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Kuniaki Otsuka,1,2 Shougo Murakami,3 Kiyotaka Okajima,4 Koichi Shibata,1 Yutaka Kubo,5 Denis G Gubin,6– 8 Larry A Beaty,2 Germaine Cornelissen2 1Tokyo Women’s Medical University, Tokyo, Japan; 2Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 3Department of Cardiovascular Medicine, Soseikai General Hospital, Kyoto, Japan; 4Cardiovascular Internal Medicine, Higashi Omiya General Hospital, Saitama, Japan; 5Department of Medicine, Machida Keisen Hospital, Tokyo, Japan; 6Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Medical University, Tyumen, 625023, Russia; 7Department of Biology, Medical University, Tyumen, 625023, Russia; 8Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, RussiaCorrespondence: Germaine Cornelissen, Halberg Chronobiology Center, University of Minnesota, MMC8609, 420 Delaware Street SE, Minneapolis, MN, 55455, USA, Email corne001@umn.edu.an Kuniaki Otsuka, Executive Medical Center, Totsuka Royal Clinic, Tokyo Women’s Medical University, Related Medical Facility, Sinjuku City, Tokyo, Japan, Email frtotk99@ba2.so-net.ne.jpBackground: Blood pressure (BP) variability is involved in the appraisal of threat and safety, and can serve as a potential marker of psychological resilience against stress. The relationship between biological rhythms of BP and resilience was cross-sectionally assessed by 7-day/24-hour chronobiologic screening in a rural Japanese community (Tosa), with focus on the 12-hour component and the “circadian-circasemidian coupling” of systolic (S) BP.Subjects and Methods: Tosa residents (N = 239, 147 women, 23– 74 years), free of anti-hypertensive medication, completed 7-day/24-hour ambulatory BP monitoring. The circadian-circasemidian coupling was determined individually by computing the difference between the circadian phase and the circasemidian morning-phase of SBP. Particip