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Your search keyword '"Pin-Chang Huang"' showing total 2 results
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2 results on '"Pin-Chang Huang"'

1. Briarane-Related Diterpenoids from Octocoral Briareum stechei

Author

Thanh-Hao Huynh, Choo-Aun Neoh, Yu-Chi Tsai, Zhi-Kang Yao, Li-Guo Zheng, Pin-Chang Huang, Zhi-Hong Wen, Jih-Jung Chen, Yu-Jen Wu, and Ping-Jyun Sung

Subjects
Briareum stechei, briarane, briaexcavatolie, briastecholide, iNOS, Organic chemistry, QD241-441
Abstract

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1–4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

Published
2021
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2. Briarane-Related Diterpenoids from Octocoral Briareum stechei

Author

Yu-Chi Tsai, Thanh-Hao Huynh, Zhi-Kang Yao, Ping-Jyun Sung, Yu-Jen Wu, Jih Jung Chen, Choo-Aun Neoh, Zhi-Hong Wen, Pin-Chang Huang, and Li-Guo Zheng

Subjects
Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, Pharmaceutical Science, briastecholide, Organic chemistry, briaexcavatolie, Article, Analytical Chemistry, Mice, QD241-441, Drug Discovery, Animals, Physical and Theoretical Chemistry, biology, Chemistry, Briareum stechei, Anthozoa, Nitric oxide synthase, iNOS, RAW 264.7 Cells, Biochemistry, Chemistry (miscellaneous), briarane, biology.protein, Molecular Medicine, Mouse Macrophage, Diterpenes
Abstract

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1–4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

Published
2021

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