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1. Mask side-effects are related to gender in long-term CPAP: results from the InterfaceVent real-life study

Author

Celia Vidal, Fanny Bertelli, Jean-Pierre Mallet, Raphael Gilson, Jean-Christian Borel, Frédéric Gagnadoux, Arnaud Bourdin, Nicolas Molinari, and Dany Jaffuel

Subjects
Sleep apnea, Leaks, Side-effects, Women, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Over the past three decades, our understanding of sleep apnea in women has advanced, revealing disparities in pathophysiology, diagnosis, and treatment compared to men. However, no real-life study to date has explored the relationship between mask-related side effects (MRSEs) and gender in the context of long-term CPAP. Methods The InterfaceVent-CPAP study is a prospective real-life cross-sectional study conducted in an apneic adult cohort undergoing at least 3 months of CPAP with unrestricted mask-access (34 different masks, no gender specific mask series). MRSE were assessed by the patient using visual analog scales (VAS). CPAP-non-adherence was defined as a mean CPAP-usage of less than 4 h per day. The primary objective of this ancillary study was to investigate the impact of gender on the prevalence of MRSEs reported by the patient. Secondary analyses assessed the impact of MRSEs on CPAP-usage and CPAP-non-adherence depending on the gender. Results A total of 1484 patients treated for a median duration of 4.4 years (IQ25–75: 2.0–9.7) were included in the cohort, with women accounting for 27.8%. The prevalence of patient-reported mask injury, defined as a VAS score ≥ 5 (p = 0.021), was higher in women than in men (9.6% versus 5.3%). For nasal pillow masks, the median MRSE VAS score for dry mouth was higher in women (p = 0.039). For oronasal masks, the median MRSE VAS score for runny nose was higher in men (p = 0.039). Multivariable regression analyses revealed that, for both women and men, dry mouth was independently and negatively associated with CPAP-usage, and positively associated with CPAP-non-adherence. Conclusion In real-life patients treated with long-term CPAP, there are gender differences in patient reported MRSEs. In the context of personalized medicine, these results suggest that the design of future masks should consider these gender differences if masks specifically for women are developed. However, only dry mouth, a side effect not related to mask design, impacts CPAP-usage and non-adherence. Trial Registration: InterfaceVent is registered with ClinicalTrials.gov (NCT03013283).First registration date is 2016–12-23.

Published
2024
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2. Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia

Author

Lloyd A. C. Chapman, Maite Aubry, Noémie Maset, Timothy W. Russell, Edward S. Knock, John A. Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, and Adam J. Kucharski

Subjects
Science
Abstract

Abstract Estimating the impact of vaccination and non-pharmaceutical interventions on COVID-19 incidence is complicated by several factors, including successive emergence of SARS-CoV-2 variants of concern and changing population immunity from vaccination and infection. We develop an age-structured multi-strain COVID-19 transmission model and inference framework to estimate vaccination and non-pharmaceutical intervention impact accounting for these factors. We apply this framework to COVID-19 waves in French Polynesia and estimate that the vaccination programme averted 34.8% (95% credible interval: 34.5–35.2%) of 223,000 symptomatic cases, 49.6% (48.7–50.5%) of 5830 hospitalisations and 64.2% (63.1–65.3%) of 1540 hospital deaths that would have occurred in a scenario without vaccination up to May 2022. We estimate the booster campaign contributed 4.5%, 1.9%, and 0.4% to overall reductions in cases, hospitalisations, and deaths. Our results suggest that removing lockdowns during the first two waves would have had non-linear effects on incidence by altering accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.

Published
2023
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3. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort

Author

Attali, Valérie, Maria-Anna, Balice, Laurent, Barthel, Rosa, Buendia, Bertien, Buyse, Laurent, Boyer, Marie-Pierre, Cadars, Pascal, Cornec, Thibaud, Damy, Jean-Marc, Davy, Geoffroy, De Faverges, Toufik, Didi, Marie-Pia, d'ortho, Frédéric, Gagnadoux, Thibaud, Gentina, François, Goupil, Frédéric, Goutorbe, Jean-Maurice, Guillemot, Carmen, Iamandi, Richard, Isnard, François, Jounieaux, Christian, Koltes, Alain, Le Coz, Benoit, Lequeux, René, Lerest, Lionel, Lerousseau, Jean-Pierre, Mallet, Francis, Martin, Jean-Claude, Meurice, Ala, Noroc, Frédéric, Ortuno, Alain, Palot, Philippe, Papola, Audrey, Paris, Hélène, Pastinelli, Jean-Louis, Pepin, Christophe, Perrin, Carole, Philippe, Sandrine, Pontier, Arnaud, Prigent, Pascaline, Priou, Vincent, Puel, Claudio, Rabec, Benjamin, Richard, Claude, Richard, Marijke, Rutten, Manuel, Sastry, Murielle, Salvat, Kamila, Sedkaoui, Bharati, Shivalkar, Renaud, Tamisier, Dries, Testelmans, Johan, Verbraecken, Tamisier, Renaud, Damy, Thibaud, Bailly, Sébastien, Goutorbe, Frédéric, Davy, Jean-Marc, Lavergne, Florent, Palot, Alain, Verbraecken, Johan A., d’Ortho, Marie-Pia, and Pépin, Jean-Louis

