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Objective: The primary objective of these studies was to evaluate the potential of a serum containing Macrocystis pyrifera ferment (MPF-Serum) to both strengthen the barrier of intact skin and enhance barrier recovery after a non-ablative laser procedure or glycolic acid chemical peel., Methods: Two whole-face clinical trials and three split-face, randomized, controlled clinical trials were conducted in women aged 31 to 65 years. The effect of MPF-Serum on barrier integrity and strength was assessed by transepidermal water loss measurement before and after controlled tape-stripping experiments and in-clinic 70% glycolic acid peel and non-ablative laser procedures., Results: Application of MPF-Serum twice daily for eight weeks on intact skin significantly increased mean moisturization by 16 percent and improved barrier integrity by 11 percent ( p ≤0.05 for both). Likewise, barrier strength across 8x tape-stripped skin showed a 30-percent improvement after eight weeks of treatment. In studies involving non-ablative laser procedures, MPF-Serum pre-treatment or post-treatment improved post-procedure barrier recovery to a greater extent than standard moisturizer. Likewise, in a study involving 70% glycolic peel, MPF-Serum pre-treatment improved post-procedure barrier recovery to a greater extent than no pre-treatment., Limitations: These clinical studies were conducted at a limited number of sites, with limited sample sizes and populations., Conclusion: This topical MPF-Serum effectively improves barrier integrity and strength and helps to reduce recovery time from dermatologic procedures such as glycolic acid peel and laser treatments., Competing Interests: DISCLOSURES: Dr. Nole has served as a consultant and an advisor for the Estée Lauder Companies. Drs. Santhanam, Emmetsberger, and Saliou are employees of the Estée Lauder Companies. Drs. Gold and Ortiz have served as consultants for the Estée Lauder Companies., (Copyright © 2025. Matrix Medical Communications. All rights reserved.)