5 results on '"Oscar R. Benavente"'
Number of results to display per page
Search Results
2. Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
- Author
-
Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Constance Turman, Marine Germain, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Peter Kraft, John‐Bjarne Hansen, John A Heit, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Sara L Pulit, Kristiina Rannikmäe, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Natalia S Rost, Peter M Rothwell, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans, and VU University medical center
- Subjects
Hemostasis ,genome-wide association study ,genetic pleiotropy ,Hematology ,Polymorphism, Single Nucleotide ,Hemostatics ,blood coagulation ,cardiovascular diseases ,Phenotype ,Cardiovascular Diseases ,Tissue Plasminogen Activator ,hemostasis ,Humans ,Genetic Predisposition to Disease ,Factor XI ,Genome-Wide Association Study - Abstract
Background: Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. Objectives: To discover novel genetic associations by combining summary data of correlated hemostatic traits and disease events. Methods: Summary statistics from genome wide-association studies (GWAS) from seven hemostatic traits (factor VII [FVII], factor VIII [FVIII], von Willebrand factor [VWF] factor XI [FXI], fibrinogen, tissue plasminogen activator [tPA], plasminogen activator inhibitor 1 [PAI-1]) and three major cardiovascular (CV) events (venous thromboembolism [VTE], coronary artery disease [CAD], ischemic stroke [IS]), were combined in 27 multi-trait combinations using metaUSAT. Genetic correlations between phenotypes were calculated using Linkage Disequilibrium Score Regression (LDSC). Newly associated loci were investigated for colocalization. We considered a significance threshold of 1.85 × 10−9 obtained after applying Bonferroni correction for the number of multi-trait combinations performed (n = 27). Results: Across the 27 multi-trait analyses, we found 4 novel pleiotropic loci (XXYLT1, KNG1, SUGP1/MAU2, TBL2/MLXIPL) that were not significant in the original individual datasets, were not described in previous GWAS for the individual traits, and that presented a common associated variant between the studied phenotypes. Conclusions: The discovery of four novel loci contributes to the understanding of the relationship between hemostasis and CV events and elucidate common genetic factors between these traits.
- Published
- 2022
3. Contributors
- Author
-
Harold P. Adams, Opeolu Adeoye, Gregory W. Albers, Andrei V. Alexandrov, Sepideh Amin-Hanjani, Hongyu An, Craig S. Anderson, Josef Anrather, Hugo J. Aparicio, Ken Arai, Jaroslaw Aronowski, Kunakorn Atchaneeyasakul, Heinrich Audebert, Roland N. Auer, Issam A. Awad, Hakan Ay, Selva Baltan, Ramani Balu, Mandana Behbahani, Oscar R. Benavente, Eric M. Bershad, Jimmy V. Berthaud, Spiros L. Blackburn, Leo H. Bonati, Julian Bösel, Marie Germaine Bousser, Joseph P. Broderick, Martin M. Brown, Wendy Brown, John C.M. Brust, Cheryl Bushnell, Patrícia Canhão, Louis R. Caplan, Julián Carrión-Penagos, Mar Castellanos, Michelle R. Caunca, Hugues Chabriat, Angel Chamorro, Jieli Chen, Jun Chen, Michael Chopp, Greg Christorforids, E. Sander Connolly, Steven C. Cramer, Brett L. Cucchiara, Alexandra L. Czap, Mark J. Dannenbaum, Patricia H. Davis, Ted M. Dawson, Valina L. Dawson, Arthur