Published
2024
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5. Did COVID-19 impact Positive Airway Pressure adherence in 2020? A cross-sectional study of 8477 patients with sleep apnea

Author

Fanny Bertelli, Carey M. Suehs, Jean-Pierre Mallet, Isabelle Court-Fortune, Frédéric Gagnadoux, Jean Christian Borel, Olivier Gaubert, Nicolas Molinari, Arnaud Bourdin, and Dany Jaffuel

Subjects
Sleep Apnea, CPAP, COVID 19, And adherence, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Whether the COVID-19 pandemic impacts Positive Airway Pressure (PAP) adherence over the long-term is unknown and only preliminary short-term data have been reported. Methods With the aim of describing the impact of the first and second waves of COVID-19 on PAP adherence during 2020 in France, we designed a cross-sectional study of Sleep-Apnea (SA)-patients under PAP telemonitoring. To examine PAP adherence in adult SA patients, we assessed de-identified data from a non-profit healthcare provider database during the period January 1, 2019 to December 31, 2020. Included patients met the following criteria: (i) PAP-treated for at least 4 months before January 1, 2019 and with continuous PAP during both 2019 and 2020; (ii) ≥ 360 daily PAP telemonitored data per year. For PAP adherence, data were collected using the PAP-software. Results 8477/10482 patients were finally included in the analysis [72.4% male, median age 70 years (IQ25–75: 61–77], 25.6%

Published
2022
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7. FACE study: 2-year follow-up of adaptive servo-ventilation for sleep-disordered breathing in a chronic heart failure cohort

Author

Tamisier, Renaud, primary, Damy, Thibaud, additional, Bailly, Sébastien, additional, Goutorbe, Frédéric, additional, Davy, Jean-Marc, additional, Lavergne, Florent, additional, Palot, Alain, additional, Verbraecken, Johan A., additional, d’Ortho, Marie-Pia, additional, Pépin, Jean-Louis, additional, Tamisier, Renaud, additional, Attali, Valérie, additional, Maria-Anna, Balice, additional, Laurent, Barthel, additional, Rosa, Buendia, additional, Bertien, Buyse, additional, Laurent, Boyer, additional, Marie-Pierre, Cadars, additional, Pascal, Cornec, additional, Thibaud, Damy, additional, Jean-Marc, Davy, additional, Geoffroy, De Faverges, additional, Toufik, Didi, additional, Marie-Pia, d'ortho, additional, Frédéric, Gagnadoux, additional, Thibaud, Gentina, additional, François, Goupil, additional, Frédéric, Goutorbe, additional, Jean-Maurice, Guillemot, additional, Carmen, Iamandi, additional, Richard, Isnard, additional, François, Jounieaux, additional, Christian, Koltes, additional, Alain, Le Coz, additional, Benoit, Lequeux, additional, René, Lerest, additional, Lionel, Lerousseau, additional, Jean-Pierre, Mallet, additional, Francis, Martin, additional, Jean-Claude, Meurice, additional, Ala, Noroc, additional, Frédéric, Ortuno, additional, Alain, Palot, additional, Philippe, Papola, additional, Audrey, Paris, additional, Hélène, Pastinelli, additional, Jean-Louis, Pepin, additional, Christophe, Perrin, additional, Carole, Philippe, additional, Sandrine, Pontier, additional, Arnaud, Prigent, additional, Pascaline, Priou, additional, Vincent, Puel, additional, Claudio, Rabec, additional, Benjamin, Richard, additional, Claude, Richard, additional, Marijke, Rutten, additional, Manuel, Sastry, additional, Murielle, Salvat, additional, Kamila, Sedkaoui, additional, Bharati, Shivalkar, additional, Renaud, Tamisier, additional, Dries, Testelmans, additional, and Johan, Verbraecken, additional

