34 results on '"Priyadarshini, E."'
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2. Aeroengine gas trajectory prediction using time-series analysis auto regressive integrated moving average
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Mary Victoria Florence, M. and Priyadarshini, E.
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- 2024
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3. Differential gene expression analysis reveals the fast-growth mechanisms in Melia dubia at different stand ages
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Rajarajan, K, Verma, Shailesh, Sahu, Sakshi, Radhakrishna, A, Kumar, Naresh, Priyadarshini, E, Handa, AK, and Arunachalam, A
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- 2023
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4. Carbon nanotubes and their biomedical applications
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Narayanrao, Kulkarni Akshay, primary, Priyadarshini, E., additional, and Kadeppagari, Ravi-Kumar, additional
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- 2023
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5. Prediction of wheat production in India through fuzzy time series.
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Priyadarshini, E., Premalathasri, R., and Vidhya, M.
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FORECASTING , *CLOUDINESS , *AMBIGUITY , *TIME series analysis - Abstract
Wheat is the main growing cereal crop in India. For the country, designing, estimating productivity is the important tool for predicting the production of wheat to determine the circumstances that would be the value of production upcoming year. Fuzzy time series deals with the problems associated with unpredictability ambiguousness and cloudiness. In this study enlargement of fuzzy time series variant model is used in forecasting wheat production. The data of previous years from 2000 to 2021 was taken for analysis and the proposed method on fuzzy time series estimates future events' precision rate. The suggested method used the percentage change as the Universe of Discourse and Average-based Partitioning. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Lung cancer identification using computerized tomography images.
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Jancy, S., Kumar, Sana Prem, Kumar, Rayapati Sai Prasanna, Latha, S. Pushpa, Selvan, Mercy Paul, Mary, A. Viji Amutha, and Priyadarshini, E.
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COMPUTED tomography ,LUNG cancer ,K-nearest neighbor classification ,CANCER diagnosis ,DISEASE risk factors - Abstract
Significant progress has been made in the field of lung cancer over the years (chemical rehabilitation, radiotherapy, individualized treatment). Nevertheless, lung cancer remains a threat to society and a leading cause of death for thousands of people worldwide. The subject of this paper is the diagnosis of lung cancer. Lung cancer is diagnosed using computerized tomography (CT) scans. To accurately diagnose lung cancer, different algorithms are used. The image is filtered through a sharp hidden filter in this case. The edges and areas of the cancer are detected using a flexible canvas method. To identify the features andpredict the risk of lung cancer, using the neural network. The K-Nearest Neighbors method is used to separate cancerand lungs. Lung cancer is diagnosed using computerized tomography (CT) scans. To accurately diagnose lung cancer, different algorithms are used. The image is filtered through a sharp hidden filter in this case. The edges and areas of the cancer are detected using a flexible canvas method. To identify the features and predict the risk of the Using a neural network to study lung cancer. The K-Nearest Neighbors method is used to separate cancer and lungs. Lung cancer has been growing in recent years, so it is very important to know if tumor has turned into cancer. Prognosis occurs early and Accurate predictions can save many lives and assist doctors in starting therapy. CT (computed tomography) is a type of imaging that uses a is important in determining the condition of a plant by determining its size, location, and other factors. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Automatic drowsiness detection using convolution neural network.
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Jancy, S., Abhishek, Konagalla, Charan, Olla Yaswanth, Latha, S. Pushpa, Mary, A. Viji Amutha, Priyadarshini, E., and Deepa, A.
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CONVOLUTIONAL neural networks ,SLEEP deprivation ,DROWSINESS ,SUMATRIPTAN - Abstract
Driver rest is one of the main sources of mishaps and passing for some individuals and the economy. As of late, specialists have started to perceive that lack of sleep is a positive, industry-driving reaction. In this article, we suggest including CNN-based savvy glasses for eye acknowledgment and rest estimation. This new response is contrasted with the customary technique in view of the strategy for comprehension. Both execution, battery utilization, and impression are assessed for execution in incorporated glass. The outcomes show that CNN has over 7% of the precision found at the algorithmic level. Moreover, migraines in memory and battery duration are genuine and make CNN a potential answer for sleep deprivation. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Stock market prediction using machine learning techniques.
