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In this study, we investigated the effect of high temperature on the mechanical behavior of Hwangdeung granite in Korea. Uniaxial compression and Brazilian tests were performed under temperatures ranging from 20 °C to 250 °C. The development of the thermally induced microcracks was observed utilizing a scanning electron microscope (SEM). The target temperature was chosen for rock engineering projects, such as high-level radioactive waste disposal, enhanced geothermal energy, and thermal energy storage. Considering the long-term strength and fracture process associated with crack development, we examined the temperature dependence of crack initiation and propagation thresholds and conventional strength and deformation parameters, as well as the stress-strain relation under high temperature. Compressive strength, tensile strength, and Young's modulus decreased with increasing temperature, particularly at temperatures above 100 °C, and Poisson's ratio decreased linearly. The changes in the tensile strength and elastic constants were more pronounced than those in uniaxial compressive strength. The stress-strain curves revealed that the thermal effect on deformation, rather than strength, was evident. Microscopic observations of the heated rock samples have revealed that high temperature promoted the interaction and networking of pre-existing and thermally induced cracks, resulting in microstructural damage before loading. We determined the crack closure stress, crack initiation stress, and crack damage stress under the respective temperatures by analyzing the stress-strain curves. An increase in temperature increased the crack closure stress and reduced the crack initiation stress, resulting in a decreased elastic range; the former increased by 12.1 MPa as the temperature increased from 20 °C to 250 °C, and the latter significantly reduced by 25.1 MPa. This finding suggests that the mechanical behavior of rocks or rock masses under high-temperature conditions, particularly at low-stress levels, is uncertain and cannot be approximated with standard material properties. No systemic relation was detected between temperature and crack damage stress; however, the volumetric strain at the crack damage stress increased consistently with temperature. [ABSTRACT FROM AUTHOR]

This article proposes a new control method for the synchronous rectifier (SR) of phase-shifted full-bridge (PSFB) converter to improve its efficiency in light-load condition. In general, the PSFB converter operates in the discontinuous conduction mode (DCM) in light-load condition to reduce the effective duty-ratio and core loss. However, the conventional control methods in the DCM cause undesirable conduction loss in SR because the output inductor current flows through the body-diode instead of the channel of SR. To figure it out, the proposed control method modulates the turn-on time of SR to eliminate the body-diode conduction. Moreover, it can be easily implemented without any auxiliary circuits. Therefore, it can improve the efficiency in light-load condition while keeping the advantages of DCM. The operating principle of PSFB converter in the DCM is first described. Thereafter, the proposed control method for SR is theoretically analyzed. Finally, its practical effectiveness is verified by experimental tests on the hardware implementation. [ABSTRACT FROM AUTHOR]

The smart inverter (SI) is an emerging technology, which enables the effective integration of distributed energy resources (DERs). Nevertheless, the operation by the only single SI function is not sufficient to deal with various conditions in a distribution system. In other words, all DERs are required to rapidly update the proper mode of SI functions depending on the system conditions. In this article, we propose the new active distribution management system (ADMS) for photovoltaic (PV)/energy storage system (ESS) integrated system based on the SI functions. It effectively regulates the system voltage, and it solves the line congestion problem in a distribution system by adaptively controlling the mode of SI functions. This method enables DER to effectively regulate its generation without the additional controllers. The effectiveness of the proposed ADMS is verified by several case studies on a practical distribution system in South Korea with the real measurements of generation from PV and load consumption based on the electromagnetic transient program. Also, the PV/ESS integrated system prototype of 100 kW is implemented for the experimental verification of the proposed ADMS. [ABSTRACT FROM AUTHOR]

Background: Since severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was first reported in Wuhan, China, in December 2019, it has spread rapidly, and many coronavirus disease (COVID‐19) cases have occurred in Gwangju, South Korea. Viral mutations following the COVID‐19 epidemic have increased interest in the characteristics of epidemics in this region, and pathogen genetic analysis is required for infection control and prevention. Methods: In this study, SARS‐CoV‐2 whole‐genome analysis was performed on samples from patients with COVID‐19 in Gwangju from 2020 to 2022 to identify the trends in COVID‐19 prevalence and to analyze the phylogenetic relationships of dominant variants. B.41 and B.1.497 prevailed in 2020, the early stage of the COVID‐19 outbreak; then, B.1.619.1 mainly occurred until June 2021. B.1.617.2, classified as sublineages AY.69 and AY.122, occurred continuously from July to December 2021. Since strict measures to strengthen national quarantine management had been implemented in South Korea until this time, the analysis of mutations was also able to infer the epidemiological relationship between infection transmission routes. Since the first identification of the Omicron variant in late December 2021, the spread of infection has been very rapid, and weekly whole‐genome analysis of specimens has enabled us to monitor new Omicron sublineages occurring in Gwangju. Conclusions: Our study suggests that conducting regional surveillance in addition to nation‐level genomic surveillance will enable more rapid and detailed variant surveillance, which will be helpful in the overall prevention and management of infectious diseases. [ABSTRACT FROM AUTHOR]

