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2. Contributors

Author

Ahmad, Muhammad Shaheez, primary, Ahmad, Saba, additional, Aitani, Abdullah, additional, Alcántara, Andres R., additional, Ameen, Ayesha, additional, Armenia, Ilaria, additional, Asghar, Asma, additional, Asharf, Warda, additional, Bari Khan, Maham Abdul, additional, Basel, Muhammad Ehtisham, additional, Berenguer-Murcia, Ángel, additional, Bernardini, Giovanni, additional, Bilal, Muhammad, additional, Borgese, Marina, additional, Bussolari, Francesca, additional, Cassinelli, Nicolas, additional, Cipolatti, Eliane, additional, Cruz-Cruz, Angelica, additional, Cárdenas-Alcaide, María Fernanda, additional, Fernández-Lafuente, Roberto, additional, Fernández-Lucas, Jesús, additional, Fuente, J.M. de la, additional, Gallo-Cordova, Alvaro, additional, Gamberoni, Federica, additional, González-González, Reyna Berenice, additional, Gornati, Rosalba, additional, Grazu, Valeria, additional, Guimarães, José R., additional, Guisán-Seijas, J.M., additional, Hafeez, Shahzar, additional, Hameed, Sidra, additional, Hanif, Maha, additional, Hassan Gilliani, Muhammad Rehan, additional, Hussain, Asim, additional, Hussain, Dilshad, additional, Hussain, Nazim, additional, Intisar, Azeem, additional, Iqbal, Rimsha, additional, Iqbal, Hafiz M.N., additional, Ismail, Fatima, additional, Jabbar, Samahar Abdullah, additional, Javed, Kashif, additional, Javed, Sana, additional, Jesionowski, Teofil, additional, Kanwal, Faiza, additional, Khalid, Maham, additional, Khan, Faisal, additional, Kumar, Adarsh, additional, Kumar, Saroj, additional, Liaqat, Sana, additional, Lopez-Gallego, Fernando, additional, Macedo de Melo, Eduardo, additional, Mahmood, Tehreem, additional, Majeed, Saadat, additional, Maqsood, Salman, additional, Mumtaz, Ayesha, additional, Munir, Shahid, additional, Naqvi, Wajahat Zahra, additional, Naseem, Amina, additional, Naz, Maimuna, additional, Ovejero, Jesús G., additional, Papait, Roberto, additional, Parra-Saldívar, Roberto, additional, Puerto Morales, M., additional, Qaisar, Uzma, additional, Rafeeq, Hamza, additional, Rafique, Sadia, additional, Ramzan, Rehana, additional, Ratna, Sheel, additional, Rios, Nathália S., additional, Rivas-Sanchez, Andrea, additional, Rizwan, Komal, additional, Rocha-Martin, Javier, additional, Rodrigues, Rafael C., additional, Rother, Doerte, additional, Safdar, Ayesha, additional, Sanchez, Manu, additional, Serio, Simone, additional, Shafi, Sameera, additional, Shahbaz, Areej, additional, Siddique, Sara, additional, Tardioli, Paulo W., additional, Zafar, Saba, additional, Zahid, Mahnoor, additional, Zdarta, Jakub, additional, and Zeshan, Muhammad, additional

Published
2023
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3. Contributors

Author

Agrawala, Paban K., primary, Alvarado, Christopher, additional, Amir, Mohammed, additional, Bernau, Ksenija, additional, Bhattacharya, Aditi, additional, Biswas, Biswajit, additional, Block, Megan, additional, Boosani, Anvitha, additional, Boosani, Chandra S., additional, Brasier, Allan R., additional, Brown, Julia A., additional, Chakraborty, Rajasree, additional, Das, Abhijit, additional, Dasari, Nikhitha, additional, DiStefano, Johanna K., additional, Dwarakanath, B.S., additional, Fukai, Tohru, additional, Gaikwad, Anil Bhanudas, additional, Gong, Fangyan, additional, Gornati, Rosalba, additional, Goswami, Ritobrata, additional, Gunasekar, Palanikumar, additional, Gupta, Noopur, additional, Hassan, Ebrahim Bani, additional, Jadhav, Gopal P., additional, Jain, Natasha Victoria, additional, Jiang, Fang, additional, Jiang, Wanlin, additional, Kreger, Jonathan, additional, Kulkarni, Yogesh A., additional, Le, Patricia N., additional, Liu, Lei, additional, Maini, Jayant, additional, Mondal, Papiya, additional, Nakai, Kenta, additional, Natarajan, Umamaheswari, additional, Olson, Michael T., additional, Pagiatakis, Christina, additional, Pandkar, Madhura R., additional, Pant, Amit M., additional, Papait, Roberto, additional, Patnaik, Srinivas, additional, Pelham, Christopher J., additional, Prakash, Anu, additional, Rathinavelu, Appu, additional, Sandbo, Nathan, additional, Sarkar, Subhajit, additional, Sharma, Ajay, additional, Sharma, Nisha, additional, Sharma, Vineeta, additional, Shiva, Niharika, additional, Shukla, Sanjeev, additional, Singh, Lakshman, additional, Singh, Sukhveer, additional, Singhal, Saurabh, additional, Srivastava, Vikas, additional, Sudhahar, Varadarajan, additional, Tiffon, Céline, additional, Ushio-Fukai, Masuko, additional, Vandenbon, Alexis, additional, Weng, Judy, additional, Woo, Jesse, additional, Wu, Xiumei, additional, Yadav, Pooja, additional, and Zeng, Melody Y., additional

