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1. White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals

Author

Dietze, Lorielle M. F., McWhinney, Sean R., Favre, Pauline, Abé, Christoph, Alexander, Nina, Barkhau, Carlotta, Benedetti, Francesco, Berk, Michael, Bøen, Erlend, Boye, Birgitte, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Carruthers, Sean P., Corkum, Emily L. V., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Dohm, Katharina, Elvsåshagen, Torbjørn, Flinkenflügel, Kira, Fortea, Lydia, Furlong, Lisa S., Goldstein, Benjamin I., Grotegerd, Dominik, Gruber, Marius, Haarman, Bartholomeus C. M., Howells, Fleur M., Jahanshad, Neda, Jamalabadi, Hamidreza, Jansen, Andreas, Karantonis, James A., Kennedy, Kody G., Kircher, Tilo T. J., Klahn, Anna Luisa, Kochunov, Peter, Kraus, Anna, Landén, Mikael, López-Jaramillo, Carlos, MacIntosh, Bradley J., Mazza, Elena, McDonald, Colm, McIntosh, Andrew M., Meinert, Hannah, Meinert, Susanne, Melloni, Elisa M. T., Mitchell, Philip B., Nenadić, Igor, Opel, Nils, Phillips, Mary, Piguet, Camille, Polosan, Mircea, Pomarol-Clotet, Edith, Pouchon, Arnaud, Radua, Joaquim, Roberts, Gloria, Ross, Alex J., Rossell, Susan L., Salvador, Raymond, Sim, Kang, Soares, Jair C., Zunta-Soares, Giovana B., Stein, Frederike, Straube, Benjamin, Suo, Chao, Teutenberg, Lea, Thomas-Odenthal, Florian, Thomopoulos, Sophia I., Usemann, Paula, Van Rheenen, Tamsyn E., Versace, Amelia, Vieta, Eduard, Vilajosana, Enric, Mwangi, Benson, Wen, Wei, Whalley, Heather C., Wu, Mon-Ju, Andreassen, Ole A., Ching, Christopher R. K., Thompson, Paul M., Houenou, Josselin, and Hajek, Tomas

Published
2024
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3. Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.

Author

Hollunder, Barbara, Ostrem, Jill, Sahin, Ilkem, Rajamani, Nanditha, Oxenford, Simón, Butenko, Konstantin, Neudorfer, Clemens, Reinhardt, Pablo, Zvarova, Patricia, Polosan, Mircea, Akram, Harith, Vissani, Matteo, Zhang, Chencheng, Sun, Bomin, Navratil, Pavel, Reich, Martin, Volkmann, Jens, Yeh, Fang-Cheng, Baldermann, Juan, Dembek, Till, Visser-Vandewalle, Veerle, Alho, Eduardo, Franceschini, Paulo, Nanda, Pranav, Finke, Carsten, Kühn, Andrea, Dougherty, Darin, Richardson, R, Bergman, Hagai, DeLong, Mahlon, Mazzoni, Alberto, Romito, Luigi, Tyagi, Himanshu, Zrinzo, Ludvic, Joyce, Eileen, Chabardes, Stephan, Li, Ningfei, Horn, Andreas, and Starr, Philip

Subjects
Humans, Deep Brain Stimulation, Brain, Motor Cortex, Parkinson Disease, Brain Mapping
Abstract

Frontal circuits play a critical role in motor, cognitive and affective processing, and their dysfunction may result in a variety of brain disorders. However, exactly which frontal domains mediate which (dys)functions remains largely elusive. We studied 534 deep brain stimulation electrodes implanted to treat four different brain disorders. By analyzing which connections were modulated for optimal therapeutic response across these disorders, we segregated the frontal cortex into circuits that had become dysfunctional in each of them. Dysfunctional circuits were topographically arranged from occipital to frontal, ranging from interconnections with sensorimotor cortices in dystonia, the primary motor cortex in Tourettes syndrome, the supplementary motor area in Parkinsons disease, to ventromedial prefrontal and anterior cingulate cortices in obsessive-compulsive disorder. Our findings highlight the integration of deep brain stimulation with brain connectomics as a powerful tool to explore couplings between brain structure and functional impairments in the human brain.

Published
2024

5. Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

Author

Spano, Luana, Marie-Claire, Cynthia, Godin, Ophélia, Lebras, Apolline, Courtin, Cindie, Laplanche, Jean-Louis, Leboyer, Marion, Aouizerate, Bruno, Lefrere, Antoine, Belzeaux, Raoul, Courtet, Philippe, Olié, Emilie, Dubertret, Caroline, Schwan, Raymund, Aubin, Valérie, Roux, Paul, Polosan, Mircea, Samalin, Ludovic, Haffen, Emmanuel, Bellivier, Frank, and Etain, Bruno

Published
2024
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6. Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)

Author

Lengvenyte, Aiste, Aouizerate, Bruno, Aubin, Valerie, Loftus, Joséphine, Marlinge, Emeline, Belzeaux, Raoul, Dubertret, Caroline, Gard, Sebastien, Haffen, Emmanuel, Schwan, Raymund, Llorca, Pierre-Michel, Passerieux, Christine, Roux, Paul, Polosan, Mircea, Etain, Bruno, Leboyer, Marion, Courtet, Philippe, and Olié, Emilie

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD.Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report.Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < .001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA.Limitations: Cross-sectional design and retrospective reporting.Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.

Published
2022
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8. Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative.