The symmetry reduction of molecular shape of cationic chromophores as a design strategy to develop organic terahertz (THz) generators is used. Electron donating group (EDG) with an asymmetric shape is introduced into two types of cationic styryl‐quinolinium chromophores, leading to the development of several novel non‐centrosymmetric crystals with high macroscopic optical nonlinearity. In contrast, when an EDG with a symmetric shape is introduced, centrosymmetric crystal structure is obtained in all investigated crystals. For THz wave generation, crystals based on asymmetrically shaped EDG exhibit several optimal crystal characteristics, including a plate‐shape morphology, a large size, and an in‐plane polar axis. Furthermore, over the entire range of molecular phonon vibrations, 0.5–4 THz, the steric hindrance group in the asymmetrically shaped EDG has a strong influence on the suppression of THz phonon vibrations, leading to a low THz absorption coefficient. The crystals based on asymmetrically shaped EDG generate an ≈40 times stronger THz electric field than the inorganic ZnTe crystal and very broad THz spectra, extending up to 16 THz. Thus, the symmetry reduction of the molecular shape of cationic chromophores through the introduction of an asymmetrically shaped EDG is an effective design approach for the development of novel organic THz crystals. [ABSTRACT FROM AUTHOR]

As renewable energy penetrates the power system, system operators are required to curtail output power from generation units to balance the power supply and demand. However, large curtailment from wind power plants (WPPs) may instantly cause excessive output power decrement, causing system frequency to drop significantly before reaching its nominal value. In order to solve this problem, this paper proposes a cooperative control framework to determine the operation of WPPs in two control methods, which are the stepwise inertial control (SIC) method and the curtailed control method. The proposed framework first determines the WPPs to operate in the curtailed control method to provide the required power curtailment. Next, it determines the WPPs to operate in the SIC method considering their releasable kinetic energy to provide an effective inertial response and compensate for the sudden excessive output power decrement caused by other WPPs operated in the curtailed control method. Therefore, each WPP is operated in one of two control methods to provide required power curtailment while reducing the sudden excessive output power decrement. To verify the effectiveness of the proposed cooperative control framework, several case studies are carried out on the practical South Korea electric power system. [ABSTRACT FROM AUTHOR]

Zolbetuximab, a monoclonal antibody targeting claudin-18 isoform 2 (CLDN18.2), has shown efficacy in patients with CLDN18.2-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma. We report the results of the SPOTLIGHT trial, which investigated the efficacy and safety of first-line zolbetuximab plus mFOLFOX6 (modified folinic acid [or levofolinate], fluorouracil, and oxaliplatin regimen) versus placebo plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma. SPOTLIGHT is a global, randomised, placebo-controlled, double-blind, phase 3 trial that enrolled patients from 215 centres in 20 countries. Eligible patients were aged 18 years or older with CLDN18.2-positive (defined as ≥75% of tumour cells showing moderate-to-strong membranous CLDN18 staining), HER2-negative (based on local or central evaluation), previously untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma, with radiologically evaluable disease (measurable or non-measurable) according to Response Evaluation Criteria in Solid Tumors version 1.1; an Eastern Cooperative Oncology Group performance status score of 0 or 1; and adequate organ function. Patients were randomly assigned (1:1) via interactive response technology and stratified according to region, number of organs with metastases, and previous gastrectomy. Patients received zolbetuximab (800 mg/m2 loading dose followed by 600 mg/m2 every 3 weeks) plus mFOLFOX6 (every 2 weeks) or placebo plus mFOLFOX6. The primary endpoint was progression-free survival assessed by independent review committee in all randomly assigned patients. Safety was assessed in all treated patients. The study is registered with ClinicalTrials.gov , NCT03504397 , and is closed to new participants. Between June 21, 2018, and April 1, 2022, 565 patients were randomly assigned to receive either zolbetuximab plus mFOLFOX6 (283 patients; the zolbetuximab group) or placebo plus mFOLFOX6 (282 patients; the placebo group). At least one dose of treatment was administered to 279 (99%) of 283 patients in the zolbetuximab group and 278 (99%) of 282 patients in the placebo group. In the zolbetuximab group, 176 (62%) patients were male and 107 (38%) were female. In the placebo group, 175 (62%) patients were male and 107 (38%) were female. The median follow-up duration for progression-free survival was 12·94 months in the zolbetuximab group versus 12·65 months in the placebo group. Zolbetuximab treatment showed a significant reduction in the risk of disease progression or death compared with placebo (hazard ratio [HR] 0·75, 95% CI 0·60–0·94; p=0·0066). The median progression-free survival was 10·61 months (95% CI 8·90–12·48) in the zolbetuximab group versus 8·67 months (8·21–10·28) in the placebo group. Zolbetuximab treatment also showed a significant reduction in the risk of death versus placebo (HR 0·75, 95% CI 0·60–0·94; p=0·0053). Treatment-emergent grade 3 or worse adverse events occurred in 242 (87%) of 279 patients in the zolbetuximab group versus 216 (78%) of 278 patients in the placebo group. The most common grade 3 or worse adverse events were nausea, vomiting, and decreased appetite. Treatment-related deaths occurred in five (2%) patients in the zolbetuximab group versus four (1%) patients in the placebo group. No new safety signals were identified. Targeting CLDN18.2 with zolbetuximab significantly prolonged progression-free survival and overall survival when combined with mFOLFOX6 versus placebo plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma. Zolbetuximab plus mFOLFOX6 might represent a new first-line treatment in these patients. Astellas Pharma, Inc. [ABSTRACT FROM AUTHOR]