Published
2023
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5. Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages.

Author

Barone, Ludovica, Cucchiara, Martina, Palano, Maria Teresa, Bassani, Barbara, Gallazzi, Matteo, Rossi, Federica, Raspanti, Mario, Zecca, Piero Antonio, De Antoni, Gianluca, Pagiatakis, Christina, Papait, Roberto, Bernardini, Giovanni, Bruno, Antonino, and Gornati, Rosalba

Subjects
DENTAL pulp, MESENCHYMAL stem cells, STEM cells, PROTEIN microarrays, ENDOTHELIAL cells
Abstract

Background: Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dental Pulp stem cells (DPSC), due to their easy biological access, ex vivo properties, and ability to support angiogenesis have been largely explored in regenerative medicine. Methods: Here, we tested the capability of Dental Pulp Stem Cell-Conditioned medium (DPSC-CM), produced in normoxic (DPSC-CM Normox) or hypoxic (DPSC-CM Hypox) conditions, to support angiogenesis via their soluble factors. CMs were characterized by a secretome protein array, then used for in vivo and in vitro experiments. In in vivo experiments, DPSC-CMs were associated to an Ultimatrix sponge and injected in nude mice. After excision, Ultimatrix were assayed by immunohistochemistry, electron microscopy and flow cytometry, to evaluate the presence of endothelial, stromal, and immune cells. For in vitro procedures, DPSC-CMs were used on human umbilical-vein endothelial cells (HUVECs), to test their effects on cell adhesion, migration, tube formation, and on their capability to recruit human CD14+ monocytes. Results: We found that DPSC-CM Hypox exert stronger pro-angiogenic activities, compared with DPSC-CM Normox, by increasing the frequency of CD31+ endothelial cells, the number of vessels and hemoglobin content in the Ultimatrix sponges. We observed that Utimatrix sponges associated with DPSC-CM Hypox or DPSC-CM Normox shared similar capability to recruit CD45− stromal cells, CD45+ leukocytes, F4/80+ macrophages, CD80+ M1-macrophages and CD206+ M2-macropages. We also observed that DPSC-CM Hypox and DPSC-CM Normox have similar capabilities to support HUVEC adhesion, migration, induction of a pro-angiogenic gene signature and the generation of capillary-like structures, together with the ability to recruit human CD14+ monocytes. Conclusions: Our results provide evidence that DPSCs-CM, produced under hypoxic conditions, can be proposed as a tool able to support angiogenesis via macrophage polarization, suggesting its use to overcome the issues and restrictions associated with the use of staminal cells. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis

Author

Serio, Simone, primary, Pagiatakis, Christina, additional, Musolino, Elettra, additional, Felicetta, Arianna, additional, Carullo, Pierluigi, additional, Laura Frances, Javier, additional, Papa, Laura, additional, Rozzi, Giacomo, additional, Salvarani, Nicolò, additional, Miragoli, Michele, additional, Gornati, Rosalba, additional, Bernardini, Giovanni, additional, Condorelli, Gianluigi, additional, and Papait, Roberto, additional

Published
2023
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7. Human Dental Pulp Mesenchymal Stem Cell-Derived Soluble Factors Combined with a Nanostructured Scaffold Support the Generation of a Vascular Network In Vivo