Author

Burdick, Katherine, Millett, Caitlin, Yocum, Anastasia, Altimus, Cara, Andreassen, Ole, Aubin, Valerie, Belzeaux, Raoul, Berk, Michael, Biernacka, Joanna, Blumberg, Hilary, Cleare, Anthony, Diaz-Byrd, Claudia, Dubertret, Caroline, Etain, Bruno, Lagerberg, Trine, Leboyer, Marion, Martinez-Aran, Anabel, McElroy, Susan, Mitchell, Philip, Olie, Emilie, Olorunfemi, Phebe, Passerieux, Christine, Peters, Amy, Pham, Daniel, Polosan, Mircea, Potter, Julia, Sajatovic, Martha, Samalin, Ludovic, Schwan, Raymund, Shanahan, Megan, Solé, Brisa, Strawbridge, Rebecca, Stuart, Amanda, Torres, Ivan, Ueland, Torrill, Vieta, Eduard, Williams, Lana, Wrobel, Anna, Yatham, Lakshmi, Young, Allan, Nierenberg, Andrew, McInnis, Melvin, Forester, Brent, Fullerton, Janice, Frye, Mark, Gard, Sébastien, Godin, Ophelia, Haffen, Emmanuel, Eyler, Lisa, and Klaus, Federica

Subjects
Humans, Bipolar Disorder, Prospective Studies, Longitudinal Studies, Affect, Cohort Studies
Abstract

OBJECTIVES: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. METHODS: Thirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived higher versus lower function as the dependent variable and selected clinical and demographic variables as predictors. RESULTS: We found high rates of functional impairment, ranging from 41 to 75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, the presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning. CONCLUSIONS: The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness.

Published
2022

9. Diet quality and associations with lactate and metabolic syndrome in bipolar disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J., Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A., Fredembach, B., Suisse, A., Denoual, Q., Polosan, M., Galliot, A.M., Brehon, L., Bonny, G., Durand, L., Feuga, V., Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A., Loftus, J., Medecin, I., Samalin, L., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Godin, Ophelia, Choi, Jaehyoung, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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10. History of learning disorders is associated with worse cognitive and functional outcomes in schizophrenia: results from the multicentric FACE-SZ cross-sectional dataset

Author

Dondé, Clément, Dubertret, Caroline, Fond, Guillaume, Andre, Myrtille, Berna, Fabrice, Boyer, Laurent, Capdevielle, Delphine, Chereau, Isabelle, Coulon, Nathalie, Dorey, Jean-Michel, Leignier, Sylvain, Llorca, Pierre-Michel, Misdrahi, David, Passerieux, Christine, Pignon, Baptiste, Rey, Romain, Schorr, Benoît, Schürhoff, Franck, Urbach, Mathieu, Polosan, Mircea, and Mallet, Jasmina

Published
2023
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11. Mitochondrial Biomarkers and Metabolic Syndrome in Bipolar Disorder

Author

Etain, B., Olié, E., Leboyer, M., Haffen, E., Llorca, PM, Barteau, V., Bensalem, S., Godin, O., Laouamri, H., Souryis, K., Hotier, S., Pelletier, A., Hergeta, F., Petrucci, J., Willaume, L., Bellivier, F., Hennion, V., Marlinge, E., Meheust, J., Richard, A., Carminati, M., Francisque, H., Dubertret, C., Mazer, N., Portalier, C., Scognamiglio, C., Bing, A., Laurent, P., Gard, S., M'Bailara, K., Elkael, C., Hoorelbeke, F., Minois, I., Sportich, J., Da Ros, N., Boukhobza, L., Courtet, P., Denat, S., Deffinis, B., Ducasse, D., Gachet, M., Lengvenyté, A., Molière, F., Nass, L., Tarquini, G., Lefrere, A., Moreau, E., Pastol, J., Groppi, F., Polomeni, H., Bauberg, J, Lescalier, L., Muraccioli, I., Suray, A., Cohen, R., Kahn, J.P., Milazzo, M., Wajsbrot-Elgrabli, O., Bougerol, T., Pouchon, A., Bertrand, A, Fredembach, B., Suisse, A., Denoual, Q, Polosan, M, Galliot, A.M., Brehon, L., Bonny, G, Durand, L, Feuga, V, Kayser, N., Roux, P., Aubin, V., Cussac, I., Dupont, M.A, Loftus, J., Medecin, I., Samalin, L., Llorca, PM., Mennetrier, M., Bonnet, T., Lacelle, D., Vayssié, M., Beal, C., Blanc, O., Zachos, Kassandra A., Choi, Jaehyoung, Godin, Ophelia, Chernega, Timofei, Kwak, Haejin Angela, Jung, Jae H., Aouizerate, Bruno, Aubin, Valérie, Bellivier, Frank, Belzeaux-R, Raoul, Courtet, Philippe, Dubertret, Caroline, Etain, Bruno, Haffen, Emmanuel, Lefrere A, Antoine, Llorca, Pierre-Michel, Olié, Emilie, Polosan, Mircea, Samalin, Ludovic, Schwan, Raymund, Roux, Paul, Barau, Caroline, Richard, Jean Romain, Tamouza, Ryad, Leboyer, Marion, and Andreazza, Ana C.

