37 results on '"P. Kokkalis"'
Search Results
2. A match-pair analysis of single row vs transosseous equivalent double row in massive posterosuperior rotator cuff tears in patients > 70 years old
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Koukos, Christos, Giannatos, Vasileios, Panagopoulos, Andreas, Kokkalis, Zinon, Latz, David, Bilsel, Kerem, Paolo, Arrigoni, and Montoya, Fredy
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- 2024
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3. On the Computation of Equilibria in Discrete First-Price Auctions
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Filos-Ratsikas, Aris, Giannakopoulos, Yiannis, Hollender, Alexandros, and Kokkalis, Charalampos
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Computer Science - Computer Science and Game Theory ,Computer Science - Computational Complexity - Abstract
We study the computational complexity of computing Bayes-Nash equilibria in first-price auctions with discrete value distributions and discrete bidding space, under general subjective beliefs. It is known that such auctions do not always have pure equilibria. In this paper, we prove that the problem of deciding their existence is NP-complete, even for approximate equilibria. On the other hand, it can be shown that mixed equilibria are guaranteed to exist; however, their computational complexity has not been studied before. We establish the PPAD-completeness of computing a mixed equilibrium and we complement this by an efficient algorithm for finding symmetric approximate equilibria in the special case of iid priors. En route to these results, we develop a computational equivalence framework between continuous and discrete first-price auctions, which can be of independent interest, and which allows us to transfer existing positive and negative results from one setting to the other. Finally, we show that correlated equilibria of the auction can be computed in polynomial time., Comment: 54 pages, 2 figures, Published in the 25th ACM Conference on Economics and Computation (EC'24)
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- 2024
4. Coracoclavicular fixation techniques for Neer IIb and 'extralateral' fractures of the distal clavicle: a systematic review
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Andreas Panagopoulos, MD, PhD, Konstantina Solou, MD, MSc, Marios Nicolaides, MSc, Ioannis K. Triantafyllopoulos, MD, PhD, Antonis Kouzelis, MD, PhD, and Zinon T. Kokkalis, MD, PhD
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Unstable extralateral distal clavicle fractures ,Neer type IIb ,Neer type IIc ,Coracoclavicular fixation ,Surgery ,RD1-811 - Abstract
Background: Unstable “extralateral” fractures of the distal clavicle (lateral to the coracoclavicular ligaments) are not distinguished in the Neer classification system and are commonly included with Neer IIb fractures. In the literature, there is no optimal surgical technique for managing unstable fractures of the distal clavicle, nonetheless for unique “extra-lateral” patterns. The aim of this study is to evaluate the effectiveness and safety of existing coracoclavicular fixation techniques for managing unstable Neer IIb and extralateral (IIc) fractures of the distal clavicle. Methods: We performed a systematic search of the literature to capture all studies evaluating the safety and effectiveness of existing coracoclavicular loop techniques for unstable Neer IIb and extralateral (IIc) fractures of the distal clavicle. We searched the PubMed (MEDLINE and PubMed Central), Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials electronic databases to retrieve studies published between January 2000 and November 2020. Our study was guided by a prospectively developed protocol and reported in accordance with the latest Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Our database search yielded a total of 564 records; of which, 21 were deemed appropriate for inclusion in our qualitative synthesis. The total number of reported IIb/c fractures managed with a coracoclavicular stabilization technique in all studies was 421. In total, 139 (33%) patients received arthroscopic-assisted treatment, and 282 (67%) patients were managed with open coracoclavicular stabilization. The reported clinical results were very good to excellent in most studies, whereas the overall major and minor complication rate was 2.6% and 12.8%, respectively. Major complications were more frequent in arthroscopic-assisted techniques (4.3%) compared with open (1.8%). Conclusion: The present systematic review of coracoclavicular stabilization techniques for unstable Neer IIb and extralateral fractures of the distal clavicle demonstrates promising clinical outcomes, including effectiveness and safety. We support the previously proposed modification of the Neer classification to include this unique type of unstable extralateral fracture (type IIc) to allow for targeted surgical management.
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- 2024
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5. Evaluation of ERA5 and NCEP reanalysis climate models for precipitation and soil moisture over a semi-arid area in Kuwait
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Kokkalis, Panagiotis, Al Jassar, Hala K., Al Sarraf, Hussain, Nair, Roshni, and Al Hendi, Hamad
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- 2024
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6. Deep learning based black spot identification on Greek road networks
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Karamanlis, Ioannis, Kokkalis, Alexandros, Profillidis, Vassilios, Botzoris, George, Kiourt, Chairi, Sevetlidis, Vasileios, and Pavlidis, George
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Computer Science - Machine Learning - Abstract
Black spot identification, a spatiotemporal phenomenon, involves analyzing the geographical location and time-based occurrence of road accidents. Typically, this analysis examines specific locations on road networks during set time periods to pinpoint areas with a higher concentration of accidents, known as black spots. By evaluating these problem areas, researchers can uncover the underlying causes and reasons for increased collision rates, such as road design, traffic volume, driver behavior, weather, and infrastructure. However, challenges in identifying black spots include limited data availability, data quality, and assessing contributing factors. Additionally, evolving road design, infrastructure, and vehicle safety technology can affect black spot analysis and determination. This study focused on traffic accidents in Greek road networks to recognize black spots, utilizing data from police and government-issued car crash reports. The study produced a publicly available dataset called Black Spots of North Greece (BSNG) and a highly accurate identification method.
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- 2023
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7. Delayed diagnosis of a primary diffuse large B-cell lymphoma of the humeral head, presenting as pathological fracture: a case report and review of the literature
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Andreas Panagopoulos, MD, PhD, Konstantina Solou, MD, Argiris Symeonidis, MD, PhD, Evgenia Verigou, MD, PhD, Olga Kouroukli, MD, Vasiliki Zolota, MD, PhD, and Zinon T. Kokkalis, MD, PhD
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Primary bone lymphoma ,Diffuse large B-cell lymphoma ,Shoulder ,Proximal humerus ,Pathological fracture ,Reverse shoulder arthroplasty ,Surgery ,RD1-811 - Published
- 2024
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8. Editorial: Lidar and ocean color remote sensing for marine ecology
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Peng Chen, Panagiotis Kokkalis, Yudi Zhou, and Iwona S. Stachlewska
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LiDAR remote sensing ,ocean optics ,ocean ecology ,atmospheric optics ,ocean remote sensing ,atmosphere remote sensing ,Geophysics. Cosmic physics ,QC801-809 ,Meteorology. Climatology ,QC851-999 - Published
- 2024
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9. Corrigendum: Towards reliable retrievals of cloud droplet number for non-precipitating planetary boundary layer clouds and their susceptibility to aerosol
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Romanos Foskinis, Athanasios Nenes, Alexandros Papayannis, Paraskevi Georgakaki, Konstantinos Eleftheriadis, Stergios Vratolis, Maria I. Gini, Mika Komppula, Ville Vakkari, and Panos Kokkalis
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aerosols ,clouds ,droplet number ,lidar ,PBL ,satellite remote sensing ,Geophysics. Cosmic physics ,QC801-809 ,Meteorology. Climatology ,QC851-999 - Published
- 2024
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10. An Overview of the Efficiency of Roundabouts: Design Aspects and Contribution toward Safer Vehicle Movement
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Konstantinos Gkyrtis and Alexandros Kokkalis
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roundabouts ,road design impact ,traffic safety ,capacity ,pavement condition ,environmental aspects ,Mechanical engineering and machinery ,TJ1-1570 ,Machine design and drawing ,TJ227-240 ,Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
Transforming intersections into roundabouts has shown that a sufficient degree of road safety and traffic capacity can be achieved. Because of the lower speeds at the area of a roundabout, drivers tend to become more easily adaptive to any kind of conflict with the surrounding environment. Despite the contribution to safety, the design elements of roundabouts are not uniformly fixed on a worldwide scale because of different traffic volumes, vehicle dimensions, drivers’ attitude, etc. The present study provides a brief overview of the contribution of roundabouts to road safety and the interactions between safety and the design elements of roundabouts. In addition, discussion points about current challenges and prospects are elaborated, including findings from the environmental assessment of roundabouts; their use and performance on the era of autonomous vehicles that will dominate in the near future; as well as the role and importance of simulation studies towards the improvement of the design and operation of roundabouts in favor of safer vehicle movement. The criticality of roundabouts, in terms of their geometric design as well as the provided road safety, lies upon the fact that roundabouts are currently used for the conventional vehicle fleet, which will be gradually replaced by new vehicle technologies. Such an action will directly impact the criteria for road network design and/or redesign, thereby continuously fostering new research initiatives.
