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Your search keyword '"Park, Ji-Yeong"' showing total 21 results
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21 results on '"Park, Ji-Yeong"'

3. TASL mediates keratinocyte differentiation by regulating intracellular calcium levels and lysosomal function

Author

Park, Ji Yeong, primary, Kim, Hyeng-Soo, additional, Hyung, Hyejin, additional, Jang, Soyeon, additional, Ko, Jiwon, additional, Lee, Jin Hong, additional, Kim, Si-Yong, additional, Park, Song, additional, Yi, Junkoo, additional, Park, Sijun, additional, Lim, Su-Geun, additional, Kim, Seonggon, additional, Lee, Sanggyu, additional, Kim, Myoung Ok, additional, Jang, Soyoung, additional, and Ryoo, Zae Young, additional

Published
2024
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5. Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin.

Author

Hwang, Juyoung, Park, Ji Yeong, Kang, Jio, Oh, Nuri, Li, Chen, Yoo, Chung‐Yul, Um, Wooram, and Kwak, Minseok

Subjects
*DRUG delivery systems, *DRUG carriers, *CARDIOTOXICITY, *TREATMENT effectiveness, *CANCER treatment, *DOXORUBICIN
Abstract

In this study, oil‐in‐water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion‐treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox‐induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locusta migratoria (Orthoptera: Acrididae) as a novel food source

Author

Kim, Sun Young, primary, Kwak, Kyu-Won, additional, Park, Ji Yeong, additional, Park, Eun-Sung, additional, Nam, Chun-Ja, additional, An, Kyu Sup, additional, Kim, Hyun-Jin, additional, Yoon, Hyung Joo, additional, Kim, Yong-Soon, additional, Park, Kwanho, additional, Kim, Eunsun, additional, Ryu, Hyeon Yeol, additional, and Kim, Sun-Don, additional

Published
2023
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17. Evaluation of subchronic oral dose toxicity and allergen of freeze-dried powder of Locustamigratoria(Orthoptera: Acrididae) as a novel food source

Author

Kim, Sun Young, Kwak, Kyu-Won, Park, Ji Yeong, Park, Eun-Sung, Nam, Chun-Ja, An, Kyu Sup, Kim, Hyun-Jin, Yoon, Hyung Joo, Kim, Yong-Soon, Park, Kwanho, Kim, Eunsun, Ryu, Hyeon Yeol, and Kim, Sun-Don

Abstract

The migratory locust, Locustamigratoria(Orthoptera: Acrididae), is a well-known edible insect which may serve as new source of human food and animal feed. However, potential toxicity and food safety of L.migratoriahad not been investigated extensively until now. Therefore, in this study, we aimed to investigate toxicity of freeze-dried powder of L.migratoria(fdLM) and identify allergic components in ELISA and PCR techniques. In this subchronic study, fdLM was administered once daily by oral gavage at the doses of 750, 1500, and 3000 mg/kg/day. No toxicological changes were observed in both sexes of rats for 13 weeks in accordance with the OECD guidelines and GLP conditions. In addition, fdLM did not induced increases of serum immunoglobulin E and 21 homologous proteins were not detected under our present conditions. In conclusion, the NOAEL (no-observed-adverse-effect level) was 3000 mg/kg/day and no target organ was identified in both sexes. In conclusion, we found that fdLM is safe with no adverse effects and offers the potential of its use as an edible ingredient or other biological uses.