Published
2024
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12. What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Author

Ching, Christopher RK, Hibar, Derrek P, Gurholt, Tiril P, Nunes, Abraham, Thomopoulos, Sophia I, Abé, Christoph, Agartz, Ingrid, Brouwer, Rachel M, Cannon, Dara M, Zwarte, Sonja MC, Eyler, Lisa T, Favre, Pauline, Hajek, Tomas, Haukvik, Unn K, Houenou, Josselin, Landén, Mikael, Lett, Tristram A, McDonald, Colm, Nabulsi, Leila, Patel, Yash, Pauling, Melissa E, Paus, Tomas, Radua, Joaquim, Soeiro‐de‐Souza, Marcio G, Tronchin, Giulia, Haren, Neeltje EM, Vieta, Eduard, Walter, Henrik, Zeng, Ling‐Li, Alda, Martin, Almeida, Jorge, Alnæs, Dag, Alonso‐Lana, Silvia, Altimus, Cara, Bauer, Michael, Baune, Bernhard T, Bearden, Carrie E, Bellani, Marcella, Benedetti, Francesco, Berk, Michael, Bilderbeck, Amy C, Blumberg, Hilary P, Bøen, Erlend, Bollettini, Irene, Bonnin, Caterina Mar, Brambilla, Paolo, Canales‐Rodríguez, Erick J, Caseras, Xavier, Dandash, Orwa, Dannlowski, Udo, Delvecchio, Giuseppe, Díaz‐Zuluaga, Ana M, Dima, Danai, Duchesnay, Édouard, Elvsåshagen, Torbjørn, Fears, Scott C, Frangou, Sophia, Fullerton, Janice M, Glahn, David C, Goikolea, Jose M, Green, Melissa J, Grotegerd, Dominik, Gruber, Oliver, Haarman, Bartholomeus CM, Henry, Chantal, Howells, Fleur M, Ives‐Deliperi, Victoria, Jansen, Andreas, Kircher, Tilo TJ, Knöchel, Christian, Kramer, Bernd, Lafer, Beny, López‐Jaramillo, Carlos, Machado‐Vieira, Rodrigo, MacIntosh, Bradley J, Melloni, Elisa MT, Mitchell, Philip B, Nenadic, Igor, Nery, Fabiano, Nugent, Allison C, Oertel, Viola, Ophoff, Roel A, Ota, Miho, Overs, Bronwyn J, Pham, Daniel L, Phillips, Mary L, Pineda‐Zapata, Julian A, Poletti, Sara, Polosan, Mircea, Pomarol‐Clotet, Edith, Pouchon, Arnaud, Quidé, Yann, Rive, Maria M, Roberts, Gloria, Ruhe, Henricus G, Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D, Schene, Aart H, and Sim, Kang

Subjects
Serious Mental Illness, Brain Disorders, Biomedical Imaging, Bipolar Disorder, Clinical Research, Behavioral and Social Science, Mental Health, Neurosciences, Mental health, Neurological, Good Health and Well Being, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Meta-Analysis as Topic, Multicenter Studies as Topic, Neuroimaging, bipolar disorder, cortical surface area, cortical thickness, ENIGMA, mega-analysis, meta-analysis, MRI, neuroimaging, psychiatry, volume, ENIGMA Bipolar Disorder Working Group, Cognitive Sciences, Experimental Psychology
Abstract

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.

Published
2022

13. Efficacy and auditory biomarker analysis of fronto-temporal transcranial direct current stimulation (tDCS) in targeting cognitive impairment associated with recent-onset schizophrenia: study protocol for a multicenter randomized double-blind sham-controlled trial

Author

Dondé, Clément, Bastin, Julien, Pouchon, Arnaud, Costes, Nicolas, Fakra, Eric, Galvão, Filipe, Gay, Aurélia, Haesebaert, Frédéric, Lamalle, Laurent, Mérida, Inès, Rigon, Maxence, Schneider, Fabien, Troprès, Irène, Brunelin, Jérôme, and Polosan, Mircea

Published
2023
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15. Refining Criteria for a Neurodevelopmental Subphenotype of Bipolar Disorders: A FondaMental Advanced Centers of Expertise for Bipolar Disorders Study

Author

Lefrere, Antoine, Godin, Ophélia, Jamain, Stéphane, Dansou, Yecodji, Samalin, Ludovic, Alda, Martin, Aouizerate, Bruno, Aubin, Valérie, Rey, Romain, Contu, Martina, Courtet, Philippe, Dubertret, Caroline, Haffen, Emmanuel, Januel, Dominique, Leboyer, Marion, Llorca, Pierre-Michel, Marlinge, Emeline, Manchia, Mirko, Neilson, Samantha, Olié, Emilie, Paribello, Pasquale, Pinna, Marco, Polosan, Mircea, Roux, Paul, Schwan, Raymund, Tondo, Leonardo, Walter, Michel, Tzavara, Eleni, Auzias, Guillaume, Deruelle, Christine, Etain, Bruno, and Belzeaux, Raoul

Published
2024
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19. Crossed clinical features between eating disorders and types of bipolar disorder: Results from the FondaMental Advanced Centers of Expertise - Bipolar Disorder cohort

Author

Flaudias, Valentin, Samalin, Ludovic, Godin, Ophélia, Gard, Sébastien, Brousse, Georges, Loftus, Joséphine, Aubin, Valérie, Belzeaux, Raoul, Dubertret, Caroline, Le Strat, Yann, Mazer, Nicolas, de Prémorel, Alix, Roux, Paul, Polosan, Mircea, Schwitzer, Thomas, Aouizerate, Bruno, Llorca, Pierre-Michel, Biseul, Isabelle, Etain, Bruno, Moirand, Remi, Olié, Emilie, Haffen, Emmanuel, Leboyer, Marion, Courtet, Philippe, Icick, Romain, and Guillaume, Sébastien

