, Marc, additional, Pansiery, Michel, additional, Soto, FrançoisXavier, additional, Boge, Antoine, additional, HadjHamou, Kamel, additional, Miliani, Ichem, additional, Molins, Guillaume, additional, Mourot, Stéphane, additional, Pelletier, Marion, additional, Ressencourt, Olivier, additional, Schaad, Frédéric, additional, Coste, Pierre, additional, Chasseriaud, Warren, additional, Poustis, Pierre, additional, Morelle, Jean-Francois, additional, Demicheli, Thibaud, additional, Range, Grégroire, additional, Thuaire, Christophe, additional, Barber-Chamoux, Nicolas, additional, Combaret, Nicolas, additional, Malclès, Guilhem, additional, Souteyrand, Géraud, additional, Buffet, Philippe, additional, Gudjonvick, Aurélie, additional, L’Huillier, Isabelle, additional, Lorgis, Luc, additional, Richard, Carole, additional, Baronne-Rochette, Gilles, additional, Bouvaist, Hélène, additional, Marlière, Stéphanie, additional, Ormezzano, Olivier, additional, Vanzetto, Gérald, additional, Trouillet, Charlotte, additional, Valy, Yann, additional, VanBelle, Eric, additional, Bauters, Christophe, additional, Delhaye, Cédric, additional, Lemesle, Gilles, additional, Rihani, Riadh, additional, Graux, Pierre, additional, Lemahieu, Jean-Michel, additional, Besnard, Cyril, additional, Courand, Pierre-Yves, additional, Dauphin, Raphaël, additional, Lantelme, Pierre, additional, Caignault, Jean-Raymond, additional, Dubreuil, Olivier, additional, Ranc, Sylvain, additional, Ritz, Bernard, additional, Rioufol, Gilles, additional, Bergerot, Cyrille, additional, Bochaton, Thomas, additional, Bonnefoy-Cudraz, Eric, additional, Bresson, Didier, additional, Dementhon, Julie, additional, Derimay, François, additional, Green, Lisa, additional, Prieur, Cyril, additional, Sanchez, Ingrid, additional, Zouaghi, Oualid, additional, Arméro, Sébastien, additional, Ben-Amer, Hakim, additional, Chevalier, Bernard, additional, Garot, Philippe, additional, Hovasse, Thomas, additional, Louvard, Yves, additional, Morice, Marie-Claude, additional, Tavolaro, Oscar, additional, Unterseeh, Thierry, additional, Cung, DinhThienTri, additional, Macia, Jean-Christophe, additional, Levy, Gilles, additional, Roth, Olivier, additional, Jacquemin, Laurent, additional, Cornillet, Luc, additional, Ledermann, Bertrand, additional, Schmutz, Laurent, additional, Karam, Nicole, additional, Rahal, Saliha, additional, Amabile, Nicolas, additional, Girard, Philippe, additional, Veugeois, Aurélie, additional, Barthélémy, Olivier, additional, Collet, Jean-Philippe, additional, Montalescot, Gilles, additional, Berland, Jacques, additional, Godin, Matthieu, additional, Landolff, Quentin, additional, Zoghlami, Bilel, additional, Bougrini, Karim, additional, Geyer, Christophe, additional, Glanenapp, Jens, additional, Mascarel, Patrick, additional, Rambaud, Geoffray, additional, ViFane, Richard, additional, Desveaux, Bernard, additional, Ivanes, Fabrice, additional, Pacouret, Gérard, additional, Quilliet, Laurent-Emmanuel, additional, SaintEtienne, Christophe, additional, Bretelle, Christophe, additional, and Champin, Stanislas, additional

Published
2021
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19. In-hospital prognostic value of TAPSE/sPAP in patients hospitalized for acute heart failure.

Author

Fauvel C, Dillinger JG, Rossanaly Vasram R, Bouleti C, Logeart D, Roubille F, Meune C, Ohlmann P, Bonnefoy-Coudraz E, Albert F, Attou S, Boukhris M, Pommier T, Merat B, Noirclerc N, Bouali N, Aghezzaf S, Schurtz G, Mansencal N, Andrieu S, Henry P, and Pezel T

Subjects
Humans, Male, Female, Aged, Prognosis, Prospective Studies, Acute Disease, Middle Aged, Hospital Mortality, Hospitalization, France, Echocardiography methods, Tricuspid Valve diagnostic imaging, Risk Assessment, ROC Curve, Pulmonary Artery diagnostic imaging, Pulmonary Artery physiopathology, Cohort Studies, Aged, 80 and over, Heart Failure diagnostic imaging, Heart Failure mortality
Abstract

Aims: Tricuspid annular plane systolic excursion over systolic pulmonary artery pressure (TAPSE/sPAP) assessed by echocardiography appears to be a good non-invasive approach for right ventricular to pulmonary artery coupling assessment. We aimed to assess the in-hospital prognostic value of TAPSE/sPAP among patients hospitalized for acute heart failure (AHF)., Methods and Results: In total, 333 consecutive patients (mean age 68 ± 14 years, 70% of male, mean left ventricular ejection fraction 44 ± 16%) were hospitalized for AHF across 39 French cardiology departments, with TAPSE/sPAP measured by echocardiography within the first 24 h of hospitalization were included in this prospective study. The primary outcome was in-hospital major adverse cardiovascular events (MACEs) defined as all-cause death, resuscitated cardiac arrest or cardiogenic shock and occurred in 50 (15%) patients. Using receiver operating characteristic curve analysis, the best TAPSE/sPAP threshold for in-hospital MACEs was 0.40 mm/mmHg. TAPSE/sPAP < 0.40 mm/mmHg was independently associated with in-hospital MACEs, even after adjustment with comorbidities [odds ratio (OR): 3.75, 95% CI (1.87-7.93), P < 0.001], clinical severity [OR: 2.80, 95% CI (1.36-5.95), P = 0.006]. Using a 1:1 propensity-matched population, TAPSE/sPAP ratio < 0.40 was associated with a higher rate of in-hospital MACEs [OR: 2.98, 95% CI (1.53-6.12), P = 0.002]. After adjustment, TAPSE/sPAP < 0.40 showed the best improvement in model discrimination and reclassification above traditional prognostic factors (C-statistic improvement: 0.05; χ2 improvement: 14.4; likelihood-ratio test P < 0.001). These results were consistent in an external validation cohort of 133 patients., Conclusion: TAPSE/sPAP < 0.40 mm/mmHg assessed by an early echocardiography during an AHF episode is independently associated with in-hospital MACEs suggesting enhanced close monitoring and strengthened heart failure-specific care in these patients., Trial Registration: ClinicalTrials.gov Identifier: NCT05063097., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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