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Jancy, S., Ashok, Vemparala, Pavan, C. H., Priyadarshini, E., Mary, A. Viji Amutha, and Selvan, Mercy Paul
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STOCKS (Finance) ,BOX-Jenkins forecasting ,FINANCIAL markets - Abstract
Neural organizations are probably the most intelligent technique for information mining involved by analysts in different fields throughout the last ten years. Securities exchange gauges and examination play had a critical influence in the present economy. The different calculations utilized in arranging can be delegated (AR, MA, ARIMA, ARMA) and nonlinear models. Here we utilize two different financial exchange shutting dates the Indian Stock Exchange (NSE) and the New York Stock Exchange. The pipeline was prepared on the securities exchange of one NSE organization and anticipated five unique organizations in the NSE and NYSE. CNN has shown that it is the best model. The channel was ready with NSE data; however, it was feasible to anticipate the NYSE. This was conceivable in light of the fact that both financial exchanges share inner qualities. Contrasting the outcomes and the ARIMA model, it was observed that the muscle strands were more than typical. [ABSTRACT FROM AUTHOR]
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- 2024
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9. Aeroengine gas trajectory prediction using time-series analysis auto regressive integrated moving average
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Mary Victoria Florence, M., primary and Priyadarshini, E., additional
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- 2023
- Full Text
- View/download PDF
10. Chapter 7 - Carbon nanotubes and their biomedical applications
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Narayanrao, Kulkarni Akshay, Priyadarshini, E., and Kadeppagari, Ravi-Kumar
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- 2023
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11. Cost Optimization and Emission Control of a Grid Connected Hybrid PV-Wind System for a Health Care Centre in India
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Memala, W Abitha, primary, Bhuvaneswari, C, additional, Susitra, D, additional, and Priyadarshini, E, additional
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- 2022
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12. Effect of Heat Source on MHD Flow Through Permeable Structure under Chemical Reaction and Oscillatory Suction
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Lawanya, T., primary, Vidhya, M., additional, Govindarajan, A., additional, and Priyadarshini, E., additional
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- 2022
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13. Prediction of CVD using binary logistic regression.
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Florence, M. Mary Victoria, Priyadarshini, E., Vidhya, M., and Govindarajan, A.
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LOGISTIC regression analysis , *HEART diseases , *DEPENDENT variables , *FORECASTING , *INDEPENDENT variables - Abstract
One of the popular method for prediction of medical related data is Binary Logistic Regression. This method helps in understanding the relation between the independent variables and the dependent variable and to explore the relationship between them. The aim of this paper is to build a binary logistic model by identifying the various factors that trigger the heart disease of a person.The various factors influencing the heart disease of a person was computed and the performance of this method were evaluated based on standard statistical measures such as MAE, MAPE, RMSE, etc. The results obtained shows that BLR model can be used to monitor the heart disease conditions satisfactorily. [ABSTRACT FROM AUTHOR]
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- 2022
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14. An axisymmetric flow over non-linear radially stretching surface with heat transfer and chemical reaction effects.
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Vidhya, M., Juliet, S. Sheeba, Govindarajan, A., and Priyadarshini, E.
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HEAT transfer ,CHEMICAL reactions ,BOUNDARY layer (Aerodynamics) ,FLUID flow - Abstract
The solution of the problem obtained using Homotopy Perturbation Method (HPM) in this paper. Considered the boundary layer fluid flow over porous medium with chemical reactions and heat transfer. Using Similarity variables in non-linear PDE it will be reduced to ordinary DE then the solution found using HPM. The fluid flow features and the different values of governing parameters are analysed using graphs. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Soret and dufour effect of radiating fluid with Hall current and ramped wall temperature past vertical porous channel.
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Sheeba, Juliet S., Vidhya, M., Govindarajan, A., and Priyadarshini, E.