Published
2023
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21. Clinical characteristics associated with discrepancies between self- and clinician-rated suicidal ideation in patients with bipolar disorder (FACE-BD cohort)

Author

Nobile, Bénédicte, Belzeaux, Raoul, Aouizerate, Bruno, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre-Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Walter, Michel, Rey, Romain, Januel, Dominique, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Courtet, Philippe, and Olié, Emilie

Published
2023
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22. Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

Author

Lengvenyte, Aiste, Strumila, Robertas, Belzeaux, Raoul, Aouizerate, Bruno, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre-Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Walter, Michel, D'Amato, Thierry, Januel, Dominique, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Navickas, Alvydas, Olié, Emilie, and Courtet, Philippe

Published
2023
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23. Handedness in bipolar disorders is associated with specific neurodevelopmental features: results of the BD-FACE cohort

Author

Mallet, Jasmina, Godin, Ophélia, Mazer, Nicolas, Le Strat, Yann, Bellivier, Frank, Belzeaux, Raoul, Etain, Bruno, Fond, Guillaume, Gard, Sébastien, Henry, Chantal, Leboyer, Marion, Llorca, Pierre-Michel, Loftus, Joséphine, Olié, Emilie, Passerieux, Christine, Polosan, Mircea, Schwan, Raymund, Roux, Paul, and Dubertret, Caroline

Published
2022
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24. Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

Author

Visser-Vandewalle, Veerle, Andrade, Pablo, Mosley, Philip E., Greenberg, Benjamin D., Schuurman, Rick, McLaughlin, Nicole C., Voon, Valerie, Krack, Paul, Foote, Kelly D., Mayberg, Helen S., Figee, Martijn, Kopell, Brian H., Polosan, Mircea, Joyce, Eileen M., Chabardes, Stephan, Matthews, Keith, Baldermann, Juan C., Tyagi, Himanshu, Holtzheimer, Paul E., Bervoets, Chris, Hamani, Clement, Karachi, Carine, Denys, Damiaan, Zrinzo, Ludvic, Blomstedt, Patric, Naesström, Matilda, Abosch, Aviva, Rasmussen, Steven, Coenen, Volker A., Schlaepfer, Thomas E., Dougherty, Darin D., Domenech, Philippe, Silburn, Peter, Giordano, James, Lozano, Andres M., Sheth, Sameer A., Coyne, Terry, Kuhn, Jens, Mallet, Luc, Nuttin, Bart, Hariz, Marwan, and Okun, Michael S.

Published
2022
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26. Direct medical cost of bipolar disorder: Insights from the FACE-BD longitudinal cohort

Author

Laidi, Charles, Godin, Ophélia, Etain, Bruno, Bellivier, Frank, Elandaloussi, Yannis, Olié, Emilie, Aouizerate, Bruno, Gard, Sébastien, Loftus, Joséphine, Belzeaux, Raoul, Dubertret, Caroline, Laouamri, Hakim, Passerieux, Christine, Pelletier, Agnès, Polosan, Mircea, Schwan, Raymund, Samalin, Ludovic, Llorca, Pierre-Michel, Courtet, Philippe, Durand-Zaleski, Isabelle, and Leboyer, Marion

Published
2022
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27. Antipsychotic medication in people with intellectual disability and schizophrenia: A 25-year updated systematic review and cross-sectional study.

Author

Courtial, Elsa, Pouchon, Arnaud, Polosan, Mircea, and Dondé, Clément

Subjects
INTELLECTUAL disabilities, PEOPLE with intellectual disabilities, BODY mass index, DISABILITY identification, ANTIPSYCHOTIC agents, ARIPIPRAZOLE
Abstract

Objectives: To determine the efficacy and safety of antipsychotic medication for treating individuals with a dual diagnosis of intellectual disability (ID) and schizophrenia. Methods: We systematically reviewed the literature to explore the risks and benefits of antipsychotics for schizophrenia in ID. In addition, a cross-sectional retrospective study on the tolerance profiles of a representative ID and schizophrenia cohort was conducted. Results: From the systematic search, we retained 18 articles detailing information on 24 cases. In almost all cases, the antipsychotic improved psychotic symptoms (e.g., hallucinations, delusions, disorganization). Negative manifestations were also improved (blunted affects, amotivation, poor rapport), as were challenging behaviors in a few cases. The most commonly reported side effects were neurological (extra-pyramidal, movement disorder, epilepsy) and metabolic manifestations. In the retrospective cross-sectional study, we reported data on 112 participants with comorbid ID and schizophrenia. In all, 103 participants were antipsychotic-treated, of which 39% were on antipsychotic monotherapy. Of these, 35% were in the obesity range, 25% in the hyperglycemic range, and 25% in the dyslipidemia range. The body mass index did not differ between the groups. Conclusions: This study provides an initial evidence base underpinning the efficacy of antipsychotic drugs on schizophrenia in the ID population. Nevertheless, there may be an increased risk of metabolic side effects, hence, close monitoring of blood glucose, lipids, and weight should be implemented when prescribing antipsychotics to this population. [ABSTRACT FROM AUTHOR]

Published
2024
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29. 8. The Relationship Between Treatment, Symptom Severity, and Brain Connectivity in Bipolar Disorder: An International Study Across 16 Enigma-Bipolar Sites

Author

Nabulsi, Leila, primary, Kang, Melody J.Y., additional, Jahanshad, Neda, additional, Haarman, Benno, additional, McDonald, Colm, additional, Stein, Dan, additional, Glahn, David, additional, Pomarol-Clotet, Edith, additional, Vieta, Eduard, additional, Houenou, Josselin, additional, Favre, Pauline, additional, Polosan, Mircea, additional, Brambilla, Paolo, additional, Bellani, Marcella, additional, Mitchell, Philip B., additional, Dannlowski, Udo, additional, Wessa, Michèle, additional, Phillips, Mary, additional, Kircher, Tilo, additional, Thompson, Paul M., additional, Andreassen, Ole A., additional, Ching, Christopher R.K., additional, and Cannon, Dara M., additional

Published
2024
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30. Exploring the Association Between Residual Mood Symptoms and Self‐Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross‐Sectional Network Analysis.