Published
2023
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9. Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia

Author

Lloyd Chapman, Maite Aubry, Noemie Maset, Timothy Russell, Edward Knock, John Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, and Adam Kucharski

Abstract

Estimation of the impact of vaccination and non-pharmaceutical interventions (NPIs) on COVID-19 incidence is complicated by several factors, including the successive emergence of SARS-CoV-2 variants of concern and changing population immunity resulting from vaccination and previous infection. We developed an age-structured multi-strain COVID-19 transmission model framework that could estimate the impact of vaccination and NPIs while accounting for these factors. We applied this framework to French Polynesia, which unlike many countries experienced multiple large COVID-19 waves from multiple variants over the course of the pandemic, interspersed with periods of elimination. We estimated that the vaccination programme averted 54.3% (95% CI 54.0-54.6%) of the 6840 hospitalisations and 60.2% (95% CI 59.9-60.5%) of the 1280 hospital deaths that would have occurred in a baseline scenario without any vaccination up to May 2022. Vaccination also averted an estimated 28.4% (95% CI 28.2-28.7%) of 193,000 symptomatic cases in the baseline scenario. We estimated the booster campaign contributed 3.4%, 2.9% and 3.3% to overall reductions in cases, hospitalisations and hospital deaths respectively. Our results suggested that removing, or altering the timings of, the lockdowns during the first two waves had non-linear effects on overall incidence owing to the resulting effect on accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.

Published
2023

10. Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia

Author

Lloyd AC Chapman, Maite Aubry, Noémie Maset, Timothy W Russell, Edward S Knock, John A Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, and Adam J Kucharski

Abstract

Estimation of the impact of vaccination and non-pharmaceutical interventions (NPIs) on COVID-19 incidence is complicated by several factors, including the successive emergence of SARS-CoV-2 variants of concern and changing population immunity resulting from vaccination and previous infection. We developed an age-structured multi-strain COVID-19 transmission model framework that could estimate the impact of vaccination and NPIs while accounting for these factors. We applied this approach to French Polynesia, which unlike many countries experienced multiple large COVID-19 waves from multiple variants over the course of the pandemic, interspersed with periods of elimination. We estimated that the vaccination programme averted 54.3% (95% CI 54.0-54.6%) of the 6840 hospitalisations and 60.2% (95% CI 59.9–60.5%) of the 1280 hospital deaths that would have occurred in a baseline scenario without any vaccination up to May 2022. Vaccination also averted an estimated 28.4% (95% CI 28.2-28.7%) of 193,000 symptomatic cases in the baseline scenario. We estimated the booster campaign contributed 3.4%, 2.9% and 3.3% to overall reductions in cases, hospitalisations and hospital deaths respectively. Our results suggested that removing, or altering the timings of, the lockdowns during the first two waves had non-linear effects on overall incidence owing to the resulting effect on accumulation of population immunity. Our estimates of vaccination and booster impact differ from those for other countries due to differences in age structure, previous exposure levels and timing of variant introduction relative to vaccination, emphasising the importance of detailed analysis that accounts for these factors.

Published
2023

11. Le lien hypertexte et le droit de l’auteur de communiquer ses œuvres au public (A propos des arrêts de la CJUE dans les affaires Svensson et Gs Media)

Author

Laroussi Chemlali and Pierre Mallet

Abstract

Placer un lien pointant vers un site tiers qui publie des œuvres protégées, sans l’autorisation du titulaire du droit d’auteur, constitue-t-il une communication de ces œuvres au public selon l’article 3, paragraphe 1, de la directive 2001/29 ? Telle était la question à laquelle la Cour de justice de l'Union européenne avait à répondre dans sa jurisprudence récente sur les liens hypertexte. Le présent article est destiné à donner un bref aperçu et une analyse critique des réponses avancées par la Cour, particulièrement dans les arrêts Svensson et Gs Media. Dans cette optique, deux cas de figures sont évoqués : dans un premier temps, nous envisageons le cas des liens hypertexte pointant vers des œuvres licitement mises en ligne. Puis, dans un second temps, il est question des liens renvoyant vers un contenu protégé mis illicitement en ligne.