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- 2024
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11. The Influence of the Planetary Boundary Layer on the Atmospheric State at an Orographic Site at the Eastern Mediterranean
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Romanos Foskinis, Kunfeng Gao, Maria I. Gini, Evangelia Diapouli, Stergios Vratolis, Konstantinos Granakis, Olga Zografou, Panagiotis Kokkalis, Mika Komppula, Ville Vakkari, Konstantinos Eleftheriadis, Athanasios Nenes, and Alexandros Papayannis
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planetary boundary layer (pbl) ,lidar ,aerosols ,bioaerosols ,ebc ,wind doppler lidar ,helmos ,(hac)2 ,Meteorology. Climatology ,QC851-999 - Abstract
We studied the influence of the Planetary Boundary Layer (PBL) on the air masses sampled at the mountaintop Hellenic Atmospheric Aerosol and Climate Change station ((HAC)2) at Mount Helmos (Greece) during the Cloud-AerosoL InteractionS in the Helmos background TropOsphere (CALISTHO) Campaign from September 2021 to March 2022. The PBL Height (PBLH) was determined from the standard deviation of the vertical wind velocity (σw) measured by a wind Doppler lidar (over a 30-min time window with 30 m spatial resolution); the height for which σw drops below a characteristic threshold of 0.1 m s–1 corresponds to the PBLH. The air mass characterization is independently carried out using in situ measurements sampled at (HAC)2 (equivalent black carbon, eBC; fluorescent particle number, aerosol size distributions, absolute humidity). We found that a distinct diurnal cycle of aerosol properties is seen when the station is inside the PBL (i.e., PBLH exceeds the (HAC)2 altitude); and a complete lack thereof when it is in the Free Tropospheric Layer (FTL). Additionally, we identified transition periods where the (HAC)2 site location alternates between the FTL (usually during the early morning hours) and the PBL (usually during the midday and late afternoon hours), during which the concentration and characteristics of the aerosols vary the most. Transition periods are also when orographic clouds are formed. The highest PBLH values occur in September [400 m above (HAC)2] followed by a transition period in November, while the lowest ones occur in January [200 m below (HAC)2]. We found also that the PBLH increases by 16 m per 1°C increase of the ground temperature.
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- 2024
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12. Study protocol: biomechanical testing, finite element analysis and prospective, randomized, clinical study of single screw cephalomedullary nailing versus integrated dual interlocking screw fixation for unstable (31A21–3) intertrochanteric fractures in patients > 70 years old
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Andreas Panagopoulos, Evangelia Argyropoulou, Zinon T. Kokkalis, Nicolaos Parchas, and Konstantinos Tserpes
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Intertrochanteric fractures ,Biomechanical testing ,Finite element analysis ,Single cephalomedullary nailing ,Integrated dual interlocking screw nailing ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Hip fractures are an increasingly common consequence of falls in older people that are associated with a high risk of death and reduced function. The vast majority of intertrochanteric fractures require surgical treatment to withstand early mobilization and weight bearing, which prevents complications due to prolonged bed rest and aids in fracture healing. Methods This study is compromised by two parts, the experimental study and the clinical part. In the first part, a standard 130° nail will be used with the appropriate lag screw(s) and dynamic distal locking in synthetic osteoporotic femurs and the transmission of forces in the proximal femur, measured by a cortical surface-strain distribution, will be evaluated using digital image correlation. Finite element parametric models of the bone, the nails and their interface will be also developed. Finite element computations of surface strains in implanted femurs, after being validated against biomechanical testing measurements, will be used to assist the comparison of the nails by deriving important data on the developed stress and strain fields, which cannot be measured through biomechanical testing. In the other part, will set up a prospective, randomized, comparative clinical study among the Gamma3 and IT cephalomedullary nailing, in order to investigate if there are any statistical important differences in the main radiological measurements and functional status in closed unstable intertrochanteric fractures (A21-3) in patients aged over 70 years old at the 24-week follow-up evaluation using patient reported disease-specific outcomes. Discussion This study will be the first to compare clinical, radiological and biomechanical measurements of the two different cephalomedullary nails. Our main hypothesis is that the IT nail would provide better radiological outcome and probably better clinical results than the Gama3 nail. Clinical trial registration International Standard Randomized Controlled Trial Number (ISRCTN): https://doi.org/10.1186/ISRCTN15588442 , registered on 19/4/2022.
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- 2023
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13. Growth and natural mortality of Maurolicus muelleri and Benthosema glaciale in the Northeast Atlantic Ocean
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Berthe M. J. Vastenhoud, Tobias K. Mildenberger, Alexandros Kokkalis, Silvia Paoletti, Paula Alvarez, Dorleta Garcia, Alina M. Wieczorek, Thor Klevjer, Webjørn Melle, Sigurður T. Jonsson, and J. Rasmus Nielsen
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Maurolicus muelleri ,Benthosema glaciale ,TropFishR ,length-based assessment ,mesopelagic zone ,data-limited stock assessment methods ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Mesopelagic fish are considered a possible future fisheries resource, but the biological sustainability of their potential exploitation has not yet been assessed. Sustainability should be evaluated at the population level, for which accurate stock-specific life-history parameters are required. Here, we use a length-based model to estimate life-history parameters related to growth and natural mortality, and their uncertainty, for the assessment of Northeast Atlantic populations of Maurolicus muelleri (Gmelin, 1789, Mueller’s Pearlside) and Benthosema glaciale (Reinhardt, 1837, glacier lantern fish). We compare three different approaches to estimate natural mortality rates and provide recommendations for future data collection and monitoring programs. For M. muelleri, we estimated an asymptotic length of 57.98 mm and a von Bertalanffy growth constant of 1.28 year−1, while for B. glaciale, we estimated an asymptotic length of 78.93 mm and a von Bertalanffy growth constant of 0.41 year−1. Estimates of natural mortality rates for M. muelleri were around 1.29 year−1 and 1.80 year−1 based on empirical formulae with the estimated growth parameters and maximum age, respectively, and around 1.51 year−1 with the length-converted catch curve method for B. glaciale estimates ranged between 0.5, 0.68, and 0.75 year−1, with the three respective methods. Due to limited data availability, the estimated uncertainty of the provided life-history parameters is large and should be considered in the evaluation of the sustainability of potential mesopelagic exploitation following the precautionary approach.