Author

Vidal, Nathan, Brunet-Gouet, Eric, Frileux, Solène, Aubin, Valérie, Belzeaux, Raoul, Courtet, Philippe, D'Amato, Thierry, Dubertret, Caroline, Etain, Bruno, Gard, Sebastien, Haffen, Emmanuel, Januel, Dominique, Leboyer, Marion, Lefrere, Antoine, Llorca, Pierre-Michel, Marlinge, Emeline, Olié, Emilie, Polosan, Mircea, Schwan, Raymund, and Walter, Michel

Subjects
DRUG side effects, BIPOLAR disorder, ENERGY dissipation, SYMPTOMS, PALPITATION
Abstract

Introduction: Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. We aimed to study the association between residual mood signs and self‐reported side effects in the euthymic phase of BD. Methods: We assessed residual mood signs using the Montgomery–Asberg Depression Rating scale (MADRS) and Young Mania Rating scale (YMRS) and self‐reported side effects using the Patient‐Rated Inventory of Side Effects (PRISE‐M) for 880 males and 1369 females with BD. We conducted a network analysis to test the associations between 52 items of the three scales for males and females separately. We then identified clusters of nodes that fit the networks well. Results: We report only positive associations between residual mood signs and side effects. An elevated mood (YMRS) in females and increased energy (YMRS) in males were central nodes, strongly influencing the development of additional mood symptoms and side effects. Furthermore, we identified three clusters of nodes in both sexes: (1) a "mood cluster", including most YMRS and MADRS items and the PRISE‐M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE‐M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE‐M) and agitation (PRISE‐M). Conclusions: The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self‐reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient‐reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications' side effects. Palpitations and agitation may contribute to the development of additional mood symptoms or somatic complaints. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Does BioAge identify accelerated aging in individuals with bipolar disorder? An exploratory study in the FACE‐BD cohort.

Author

Etain, Bruno, Marie‐Claire, Cynthia, Spano, Luana, Bellivier, Frank, Leboyer, Marion, Gard, Sébastien, Lefrere, Antoine, Belzeaux, Raoul, Courtet, Philippe, Dubertret, Caroline, Schwan, Raymund, Aubin, Valerie, Roux, Paul, Polosan, Mircea, Samalin, Ludovic, Haffen, Emmanuel, Olié, Emilie, Godin, Ophelia, Etain, B., and Olié, E.

Subjects
SLEEP interruptions, AGE, AGE groups, BODY mass index, BIPOLAR disorder
Abstract

Background: Individuals with bipolar disorders (BD) have an estimated loss of life expectancy around 10–15 years. Several laboratory‐measured biomarkers of accelerated aging exist (e.g., telomere length), however with a questionable transferability to bedside. There is a need for easily and inexpensively measurable markers of aging, usable in routine practice, such as BioAge. Methods: We calculated BioAge that estimates biological age based on routine blood tests and a physical exam, in a sample of 2220 outpatients with BD. We investigated associations between BioAge Acceleration (BioAgeAccel), which is an indicator of accelerated aging, and sociodemographic variables, clinical variables, and current psychotropic medication use. Results: Mean chronological age was 40.2 (±12.9). Mean BioAge was 39.1 (±12.4). Mean BioAgeAccel was 0.08 (±1.8). A minority of individuals (15%) had a BioAgeAccel above 2 years. Multivariable analyses suggested strong associations between a higher BioAgeAccel and younger age, male sex, overweight and sleep disturbances. Regarding current psychotropic medication use, discrepancies between univariate and multivariate analyses were observed. Conclusions: A minority of individuals with BD had an accelerated aging as measured by BioAge. We identified associations with potentially modifiable factors, such as higher body mass index and sleep disturbances, that are however nonspecific to BD. These results require replications in independent samples of individuals with BD, and comparisons with a control group matched for age and gender. Longitudinal studies are also required to test whether any change in metabolic health, or sleep might decrease BioAgeAccel. [ABSTRACT FROM AUTHOR]

Published
2024
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33. P-215 Variations journalières et saisonnières des concentrations circulantes de sérotonine et de cortisol chez les donneurs volontaires; liens avec le climat et le stress lié au don de sang

Author

Manches, Olivier, primary, Lepeule, Johanna, additional, Saas, Philippe, additional, Slama, Rémy, additional, Bastin, Julien, additional, Polosan, Mircea, additional, Morand, Christelle, additional, Cognasse, Fabrice, additional, and Chaperot, Laurence, additional

Published
2023
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34. Predictors of Functional Impairment in Bipolar Disorder: Results From 13 Cohorts From Seven Countries by the Global Bipolar Cohort Collaborative