Published
2022

12. The search for manganese incorporation in MoSe 2 monolayer epitaxially grown on graphene

Author

Maxime Gay, Minh-Tuan Dau, Céline Vergnaud, Alain Marty, Frédéric Bonell, Hervé Boukari, Colin Paillet, Bérangère Hyot, Hanako Okuno, Pierre Mallet, Jean-Yves Veuillen, Olivier Renault, Matthieu Jamet, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Nanophysique et Semiconducteurs (NPSC), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Modélisation et Exploration des Matériaux (MEM), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Nano-Electronique Quantique et Spectroscopie (QuNES), ANR-18-CE24-0007,MAGICVALLEY,Polarisation de vallée induite par couplage d'échange magnétique dans les matériaux 2D à grande échelle(2018), ANR-10-LABX-0051,LANEF,Laboratory of Alliances on Nanosciences - Energy for the Future(2010), Nanophysique et Semiconducteurs (NEEL - NPSC), and Nano-Electronique Quantique et Spectroscopie (NEEL - QuNES)

Subjects
Materials science, Graphene, General Physics and Astronomy, chemistry.chemical_element, 02 engineering and technology, Manganese, 2D materials, 021001 nanoscience & nanotechnology, Epitaxy, 01 natural sciences, law.invention, Crystallography, chemistry, law, 0103 physical sciences, Monolayer, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Magnetic doping, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Scanning tunneling microscopy, 010306 general physics, 0210 nano-technology, Molecular beam epitaxy, Transmission electron microscopy, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2022

13. Ferromagnetism and Rashba Spin–Orbit Coupling in the Two-Dimensional (V,Pt)Se2 Alloy

Author

Emilio Vélez-Fort, Ali Hallal, Roberto Sant, Thomas Guillet, Khasan Abdukayumov, Alain Marty, Céline Vergnaud, Jean-François Jacquot, Denis Jalabert, Jun Fujii, Ivana Vobornik, Julien Rault, Nicholas B. Brookes, Danilo Longo, Philippe Ohresser, Abdelkarim Ouerghi, Jean-Yves Veuillen, Pierre Mallet, Hervé Boukari, Hanako Okuno, Mairbek Chshiev, Frédéric Bonell, Matthieu Jamet, SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), European Synchrotron Radiation Facility (ESRF), Conception d’Architectures Moléculaires et Processus Electroniques (CAMPE ), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Modélisation et Exploration des Matériaux (MEM), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Laboratorio TASC (IOM CNR), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), CNR Istituto Officina dei Materiali (IOM), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Nano-Electronique Quantique et Spectroscopie (NEEL - QuNES), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Nanophysique et Semiconducteurs (NEEL - NPSC), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-18-CE24-0007,MAGICVALLEY,Polarisation de vallée induite par couplage d'échange magnétique dans les matériaux 2D à grande échelle(2018), ANR-10-LABX-0051,LANEF,Laboratory of Alliances on Nanosciences - Energy for the Future(2010), and European Project: 785219,H2020,GrapheneCore2(2018)

Subjects
Condensed Matter::Materials Science, Materials Chemistry, Electrochemistry, Condensed Matter::Strongly Correlated Electrons, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Electronic, Optical and Magnetic Materials
Abstract

5 pages, 5 figures; International audience; We report on a two-dimensional (2D) V1–xPtxSe2 alloy that exhibits ferromagnetic order and Rashba spin–orbit coupling. Although ferromagnetism is absent in 1T-VSe2 because of the competition with the charge density wave phase, we demonstrate theoretically and experimentally that the substitution of vanadium by platinum in VSe2 (10–50%) to form a homogeneous 2D alloy restores ferromagnetic order down to one monolayer of V0.65Pt0.35Se2. Moreover, the presence of platinum atoms gives rise to Rashba spin–orbit coupling in (V,Pt)Se2, providing an original platform to study the interplay between ferromagnetism and spin–orbit coupling in the 2D limit.

Published
2022

16. Évolution à 6 mois de la qualité du sommeil dans le syndrome d’apnées centrales du sommeil (SACS) traitées par VAA : étude FACIL-VAA

Author

Renaud Tamisier, Carole Philippe, Arnaud Prigent, Christelle Charley-Monaca, Marie-Pia D’Ortho, Thibaut Gentina, Frédéric Gagnadoux, Claire Launois, Jean-Pierre Mallet, Toufik Didi, Tiphaine Guy, Frédéric Goutorbe, Christophe Perrin, Sandrine Pontier-Marchandise, Jean-François Timsit, Jean-Louis Pepin, and Jean Claude Meurice

Subjects
Behavioral Neuroscience, Neuropsychology and Physiological Psychology, Neurology, Cognitive Neuroscience, Neurology (clinical)
Published
2023

17. Les mouvements mandibulaires peuvent-ils être utilisés comme moyen de dépistage des patients candidats à une polysomnographie ?