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- 2023
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14. Surgical Treatment of Monteggia-Like Lesions With a Modified Boyd Approach
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Zinon T. Kokkalis , MD, PhD, Aikaterini Bavelou , MD, Dimitrios Kalavrytinos , MD, MsC, George Sinos , MD, Panagiotis Antzoulas , MD, MsC, and Andreas Panagopoulos , MD, PhD
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Orthopedic surgery ,RD701-811 - Abstract
Introduction Monteggia-like lesions are rare injuries in adults that include a wide spectrum of complex fracture-dislocations of the proximal ulna and radius. In this retrospective study, we performed a modified Boyd approach and a standard surgical protocol for the treatment of these lesions. Our aim was to evaluate the results of the operative treatment for patients with Monteggia-like lesions, using a modified Boyd approach. Materials and Methods We present a retrospective study of 14 patients who underwent surgical treatment for Monteggia-like lesions. Preoperative clinical and radiological evaluation was performed. In 5 cases radial head prosthesis was placed, and in 3 cases the radial fracture was stabilized with the use of interfragmental screws. Regarding the proximal ulnar fracture, ORIF-anatomical plate and ORIF-straight plate was used in 12 and 2 cases, respectively. Results Average clinical follow up was 16.9 months. Postoperatively, the mean Mayo Elbow Performance score was 83.4 points (range 70-100) and the mean visual analog scale was 1.7 (range 0-14). Mean flexion and loss of extension were 122.1° (range 80°-140°) and 21.4° (range 5°-40°), respectively. Mean supination of the forearm was 66.8° (range 50°-80°) and the mean pronation was 67.5° (range 60°-75°). Heterotopic ossification was observed in 3 patients (21.4%) and 1 patient developed stiffness (7.1%). The patient who developed stiffness underwent reoperation for plate removal and arthrolysis, with satisfactory results. Conclusions The surgical treatment of Monteggia-like lesions in adults remains a challenge. In the present study, the use of a standard surgical protocol, with a modified Boyd approach, successfully restores the movement and stability of the elbow, with a low complication rate.
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- 2023
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15. Optical and Microphysical Properties of the Aerosols during a Rare Event of Biomass-Burning Mixed with Polluted Dust
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Marilena Gidarakou, Alexandros Papayannis, Panagiotis Kokkalis, Nikolaos Evangeliou, Stergios Vratolis, Emmanouella Remoundaki, Christine Groot Zwaaftink, Sabine Eckhardt, Igor Veselovskii, Maria Mylonaki, Athina Argyrouli, Konstantinos Eleftheriadis, Stavros Solomos, and Maria I. Gini
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Raman lidar ,aerosols ,dust ,biomass-burning ,Sahara ,Kazakhstan ,Meteorology. Climatology ,QC851-999 - Abstract
A rare event of mixed biomass-burning and polluted dust aerosols was observed over Athens, Greece (37.9° N, 23.6° E), during 21–26 May 2014. This event was studied using a synergy of a 6-wavelength elastic-Raman-depolarization lidar measurements, a CIMEL sun photometer, and in situ instrumentation. The FLEXPART dispersion model was used to identify the aerosol sources and quantify the contribution of dust and black carbon particles to the mass concentration. The identified air masses were found to originate from Kazakhstan and Saharan deserts, under a rare atmospheric pressure system. The lidar ratio (LR) values retrieved from the Raman lidar ranged within 25–89 sr (355 nm) and 35–70 sr (532 nm). The particle linear depolarization ratio (δaer) ranged from 7 to 28% (532 nm), indicating mixing of dust with biomass-burning particles. The aerosol optical depth (AOD) values derived from the lidar ranged from 0.09–0.43 (355 nm) to 0.07–0.25 (532 nm). An inversion algorithm was used to derive the mean aerosol microphysical properties (mean effective radius (reff), single scattering albedo (SSA), and mean complex refractive index (m)) inside selected atmospheric layers. We found that reff was 0.12–0.51 (±0.04) µm, SSA was 0.94–0.98 (±0.19) (at 532 nm), while m ranged between 1.39 (±0.05) + 0.002 (±0.001)i and 1.63 (±0.05) + 0.008 (±0.004)i. The polarization lidar photometer networking (POLIPHON) algorithm was used to estimate the vertical profile of the mass concentration for the dust and non-dust components. A mean mass concentration of 15 ± 5 μg m−3 and 80 ± 29 μg m−3 for smoke and dust was estimated for selected days, respectively. Finally, the retrieved aerosol microphysical properties were compared with column-integrated sun photometer CIMEL data with good agreement.
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- 2024
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16. ES-SCLC Patients with PD-L1+ CTCs and High Percentages of CD8+PD-1+T Cells in Circulation Benefit from Front-Line Immunotherapy Treatment
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Anastasia Xagara, Argyro Roumeliotou, Alexandros Kokkalis, Konstantinos Tsapakidis, Dimitris Papakonstantinou, Vassilis Papadopoulos, Ioannis Samaras, Evagelia Chantzara, Galatea Kallergi, and Athanasios Kotsakis
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ES-SCLC ,CTCs ,PD-L1+CTCs ,CD8+ T-cells ,PD-1+ T-cells ,ICI therapy ,Biology (General) ,QH301-705.5 - Abstract
SCLC is an aggressive cancer type with high metastatic potential and bad prognosis. CTCs are a valuable source of tumor cells in blood circulation and are among the major contributors to metastasis. In this study we evaluated the number of CTCs that express PD-L1 in treatment-naïve ES-SCLC patients receiving ICI in a front-line setting. Moreover, we explored the percentages of different immune T-cell subsets in circulation to assess their potential role in predicting responses. A total of 43 patients were enrolled—6 of them with LS-SCLC, and 37 with ES-SCLC disease. In addition, PBMCs from 10 healthy donors were used as a control group. Different T-cell subtypes were examined through multicolor FACS analysis and patients’ CTCs were detected using immunofluorescence staining. SCLC patients had higher percentages of PD-1-expressing CD3+CD4+ and CD3+CD8+ T-cells, as well as elevated PD-1 protein expression compared to healthy individuals. Additionally, in ES-SCLC patients, a positive correlation between CD3+CD8+PD-1+ T-cells and PD-L1+ CTCs was detected. Importantly, patients harboring higher numbers of CD3+CD8+PD-1+ T-cells together with PD-L1+CTCs had a survival advantage when receiving front-line immunotherapy. Thus, this study proposes, for first time possible, immune cell–CTCs interaction, as well as a potential novel clinical biomarker for ICI responses in ES-SCLC patients.