Like conventional two-switch leg converters, the three-switch leg converters also have short-circuit risks and a dangerous shoot-through current is generated if switches of the same leg are turned on simultaneously. In this article, a new dual-buck structure is proposed for three-switch leg converters. The proposed structure is reliable because of no shoot-through concerns and high quality of output waveforms can be obtained due to the reduction in pulsewidth modulation deadtime. Unlike the conventional dual-buck three-switch leg that uses many passive components such as four current limiting inductors and three external diodes, the new dual-buck three-switch leg uses only one current limiting inductor with two external diodes. To verify the performance, the proposed three-switch legs are used in single-phase dual-output inverter and detailed theoretical analysis, simulation, and experiments are performed. Both continuous and discontinuous modulation schemes are applied and it has been figured out that discontinuous modulation scheme can improve the dc-link voltage utilization in the common-frequency mode of operation. [ABSTRACT FROM AUTHOR]

We developed a geothermal monitoring system with an open-source Internet of Things (IoT) system. The study's objective is to achieve an economical alternative solution to the expensive commercial data loggers, local PC-based control, data storage limitation, the number of sensor connections, and secure data transmission over the Internet in a decentralized renewable energy system. The developed system consists of hardware and software customized with open-source support that helps resolve the conventional limitations that the commercial system inherently has. We have applied the system to a geothermal energy system deployed at a residential care facility for the elderly in Chuncheon, South Korea. The proposed system enabled us to acquire the data of temperature and fluid flow in real-time and for a prolonged period (i.e., years) at an affordable price compared to installing a conventional data-acquisition system. The real-time multi-year-long data helped confirm seasonality in heating and cooling. We can also apply the same proposed system to the other renewable energy systems monitoring temperature, pressure, wind speed, displacement, noise, seismicity, etc. • Development of a geothermal monitoring system with an open-source IoT system. • The system was applied to a geothermal system deployed at a residential care facility. • The real-time multi-year-long data helped confirm seasonality in heating and cooling. • We can also apply the same proposed system to the other renewable energy. [ABSTRACT FROM AUTHOR]