Author

Burdick, Katherine E., primary, Millett, Caitlin E., additional, Yocum, Anastasia K., additional, Altimus, Cara M., additional, Andreassen, Ole A., additional, Aubin, Valerie, additional, Belzeaux, Raoul, additional, Berk, Michael, additional, Biernacka, Joanna M., additional, Blumberg, Hilary P., additional, Cleare, Anthony J., additional, Diaz-Byrd, Claudia, additional, Dubertret, Caroline, additional, Etain, Bruno, additional, Eyler, Lisa T., additional, Forester, Brent P., additional, Fullerton, Janice M., additional, Frye, Mark A., additional, Gard, Sébastien, additional, Godin, Ophelia, additional, Haffen, Emmanuel, additional, Klaus, Federica, additional, Lagerberg, Trine Vik, additional, Leboyer, Marion, additional, Martinez-Aran, Anabel, additional, McElroy, Susan, additional, Mitchell, Philip B., additional, Olie, Emilie, additional, Olorunfemi, Phebe, additional, Passerieux, Christine, additional, Peters, Amy T., additional, Pham, Daniel L., additional, Polosan, Mircea, additional, Potter, Julia R., additional, Sajatovic, Martha, additional, Samalin, Ludovic, additional, Schwan, Raymund, additional, Shanahan, Megan, additional, Solé, Brisa, additional, Strawbridge, Rebecca, additional, Stuart, Amanda L., additional, Torres, Ivan, additional, Ueland, Torrill, additional, Vieta, Eduard, additional, Williams, Lana J., additional, Wrobel, Anna L., additional, Yatham, Lakshmi N., additional, Young, Allan H., additional, Nierenberg, Andrew A., additional, and McInnis, Melvin G., additional

Published
2023
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35. Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1

Author

Marie-Claire, Cynthia, primary, Spano, Luana, additional, Godin, Ophelia, additional, Lebras, Apolline, additional, Courtin, Cindie, additional, Laplanche, Jean-Louis, additional, Leboyer, Marion, additional, Aouizerate, Bruno, additional, Lefrere, Antoine, additional, Belzeaux, Raoul, additional, Courtet, Philippe, additional, Olié, Emilie, additional, Dubertret, Caroline, additional, SCHWAN, Raymund, additional, Aubin, Valérie, additional, Roux, Paul, additional, Polosan, Mircea, additional, Samalin, Ludovic, additional, haffen, emmanuel, additional, Collaborators, FondaMental Advanced Centers of Expertise in Bipolar Disorde, additional, Bellivier, Frank, additional, and Etain, Bruno, additional

Published
2023
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36. Factors associated with lamotrigine concentration/dose ratio in individuals with bipolar disorders

Author

Chouchana, Margot, primary, Delage, Clément, additional, Godin, Ophélia, additional, Fontan, Jean- Eudes, additional, Bellivier, Frank, additional, Gard, Sebastien, additional, Aubin, Valérie, additional, Belzeaux, Raoul, additional, Dubertret, Caroline, additional, Haffen, Emmanuel, additional, Leboyer, Marion, additional, Olie, Emilie, additional, Courtet, Philippe, additional, Polosan, Mircea, additional, Roux, Paul, additional, Samalin, Ludovic, additional, Schwan, Raymund, additional, Lefrere, Antoine, additional, Bloch, Vanessa, additional, and Etain, Bruno, additional

Published
2023
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39. 292. Large-Scale Investigation of Bipolar Disorder Topological Variance: A Graph Theory Analysis of 959 Individuals From the Enigma Bipolar Disorder Working Group

Author

Nabulsi, Leila, primary, Jahanshad, Neda, additional, Haarman, Benno, additional, McDonald, Colm, additional, Stein, Dan, additional, Glahn, David, additional, Pomarol-Clotet, Edith, additional, Vieta, Eduard, additional, Houenou, Josselin, additional, Polosan, Mircea, additional, Brambilla, Paolo, additional, Mitchell, Philip, additional, Dannlowski, Udo, additional, Wessa, Michèle, additional, Phillips, Mary, additional, Kircher, Tilo, additional, Thompson, Paul M., additional, Ching, Christopher R.K., additional, Andreassen, Ole A., additional, and Cannon, Dara M., additional

Published
2023
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41. Subjects suffering from bipolar disorder taking lithium are less likely to report physical pain: a FACE-BD study.

Author

Risch, Nathan, Dubois, Jonathan, Etain, Bruno, Aouizerate, Bruno, Bellivier, Frank, Belzeaux, Raoul, Dubertret, Caroline, Haffen, Emmanuel, Januel, Dominique, Leboyer, Marion, Lefrere, Antoine, Samalin, Ludovic, Polosan, Mircea, Rey, Romain, Roux, Paul, Schwan, Raymund, Walter, Michel, Courtet, Philippe, and Olié, Emilie

Subjects
LITHIUM carbonate, BIPOLAR disorder, SLEEP quality, SUICIDE risk factors, ATTEMPTED suicide
Abstract

Background. Physical pain is a common issue in people with bipolar disorder (BD). It worsens mental health and quality of life, negatively impacts treatment response, and increases the risk of suicide. Lithium, which is prescribed in BD as a mood stabilizer, has shown promising effects on pain. Methods. This naturalistic study included 760 subjects with BD (FACE-BD cohort) divided in two groups: with and without self-reported pain (evaluated with the EQ-5D-5L questionnaire). In this sample, 176 subjects were treated with lithium salts. The objectives of the study were to determine whether patients receiving lithium reported less pain, and whether this effect was associated with the recommended mood-stabilizing blood concentration of lithium. Results. Subjects with lithium intake were less likely to report pain (odds ratio [OR] = 0.59, 95% confidence interval [CI], 0.35-0.95; p = 0.036) after controlling for sociodemographic variables, BD type, lifetime history of psychiatric disorders, suicide attempt, personality traits, current depression and anxiety levels, sleep quality, and psychomotor activity. Subjects taking lithium were even less likely to report pain when lithium concentration in blood was =0.5 mmol/l (OR = 0.45, 95% CI, 0.24-0.79; p = 0.008). Conclusions. This is the first naturalistic study to show lithium's promising effect on pain in subjects suffering from BD after controlling for many confounding variables. This analgesic effect seems independent of BD severity and comorbid conditions. Randomized controlled trials are needed to confirm the analgesic effect of lithium salts and to determine whether lithium decreases pain in other vulnerable populations. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Childhood maltreatment contributes to the medical morbidity of individuals with bipolar disorders.