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- 2024
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17. Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma
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Waldschmidt, Johannes M., Yee, Andrew J., Vijaykumar, Tushara, Pinto, Ricardo A., Frede, Julia, Anand, Praveen, Bianchi, Giada, Guo, Guangwu, Potdar, Sayalee, Seifer, Charles, Nair, Monica S., Kokkalis, Antonis, Kloeber, Jake A., Shapiro, Samantha, Budano, Lillian, Mann, Mason, Friedman, Robb, Lipe, Brea, Campagnaro, Erica, O’Donnell, Elizabeth K., Zhang, Cheng-Zhong, Laubach, Jacob P., Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C., Raje, Noopur S., Knoechel, Birgit, and Lohr, Jens G.
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- 2022
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18. First Maximum Sustainable Yield advice for the Nephrops norvegicus stocks of the Northwest Iberian coast using stochastic Surplus Production model in Continuous Time (SPiCT)
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Isabel González Herraiz, Yolanda Vila, Massimiliano Cardinale, Casper W. Berg, Henning Winker, Manuela Azevedo, Tobias K. Mildenberger, Alexandros Kokkalis, A. Armando Vázquez Vilamea, Roberto Morlán, Raquel Somavilla, and Maria Grazia Pennino
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fisheries management ,stock assessment ,Norway lobster ,North Galicia ,West Galicia and North Portugal ,Cantabrian Sea ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The assessment of the status of fisheries resources is pivotal due to the importance of marine resources in global food security and to halt the ongoing decline in marine biodiversity. Norway lobster (Nephrops norvegicus) is one of the most valuable resources in the Northeast Atlantic. However, overfishing has caused the decline of several Nephrops stocks over the last decades, particularly in the Nephrops Functional Units (FUs) 25 (NW Spain), 26-27 (NW Spain and North Portugal) and 31 (Cantabrian Sea, North Spain). Since 2003, the information provided by the very low level of landings and fishing effort of these three stocks was insufficient to carry out an adequate analytical assessment, so the base of the assessment has been the trends from commercial catch per unit effort (CPUE). The objective of this study was to carry out the first assessment of these three stocks with an analytical MSY-based model. A review of the available data was made and the stochastic Surplus Production Model in Continuous Time (SPiCT) was fitted for each FU. The results indicate an extremely low biomass for FUs 25 and 26-27 since the mid-nineties well below the reference points. For FU 31, on the other hand, estimated biomass is larger. Our findings also identified long-term temporal and spatial changes in the population dynamic of Nephrops in the Northwest Iberian coast. The results were compare with those obtained in the same stocks with other data-limited methods. Also the role of abiotic factors on the observed dynamic of the stocks was explored. The results of this study are not only relevant for the sustainable exploitation of Norway lobster stocks off the Northwest Iberian coast but provide valuable insights into the suitability and limitations of production models for the assessment of crustacean stocks in general.
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- 2023
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19. Molecular Epidemiology and Treatment Patterns of Patients With EGFR Exon 20-Mutant NSCLC in the Precision Oncology Era: The European EXOTIC Registry
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Giannis Mountzios, MD, PhD, David Planchard, MD, PhD, Giulio Metro, MD, PhD, Dora Tsiouda, Arsela Prelaj, MD, Sofia Lampaki, MD, PhD, Walid Shalata, MD, Mariona Riudavets, Petros Christopoulos, MD, PhD, Nicolas Girard, MD, PhD, Víctor Albarrán-Artahona, Rosario Garcia Campelo, MD, PhD, Konstantinos Samitas, MD, PhD, Giuseppe Luigi Banna, MD, Ioannis Boukovinas, MD, PhD, Abed Agbarya, MD, PhD, Anna Koumarianou, MD, Eleni-Isidora Perdikouri, Paris Kosmidis, Helena Linardou, MD, PhD, David Mauri, MD, PhD, Dimitrios Mavroudis, MD, PhD, Ilias Athanasiadis, MD, PhD, Haralambos Kalofonos, Nikolaos Xenidis, MD, PhD, Ippokratis Korantzis, MD, Alexandros Ardavanis, Grigorios Rallis, MD, Achille Bottiglieri, Konstantinos Efthymiadis, MD, Georgios Oikonomopoulos, MD, Alexandros Kokkalis, MD, Emmanouil Saloustros, MD, PhD, Nikolaos Tsoukalas, MD, Dimitra Bartzi, MD, Panagiota Economopoulou, Amanda Psyrri, MD, PhD, Martin Reck, and Giuseppe Lo Russo, MD, PhD
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Non–small-cell lung cancer ,Epidermal growth factor receptor ,Exon 20 ,Real-world data ,Exotic ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Real-world evidence regarding molecular epidemiology and management patterns of patients with EGFR exon-20 mutated, advanced NSCLC outside the context of clinical trials is lacking. Methods: We created a European registry for patients with advanced EGFR exon 20-mutant NSCLC diagnosed from January 2019 to December 2021. Patients enrolled in clinical trials were excluded. Clinicopathologic and molecular epidemiology data were collected, and treatment patterns were recorded. Clinical end points according to treatment assignment were assessed using Kaplan-Meier curves and Cox regression models. Results: Data on 175 patients from 33 centers across nine countries were included in the final analysis. Median age was 64.0 (range: 29.7–87.8) years. Main features included female sex (56.3%), never or past smokers (76.0%), adenocarcinoma (95.4%), and tropism for bone (47.4%) and brain (32.0%) metastases. Mean programmed death-ligand 1 tumor proportional score was 15.8% (range: 0%–95%) and mean tumor mutational burden was 7.06 (range: 0–18.8) mutations per megabase. Exon 20 was detected in the tissue (90.7%), plasma (8.7%), or both (0.6%), using mostly targeted next-generation sequencing (64.0%) or polymerase chain reaction (26.0%). Mutations were mainly insertions (59.3%), followed by duplications (28.1%), deletions-insertions (7.7%), and the T790M (4.5%). Insertions and duplications were located mainly in the near loop (codons 767–771, 83.1%) and the far loop (codons 771–775, 13%) and only in 3.9% within the C helix (codons 761–766). Main co-alterations included mutations in TP53 (61.8%) and MET amplifications (9.4%). Treatment on mutation identification included chemotherapy (CT) (33.8%), CT-immunotherapy (IO) (18.2%), osimertinib (22.1%), poziotinib (9.1%), mobocertinib (6.5%), mono-IO (3.9%), and amivantamab (1.3%). Disease control rates were 66.2% with CT plus or minus IO, 55.8% with osimertinib, 64.8% with poziotinib, and 76.9% with mobocertinib. Corresponding median overall survival was 19.7, 15.9, 9.2, and 22.4 months, respectively. In multivariate analysis, type of treatment (new targeted agents versus CT ± IO) affected progression-free survival (p = 0.051) and overall survival (p = 0.03). Conclusions: EXOTIC represents the largest academic real-world evidence data set on EGFR exon 20-mutant NSCLC in Europe. Indirectly compared, treatment with new exon 20-targeting agents is likely to confer survival benefit than CT plus or minus IO.
