1. Survival and Larynx Preservation in Early Glottic Cancer: A Randomized Trial Comparing Laser Surgery and Radiation Therapy
- Author
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Pihla Pakkanen, Heikki Irjala, Taru Ilmarinen, Elina Halme, Paula Lindholm, Antti Mäkitie, Tuija Wigren, Leena-Maija Aaltonen, Korva-, nenä- ja kurkkutautien klinikka, HUS Head and Neck Center, Faculty Common Matters (Faculty of Medicine), Clinicum, and Research Program in Systems Oncology
- Subjects
Male ,Glottis ,Cancer Research ,CARCINOMA ,3122 Cancers ,VOICE QUALITY ,QUALITY-OF-LIFE ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Laryngeal Neoplasms ,METAANALYSIS ,Neoplasm Staging ,Retrospective Studies ,Radiation ,Squamous Cell Carcinoma of Head and Neck ,CO2-LASER SURGERY ,3126 Surgery, anesthesiology, intensive care, radiology ,Tongue Neoplasms ,Survival Rate ,Treatment Outcome ,Oncology ,Head and Neck Neoplasms ,Female ,Laser Therapy ,RADIOTHERAPY - Abstract
Purpose: The prognosis of glottic T1a laryngeal squamous cell carcinoma (LSCC) is excellent with both transoral laser surgery (TLS) and radiation therapy (RT). Our aim was to compare TLS and RT treatment results in a randomized study. Methods and Materials: Of 56 male patients with glottic T1a LSCC, 31 were randomized for TLS and 25 for RT. Survival and larynx preservation data were collected from medical records. Results: Five-year overall survival (OS) was 87%, disease-specific survival (DSS) was 97%, and recurrence-free survival (RFS) was 81% in patients treated with TLS. Five-year OS was 92%, DSS was 100%, and RFS was 88% in patients treated with RT. The primary treatment method was not associated with OS, RFS, or DSS in a log-rank test. The larynx preservation rate was similar in both groups (TLS, 97%; RT, 92%; P = .575). Conclusions: In a prospective randomized setting oncological outcomes of both treatment modalities (TLS or RT) for T1a LSCC were similar. (C) 2022 Elsevier Inc. All rights reserved.
- Published
- 2022
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