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THERMOPHORESIS ,VISCOUS flow ,HALL effect ,FLUIDS ,TEMPERATURE ,HYDROELECTRIC power plants - Abstract
Soret and Dufour effect with hall current of a magneto hydro dynamic flow of a viscous fluid through vertical porous channel is studied here. Also studied the impacts of ramped wall temperature on the incompressible fluid. Using regular perturbation technique with boundary conditions the velocity, temperature and concentration of the fluid are calculated and it shows the velocity of the fluid increases when Soret number increases and velocity decreases with the increasing values of Dufour number. Also the variations in temperature and concentration also studied with the help of graphs. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Modeling and forecasting using auto regressive integrated moving average
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Priyadarshini, E., primary, Preethi, E. Sharon, additional, Vidhya, M., additional, Chakkravarthi, Samuel, additional, and Govindarajan, A., additional
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- 2022
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17. Forecasting the spread of COVID-19 using supervised machine learning models.
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Kamalam, G. K., Lalitha, K., Priyadarshini, E., Janani, V. C., and Sasidhar, P. M.
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COVID-19 ,COVID-19 pandemic ,MACHINE learning ,STATISTICAL smoothing ,FORECASTING ,DEATH rate - Abstract
Coronavirus disease of 2019 (COVID-19) has become widespread within few months and it has lead to a dramatic loss for human life worldwide. This pandemic impacts tens of millions of deaths each day and the number of people were dead by covid-19 is gradually increasing throughout the globe. During this pandemic situation control, we tend to propose a future prediction using Machine Learning algorithms on the death rate, the number of recovered estimates and the number of daily confirmed COVID-19 cases reported within the next ten days. It is based on Machine Learning technique. This forecasting method will predict the upcoming number of COVID-19 cases. Here we use four standard models for forecasting includes linear Regression (LR), The Lowest Absolute and Selective Shrinking Operator (LASSO), Vector Assistance (SVM) and exponential smoothing (ES) will predict the number of COVID-19 cases in future. These four models make three predictions: the mortality rates, the number of newly affected COVID-19 cases and the cummulative number of recovered cases in the next 10 days. These methods are better used in the COVID-19 situation. Based upon the findings, it is a encouraging method to use these standard models in the current situation of COVID-19 spread. The analysis shows that among all the standard forecasting models, ES model performs best, then LR and LASSO which also performs well in predicting the new infected cases of corona, death rate and recovery cases. Whereas the results of SVM were very bad in all the prediction scenarios from the given covid-19 data set. The predictions made by these models relating to the current situation are accurate and will also be useful for future awareness of the future situation. This paper will be enhanced continuously and next we are planning to traverse the prediction methodology using the updated covid-19 data set and we will make use of the most precise and best Machine Learning models for forecasting in future. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Contributors
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Ahmed, S.M., Azadi, Elham, Bansal, Ishita, Behranvand, Vajiheh, Binod, Parameswaran, Chauhan, Priya, Chawla, Shashi, Demirci, Sahin, Diwan, Anchita, Ganesh Kumar, Baskaran, Gizer, S. Gorkem, Gopal, Dharshini, Goyal, Kartika, Gulati, Shikha, Hussain, Chaudhery Mustansar, Kadeppagari, Ravi-Kumar, Kailasa, Suresh Kumar, Kandasamy, Ruckmani, Kaushal, Nikita, Krishnaswami, Venkateshwaran, Kumar, Manish, Kumar, Sanjay, Kumari, Beena, Kumari, Sweta, Kurt, Saliha B., Latha, M.S., Madhavan, Aravind, Mallakpour, Shadpour, Mansour, N.A., Maruthamuthu, Vijayalakshmi, Mehta, Vaibhavkumar N., Melappa, Govindappa, Misra, Shashi Kiran, Mondal, Shibsankar, Mongia, Ayush, Narayanrao, Kulkarni Akshay, Pandey, Annu, Pandey, Ashok, Pathak, Kamla, Paul, Swastik, Philip, Eapen, Polat, Osman, Prajapati, Vimalkumar S., Prakash, K.S., Priyadarshini, E., Rai, Prateek, Rajagopal, Rampriya Alagarsamy, Raut, Shishir, Raval, Juhi B., Reshmy, R., Rohit, Jigneshkumar V., Roy, Subhasis, Sadek, E.M., Saha, Ankit, Sahiner, Mehtap, Sahiner, Nurettin, Shah, Chirantan, Shah, Manan, Shah, Vraj, Sharma, Nandini, Shikha, Sindhu, Raveendran, Singh, Parinita, Skariyachan, Sinosh, Suner, Selin S., Thomas, Deepa, Unni, Rekha, Vaisakh, P.H., and Vijayan, Sneha
- Published
- 2023
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19. Retraction Note: Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice.