Author

Godin, Ophélia, Leboyer, Marion, Grillault Laroche, Diane, Aubin, Valérie, Belzeaux, Raoul, Courtet, Philippe, Dubertret, Caroline, Gard, Sébastien, Haffen, Emmanuel, Olie, Emilie, Polosan, Mircea, Roux, Paul, Samalin, Ludovic, Schwan, Raymund, Bellivier, Frank, and Etain, Bruno

Subjects
DISEASE risk factors, MIGRAINE complications, THYROID diseases, CHILD abuse, CROSS-sectional method, MULTIVARIATE analysis, RISK assessment, QUESTIONNAIRES, DESCRIPTIVE statistics, RESEARCH funding, HEADACHE, DUODENAL ulcers, BIPOLAR disorder, COMORBIDITY, DISEASE complications
Abstract

Background: Individuals with bipolar disorders (BD) are at risk of premature death, mainly due to medical comorbidities. Childhood maltreatment might contribute to this medical morbidity, which remains underexplored in the literature. Methods: We assessed 2891 outpatients with BD (according to DSM-IV criteria). Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Lifetime diagnoses for medical disorders were retrospectively assessed using a systematic interview and checked against medical notes. Medical morbidity was defined by the sum of medical disorders. We investigated associations between childhood maltreatment (neglect and abuse) and medical morbidity while adjusting for potential confounders. Results: One quarter of individuals had no medical comorbidities, while almost half of them had at least two. Multivariable regression showed that childhood maltreatment (mainly abuse, but also sexual abuse) was associated with a higher medical morbidity. Medical morbidity was also associated with sex, age, body mass index, sleep disturbances, lifetime anxiety disorders and lifetime density of mood episodes. Childhood maltreatment was associated with an increased prevalence of four (i.e. migraine/headache, drug eruption, duodenal ulcer, and thyroid diseases) of the fifteen most frequent medical disorders, however with no difference in terms of age at onset. Conclusions: This large cross-sectional study confirmed a high medical morbidity in BD and its association with childhood maltreatment. The assessment of childhood maltreatment in individuals with BD should be systematically included in routine care and the potential impact on physical health of psycho-social interventions targeting childhood maltreatment and its consequences should be evaluated. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Mapping Dysfunctional Circuits in the Frontal Cortex Using Deep Brain Stimulation

Author

Hollunder, Barbara, primary, Ostrem, Jill L., additional, Sahin, Ilkem Aysu, additional, Rajamani, Nanditha, additional, Oxenford, Simón, additional, Butenko, Konstantin, additional, Neudorfer, Clemens, additional, Reinhardt, Pablo, additional, Zvarova, Patricia, additional, Polosan, Mircea, additional, Akram, Harith, additional, Vissani, Matteo, additional, Zhang, Chencheng, additional, Sun, Bomin, additional, Navratil, Pavel, additional, Reich, Martin M., additional, Volkmann, Jens, additional, Yeh, Fang-Cheng, additional, Baldermann, Juan Carlos, additional, Dembek, Till A., additional, Visser-Vandewalle, Veerle, additional, Alho, Eduardo Joaquim Lopes, additional, Franceschini, Paulo Roberto, additional, Nanda, Pranav, additional, Finke, Carsten, additional, Kühn, Andrea A., additional, Dougherty, Darin D., additional, Richardson, R. Mark, additional, Bergman, Hagai, additional, DeLong, Mahlon R., additional, Mazzoni, Alberto, additional, Romito, Luigi M., additional, Tyagi, Himanshu, additional, Zrinzo, Ludvic, additional, Joyce, Eileen M., additional, Chabardes, Stephan, additional, Starr, Philip A., additional, Li, Ningfei, additional, and Horn, Andreas, additional

Published
2023
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45. Troubles du sommeil dans les stades précoces de trouble psychotique chronique et de trouble bipolaire : revue systématique et méta-analyse de la littérature

Author

Donde Coquelet, Clément, primary, Jaffiol, Antoine, additional, Khouri, Charles, additional, Pouchon, Arnaud, additional, Tamisier, Renaud, additional, Lejoyeux, Michel, additional, D’Ortho, Marie-Pia, additional, Polosan, Mircea, additional, and Geofrroy, Pierre-Alexis, additional

Published
2023
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47. Definition of early age at onset in bipolar disorder according to distinctive neurodevelopmental pathways:Insights from the FACE-BD study