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- 2023
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20. What is the optimal surgical treatment for Neer type IIB (IIC) distal clavicle fractures? A systematic review and meta-analysis
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Panagopoulos, Andreas, Solou, Konstantina, Tatani, Irini, Triantafyllopoulos, Ioannis K., Lakoumentas, John, Kouzelis, Antonis, Athanasiou, Vasileios, and Kokkalis, Zinon T.
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- 2022
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21. Intraneural ganglion cysts of the peroneal nerve
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Kokkalis, Zinon T., Kalavrytinos, Dimitrios, Kokkineli, Stefania, Kouzelis, Antonios, Sioutis, Spyros, Mavrogenis, Andreas F., and Panagopoulos, Andreas
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- 2021
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22. Deep Learning-Based Black Spot Identification on Greek Road Networks
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Ioannis Karamanlis, Alexandros Kokkalis, Vassilios Profillidis, George Botzoris, Chairi Kiourt, Vasileios Sevetlidis, and George Pavlidis
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AI ,black spot ,road safety ,dataset ,Bibliography. Library science. Information resources - Abstract
Black spot identification, a spatiotemporal phenomenon, involves analysing the geographical location and time-based occurrence of road accidents. Typically, this analysis examines specific locations on road networks during set time periods to pinpoint areas with a higher concentration of accidents, known as black spots. By evaluating these problem areas, researchers can uncover the underlying causes and reasons for increased collision rates, such as road design, traffic volume, driver behaviour, weather, and infrastructure. However, challenges in identifying black spots include limited data availability, data quality, and assessing contributing factors. Additionally, evolving road design, infrastructure, and vehicle safety technology can affect black spot analysis and determination. This study focused on traffic accidents in Greek road networks to recognize black spots, utilizing data from police and government-issued car crash reports. The study produced a publicly available dataset called Black Spots of North Greece (BSNG) and a highly accurate identification method.
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- 2023
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23. The association of bullous pemphigoid with dipeptidyl-peptidase 4 inhibitors: a ten-year prospective observational study
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Lambadiari, Vaia, Kountouri, Aikaterini, Kousathana, Foteini, Korakas, Emmanouil, Kokkalis, Georgios, Theotokoglou, Sofia, Palaiodimou, Lina, Katsimbri, Pelagia, Ikonomidis, Ignatios, Theodoropoulos, Konstantinos, and Papadavid, Evangelia
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- 2021
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24. Profiling of aerosol microphysical properties at several EARLINET/AERONET sites during July 2012 ChArMEx/EMEP campaign
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M. J. Granados-Muñoz, F. Navas-Guzmán, J. L. Guerrero-Rascado, J. A. Bravo-Aranda, I. Binietoglou, S. N. Pereira, S. Basart, J. M. Baldasano, L. Belegante, A. Chaikovsky, A. Comerón, G. D'Amico, O. Dubovik, L. Ilic, P. Kokkalis, C. Muñoz-Porcar, S. Nickovic, D. Nicolae, F. J. Olmo, A. Papayannis, G. Pappalardo, A. Rodríguez, K. Schepanski, M. Sicard, A. Vukovic, U. Wandinger, F. Dulac, L. Alados-Arboledas, Laboratoire d’Optique Atmosphérique - UMR 8518 (LOA), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
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010504 meteorology & atmospheric sciences ,QC801-809 ,[SDU]Sciences of the Universe [physics] ,Geophysics. Cosmic physics ,010501 environmental sciences ,01 natural sciences ,0105 earth and related environmental sciences - Abstract
The analysis of aerosol microphysical properties profiles at different European stations is made in the framework of the ChArMEx/EMEP 2012 field campaign (9–11 July 2012). During and in support to this campaign, five lidar ground-based stations (Athens, Barcelona, Bucharest, Évora and Granada) performed 72 h of continuous lidar and collocated and coincident sun-photometer measurements. Therefore it was possible to retrieve volume concentration profiles with the Lidar Radiometer Inversion Code (LIRIC). Results indicated the presence of a mineral dust plume affecting the Western Mediterranean region (mainly Granada station) whereas a different aerosol plume was observed over the Balkans area. LIRIC profiles showed a predominance of coarse spheroid particles above Granada, as expected for mineral dust, and an aerosol plume composed mainly of fine and coarse spherical particles above Athens and Bucharest. Due to the exceptional characteristics of the ChArMEx database, the analysis of the microphysical properties profiles temporal evolution was also possible. An in depth analysis was performed mainly at Granada station because of the availability of continuous lidar measurements and frequent AERONET inversion retrievals. The analysis at Granada was of special interest since the station was affected by mineral dust during the complete analyzed period. LIRIC was found to be a very useful tool for performing continuous monitoring of mineral dust, allowing for the analysis of the dynamics of the dust event in the vertical and temporal coordinates. Results obtained here illustrate the importance of having collocated and simultaneous advanced lidar and sun-photometer measurements in order to characterize the aerosol microphysical properties both in the vertical and temporal coordinates at a regional scale. In addition, this study revealed that the use of the depolarization information as input in LIRIC in the stations of Bucharest, Évora and Granada was crucial for the characterization of the aerosol types and their distribution in the vertical column, whereas in stations lacking of depolarization lidar channels ancillary information was needed. Results obtained were also used for the validation of different mineral dust models. In general, the models better forecast the vertical distribution of the mineral dust than the column integrated mass concentration, which was underestimated in most of the cases.
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- 2022
25. Semi-batch heterotrophic cultivation of Chlorella sorokinianaand Chlorella kessleri: lipid and protein content, fatty acid distribution and FAME properties
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Papapolymerou, G., Gougoulias, N., Mpesios, A., Kokkalis, A., Spiliotis, X., Papadopoulou, A., Kasiteropoulou, D., and Metsoviti, M.N.
- Abstract
In the present study the heterotrophic growth of Chlorella sorokinianaand Chlorella kesslericultivated in a fed-batch mode, using crude glycerol as the sole carbon source, was investigated. The effect of the mode of the organic carbon addition on the lipid and protein content of the biomass, the fatty acid (FAs) distribution of the bio-oil and the fatty acid methyl ester (FAME) properties was studied. The FAME properties namely, the saponification number, the iodine value, the cetane number and the higher heating value, were estimated from empirical equations. The duration all cultivations was 26 d and until the 20th day 800 mL glycerol were added in the cultivation medium (2.3% v/v). For C. sorokiniana, during the cultivation period, 400, 200 and 80 mL glycerol were added in the cultivation medium at 2, 4 and 10 equal intervals respectively. For C. kessleri400, 200, 100 and 40 mL glycerol were added at 2, 4, 8 and 20 equal intervals, respectively. For C. sorokinianalipid and protein content ranged from 35.1% to 47.5% and 16.4% to 21.8%, respectively. The percentage of short chain FAs (C10-C14), medium chain FAs (C16-C18) and long chain FAs (>C18) in the total FAs ranged from 6.6% to 19.8%, 80.2% to 91.3% and 0% to 13.1%, respectively. The percentage of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) of the total FAs ranged from 25.9% to 37.2%, 38.4% to 60.0% and 14.1% to 24.4%, respectively. For C. kesslerilipid and protein content ranged from 27.7% to 35.1% and 21.5% to 29.8%, respectively. The percentage of short chain FAs, medium chain FAs and long chain FAs of the total FAs ranged from 15.8% to 30.6%, 66.2% to 76.8% and 1.9% to 14.7%, respectively. The percentage of SFAs, MUFAs and PUFAs of the total FAs ranged from 38.7% to 54.1%, 40.7% to 53.1% and 5.2% to 16.3%, respectively. Although the treatment 2 × 400 mL of glycerol shows very good FAME properties for both species, the lipid productivities of C. sorokinianaare higher compared to those of C. kessleriand thus, C. sorokinianais a better option compared to C. kesslerifor potential use in biodiesel production.