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Geetha R, Radika MK, Priyadarshini E, Bhavani K, and Anuradha CV
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- 2024
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20. Nano-bio convergence unveiled: Systematic review on quantum dots-protein interaction, their implications, and applications.
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Gupta J, Vaid PK, Priyadarshini E, and Rajamani P
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- Humans, Nanotechnology, Protein Binding, Proteins chemistry, Proteins metabolism, Quantum Dots chemistry, Quantum Dots metabolism
- Abstract
Quantum dots (QDs) are semiconductor nanocrystals (2-10 nm) with unique optical and electronic properties due to quantum confinement effects. They offer high photostability, narrow emission spectra, broad absorption spectrum, and high quantum yields, making them versatile in various applications. Due to their highly reactive surfaces, QDs can conjugate with biomolecules while being used, produced, or unintentionally released into the environment. This systematic review delves into intricate relationship between QDs and proteins, examining their interactions that influence their physicochemical properties, enzymatic activity, ligand binding affinity, and stability. The research utilized electronic databases like PubMed, WOS, and Proquest, along with manual reviews from 2013 to 2023 using relevant keywords, to identify suitable literature. After screening titles and abstracts, only articles meeting inclusion criteria were selected for full text readings. This systematic review of 395 articles identifies 125 articles meeting the inclusion criteria, categorized into five overarching themes, encompassing various mechanisms of QDs and proteins interactions, including adsorption to covalent binding, contingent on physicochemical properties of QDs. Through a meticulous analysis of existing literature, it unravels intricate nature of interaction, significant influence on nanomaterials and biological entities, and potential for synergistic applications harnessing both specific and nonspecific interactions across various fields., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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21. Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review.
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Priyadarshini E, Kumar R, Balakrishnan K, Pandit S, Kumar R, Jha NK, and Gupta PK
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- Humans, Prostheses and Implants, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Quantum Dots chemistry, Particle Size, Microbial Sensitivity Tests, Materials Testing, Equipment and Supplies microbiology, Biofilms drug effects, Carbon chemistry, Carbon pharmacology, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry
- Abstract
Biofilms are an intricate community of microbes that colonize solid surfaces, communicating via a quorum-sensing mechanism. These microbial aggregates secrete exopolysaccharides facilitating adhesion and conferring resistance to drugs and antimicrobial agents. The escalating global concern over biofilm-related infections on medical devices underscores the severe threat to human health. Carbon dots (CDs) have emerged as a promising substrate to combat microbes and disrupt biofilm matrices. Their numerous advantages such as facile surface functionalization and specific antimicrobial properties, position them as innovative anti-biofilm agents. Due to their minuscule size, CDs can penetrate microbial cells, inhibiting growth via cytoplasmic leakage, reactive oxygen species (ROS) generation, and genetic material fragmentation. Research has demonstrated the efficacy of CDs in inhibiting biofilms formed by key pathogenic bacteria such as Escherichia coli , Staphylococcus aureus , and Pseudomonas aeruginosa. Consequently, the development of CD-based coatings and hydrogels holds promise for eradicating biofilm formation, thereby enhancing treatment efficacy, reducing clinical expenses, and minimizing the need for implant revision surgeries. This review provides insights into the mechanisms of biofilm formation on implants, surveys major biofilm-forming pathogens and associated infections, and specifically highlights the anti-biofilm properties of CDs emphasizing their potential as coatings on medical implants.
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- 2024
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22. Synergistic reduction of nitrophenols by Au-CDs nanoconjugates with NaBH 4 .