Background: Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses is a frequently reported acute hemorrhagic fever in South Korea. These viruses are transmitted by various rodent species such as Apodemus agrarius. Methodology/Principal findings: To investigate hantavirus infection and seroprevalence in rodents, wild rodents were captured from two districts in the suburbs of Gwangju Metropolitan City from January 2016 to December 2018. Nested reverse-transcription polymerase chain reaction (RT-PCR) targeting the hantavirus-specific L segment and indirect immunofluorescence antibody (IFA) assay using Hantaan virus antigen slides were performed. A total of 585 wild rodents were captured—512 A. agrarius, 49 Crocidura lasiura, and 24 Myodes regulus. Nested RT-PCR was performed to examine the rate of hantavirus infection in wild rodents, and 1.88% (11/585) of all rodents, 1.17% (6/512) of A. agrarius, 6.12% (3/49) of C. lasiura, and 8.33% (2/24) of M. regulus tested positive. The nucleotide sequence analysis of the eleven PCR-positive products revealed that six PCR products showed over 85% sequence similarity with the Jeju virus, four showed over 99.7% similarity with the Hantaan virus, and one showed over 95.3% homology with the Imjin virus. Moreover, IgG antibodies against the Hantaan virus were detected in 6.15% (36/585) of all rodents, 6.8% (35/512) of A. agrarius, and 4.17% (1/24) of M. regulus. IgG antibodies were not detected in C. lasiura. Conclusions/Significance: Hantaviruses were detected in all three wild rodent species of A. agrarius, C. lasiura, and M. regulus captured in the suburbs of Gwangju Metropolitan City, South Korea, and it was demonstrated that they were various strains of hantaviruses such as the Hantaan, Jeju, and Imjin viruses. Author summary: Hantaviruses (family Hantaviridae, genus Hantavirus) are rodent viruses that can cause two fatal human diseases—hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. These viruses are transmitted by various rodent species such as Apodemus agrarius. In the present study, wild rodents captured in the suburbs of Gwangju Metropolitan City were analyzed by nested reverse-transcription polymerase chain reaction targeting the hantavirus-specific L segment and indirect immunofluorescence antibody assay using Hantaan virus antigen slides. A total of 585 wild rodents were captured and 1.88% (11/585) of all rodents, 1.17% (6/512) of A. agrarius, 6.12% (3/49) of Crocidura lasiura, and 8.33% (2/24) of Myodes regulus were PCR-positive. Of the eleven PCR-positive wild rodents, six PCR products showed over 85% sequence similarity with the Jeju virus, four showed over 99.7% similarity with the Hantaan virus, and one showed over 95.3% homology with the Imjin virus. Moreover, IgG antibodies against the Hantaan virus were detected in 6.15% (36/585) of all rodents, 6.8% (35/512) of A. agrarius, and 4.17% (1/24) of M. regulus. IgG antibodies were not detected in C. lasiura. When we examined the detection rate of hantavirus genes in different seasons, hantaviruses were most commonly detected in fall (seven cases [5.69%]) and winter (four cases [2.76%]). No hantaviruses were detected in spring or summer. However, the seasonal prevalence of IgG antibodies was higher in spring and summer (12 [7.32%] and 11 [7.10%] cases, respectively) than in fall and winter (seven [5.69%] and six [4.14%] cases, respectively). This study was performed on a monthly basis throughout a three-year period, and thus, it provides reliable data that may provide insight into preventive measures against HFRS. Our results suggest that various types of hantaviruses, including Hantaan, Jeju, and Imjin viruses, are distributed throughout Gwangju Metropolitan City, South Korea. Data regarding the rate of Hantaan virus infection in rodents in Gwangju and knowledge of the hantavirus seroprevalence, species, and genotypes circulating in these domestic rodent species will provide useful information for developing vaccines and diagnostic testing using sequence data. These will help increase preparedness for the emergence of new species. [ABSTRACT FROM AUTHOR]

This article proposes the new noninverting buck–boost ac–ac converter, which can minimize the reverse recovery loss by disabling the body diodes of switches and using the external fast recovery diodes for its current freewheeling. In particular, the proposed ac–ac converter takes advantages of metal-oxide semiconductor field effect transistors and external fast recovery diodes to achieve the high efficiency. Also, it has the high reliability without the shoot-through and dead-time considerations in the circuit. Moreover, it can be simply implemented without employing the conventional commutation control. This results in decreasing the control complexity. As its proper application, a new type of dynamic voltage restorer (DVR) based on the proposed noninverting buck–boost converter is described. It enables to solve the voltage sag and swell problems by utilizing both positive and negative gains of converter. Then, the hardware prototype of proposed ac–ac converter and DVR are implemented to verify their practical effectiveness. [ABSTRACT FROM AUTHOR]

In this article, we present a new type of Z-source inverter (ZSI) that replaces two inductors in the original quasi-ZSI with two transformers. It can produce a very high output voltage with the high value of the modulation index. Moreover, it enables both to provide a better power quality of output and to reduce the switching loss. In particular, the proposed quasi-clamped ZSI with two transformers give a unique solution to obtain high gain by reducing the turns ratio, rather than increasing it. Also, the leakage inductance of the transformer might cause huge voltage spikes across the inverter bridge. To deal with this problem, an effective clamping technique is proposed. As a result, this increases the overall efficiency of the system by utilizing the low-power switching devices. The characteristics of the proposed quasi-clamped ZSI with two transformers are comprehensively discussed with the detailed theoretical analysis. Thereafter, its performances are evaluated by both simulation and experimental tests. [ABSTRACT FROM AUTHOR]

