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Background/Objectives: Vedolizumab (VDZ) is approved in the treatment of patients with moderate to severe ulcerative colitis (UC) or Crohn's disease (CD). VDZ exhibits considerable variability in its pharmacokinetic (PK) profile, and its exposure-response relationship is not yet fully understood. The aim was to investigate the variability in VDZ trough levels and PK parameters, to assess the relationship between VDZ PK and biochemical response, as well as clinical and endoscopic outcomes. Methods: We included 61 UC and 45 CD patients. Patients' data and trough VDZ concentrations were retrospectively obtained. Population PK analysis was performed using non-linear mixed-effects modelling with NONMEM (version 7.5). Graphs and statistical analyses were performed using R (version 4.1.3). Results: In total, 116 trough VDZ concentrations from 106 patients were described by a two-compartment model. For a typical patient, clearance (CL) was estimated at 0.159 L/day, while in patients previously treated with anti-TNFα agents, VDZ CL increased by 26.4% on average. In univariate binary logistic regression, VDZ trough concentration was not statistically significant predictor of remission, whereas CL was. Moreover, combined CL and faecal calprotectin (FCP) were a statistically significant predictors of remission. The hazard ratio (HR) for CL above 0.1886 L/day was 0.35 (p = 0.05) and for FCP below 250 µg/g was 2.66 (p = 0.02) in a time-to-event analysis. Conclusions: Our population PK model incorporates the effect of prior anti-TNFα agents on CL, suggesting its association with more severe forms of IBD. VDZ CL emerged as a more robust and clinically relevant predictor of remission in IBD patients than trough concentration. [ABSTRACT FROM AUTHOR]

Providing memorable experiences is considered very effective strategy for gaining a sustainable competitive advantage. Memorable tourism experience (MTE) is still a relatively novel concept, hence its antecedents and outcomes are not completely identified. The primary goal of this research was to explore tourist personality and travel motivation as antecedents and the perceived destination personality, satisfaction, and revisit intention as outcomes of an MTE. The study was conducted on a sample of 614 foreign visitors to three biggest urban destinations in Serbia (Belgrade, Novi Sad, and Nis). For testing hypothesis, SEM (structural equation modelling) was applied. The results show that personality trait openness to experience and motivational factor knowledge and experience showed the strongest influence on MTEs. Also, all seven dimensions of memorable experience affected perceived destination personality. Practical implications and potential future research approaches are also highlighted in the conclusion. [ABSTRACT FROM AUTHOR]

The main objectives of this research were twofold: firstly, to evaluate tourists' perception of Gornje Podunavlje Special Nature Reserve, one of the four significant protected areas within the Serbian part of Mura-Drava-Danube Biosphere Reserve, and secondly, to identify the motivations behind tourists' visits to wetlands and their overall satisfaction with the visits. In addition, this study was also focused on the relationships between aforementioned constructs and tourists' socio-demographic characteristics and visit characteristics. Finally, this study attempts to address the relationships between tourists' motives for their visit, their image perception and satisfaction. The research findings showed that each of the three remaining factors had significant relationships with Satisfaction and experience. The research was conducted in the form of the survey in the period between May 2020 and April 2022 on the sample of 216 visitors. The research findings showed that each of three remaining factors had significant relationships with Satisfaction and experience. Relationships are also found between identified improvement requirements, Motivation for spending time particularly in wetlands, and perceived biodiversity image. Finally, there are significant relationships between duration of the visit with Satisfaction and experience and Motivation for spending time in nature and future behavior. Practical implications of the research results might be beneficial for managers of wetland destinations, in order to improve the offer in line with tourists' preferences. [ABSTRACT FROM AUTHOR]

Local communities face a double-edged sword when it comes to tourism development; their attitude directly influences tourism growth and helps spread the word within the community. The local community is increasingly affected socioeconomically by tourism development, which results in the development of attitudes (both positive and negative) based on the perceived effects. This study aimed to investigate the effects of tourism and local support for tourism development in a national park in western Serbia. The data were gathered from locals (580) who reside in the municipality where the national park belongs. Based on their own experiences and their belief that tourism can preserve natural and cultural resources and protect them for future generations, the Tara National Park community was found to favor further tourism development. They disagree that problems would arise from factors often associated with increasing tourism, such as traffic, price increases, or pollution. This study was carried out during the pandemic crisis, which is seen as a paradigm shift in the travel and tourism sectors and offers an opportunity to do better and continue operating in a more sustainable way. Therefore, we propose that these findings be taken into account when developing sustainable tourist management strategies, particularly in national parks and other protected places while respecting the needs and rights of the local people. [ABSTRACT FROM AUTHOR]

This study aims to investigate how national parks, identified as remarkable and, therefore, worthy of the trip, are visited and experienced. The main objective of this study was to explore the influence of memorable tourism experiences on environmentally responsible behavior, satisfaction, and behavioral intentions as its outcome. By giving an account of how national parks may be experienced by nature-based tourists, its main focus is on the concept of memorable nature-based tourist experience (MNBTE). The data for this research were collected through a survey from tourists visiting national parks in Serbia. The results demonstrate the significance of MNBTE as an important relationship mediator. The study's key contributions are the extension of the memorable tourism experience construct and the inclusion of tourist satisfaction, intention to revisit, recommend, share the experience, and the environmental responsibility of tourists. Practical implications and potential future research approaches are also highlighted in the conclusion. [ABSTRACT FROM AUTHOR]

One of the most important elements of tourism development is encouraging the participation of the local community. In order to encourage their participation, it is necessary to be aware of the attitudes of the local residents with respect to the development of tourism. The aim of this research is to determine the attitudes of the local community towards the development of sustainable tourism and ecotourism in the protected area Tikvara, along with the local residents' level of nature protection and preservation in the Tikvara Nature Park. A survey was conducted among 301 residents and the results indicate that while good community support for sustainable tourism activities in each area captured by the survey (planning, participation, activities, and decision-making) exists, local residents' attitudes are affected by their sociodemographic characteristics. Nonetheless, a large number of locals were happy to participate in protection programs and believed that the environment should be protected for future generations to enjoy the natural and cultural resources of this area. These findings should be considered when designing sustainable tourism management strategies, while respecting the needs and rights of the local community, as the willingness of locals to develop sustainable tourism is essential for the success of this sector. [ABSTRACT FROM AUTHOR]

The aim of this research is to explore the attitudes of the local community towards sustainable tourism development in the protected area River Gradac and examine the effectiveness of the sustainable tourism attitude scale. Sustainable tourism attitude scale (SUS-TAS) is used for analyzing local residents' attitudes towards sustainable tourism development. Confirmatory factor analysis (CFA) was implemented to determine the dimensions of the sustainable tourism attitude scale. The findings of this study support a seven-dimension SUS-TAS model using 28 items that maintained construct validity and internal consistency. The survey's results indicate that Gradac River gorge has a really good community to support sustainable tourism activities in each area considered. Research on residents' attitudes toward tourism development suggests that the support of local residents to be highly important if a community's tourism industry is to be successful and sustainable in the long-term. The results of this overall research study provided essential management implications for tourism planning of the Gradac River gorge in Serbia including the need to incorporate residents' attitudes into tourism planning efforts and decision-making. Through understanding residents' attitudes toward sustainable tourism, it is possible to prioritize management strategies while respecting the needs and rights of the local community. [ABSTRACT FROM AUTHOR]

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