Author

Marie-Caroline Rotty, Nicolas Molinari, Carey M. Suehs, Dany Jaffuel, Jean Pierre Mallet, Arnaud Bourdin, and Jean-Christian Borel

Subjects
Behavioral Neuroscience, apnée du sommeil, Neuropsychology and Physiological Psychology, Neurology, polysomnography, Cognitive Neuroscience, screening, Brizzy, Neurology (clinical), SAHOS, sleep apnea, poster, mandibular movements
Abstract

Objectif Les mouvements mandibulaires (MM) sont desormais consideres comme une mesure diagnostique de l’effort respiratoire et pourraient etre utilises comme methode de depistage des patients eligibles a une polysomnographie (PSG). Nous rapportons ici la faisabilite d’un depistage fonde sur la mesure d’un index respiratoire associe a des mouvements mandibulaires (MM-RDI). Methodes Au total, 4231 patients ont effectue en ambulatoire un test de depistage Brizzy (depist-By) a l’aide un capteur magnetique (Nomics©) ; 918 patients ont simultanement beneficie d’une oxymetrie. Le patient etait considere comme positif et necessitant une PSG si le MM-RDI etait > 13,5/h ou si l’indice de desaturation de l’oxygene (IDO) etait > 18,5/h (sous condition d’une estimation du temps de sommeil total [eTST] > 4 heures). Resultats Parmi les tests, 3,9 % etaient non exploitables en raison d’une defaillance technique. Seulement 3,2 % de la population analysable avait une eTST Conclusion Cette etude preliminaire confirme la faisabilite du MM-RDI comme outil de depistage pour les patients candidats a la PSG. Elle suggere une complementarite de l’oxymetrie et du depist-By.

Published
2022
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20. Amikacin Liposomal Inhalation Suspension in the Treatment of Mycobacterium abscessus Lung Infection: A French Observational Experience

Author

Raphael Chiron, Wouter Hoefsloot, Jakko Van Ingen, Hélène Marchandin, Laurent Kremer, Hélène Morisse-Pradier, Jeremy Charriot, Jean-Pierre Mallet, Jean-Louis Herrmann, Davide Caimmi, Johan Moreau, Yann Dumont, Sylvain Godreuil, Anne Bergeron, Margot Drevait, Elodie Bouzat-Rossigneux, Nicolas Terrail, Claire Andrejak, Nicolas Veziris, Dominique Grenet, Alexandre Coudrat, Emilie Catherinot, Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Radboud University Medical Center [Nijmegen], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Hopital Saint-Louis [AP-HP] (AP-HP), Equipe 2 : ECSTRA - Epidémiologie Clinique, STatistique, pour la Recherche en Santé (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Foch [Suresnes], Centre National de Référence des Mycobactéries et de la Résistance aux Antituberculeux [CHU Pitié-Salpêtrière] (CNR-MyRMA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and MORNET, Dominique

Subjects
Mycobacterium abscessus, Amikacin liposomal inhalation suspension, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Cystic fibrosis, Treatment, All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, Oncology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Nontuberculous mycobacteria
Abstract

Background Mycobacterium abscessus infections remain difficult to manage in both cystic fibrosis (CF) and non-CF patients and reported clinical outcomes are largely unsatisfactory. Clinical trial data are limited and no approved therapies are currently available for the management of M abscessus lung diseases. As an alternative, cohort studies may provide insightful information into the management of M abscessus pulmonary disease. Methods Based on a retrospective observational cohort study, we investigated the safety and efficacy of amikacin liposome inhaled suspension (ALIS) as an adjunct to a standard antibiotic regimen for M abscessus lung infection in both CF and non-CF patients. We also assessed the association of patient drug compliance with culture conversion and clinical outcomes. Results Twenty-six patients had long-term follow-up data available. Culture conversion was achieved in 54% (14/26) of the patients with no difference between CF and non-CF patients after an average treatment duration of 10 months. Patient treatment compliance was significantly better in the converter group compared to nonconverters with an odds ratio of 44.78 associated with good compared to poor patient compliance. Overall, 9 patients (35%) experienced an adverse event that led to treatment discontinuation. Conclusions ALIS appears beneficial in both CF and non-CF populations with M abscessus lung disease.

Published
2022

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