Lyme disease is a tick-borne infectious disease caused by the Borrelia burgdorferi sensu lato complex. However, the distribution of Borrelia genospecies and the tissue detection rate of Borrelia in wild rodents have rarely been investigated. Here, we studied 27 wild rodents (Apodemus agrarius) captured in October and November 2016 in Gwangju, South Korea, and performed nested polymerase chain reaction targeting pyrG and ospA to confirm Borrelia infection. Eight rodents (29.6%) tested positive for Borrelia infection. The heart showed the highest infection rate (7/27; 25.9%), followed by the spleen (4/27; 14.8%), kidney (2/27; 7.4%), and lungs (1/27; 3.7%). The B. afzelii infection rate was 25.9%, with the highest rate observed in the heart (7/27; 25.9%), followed by that in the kidney and spleen (both 2/27; 7.4%). B. garinii and B. burgdorferi sensu stricto were detected only in the spleen (1/27; 3.7%). This is the first report of B. burgdorferi sensu stricto infection in wild rodents in South Korea. The rodent hearts showed a high B. afzelii infection rate, whereas the rodent spleens showed high B. garinii and B. burgdorferi sensu stricto infection rates. Besides B. garinii and B. afzelii, B. burgdorferi sensu stricto may cause Lyme disease in South Korea. [ABSTRACT FROM AUTHOR]

This article proposes a family of single-phase transformer based Z-source ac–ac converters (ZSACs). The proposed converters inherit all the benefits associated with the classical single-phase ZSAC, which are providing the buck–boost operation, maintaining or reversing the phase angle, and improving reliability. The proposed converters also have the improved input profile, continuous input current, and shared ground between input and output. Moreover, they use the turns ratio of transformers to produce the required voltage gain, which can be tuned by either increasing or decreasing the turns ratio of transformer depending on the configuration of Z-source structure. A safe-commutation strategy is also presented to achieve the soft commutation, which eliminates the voltage and current spikes without any additional snubber circuits. The features of proposed converters are comprehensively discussed with the detailed theoretical analysis. Thereafter, its performances are evaluated by both simulation and experimental tests. [ABSTRACT FROM AUTHOR]

Numerical simulations become a necessity when experimental approaches cannot cover the required physical and time scale of interest. One of such area is a simulation of long-term host rock behaviors for nuclear waste disposal and simulation tools involved in the assessment must go through rigorous validation tests. The DECOVALEX project (Development of COupled models and their VAlidation against EXperiments) is dedicated to this purpose by international participants. a a www.decovalex.org. This work is part of the ongoing phase DECOVALEX–2023 (D–2023, Task G) particularly aiming to simulate fracture behaviors under various conditions. Here, we cross-verified a variety of numerical methods including continuous and discontinuous approaches against four benchmark exercises with emphasis on numerical accuracy and parameterization of the various numerical approaches. The systematic inter-comparisons of test cases highlight advantages and disadvantages of the different numerical models. Numerical details on discretization effects (e.g. mesh density and orientation) and domain size were investigated in detail for practical applications. It became evident that meticulous attention to mesh resolution and domain size is imperative for achieving accurate numerical simulations, even for static cracks. Moreover, when comparing numerical methods to closed-form solutions for static cracks, all models successfully reproduced the maximum crack opening but encountered challenges near the crack tips. Finally, the paper discusses how to convert between and therefore compare parameters of various numerical approaches. Our benchmark studies reveal that each model necessitates a distinct number of parameters, even in simple scenarios like static crack aperture benchmarks. It is generally more practical to employ fewer parameters to mitigate model over-parameterization and enhance experimental feasibility. • Systematic benchmarks on numerical accuracy & parameterizations for hydro-mechanical fracture mechanics. • Study explores discretization effects and domain size in practical applications. • Compare various numerical approaches' parameterizations. [ABSTRACT FROM AUTHOR]

The high penetration of wind power decreases the system inertia and primary frequency reserve while replacing the conventional synchronous generators (SGs). Therefore, if the system operator does not take appropriate action on the remaining generation units (GUs) operation, high penetration of wind power will aggravate the frequency stability. To solve this problem, wind power plants (WPPs) may provide the inertial response and primary frequency response (PFR) to support the frequency stability. However, due to the variability of renewable energy, WPPs may not provide adequate frequency response whenever it is required. This paper proposes an algorithm to determine the operation of GUs to provide appropriate PFR for a power system with high penetration of wind power. Through the proposed algorithm, it calculates the required PFR to restore the decreased frequency stability caused by the high penetration of wind power. Then, while considering the available PFR from WPPs, it redetermines the droop coefficient of SGs governor to provide the sufficient PFR to recover the frequency stability. Finally, the effectiveness of the proposed algorithm is verified on the practical Korean electric power system. [ABSTRACT FROM AUTHOR]