L. Day, T. Michael De Silva, Diana Aguiar de Sousa, Victor J. Del Brutto, Gregory J. del Zoppo, Colin P. Derdeyn, Marco R. Di Tullio, Hans Christoph Diener, Michael N. Diringer, Bruce H. Dobkin, Imanuel Dzialowski, Mitchell S.V. Elkind, Jordan Elm, Valery L. Feigin, José Manuel Ferro, Thalia S. Field, Marlene Fischer, Myriam Fornage, Karen L. Furie, Lidia Garcia-Bonilla, Steven L. Giannotta, Y. Pierre Gobin, Mark P. Goldberg, Larry B. Goldstein, Nicole R. Gonzales, David M. Greer, James C. Grotta, Ruiming Guo, Jose Gutierrez, Peter Harmel, George Howard, Virginia J. Howard, Jee-Yeon Hwang, Costantino Iadecola, Reza Jahan, Glen C. Jickling, Anne Joutel, Scott E. Kasner, Mira Katan, Christopher P. Kellner, Muhib Khan, Chelsea S. Kidwell, Helen Kim, Jong S. Kim, Charles E. Kircher, Timo Krings, Rita V. Krishnamurthi, Tobias Kurth, Maarten G. Lansberg, Elad I. Levy, David S. Liebeskind, Sook-Lei Liew, David J. Lin, Benjamin Lisle, Eng H. Lo, Patrick D. Lyden, Takakuni Maki, Georgios A. Maragkos, Miklos Marosfoi, Louise D. McCullough, Jason M. Meckler, James Frederick Meschia, Steven R. Messé, J Mocco, Maxim Mokin, Michael A. Mooney, Lewis B. Morgenstern, Michael A. Moskowitz, Michael T. Mullen, Steffen Nägel, Maiken Nedergaard, Justin A. Neira, Sarah Newman, Patrick J. Nicholson, Bo Norrving, Martin O’Donnell, Dimitry Ofengeim, Jun Ogata, Christopher S. Ogilvy, Emanuele Orrù, Santiago Ortega-Gutiérrez, Matthew Maximillian Padrick, Kaushik Parsha, Mark Parsons, Neil V. Patel, Virendra I. Patel, Ludmila Pawlikowska, Adriana Pérez, Miguel A. Perez-Pinzon, John M. Picard, Sean P. Polster, William J. Powers, Volker Puetz, Jukka Putaala, Margarita Rabinovich, Bruce R. Ransom, Jorge A. Roa, Gary A. Rosenberg, Christina P. Rossitto, Tatjana Rundek, Jonathan J. Russin, Ralph L. Sacco, Apostolos Safouris, Edgar A. Samaniego, Lauren H. Sansing, Nikunj Satani, Ronald J. Sattenberg, Jeffrey L. Saver, Sean I. Savitz, Christian Schmidt, Sudha Seshadri, Vijay K. Sharma, Frank R. Sharp, Kevin N. Sheth, Omar K. Siddiqi, Aneesh B. Singhal, Christopher G. Sobey, Clemens J. Sommer, Robert F. Spetzler, Christopher J. Stapleton, Ben A. Strickland, Hua Su, José I. Suarez, Hiroo Takayama, Joseph Tarsia, Turgut Tatlisumak, Ajith J. Thomas, John W. Thompson, Georgios Tsivgoulis, Elizabeth Tournier-Lasserve, Gabriel Vidal, Ajay K. Wakhloo, Babette B. Weksler, Joshua Z. Willey, Max Wintermark, Lawrence K.S. Wong, Guohua Xi, Jinchong Xu, Shadi Yaghi, Takenori Yamaguchi, Tuo Yang, Masahiro Yasaka, Darin B. Zahuranec, Feng Zhang, John H. Zhang, Zhitong Zheng, R. Suzanne Zukin, and Richard M. Zweifler
- Published
- 2022
4. Lesions in putative language and attention regions are linked to more severe strokes in patients with higher white matter hyperintensity burden
- Author
-
Jaume Roquer, Daniel Woo, Oscar R. Benavente, Tatjana Rundek, Alessandro Sousa, Stefan Ropele, Turgut Tatlisumak, E. Murat Arsava, Christoph J. Griessenauer, Robert W. Regenhardt, Reinhold Schmidt, Chia-Ling Phuah, Brandon L. Hancock, Sungmin Hong, Pankaj Sharma, Anna K. Bonkhoff, Caitrin W. McDonough, Daniel Strbian, Polina Golland, Tara M. Stanne, Bradford B. Worrall, Steven J. T. Mocking, Lukas Holmegaard, Jonathan Rosand, Johan Wassélius, James F. Meschia, Natalia S. Rost, Markus D. Schirmer, Mark R Etherton, Martin Bretzner, Christina Jern, Kathleen L. Donahue, Ona Wu, Jordi Jimenez-Conde, Marco Nardin, Ramin Zand, Agnieszka Slowik, Elissa C. McIntosh, Steven J. Kittner, Patrick F. McArdle, Giscome Investigators, Danilo Bzdok, John W. Cole, Robin Lemmens, Amanda Donatti, Achala Vagal, Arndt Rolfs, Katarina Jood, Jane Maguire, John Attia, Adrian V. Dalca, Vincent Thijs, Ralph L. Sacco, Anne-Katrin Giese, Martin Söderholm, Laura Heitsch, Arne Lindgren, and Christopher R Levi