Author

Corponi, Filippo, Lefrere, Antoine, Leboyer, Marion, Bellivier, Frank, Godin, Ophelia, Loftus, Josephine, Courtet, Philippe, Dubertret, Caroline, Haffen, Emmanuel, Llorca, Pierre Michel, Roux, Paul, Polosan, Mircea, Schwan, Raymund, Samalin, Ludovic, Olié, Émilie, Etain, Bruno, Seriès, Peggy, Belzeaux, Raoul, University of Edinburgh, Assistance Publique - Hôpitaux de Marseille (APHM), Fondation FondaMental [Créteil], Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Princesse Grace, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Louis Mourier - AP-HP [Colombes], Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) (NEURO), Université de Franche-Comté (UFC), CHU Clermont-Ferrand, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, CHU Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Psychothérapique de Nancy [Laxou] (CPN), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Pôle Digestif [CHRU Montpellier]

Subjects
bipolar disorder, machine learning, neurodevelopment, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Age at onset, age at onset
Abstract

BackgroundConverging evidence suggests that a subgroup of bipolar disorder (BD) with an early age at onset (AAO) may develop from aberrant neurodevelopment. However, the definition of early AAO remains unprecise. We thus tested which age cut-off for early AAO best corresponds to distinguishable neurodevelopmental pathways.MethodsWe analyzed data from the FondaMental Advanced Center of Expertise-Bipolar Disorder cohort, a naturalistic sample of 4421 patients. First, a supervised learning framework was applied in binary classification experiments using neurodevelopmental history to predict early AAO, defined either with Gaussian mixture models (GMM) clustering or with each of the different cut-offs in the range 14 to 25 years. Second, an unsupervised learning approach was used to find clusters based on neurodevelopmental factors and to examine the overlap between such data-driven groups and definitions of early AAO used for supervised learning.ResultsA young cut-off, i.e. 14 up to 16 years, induced higher separability [mean nested cross-validation test AUROC = 0.7327 (± 0.0169) for ⩽16 years]. Predictive performance deteriorated increasing the cut-off or setting early AAO with GMM. Similarly, defining early AAO below 17 years was associated with a higher degree of overlap with data-driven clusters (Normalized Mutual Information = 0.41 for ⩽17 years) relatively to other definitions.ConclusionsEarly AAO best captures distinctive neurodevelopmental patterns when defined as ⩽17 years. GMM-based definition of early AAO falls short of mapping to highly distinguishable neurodevelopmental pathways. These results should be used to improve patients' stratification in future studies of BD pathophysiology and biomarkers.

Published
2023
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48. Physical and Mental Health Status of Former Smokers and Non-Smokers Patients with Bipolar Disorder

Author

Nobile, Bénédicte, Godin, Ophélia, Gard, Sébastien, Samalin, Ludovic, Brousse, Georges, Loftus, Joséphine, Aubin, Valérie, Belzeaux, Raoul, Dubertret, Caroline, Le Strat, Yann, Mazer, Nicolas, Prémorel, Alix, Roux, Paul, Polosan, Mircea, Schwintzer, Thomas, Llorca, Pierre-Michel, Biseul, Isabelle, Etain, Bruno, Moirand, Remi, Olié, Emilie, Haffen, Emmanuel, Leboyer, Marion, Courtet, Philippe, Guillaume, Sébastien, Icick, Romain, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Fondation FondaMental [Créteil], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre Hospitalier Princesse Grace, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Psychothérapique de Nancy [Laxou] (CPN), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)

Subjects
Psychiatry and Mental health, substance use disorders, Bipolar disorder, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Tobacco, Addiction, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Former smokers, metabolic syndrome
Abstract

International audience; Objectives Up to 70% individuals with bipolar disorder (BD) are lifetime tobacco smokers, a major modifiable risk factor for morbidity. However, quitting smoking is rarely proposed to individuals with BD, mainly because of fear of unfavorable metabolic or psychiatric changes. Evaluating the physical and mental impact of tobacco cessation is primordial. The aim of this study was to characterize the psychiatric and non-psychiatric correlates of tobacco smoking status (never- versus current vs former smokers) in individuals with BD.Methods 3,860 individuals with ascertained BD recruited in the network of Fondamental expert centers for BD between 2009 and 2020 were categorized into current, former, and never tobacco smokers. We compared the sociodemographic and clinical characteristics assessed by standard instruments (e.g. BD type, current symptoms load, and non-psychiatric morbidity \textendash including anthropometric and biological data) of the three groups using multinomial regression logistic models. Corrections for multiple testing were applied.Results Current smokers had higher depression, anxiety, and impulsivity levels than former and never-smokers, and also higher risk of comorbid substance use disorders with a gradient from never to former to current smokers \textendash suggesting shared liability. Current smokers were at higher risk to have a metabolic syndrome than never-smokers, although this was only evidenced in cases, who were not using antipsychotics.Conclusions Tobacco smoking was associated with high morbidity level. Strikingly, as in the general population, quitting smoking seemed associated with their return to the never-smokers' levels. Our findings strongly highlight the need to spread strategies to treat tobacco addiction in the BD population.

Published
2023
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49. Additional file 1 of Efficacy and auditory biomarker analysis of fronto-temporal transcranial direct current stimulation (tDCS) in targeting cognitive impairment associated with recent-onset schizophrenia: study protocol for a multicenter randomized double-blind sham-controlled trial

Author

Dondé, Clément, Bastin, Julien, Pouchon, Arnaud, Costes, Nicolas, Fakra, Eric, Galvão, Filipe, Gay, Aurélia, Haesebaert, Frédéric, Lamalle, Laurent, Mérida, Inès, Rigon, Maxence, Schneider, Fabien, Troprès, Irène, Brunelin, Jérôme, and Polosan, Mircea

Abstract

Additional file 1. Ethical approval.

Published
2023
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