Author

Barone, Ludovica, primary, Gallazzi, Matteo, additional, Rossi, Federica, additional, Papait, Roberto, additional, Raspanti, Mario, additional, Zecca, Piero Antonio, additional, Buonarrivo, Luca, additional, Bassani, Barbara, additional, Bernardini, Giovanni, additional, Bruno, Antonino, additional, and Gornati, Rosalba, additional

Published
2023
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10. Highly connected 3D chromatin networks established by an oncogenic fusion protein shape tumor cell identity

Author

Sanalkumar, Rajendran, primary, Dong, Rui, additional, Lee, Lukuo, additional, Xing, Yu-Hang, additional, Iyer, Sowmya, additional, Letovanec, Igor, additional, La Rosa, Stefano, additional, Finzi, Giovanna, additional, Musolino, Elettra, additional, Papait, Roberto, additional, Chebib, Ivan, additional, Nielsen, G. Petur, additional, Renella, Raffaele, additional, Cote, Gregory M., additional, Choy, Edwin, additional, Aryee, Martin, additional, Stegmaier, Kimberly, additional, Stamenkovic, Ivan, additional, Rivera, Miguel N., additional, and Riggi, Nicolò, additional

Published
2023
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11. Thermal tuning of enzyme activity by magnetic heating

Author

European Commission, European Research Council, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, European Science Foundation, Gobierno de Aragón, Armenia, Ilaria, Bussolari, Francesca, Sánchez, Manu, Gallo-Cordova, Álvaro, Ovejero, Jesús G., Macedo de Melo, Eduardo, Gamberoni, Federica, Borgese, Marina, Serio, Simone, Guisán, José Manuel, Fuente, Jesús M. de la, Papait, Roberto, Gornati, Rosalba, Bernardini, Giovanni, Cassinelli, Nicolas, Rother, Dörte, Morales, M. P., López-Gallego, Fernando, Grazú, Valeria, European Commission, European Research Council, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, European Science Foundation, Gobierno de Aragón, Armenia, Ilaria, Bussolari, Francesca, Sánchez, Manu, Gallo-Cordova, Álvaro, Ovejero, Jesús G., Macedo de Melo, Eduardo, Gamberoni, Federica, Borgese, Marina, Serio, Simone, Guisán, José Manuel, Fuente, Jesús M. de la, Papait, Roberto, Gornati, Rosalba, Bernardini, Giovanni, Cassinelli, Nicolas, Rother, Dörte, Morales, M. P., López-Gallego, Fernando, and Grazú, Valeria

Abstract

Enzymes are selective, specific, efficient, and more sustainable catalysts than their chemical counterparts. From an industrial perspective, multienzymatic systems to produce chemical compounds are particularly attractive since they comply with most green production principles including the minimization of wastes and their ecological footprints. However, the number of industrial processes based on the use of enzymes as catalysts remains limited. Indeed, incompatibility issues of enzymes with respect to reaction conditions or cross-reactivity are still challenging aspects that make one-pot enzyme cascade reactions hard to perform. The urgent need for more sustainable industrial processes has made different research fields, not accustomed to working together, join efforts to develop innovative technologies that could be key enabling to overcome these challenges. Among these technologies are those that seek to synergistically integrate the specific recognition and unique catalytic properties of enzymes with the size-dependent unique properties of nanoparticles. However, rather than giving a complete overview of the use of nanomaterials in biocatalysts, here it will be discussed the feasibility of triggering magnetic nanoparticles (MNPs) into hotspots by remote nanoactuation for the thermal modulation of discrete enzyme molecules activity with minimal collateral heating., The possibility of heating discrete and defined local regions within a sample offers the potential to introduce a game-changing breakthrough in industrial biocatalysis by achieving coordinated enzyme function and thus concurrent multienzyme reactions. Therefore, not only the principles behind the activation of MNPs as hotspots, but also those examples that report the selective control of enzyme activity by magnetic heating, together with the foreseen challenges for the transfer of this technology to the industry, will be discussed.