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- 2022
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26. Enhancing Academic Integrity Among Students in GenAI Era:A Holistic Framework
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Rasul, Tareq, Nair, Sumesh, Kalendra, Diane, Balaji, M.S., Santini, Fernando de Oliveira, Ladeira, Wagner Junior, Rather, Raouf Ahmad, Yasin, Naveed, Rodriguez, Raul V., Kokkalis, Panagiotis, Murad, Wahid, and Hossain, Md. Uzir
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The introduction of Artificial Intelligence (AI), specifically Generative AI (GenAI), has significantly transformed the higher education landscape. Despite the opportunities GenAI offers to students, they pose significant challenges for academic integrity. Thus, it is crucial for higher education institutions (HEI) to balance the use of GenAI for enhancing the learning experience of students with its ethical and responsible use in their educational journey. The present study proposes a comprehensive academic integrity framework focusing on three key stakeholders: students, educators, and institutions. We propose eight strategies ranging from collaborative learning for students to developing a comprehensive GenAI policy for institutions in maintaining academic integrity among students in HEI. Furthermore, we identified four challenges, namely financial, strategic, operational, and cultural, in the implementing a comprehensive academic integrity framework in the GenAI era. This study offers significant insights for HEI to maintain academic integrity among students in the GenAI era.
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- 2024
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27. Combinatorial analysis of CD4 + Tregs and CD8 + Teff to predict response to ICI in patients with ES-SCLC.
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Tsapakidis, Konstantinos, Xagara, Anastasia, Kokkalis, Alexandros, Markou, Alexandra, Aidarinis, Chrysovalantis, Lazarou, Alexandros, Kallergi, Galatea, Papadopoulos, Vasileios, Saloustros, Emmanouil S., Samaras, Ioannis, and Kotsakis, Athanasios
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- 2023
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28. Peripheral pre-existing cancer-antigen specific T-cell immunity as predictive biomarker for immunotherapy in NSCLC patients.
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Xagara, Anastasia, Fortis, Sotirios P., Goulielmaki, Maria, Koinis, Filippos, Chantzara, Evangelia, Kokkalis, Alexandros, Samaras, Ioannis, Papadopoulos, Vasileios, Georgoulias, Vasileios, Baxevanis, Constantin N, and Kotsakis, Athanasios
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- 2023
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29. Molecular Epidemiology and Treatment Patterns of Patients With EGFR Exon 20-Mutant NSCLC in the Precision Oncology Era: The European EXOTIC Registry
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Mountzios, Giannis, Planchard, David, Metro, Giulio, Tsiouda, Dora, Prelaj, Arsela, Lampaki, Sofia, Shalata, Walid, Riudavets, Mariona, Christopoulos, Petros, Girard, Nicolas, Albarrán-Artahona, Víctor, Garcia Campelo, Rosario, Samitas, Konstantinos, Banna, Giuseppe Luigi, Boukovinas, Ioannis, Agbarya, Abed, Koumarianou, Anna, Perdikouri, Eleni-Isidora, Kosmidis, Paris, Linardou, Helena, Mauri, David, Mavroudis, Dimitrios, Athanasiadis, Ilias, Kalofonos, Haralambos, Xenidis, Nikolaos, Korantzis, Ippokratis, Ardavanis, Alexandros, Rallis, Grigorios, Bottiglieri, Achille, Efthymiadis, Konstantinos, Oikonomopoulos, Georgios, Kokkalis, Alexandros, Saloustros, Emmanouil, Tsoukalas, Nikolaos, Bartzi, Dimitra, Economopoulou, Panagiota, Psyrri, Amanda, Reck, Martin, and Lo Russo, Giuseppe
- Abstract
Real-world evidence regarding molecular epidemiology and management patterns of patients with EGFR exon-20 mutated, advanced NSCLC outside the context of clinical trials is lacking.
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- 2022
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30. What is the optimal surgical treatment for Neer type IIB (IIC) distal clavicle fractures? A systematic review and meta-analysis
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Andreas Panagopoulos, Konstantina Solou, Irini Tatani, Ioannis K. Triantafyllopoulos, John Lakoumentas, Antonis Kouzelis, Vasileios Athanasiou, and Zinon T. Kokkalis
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Distal clavicle fractures ,Neer type IIB ,Coracoclavicular stabilization ,Hook plate ,Locking plate ,ACJ transfixation ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background The purpose of the present study was to systematically review the current treatment strategies for the treatment of Neer type IIB distal clavicle fractures in terms of functional outcome and complication rates and to examine the most appropriate surgical method by comparing all the available surgical techniques and implants. Methods We performed a systematic review of the existing literature (2000–2021) in accordance with the PRISMA statement. We searched PubMed, Scopus, Web of Science, Research Gate and Google Scholar using the general terms ‘distal AND clavicle AND fracture’ to capture as many reports as possible. The MINORS tool was used to assess the risk of bias of the nonrandomized studies. We categorized the reported surgical techniques into four main types: open or arthroscopic coracoclavicular (CC) stabilization, locking plate fixation with or without CC augmentation, hook plate fixation and acromioclavicular joint (ACJ) transfixation. We reported findings for two main outcomes: clinical results and complication rates categorized into major and minor. Results Our database search yielded a total of 630 records; 34 studies were appropriate for qualitative analysis. There were 790 patients, with a mean age of 40.1 years, a female percentage of 37% and a mean follow-up period of 29.3 months. In total, 132 patients received a hook plate, 252 received a locking plate, 368 received CC stabilization and 41 received transacromial transfixation. All studies were retrospective and had fair MINORS scores. Locking plate, CC stabilization and ACJ transfixation showed similar clinical results but were much better than hook plate fixation; CC augmentation did not significantly improve the outcome of locking plate fixation. The rate of major complications was similar among groups; hook plate and AC joint transfixation had the worst rates of minor complications. Open CC techniques were slightly better than arthroscopic techniques. Conclusions The present systematic review for the optimal fixation method for Neer type IIB fractures of the distal clavicle showed similar major complication rates among techniques; the hook plate technique demonstrated inferior clinical results to other techniques. Open CC stabilization and locking plate fixation without CC augmentation seem to be the best available treatment options.
