1. The role of computational models in mechanobiology of growing bone
- Author
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Ester Comellas, Sandra J. Shefelbine, Universitat Politècnica de Catalunya. Departament de Física, and Universitat Politècnica de Catalunya. L'AIRE - Laboratori Aeronàutic i Industrial de Recerca i Estudis
- Subjects
Ossificació ,Finite element method ,Histology ,Finite element model (FE model) ,Elements finits, Mètode dels ,Biomedical Engineering ,Endochondral ossification ,Biomecànica ,Bioengineering ,Ossification ,Bone growth and development ,Mechanobiology ,Ossos -- Propietats mecàniques ,Enginyeria biomèdica::Biomecànica [Àrees temàtiques de la UPC] ,Biomechanics ,Bones -- Mechanical properties ,Biotechnology - Abstract
Endochondral ossification, the process by which long bones grow in length, is regulated by mechanical forces. Computational models, specifically finite element models, have been used for decades to understand the role of mechanical loading on endochondral ossification. This perspective outlines the stages of model development in which models are used to: 1) explore phenomena, 2) explain pathologies, 3) predict clinical outcomes, and 4) design therapies. As the models progress through the stages, they increase in specificity and biofidelity. We give specific examples of models of endochondral ossification and expect models of other mechanobiological systems to follow similar development stages.
- Published
- 2022
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