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Your search keyword '"Perlin, Julie R"' showing total 5 results
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5 results on '"Perlin, Julie R"'

1. ISSCR Education Committee syllabus and learning guide for enhancing stem cell literacy

Author

Perlin, Julie R, Anderson, William J, Bartfeld, Sina, Couturier, Anna, de Soysa, Yvanka, Hawley, R Scott, Hu, Ping, Loh, Yuin-Han, Mandal, Lolitika, Master, Zubin, Muotri, Alysson R, Piddini, Eugenia, Polo, Jose M, and Mazzoni, Esteban O

Subjects
Biochemistry and Cell Biology, Biological Sciences, Regenerative Medicine, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Quality Education, Curriculum, Literacy, Stem Cells, Clinical Sciences, Biochemistry and cell biology
Abstract

The rapidly evolving stem cell field puts much stress on developing educational resources. The ISSCR Education Committee has created a flexible stem cell syllabus rooted in core concepts to facilitate stem cell literacy. The free syllabus will be updated regularly to maintain accuracy and relevance.

Published
2023

2. Transcription factor induction of vascular blood stem cell niches in vivo

Author

Hagedorn, Elliott J., Perlin, Julie R., Freeman, Rebecca J., Wattrus, Samuel J., Han, Tianxiao, Mao, Clara, Kim, Ji Wook, Fernández-Maestre, Inés, Daily, Madeleine L., D’Amato, Christopher, Fairchild, Michael J., Riquelme, Raquel, Li, Brian, Ragoonanan, Dana A.V.E., Enkhbayar, Khaliun, Henault, Emily L., Wang, Helen G., Redfield, Shelby E., Collins, Samantha H., Lichtig, Asher, Yang, Song, Zhou, Yi, Kunar, Balvir, Gomez-Salinero, Jesus Maria, Dinh, Thanh T., Pan, Junliang, Holler, Karoline, Feldman, Henry A., Butcher, Eugene C., van Oudenaarden, Alexander, Rafii, Shahin, Junker, J. Philipp, and Zon, Leonard I.

Published
2023
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3. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C

Author

Binder, Vera, Li, Wantong, Faisal, Muhammad, Oyman, Konur, Calkins, Donn L., Shaffer, Jami, Teets, Emily M., Sher, Steven, Magnotte, Andrew, Belardo, Alex, Deruelle, William, Gregory, T. Charles, Orwick, Shelley, Hagedorn, Elliott J., Perlin, Julie R., Avagyan, Serine, Lichtig, Asher, Barrett, Francesca, Ammerman, Michelle, Yang, Song, Zhou, Yi, Carson, William E., Shive, Heather R., Blachly, James S., Lapalombella, Rosa, Zon, Leonard I., and Blaser, Bradley W.

Published
2023
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4. Transcription factor induction of vascular blood stem cell niches in vivo

Author

Hagedorn, Elliott J, Perlin, Julie R, Freeman, Rebecca J, Wattrus, Samuel J, Han, Tianxiao, Mao, Clara, Kim, Ji Wook, Fernández-Maestre, Inés, Daily, Madeleine L, D'Amato, Christopher, Fairchild, Michael J, Riquelme, Raquel, Li, Brian, Ragoonanan, Dana A V E, Enkhbayar, Khaliun, Henault, Emily L, Wang, Helen G, Redfield, Shelby E, Collins, Samantha H, Lichtig, Asher, Yang, Song, Zhou, Yi, Kunar, Balvir, Gomez-Salinero, Jesus Maria, Dinh, Thanh T, Pan, Junliang, Holler, Karoline, Feldman, Henry A, Butcher, Eugene C, van Oudenaarden, Alexander, Rafii, Shahin, Junker, J Philipp, Zon, Leonard I, Hagedorn, Elliott J, Perlin, Julie R, Freeman, Rebecca J, Wattrus, Samuel J, Han, Tianxiao, Mao, Clara, Kim, Ji Wook, Fernández-Maestre, Inés, Daily, Madeleine L, D'Amato, Christopher, Fairchild, Michael J, Riquelme, Raquel, Li, Brian, Ragoonanan, Dana A V E, Enkhbayar, Khaliun, Henault, Emily L, Wang, Helen G, Redfield, Shelby E, Collins, Samantha H, Lichtig, Asher, Yang, Song, Zhou, Yi, Kunar, Balvir, Gomez-Salinero, Jesus Maria, Dinh, Thanh T, Pan, Junliang, Holler, Karoline, Feldman, Henry A, Butcher, Eugene C, van Oudenaarden, Alexander, Rafii, Shahin, Junker, J Philipp, and Zon, Leonard I

Abstract

The hematopoietic niche is a supportive microenvironment composed of distinct cell types, including specialized vascular endothelial cells that directly interact with hematopoietic stem and progenitor cells (HSPCs). The molecular factors that specify niche endothelial cells and orchestrate HSPC homeostasis remain largely unknown. Using multi-dimensional gene expression and chromatin accessibility analyses in zebrafish, we define a conserved gene expression signature and cis-regulatory landscape that are unique to sinusoidal endothelial cells in the HSPC niche. Using enhancer mutagenesis and transcription factor overexpression, we elucidate a transcriptional code that involves members of the Ets, Sox, and nuclear hormone receptor families and is sufficient to induce ectopic niche endothelial cells that associate with mesenchymal stromal cells and support the recruitment, maintenance, and division of HSPCs in vivo. These studies set forth an approach for generating synthetic HSPC niches, in vitro or in vivo, and for effective therapies to modulate the endogenous niche.

Published
2023

5. Transcription factor induction of vascular blood stem cell niches in vivo

Author

CMM Sectie Molecular Cancer Research, Cancer, Hubrecht Institute with UMC, Hagedorn, Elliott J., Perlin, Julie R., Freeman, Rebecca J., Wattrus, Samuel J., Han, Tianxiao, Mao, Clara, Kim, Ji Wook, Fernández-Maestre, Inés, Daily, Madeleine L., D'Amato, Christopher, Fairchild, Michael J., Riquelme, Raquel, Li, Brian, Ragoonanan, Dana A.V.E., Enkhbayar, Khaliun, Henault, Emily L., Wang, Helen G., Redfield, Shelby E., Collins, Samantha H., Lichtig, Asher, Yang, Song, Zhou, Yi, Kunar, Balvir, Gomez-Salinero, Jesus Maria, Dinh, Thanh T., Pan, Junliang, Holler, Karoline, Feldman, Henry A., Butcher, Eugene C., van Oudenaarden, Alexander, Rafii, Shahin, Junker, J. Philipp, Zon, Leonard I., CMM Sectie Molecular Cancer Research, Cancer, Hubrecht Institute with UMC, Hagedorn, Elliott J., Perlin, Julie R., Freeman, Rebecca J., Wattrus, Samuel J., Han, Tianxiao, Mao, Clara, Kim, Ji Wook, Fernández-Maestre, Inés, Daily, Madeleine L., D'Amato, Christopher, Fairchild, Michael J., Riquelme, Raquel, Li, Brian, Ragoonanan, Dana A.V.E., Enkhbayar, Khaliun, Henault, Emily L., Wang, Helen G., Redfield, Shelby E., Collins, Samantha H., Lichtig, Asher, Yang, Song, Zhou, Yi, Kunar, Balvir, Gomez-Salinero, Jesus Maria, Dinh, Thanh T., Pan, Junliang, Holler, Karoline, Feldman, Henry A., Butcher, Eugene C., van Oudenaarden, Alexander, Rafii, Shahin, Junker, J. Philipp, and Zon, Leonard I.

Published
2023

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