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- 2022
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31. Towards reliable retrievals of cloud droplet number for non-precipitating planetary boundary layer clouds and their susceptibility to aerosol
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Romanos Foskinis, Athanasios Nenes, Alexandros Papayannis, Paraskevi Georgakaki, Konstantinos Eleftheriadis, Stergios Vratolis, Maria I. Gini, Mika Komppula, Ville Vakkari, and Panos Kokkalis
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aerosols ,clouds ,droplet number ,lidar ,PBL ,satellite remote sensing ,Geophysics. Cosmic physics ,QC801-809 ,Meteorology. Climatology ,QC851-999 - Abstract
Remote sensing has been a key resource for developing extensive and detailed datasets for studying and constraining aerosol-cloud-climate interactions. However, aerosol-cloud collocation challenges, algorithm limitations, as well as difficulties in unraveling dynamic from aerosol-related effects on cloud microphysics, have long challenged precise retrievals of cloud droplet number concentrations. By combining a series of remote sensing techniques and in situ measurements at ground level, we developed a semi-automated approach that can address several retrieval issues for a robust estimation of cloud droplet number for non-precipitating Planetary Boundary Layer (PBL) clouds. The approach is based on satellite retrievals of the PBL cloud droplet number (Ndsat) using the geostationary meteorological satellite data of the Optimal Cloud Analysis (OCA) product, which is obtained by the Spinning Enhanced Visible and InfraRed Imager (SEVIRI) of the European Organization for the Exploitation of Meteorological Satellites (EUMETSAT). The parameters of the retrieval are optimized through closure with droplet number obtained from a combination of ground-based remote sensing data and in situ observations at ground level. More specifically, the remote sensing data are used to retrieve cloud-scale vertical velocity, and the in situ aerosol measurements at ground level were used constrain as input to a state-of-the-art droplet activation parameterization to predict the respective Cloud Condensation Nuclei (CCN) spectra, cloud maximum supersaturation and droplet number concentration (Nd), accounting for the effects of vertical velocity distribution and lateral entrainment. Closure studies between collocated Nd and Ndsat are then used to evaluate exising droplet spectral width parameters used for the retrieval of droplet number, and determine the optimal values for retrieval. This methodology, used to study aerosol-cloud interactions for non-precipitating clouds formed over the Athens Metropolitan Area (AMA), Greece, during the springtime period from March to May 2020, shows that droplet closure can be achieved to within ±33.4%, comparable to the level of closure obtained in many in situ studies. Given this, the ease of applying this approach with satellite data obtained from SEVIRI with high temporal (15 min) and spatial resolution (3.6 km × 4.6 km), opens the possibility of continuous and reliable Ndsat, giving rise to high value datasets for aerosol-cloud-climate interaction studies.
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- 2022
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32. Long-stemmed Hemiarthroplasty with Cerclage Wiring for the Treatment of Split-Head Fractures of the Proximal Humerus with Metaphyseal Extension: A Report of 2 Cases
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A. Panagopoulos MD, PhD, K. Solou MD, A. Kouzelis MD, PhD, S. Papagiannis MD, I. Tatani MD, PhD, and Z. T. Kokkalis MD, PhD
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Orthopedic surgery ,RD701-811 - Abstract
Introduction Complex fractures of the proximal humerus with splitting-head component and metaphyseal propagation are very rare injuries that are difficult to treat. Preservation of the humeral head is always considered except in cases with severe comminution and compromised vascularity where shoulder hemiarthroplasty is an alternative option. Case Report We present two male patients, 57- and 62-years-old who sustained such a complex proximal humeral fracture after a high-energy injury. They both managed with long-stemmed shoulder hemiarthroplasty and cerclage wiring of the metaphyseal area. They both demonstrated good clinical and radiological outcome at 32- and 24-months postoperatively. Conclusion We report the functional and radiological outcomes of two cases of a rare proximal humeral fracture's pattern - combination of splitting-head and metaphyseal comminution – that were managed with long-stemmed hemiarthroplasty and cerclage wire and demonstrated good midterm clinical outcome.
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- 2022
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33. Metastatic rectal cancer in the ampulla of Vater: A unique case
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Athina A. Samara, Ioanna‐Konstantina Sgantzou, Alexandros Diamantis, Alexandros Kokkalis, Konstantinos Tsapakidis, Maria Tolia, Gregory Christodoulidis, Christos Rountas, and Dimitris Zacharoulis
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immunochemistry ,metastatic ,rectal cancer ,secondary ,Vater ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background A metastatic lesion located in the ampulla of Vater is considered extremely rare, with only 32 cases reported globally. Case A 65‐year‐old patient was primarily diagnosed with a rectal adenocarcinoma. Twenty‐four months later as part of the oncological follow‐up, the patient was diagnosed with a single secondary tumor in the ampulla of Vater. After undergoing a pancreaticoduodenectomy (Whipple procedure), the patient experienced an uneventful recovery and received adjuvant chemotherapy. Sixteen months later the patient remained disease‐free. Conclusion To the best of our knowledge, the present case represents the first reported metastatic tumor in the ampulla of Vater, originating from a rectal adenocarcinoma. This case underlines the critical role of immunohistochemistry in arriving at a correct diagnosis in order to guide clinical decision‐making.
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- 2022
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34. Reverse Shoulder Arthroplasty for Failed Operative Treatment of Proximal Humeral Fractures
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Zinon T Kokkalis PhD, Aikaterini Bavelou MD, Efstratios Papanikos MD, Dimitrios Kalavrytinos MD, and Andreas Panagopoulos PhD
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Orthopedic surgery ,RD701-811 - Abstract
Introduction Failure after operative treatment of complex proximal humeral fractures (PHF) can prove challenging even for experienced surgeons. Reverse shoulder arthroplasty (RSA) seems to offer a satisfactory revision procedure with good clinical outcomes. Materials and Methods We present a case series of 14 patients, who were treated during a 3.5 years period (from 01/2016 until 06/2019). They all underwent revision surgery with RSA for failed operative treatment of PHF. Their mean age was 68 years (range, 51-84 years). 2 patients (14.3%) had been primarily treated with open reduction and internal fixation (ORIF), 5 patients (35.7%) with hemiarthroplasty, 3 patients (21.4%) with closed reduction and percutaneous fixation and 4 patients (28.6%) with transosseous suture fixation (TSF). We evaluated their absolute Constant score (CS), Visual Analogue Scale (VAS) score, and Range of Motion at their final follow-up, and we made a full clinical and radiological assessment to detect any postoperative complications. Results The mean absolute CS, VAS score, active anterior elevation, active abduction significantly improved compared with the preoperative status. Less significant difference was found in external rotation when comparing with the preoperative status ( P = .0304). No significant differences were found when comparing RSA for different failed primary techniques ( P > .05). No complications were detected following the revision surgeries of all patients. Conclusion RSA is an appropriate treatment as a revision technique for failed primary surgical treatment of PHFs. Though challenging it can offer good clinical results and pain relief.