Published
2023
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19. Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes [Corrigendum]

Author

Jang, Soyeon, primary, Jang, Soyoung, additional, Kim, Si-Yong, additional, Ko, Jiwon, additional, Kim, Eungyung, additional, Park, Ji Yeong, additional, Hyung, Hyejin, additional, Lee, Jin Hong, additional, Lim, Su-Geun, additional, Park, Sijun, additional, Yi, Junkoo, additional, Lee, Heon-Jin, additional, Kim, Myoung Ok, additional, Lee, Hyun-Shik, additional, and Ryoo, Zae Young, additional

Published
2021
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20. Ethanol Extract of Ampelopsis brevipedunculata Rhizomes Suppresses IgE-Mediated Mast Cell Activation and Anaphylaxis

Author

Park, Ji-Yeong, Kim, Min-Jong, Choi, Young-Ae, Woong Lee, Seung, Lee, Soyoung, Hyun Jang, Yong, and Kim, Sang-Hyun

Abstract

More than 20% of the world’s population suffers from allergic diseases, including allergic asthma, rhinitis, and atopic dermatitis that severely reduce the patient’s quality of life. The treatment of allergy has been developed, but there are still unmet needs. Ampelopsis brevipedunculata (Maxim.) Trautv. is a traditional medicinal herb with beneficial bioactivities, such as antioxidant, anti-hypertension, anti-viral, anti-mutagenic, and skin and liver (anti-hepatotoxic) protective actions. However, its anti-allergic effect has not been addressed. This study designed to investigate the pharmacological effect of an ethanol extract of A. brevipedunculata rhizomes (ABE) on mast cell and anaphylaxis models. For in vivo studies, we used ovalbumin-induced active systemic anaphylaxis (ASA) and immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis (PCA) models. In ASA model, oral administration of ABE (1, 10, and 100 mg/kg) attenuated the anaphylactic responses, such as hypothermia, serum histamine, and IgE productions. In PCA model, ABE also suppressed the plasma extravasation and swelling. The underlying mechanisms of action were identified in various mast cell types. In vitro, ABE (10, 30, and 60 µg/mL) inhibited the release of essential allergic mediators, such as histamine and β-hexosaminidase, in a concentration-dependent manner. ABE prevented the rapid increase in intracellular calcium levels induced by the DNP-HSA challenge. In addition, ABE downregulated the tumor necrosis factor-α and interleukin-4 by suppressing the activation of nuclear factor-κB. Collectively, this study is the first to identify the anti-allergic effect of ABE, suggesting that ABE is a promising candidate for treating allergic diseases.

Published
2024
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21. HSPA9 reduction exacerbates symptoms and cell death in DSS-Induced inflammatory colitis.

Author

Jang S, Jang S, Ko J, Bae JE, Hyung H, Park JY, Lim SG, Park S, Park S, Yi J, Kim S, Kim MO, Cho DH, and Ryoo ZY

Subjects
Animals, Mice, Cell Death, Colon metabolism, Cytokines metabolism, Dextran Sulfate toxicity, Disease Models, Animal, Macrophages metabolism, Mice, Inbred C57BL, Oxidative Stress, Colitis metabolism, Inflammatory Bowel Diseases metabolism
Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory condition that is influenced by various factors, including environmental factors, immune responses, and genetic elements. Among the factors that influence IBD progression, macrophages play a significant role in generating inflammatory mediators, and an increase in the number of activated macrophages contributes to cellular damage, thereby exacerbating the overall inflammatory conditions. HSPA9, a member of the heat shock protein 70 family, plays a crucial role in regulating mitochondrial processes and responding to oxidative stress. HSPA9 deficiency disrupts mitochondrial dynamics, increasing mitochondrial fission and the production of reactive oxygen species. Based on the known functions of HSPA9, we considered the possibility that HSPA9 reduction may contribute to the exacerbation of colitis and investigated its relevance. In a dextran sodium sulfate-induced colitis mouse model, the downregulated HSPA9 exacerbates colitis symptoms, including increased immune cell infiltration, elevated proinflammatory cytokines, decreased tight junctions, and altered macrophage polarization. Moreover, along with the increased mitochondrial fission, we found that the reduction in HSPA9 significantly affected the superoxide dismutase 1 levels and contributed to cellular death. These findings enhance our understanding of the intricate mechanisms underlying colitis and contribute to the development of novel therapeutic approaches for this challenging condition., (© 2024. The Author(s).)

Published
2024
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