Published
2023

12. Iron oxide nanoparticles with and without cobalt functionalization provoke changes in the transcription profile via epigenetic modulation of enhancer activity

Author

European Commission, Ministero dell'Istruzione, dell'Università e della Ricerca, Gamberoni, Federica, Borgese, Marina, Pagiatakis, Christina, Armenia, Ilaria, Grazú, Valeria, Gornati, Rosalba, Serio, Simone, Papait, Roberto, Bernardini, Giovanni, European Commission, Ministero dell'Istruzione, dell'Università e della Ricerca, Gamberoni, Federica, Borgese, Marina, Pagiatakis, Christina, Armenia, Ilaria, Grazú, Valeria, Gornati, Rosalba, Serio, Simone, Papait, Roberto, and Bernardini, Giovanni

Abstract

Despite the progress in the field of nanotoxicology, much about the cellular mechanisms that mediate the adverse effects of nanoparticles (NPs) and, in particular, the possible role of epigenetics in nanotoxicity, remains to be clarified. Therefore, we studied the changes occurring in the genome-wide distribution of H3K27ac, H3K4me1, H3K9me2, and H3K27me3 histone modifications and compared them with the transcriptome after exposing NIH3T3 cells to iron-based magnetic NPs (i.e., Fe2O3 and Fe2O3@Co NPs). We found that the transcription response is mainly due to changes in the genomic distribution of H3K27ac that can modulate the activity of enhancers. We propose that alteration of the epigenetic landscape is a key mechanism in defining the gene expression program changes resulting in nanotoxicity. With this approach, it is possible to construct a data set of genomic regions that could be useful for defining toxicity in a manner that is more comprehensive than what is possible with the present toxicology assays.

Published
2023

14. Chapter 5 - Thermal tuning of enzyme activity by magnetic heating

Author

Armenia, Ilaria, Bussolari, Francesca, Sanchez, Manu, Gallo-Cordova, Alvaro, Ovejero, Jesús G., Macedo de Melo, Eduardo, Gamberoni, Federica, Borgese, Marina, Serio, Simone, Guisán-Seijas, J.M., Fuente, J.M. de la, Papait, Roberto, Gornati, Rosalba, Bernardini, Giovanni, Cassinelli, Nicolas, Rother, Doerte, Puerto Morales, M., Lopez-Gallego, Fernando, and Grazu, Valeria

Published
2023
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17. Contributors

Author

Ahmad, Muhammad Shaheez, Ahmad, Saba, Aitani, Abdullah, Alcántara, Andres R., Ameen, Ayesha, Armenia, Ilaria, Asghar, Asma, Asharf, Warda, Bari Khan, Maham Abdul, Basel, Muhammad Ehtisham, Berenguer-Murcia, Ángel, Bernardini, Giovanni, Bilal, Muhammad, Borgese, Marina, Bussolari, Francesca, Cassinelli, Nicolas, Cipolatti, Eliane, Cruz-Cruz, Angelica, Cárdenas-Alcaide, María Fernanda, Fernández-Lafuente, Roberto, Fernández-Lucas, Jesús, Fuente, J.M. de la, Gallo-Cordova, Alvaro, Gamberoni, Federica, González-González, Reyna Berenice, Gornati, Rosalba, Grazu, Valeria, Guimarães, José R., Guisán-Seijas, J.M., Hafeez, Shahzar, Hameed, Sidra, Hanif, Maha, Hassan Gilliani, Muhammad Rehan, Hussain, Asim, Hussain, Dilshad, Hussain, Nazim, Intisar, Azeem, Iqbal, Rimsha, Iqbal, Hafiz M.N., Ismail, Fatima, Jabbar, Samahar Abdullah, Javed, Kashif, Javed, Sana, Jesionowski, Teofil, Kanwal, Faiza, Khalid, Maham, Khan, Faisal, Kumar, Adarsh, Kumar, Saroj, Liaqat, Sana, Lopez-Gallego, Fernando, Macedo de Melo, Eduardo, Mahmood, Tehreem, Majeed, Saadat, Maqsood, Salman, Mumtaz, Ayesha, Munir, Shahid, Naqvi, Wajahat Zahra, Naseem, Amina, Naz, Maimuna, Ovejero, Jesús G., Papait, Roberto, Parra-Saldívar, Roberto, Puerto Morales, M., Qaisar, Uzma, Rafeeq, Hamza, Rafique, Sadia, Ramzan, Rehana, Ratna, Sheel, Rios, Nathália S., Rivas-Sanchez, Andrea, Rizwan, Komal, Rocha-Martin, Javier, Rodrigues, Rafael C., Rother, Doerte, Safdar, Ayesha, Sanchez, Manu, Serio, Simone, Shafi, Sameera, Shahbaz, Areej, Siddique, Sara, Tardioli, Paulo W., Zafar, Saba, Zahid, Mahnoor, Zdarta, Jakub, and Zeshan, Muhammad

Published
2023
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