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- 2022
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35. Validation of NASA SMAP Satellite Soil Moisture Products over the Desert of Kuwait
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Hala AlJassar, Marouane Temimi, Mohamed Abdelkader, Peter Petrov, Panagiotis Kokkalis, Hussain AlSarraf, Nair Roshni, and Hamad Al Hendi
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SMAP ,validation ,volumetric soil moisture (VSM) ,desert ,Kuwait ,Science - Abstract
The goal of this study is to validate and analyze NASA’s Soil Moisture Active Passive (SMAP) products over the desert of Kuwait. The study period was between April 2015 and April 2020. The study domain includes a mission candidate calibration/validation (Cal/Val) site that comprises six permanent soil moisture stations used to verify SMAP estimates. In addition, intensive field campaigns were conducted within and around the candidate Cal/Val site during the study period to collect additional thermogravimetric samples. The mean difference (MD), root mean squared difference (RMSD), unbiased root mean square difference (ubRMSD), and correlation coefficient (R) were computed to assess the agreement between SMAP SM products and in situ observations. The comparison of the six ground station sensors’ observations with the thermogravimetric samples led to an absolute mean bias (AMB) of 0.034 m3 m−3, which was then used to calibrate the sensors and bias-correct their measurements. The temporal consistency of the readings from the test site and calibrated sensors was assessed using the mean relative difference (MRD) and its standard deviation of relative difference (SDRD). Using a sampling density analysis, it was determined that a minimum of four ground stations would be required to validate the test site. Furthermore, the consistency between SMAP satellite soil moisture data and those derived from the Soil Moisture and Ocean Salinity (SMOS) satellite operated by the European Space Agency, and their agreement with in situ samples, was analyzed. The comparison of SMAP and SMOS soil moisture data with in situ observations showed that both satellites successfully captured the spatial and temporal distribution of soil moisture. For SMAP and SMOS, the lowest ubRMSE statistics were 0.043 m3 m−3 and 0.045 m3 m−3, respectively, which are slightly higher than the mission target of 0.04 m3 m−3.
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- 2022
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36. Australian Bushfires (2019–2020): Aerosol Optical Properties and Radiative Forcing
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Christina-Anna Papanikolaou, Panagiotis Kokkalis, Ourania Soupiona, Stavros Solomos, Alexandros Papayannis, Maria Mylonaki, Dimitra Anagnou, Romanos Foskinis, and Marilena Gidarakou
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Australian bushfires ,biomass burning aerosols ,tropospheric aerosols ,stratospheric aerosols ,CALIPSO ,optical properties ,Meteorology. Climatology ,QC851-999 - Abstract
In the present study, we present the aerosol optical properties and radiative forcing (RF) of the tropospheric and stratospheric smoke layers, observed by the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite, during the extraordinary Australian biomass burning (BB) event in 2019–2020. These BB layers were studied and analyzed within the longitude range 140° E–20° W and the latitude band 20°–60° S, as they were gradually transported from the Australian banks to the South American continent. These layers were found to be trapped within the Andes circulation, staying for longer time periods in the same longitude region. The BB aerosols reached altitudes even up to 22 km amsl., and regarding their optical properties, they were found to be nearly spherical (particle linear depolarization ratio (PLDR) < 0.10) in the troposphere; while, in the stratosphere, they were more depolarizing with PLDR values reaching up to 0.20. Fine and ultrafine smoke particles were dominant in the stratosphere, according to the observed Ångström exponent, related to the backscatter coefficients obtained by the pair of wavelengths 532 and 1064 nm (Åb up to 3), in contrast to the Åb values in the troposphere (Åb < 1) indicative of the presence of coarser particles. As the aerosols fend off the source, towards North America, a slightly descending trend was observed in the tropospheric Åb values, while the stratospheric ones were lightly increased. A maximum aerosol optical depth (AOD) value of 0.54 was recorded in the lower troposphere over the fire spots, while, in the stratosphere, AOD values up to 0.29 were observed. Sharp changes of carbon monoxide (CO) and ozone (O3) concentrations were also recorded by the Copernicus Atmosphere Monitoring Service (CAMS) in various atmospheric heights over the study region, associated with fire smoke emissions. The tropospheric smoke layers were found to have a negative mean radiative effect, ranging from −12.83 W/m2 at the top of the atmosphere (TOA), to −32.22 W/m2 on the surface (SRF), while the radiative effect of the stratospheric smoke was estimated between −7.36 at the TOA to −18.51 W/m2 at the SRF.
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- 2022
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37. Vertical Profiling of Fresh Biomass Burning Aerosol Optical Properties over the Greek Urban City of Ioannina, during the PANACEA Winter Campaign
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Christina-Anna Papanikolaou, Alexandros Papayannis, Maria Mylonaki, Romanos Foskinis, Panagiotis Kokkalis, Eleni Liakakou, Iasonas Stavroulas, Ourania Soupiona, Nikolaos Hatzianastassiou, Maria Gavrouzou, Eleni Kralli, and Dimitra Anagnou
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lidar ,depolarization ratio ,fresh biomass burning aerosols ,domestic heating ,black carbon ,PM2.5 ,Meteorology. Climatology ,QC851-999 - Abstract
Vertical profiling of aerosol particles was performed during the PANhellenic infrastructure for Atmospheric Composition and climatE chAnge (PANACEA) winter campaign (10 January 2020–7 February 2020) over the city of Ioannina, Greece (39.65° N, 20.85° E, 500 m a.s.l.). The middle-sized city of Ioannina suffers from wintertime air pollution episodes due to biomass burning (BB) domestic heating activities. The lidar technique was applied during the PANACEA winter campaign on Ioannina city, to fill the gap of knowledge of the spatio-temporal evolution of the vertical mixing of the particles occurring during these winter-time air pollution episodes. During this campaign the mobile single-wavelength (532 nm) depolarization Aerosol lIdAr System (AIAS) was used to measure the spatio-temporal evolution of the aerosols’ vertical profiles within the Planetary Boundary Layer (PBL) and the lower free troposphere (LFT; up to 4 km height a.s.l.). AIAS performed almost continuous lidar measurements from morning to late evening hours (typically from 07:00 to 19:00 UTC), under cloud-free conditions, to provide the vertical profiles of the aerosol backscatter coefficient (baer) and the particle linear depolarization ratio (PLDR), both at 532 nm. In this study we emphasized on the vertical profiling of very fresh (~hours) biomass burning (BB) particles originating from local domestic heating activities in the area. In total, 33 out of 34 aerosol layers in the lower free troposphere were characterized as fresh biomass burning ones of local origin, showing a mean particle linear depolarization value of 0.04 ± 0.02 with a range of 0.01 to 0.09 (532 nm) in a height region 1.21–2.23 km a.s.l. To corroborate our findings, we used in situ data, particulate matter (PM) concentrations (PM2.5) from a particulate sensor located close to our station, and the total black carbon (BC) concentrations along with the respective contribution of the fossil fuel (BCff) and biomass/wood burning (BCwb) from the Aethalometer. The PM2.5 mass concentrations ranged from 5.6 to 175.7 μg/m3, while the wood burning emissions from residential heating were increasing during the evening hours, with decreasing temperatures. The BCwb concentrations ranged from 0.5 to 17.5 μg/m3, with an extremely high mean contribution of BCwb equal to 85.4%, which in some cases during night-time reached up to 100% during the studied period.
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- 2022
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