- Subjects
0303 health sciences ,medicine.medical_specialty ,Stroke scale ,business.industry ,Stroke severity ,medicine.disease ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,White matter hyperintensity ,Neuroimaging ,Modified Rankin Scale ,Internal medicine ,Cardiology ,medicine ,In patient ,medicine.symptom ,business ,Stroke ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
ObjectiveTo examine whether high white matter hyperintensity (WMH) burden is associated with greater stroke severity and worse functional outcomes in lesion pattern-specific ways.MethodsMR neuroimaging and National Institutes of Health Stroke Scale data at index stroke, as well as modified Rankin Scale (mRS) at 3-6 months post-stroke were obtained from MRI-GENIE study of acute ischemic stroke (AIS) patients. Individual WMH volume was automatically derived from FLAIR-images. Stroke lesions were automatically segmented from DWI-images, spatially normalized and parcellated into atlas-defined brain regions. Stroke lesion effects on AIS severity and unfavorable outcomes (mRS>2) were modeled within a purpose-built machine learning and Bayesian regression framework. In particular, interaction effects between stroke lesions and a high versus low WMH burden were integrated via hierarchical model structures. Models were adjusted for the covariates age, age2, sex, total DWI-lesion and WMH volumes, and comorbidities. Data were split into derivation and validation cohorts.ResultsA total of 928 AIS patients contributed to stroke severity analyses (mean age: 64.8(14.5), 40% women), 698 patients to functional outcome analyses (mean age: 65.9(14.7), 41% women). Individual stroke lesions were represented in five anatomically distinct left-hemispheric and five right-hemispheric lesion patterns. Across all patients, acute stroke severity was substantially explained by three of these patterns, that were particularly focused on bilateral subcortical and left-hemispherically pronounced cortical regions. In high WMH burden patients, two lesion patterns consistently emerged as more pronounced in case of stroke severity: the first pattern was centered on left-hemispheric insular, opercular and inferior frontal regions, while the second pattern combined right-hemispheric temporo-parietal regions. Bilateral subcortical regions were most relevant in explaining long term unfavorable outcome. No WMH-specific lesion patterns of functional outcomes were substantiated. However, a higher overall WMH burden was associated with higher odds of unfavorable outcomes.ConclusionsHigher WMH burden increases stroke severity in case of stroke lesions involving left-hemispheric insular, opercular and inferior frontal regions (potentially linked to language functions) and right-hemispheric temporo-parietal regions (potentially linked to attention). These findings may contribute to augment stroke outcome predictions and motivate a WMH burden and stroke lesion pattern-specific clinical management of AIS patients.
