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10 results on '"Paul, Nicodème"'

1. Platelets favor the outgrowth of established metastases

Author

Garcia-Leon, Maria J., Liboni, Cristina, Mittelheisser, Vincent, Bochler, Louis, Follain, Gautier, Mouriaux, Clarisse, Busnelli, Ignacio, Larnicol, Annabel, Colin, Florent, Peralta, Marina, Osmani, Naël, Gensbittel, Valentin, Bourdon, Catherine, Samaniego, Rafael, Pichot, Angélique, Paul, Nicodème, Molitor, Anne, Carapito, Raphaël, Jandrot-Perrus, Martine, Lefebvre, Olivier, Mangin, Pierre H., and Goetz, Jacky G.

Published
2024
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3. Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma

Author

Spenlé, Caroline, primary, Loustau, Thomas, primary, Murdamoothoo, Devadarssen, primary, Erne, William, primary, Beghelli-de la Forest Divonne, Stephanie, primary, Veber, Romain, primary, Petti, Luciana, primary, Bourdely, Pierre, primary, Mörgelin, Matthias, primary, Brauchle, Eva-Maria, primary, Cremel, Gérard, primary, Randrianarisoa, Vony, primary, Camara, Abdouramane, primary, Rekima, Samah, primary, Schaub, Sebastian, primary, Nouhen, Kelly, primary, Imhof, Thomas, primary, Hansen, Uwe, primary, Paul, Nicodème, primary, Carapito, Raphael, primary, Pythoud, Nicolas, primary, Hirschler, Aurélie, primary, Carapito, Christine, primary, Dumortier, Hélène, primary, Mueller, Christopher G., primary, Koch, Manuel, primary, Schenke-Layland, Katja, primary, Kon, Shigeyuki, primary, Sudaka, Anne, primary, Anjuère, Fabienne, primary, Van Obberghen-Schilling, Ellen, primary, and Orend, Gertraud, primary

Published
2023
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4. Supplementary Data from Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma

Author

Spenlé, Caroline, primary, Loustau, Thomas, primary, Murdamoothoo, Devadarssen, primary, Erne, William, primary, Beghelli-de la Forest Divonne, Stephanie, primary, Veber, Romain, primary, Petti, Luciana, primary, Bourdely, Pierre, primary, Mörgelin, Matthias, primary, Brauchle, Eva-Maria, primary, Cremel, Gérard, primary, Randrianarisoa, Vony, primary, Camara, Abdouramane, primary, Rekima, Samah, primary, Schaub, Sebastian, primary, Nouhen, Kelly, primary, Imhof, Thomas, primary, Hansen, Uwe, primary, Paul, Nicodème, primary, Carapito, Raphael, primary, Pythoud, Nicolas, primary, Hirschler, Aurélie, primary, Carapito, Christine, primary, Dumortier, Hélène, primary, Mueller, Christopher G., primary, Koch, Manuel, primary, Schenke-Layland, Katja, primary, Kon, Shigeyuki, primary, Sudaka, Anne, primary, Anjuère, Fabienne, primary, Van Obberghen-Schilling, Ellen, primary, and Orend, Gertraud, primary

Published
2023
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5. Supplementary Data from Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype

Author

Deligne, Claire, primary, Murdamoothoo, Devadarssen, primary, Gammage, Anís N., primary, Gschwandtner, Martha, primary, Erne, William, primary, Loustau, Thomas, primary, Marzeda, Anna M., primary, Carapito, Raphael, primary, Paul, Nicodème, primary, Velazquez-Quesada, Inés, primary, Mazzier, Imogen, primary, Sun, Zhen, primary, Orend, Gertraud, primary, and Midwood, Kim S., primary

Published
2023
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6. Data from Matrix-Targeting Immunotherapy Controls Tumor Growth and Spread by Switching Macrophage Phenotype

Author

Deligne, Claire, primary, Murdamoothoo, Devadarssen, primary, Gammage, Anís N., primary, Gschwandtner, Martha, primary, Erne, William, primary, Loustau, Thomas, primary, Marzeda, Anna M., primary, Carapito, Raphael, primary, Paul, Nicodème, primary, Velazquez-Quesada, Inés, primary, Mazzier, Imogen, primary, Sun, Zhen, primary, Orend, Gertraud, primary, and Midwood, Kim S., primary

Published
2023
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7. Identification of early-induced broadly neutralizing activities against transmitted founder HIV strains

Author

Lucas, Julie, primary, Lin, Li-Yun, additional, Paul, Nicodème, additional, Laumond, Géraldine, additional, Klingler, Jéromine, additional, Schmidt, Sylvie, additional, Frappier, Julia, additional, Essat, Asma, additional, Meyer, Laurence, additional, Gordon, Alicia Castro, additional, Goujard, C.é.cile, additional, Bahram, Seiamak, additional, and Moog, Christiane, additional

Published
2022
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10. A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease.

Author

Molitor A, Lederle A, Radosavljevic M, Sapuru V, Zavorka Thomas ME, Yang J, Shirin M, Collin-Bund V, Jerabkova-Roda K, Miao Z, Bernard A, Rolli V, Grenot P, Castro CN, Rosenzwajg M, Lewis EG, Person R, Esperón-Moldes US, Kaare M, Nokelainen PT, Batzir NA, Hoffer GZ, Paul N, Stemmelen T, Naegely L, Hanauer A, Bibi-Triki S, Grün S, Jung S, Busnelli I, Tripolszki K, Al-Ali R, Ordonez N, Bauer P, Song E, Zajo K, Partida-Sanchez S, Robledo-Avila F, Kumanovics A, Louzoun Y, Hirschler A, Pichot A, Toker O, Mejía CAM, Parvaneh N, Knapp E, Hersh JH, Kenney H, Delmonte OM, Notarangelo LD, Goetz JG, Kahwash SB, Carapito C, Bajwa RPS, Thomas C, Ehl S, Isidor B, Carapito R, Abraham RS, Hite RK, Marcus N, Bertoli-Avella A, and Bahram S

Subjects
Humans, Male, Female, Calcium metabolism, Child, Mutation, Jurkat Cells, Child, Preschool, Genes, Dominant, Pedigree, Phenotype, Inositol 1,4,5-Trisphosphate Receptors genetics, Inositol 1,4,5-Trisphosphate Receptors metabolism
Abstract

Inositol 1,4,5-trisphosphate (IP3) receptor type 1 ( ITPR1 ), 2 ( ITPR2 ), and 3 ( ITPR3 ) encode the IP3 receptor (IP3R), a key player in intracellular calcium release. In four unrelated patients, we report that an identical ITPR3 de novo variant-NM_002224.3:c.7570C>T, p.Arg2524Cys-causes, through a dominant-negative effect, a complex multisystemic disorder with immunodeficiency. This leads to defective calcium homeostasis, mitochondrial malfunction, CD4 + lymphopenia, a quasi-absence of naïve CD4 + and CD8 + cells, an increase in memory cells, and a distinct TCR repertoire. The calcium defect was recapitulated in Jurkat knock-in. Site-directed mutagenesis displayed the exquisite sensitivity of Arg 2524 to any amino acid change. Despite the fact that all patients had severe immunodeficiency, they also displayed variable multisystemic involvements, including ectodermal dysplasia, Charcot-Marie-Tooth disease, short stature, and bone marrow failure. In conclusion, unlike previously reported ITPR1-3 deficiencies leading to narrow, mainly neurological phenotypes, a recurrent dominant ITPR3 variant leads to a multisystemic disease, defining a unique role for IP3R3 in the tetrameric IP3R complex.

Published
2024
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