Search

O tumor ósseo multilobular é uma neoplasia primária rara em cães que acomete ossos chatos do crânio, potencialmente maligna, localmente invasiva e de crescimento lento. Normalmente atinge cães de raças de médio a grande porte e de meia idade a idosos. As alterações clínicas irão depender do comportamento biológico do tumor e estão associadas às estruturas que sofrem compressão pela massa. O objetivo deste trabalho foi relatar o caso de tumor ósseo multilobular craniano em uma cadela, sem raça definida, de nove anos de idade. A paciente apresentou o desenvolvimento progressivo de uma massa firme na região dorsal dos ossos frontais e parietais do crânio, que resultou em ceratoconjuntivite devido à tensão excessiva da pele na região palpebral. A radiografia craniana demonstrou a presença de uma massa de grande radiopacidade e aspecto granular. O exame citopatológico evidenciou achados sugestivos de tumor ósseo multilobular, optando-se pela excisão cirúrgica da massa. Foi realizada a excisão da neoplasia por meio da divulsão dos tecidos adjacentes e secção da neoplasia na base do crânio. Devido ao grau de invasividade do tumor não foi possível o estabelecimento de margem cirúrgica. O diagnóstico foi confirmado por meio do exame histopatológico. A paciente apresentou boa recuperação após a cirurgia, inclusive da lesão ocular, porém após cinco meses houve recidiva local da neoplasia. Uma segunda intervenção cirúrgica não foi possível, pois a paciente veio a óbito por intoxicação por bufotoxina. A remoção cirúrgica da neoplasia, mesmo com margens comprometidas, melhorou significativamente a qualidade de vida da paciente.

ABSTRACT We report two cases of hemochromatosis-like disease in captive Brazilian tapirs, Tapirus terrestris in Pará state, Brazil. Both animals presented symptoms of chronic hepatopathy associated with marked accumulation of hemosiderin. The coloration of Perls demonstrated pronounced iron accumulation in macrophages in the portal space, Kupffer cells, and, to a lesser extent, in the hepatocytes of the periportal region. Marked portal fibrosis was evidenced by Masson’s trichrome. The pathological mechanisms of this disease in tapirs are not yet well established. It has been suggested that the species may have different mechanisms of iron absorption and elimination, rendering them sensitive to elevation in dietary levels of this metal. Two previous reports of this disease in T. terrestris exist from zoos in Australia and Scotland. This is the first report of this disease in tapirs in Brazil based on histopathological and histochemical findings.

ABSTRACT: Polioencephalomalacia (PEM) is a nervous disease that affects ruminants, has a worldwide distribution and causes significant economic losses. PEM is abundantly described and studied in cattle and small ruminants, but there is little information about the disease in buffaloes, especially in Brazil. The objective of this work is to describe the clinical and pathological aspects of an outbreak of PEM in buffaloes in a feedlot in the state of Pará, Brazil. The outbreak occurred in a flock of 76 Murrah buffaloes, with an average age of five months, in a feedlot. Twenty-eight of these buffaloes became ill, and thirteen showed neurological signs and died. Two buffaloes underwent necropsy. The brain and fragments of various abdominal and thoracic cavity organs were fixed in 10% formalin and sent for histopathological examination. In the frontal, parietal, and occipital telencephalic lobes, the convolutions were flattened and yellowish, and when cut, there was a clear line of demarcation between the superficial and deep layers. Histologically, the intermediate layers of the cerebral cortex showed mild to moderate vacuolization of the neuropil, moderate enlargement of the perivascular, perineuronal, and periastrocyte spaces, moderate swelling and edema of astrocytes, and a large number of necrotic neurons. The work demonstrates that, despite being poorly documented in Brazil, PEM should be considered in the differential diagnosis of neurological syndromes in buffaloes.