- Published
- 2021
5. Genetic Contributions to Early and Late Onset Ischemic Stroke
- Author
-
Cristina Sanchez-Mora, Jie Hu, Philippe Amouyel, Annette Peters, Charles C Hong, Mary Cushman, Kathleen A. Ryan, Jiang Li, Liming Li, Thomas Jaworek, Sylvia Wassertheil-Smoller, Tiina Metso, Martin Soderholm, Kathryn M. Rexrode, Nicholas L. Smith, Jane Maguire, Martina Müller-Nurasyid, Agnieszka Slowik, Marguerite R. Irvin, Adam S. Butterworth, Martin O’Donnell, Leema Reddy Peddareddygari, Rainer Malik, Ralph L. Sacco, Brady Gaynor, Christian Geiger, Debashree Ray, Anne-Katrin Giese, John W. Cole, Jon Peter Durda, Vincent Thijs, Jukka Putaala, Michiaki Kubo, O. Colin Stine, Rebecca D. Jackson, Israel Fernandez-Cadenas, Reinhold Schmidt, Aki S. Havulinna, Kuang Lin, Christopher Levi, Steven Bell, Timothy O’Connor, Daniel Woo, Jara Cárcel-Márquez, Braxton D. Mitchell, Christina Jern, Jonathan Rosand, Sharon L.R. Kardia, Pankaj Sharma, Mina A. Jacob, Masaru Koido, Vida Abedi, Yoichiro Kamatani, Kristiina Rannikmäe, Michael Chong, Nuria P. Torres-Aguila, Cathie L. M. Sudlow, Ramin Zand, Elizabeth Holliday, Tatjana Rundek, Jessica D. Faul, Leslie Lange, Gunnar Engstrom, Marc C. Hochberg, Bradford B. Worrall, Hugh S. Markus, Joanna Pera, Jordi Jimenez-Conde, Caitrin W. McDonough, Raji P. Grewal, Owen Ross, Robin G. Walters, David J. Duggan, Guillaume Paré, Turgut Tatlisumak, Laura Heitsch, Jin-Moo Lee, Natalie Fecteau, Robin Lemmens, Jennifer A. Smith, Daniel Strbian, Patrick F. McArdle, Martin Dichgans, Jan H. Veldink, Liisa Tomppo, Arne G. Lindgren, Zhengming Chen, Chikashi Terao, Ulrike Grittner, Marta Ribasés, David R. Weir, James F. Meschia, Sothear Luke, Raquel Rabionet Janssen, Tara M. Stanne, Stephanie Debette, Nicole D. Armstrong, James A. Perry, Julie A. Johnson, Huichun Xu, Christopher D. Anderson, Giorgio B. Boncoraglio, Christian Enzinger, Haley Lopez, Anil Man Tuladhar, Oscar R. Benavente, Veikko Salomaa, David-Alexandre Trégouët, John Danesh, F-E de Leeuw, John Attia, Peter M. Rothwell, Steven J. Kittner, Andreea Ilinca, and Carlos Cruchaga
- Subjects
0303 health sciences ,medicine.medical_specialty ,business.industry ,Late onset ,Locus (genetics) ,030204 cardiovascular system & hematology ,medicine.disease ,3. Good health ,03 medical and health sciences ,Venous thrombosis ,0302 clinical medicine ,ABO blood group system ,Internal medicine ,Ischemic stroke ,medicine ,Cardiology ,SNP ,business ,Stroke ,030304 developmental biology ,Genetic association - Abstract
ObjectiveTo determine the contribution of common genetic variants to risk of early onset ischemic stroke (IS).MethodsWe performed a meta-analysis of genome-wide association studies of early onset IS, ages 18-59, using individual level data or summary statistics in 16,927 cases and 576,353 non-stroke controls from 48 different studies across North America, Europe, and Asia. We further compared effect sizes at our most genome-wide significant loci between early and late onset IS and compared polygenic risk scores for venous thromboembolism between early versus later onset IS.ResultsWe observed an association between early onset IS and ABO, a known stroke locus. The effect size of the peak ABO SNP, rs8176685, was significantly larger in early compared to late onset IS (OR 1.17 (95% C.I.: 1.11-1.22) vs 1.05 (0.99-1.12); p for interaction = 0.008). Analysis of genetically determined ABO blood groups revealed that early onset IS cases were more likely to have blood group A and less likely to have blood group O compared to both non-stroke controls and to late onset IS cases. Using polygenic risk scores, we observed that greater genetic risk for venous thromboembolism, another prothrombotic condition, was more strongly associated with early, compared to late, onset IS (p=0.008).ConclusionThe ABO locus, genetically predicted blood group A, and higher genetic propensity for venous thrombosis are more strongly associated with early onset IS, compared with late onset IS, supporting a stronger role of prothrombotic factors in early onset IS.
- Published
- 2021
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.