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Priyadarshini E, Minzar M, Pandey S, and Rawat K
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Developing sustainable and innovative approaches for the efficient reduction of nitrophenols is crucial for environmental remediation, for managing health concerns posed by their widespread presence as hazardous pollutants in industrial effluents and contaminated water. We report the use of 12.9 ± 1 nm (TEM data) sized gold carbon dot nanoconjugates (Au@CDs) for catalytic conversion of o, m, p-nitrophenols to aminophenols by sodium borohydride. A simple approach was followed to synthesize ultra-small and highly stable Au@CDs, using citric acid and PEG as reducing and stabilizing agents. X-ray diffraction analysis verified the formation of nano-crystalline nanoconjugates. These nanoconjugates showed a remarkable catalytic activity in the range of 0.22-0.33 s
-1 (varying with nanoconjugate concentration) which was much higher compared to conventional chemical methods of reduction. All the catalytic reaction experiments were performed at room temperature (27 ± 2 °C). Furthermore, an increase in rate constant was observed with increasing concentration of nanoconjugates. The catalytic activity of Au@CDs nanoconjugates was observed to be in order of m-nitrophenol > o-nitrophenol > p-nitrophenol with apparent rate constant ( kaap ) values of 0.068, 0.043 and 0.031, respectively. Comparative analysis with GNPs, CDs and Au@CDs nanoconjugates stated that the nanoconjugates had superior catalytic activity. The research can have significant implications in the development of new strategies for environmental remediation and biomedical applications., (© 2024 IOP Publishing Ltd.)- Published
- 2024
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23. Assessing the impact and mechanisms of environmental pollutants (heavy metals and pesticides) on the male reproductive system: a comprehensive review.
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Gautam R, Priyadarshini E, Patel AK, and Arora T
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- Humans, Male, Endocrine Disruptors toxicity, Environmental Exposure, Oxidative Stress drug effects, Reproduction drug effects, Environmental Pollutants toxicity, Genitalia, Male drug effects, Metals, Heavy toxicity, Pesticides toxicity
- Abstract
The escalation of technological advancements, coupled with the increased use of hazardous chemicals, has emerged as a significant concern for human health. Exposure to environmental pollutants like heavy metals and pesticides (insecticides, herbicides and fungicides) is known to significantly contribute to various health problems, particularly affecting reproductive health. Disturbances in reproductive potential and reproductive toxicity in males are particularly worrisome. Existing literature suggests that exposure to these environmental pollutants significantly alters male reproductive parameters. Thus, it is imperative to thoroughly analyze, comprehend, and evaluate their impact on male reproductive toxicity. Oxidative stress and disruptions in redox equilibrium are major factors through which these pollutants induce changes in sperm parameters and affect the reproductive system. Insecticides, fungicides, and herbicides act as endocrine disruptors, interfering with the secretion and function of reproductive hormones such as testosterone and luteinizing hormone (LH), consequently impacting spermatogenesis. Additionally, heavy metals are reported to bio-accumulate in reproductive organs, acting as endocrine disruptors and triggering oxidative stress. The co-operative association of these pollutants can lead to severe damage. In this comprehensive review, we have conducted an in-depth analysis of the impact of these environmental pollutants on the male reproductive system, shedding light on the underlying mechanisms of action.
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- 2024
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24. Biocompatible gelatin/carbon dot nanocomposite based urea sensor and the effect of nitrogen ion implantation.
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Priyadarshini E, Minzar M, Pandey S, and Rawat K
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- Urea, Gelatin, Electrodes, Ions, Electrochemical Techniques, Carbon, Nanocomposites
- Abstract
In this study, we have fabricated a novel platform for sensing of urea using gelatin/carbon dots nanocomposite system. The sensor electrode was created by depositing the nanocomposite gel onto thin glass plates coated with indium tin oxide (ITO) using the drop casting technique. The behavior of these electrodes was investigated against a number of bioanalytes in the concentration range of 2-20 mM by cyclic voltammetry. The system was observed to be highly selective for urea with a sensitivity of 1.65 μA/mM/cm in the experimental linear range of 2-20 mM. Furthermore, the gelatin/CD-ITO electrode were also subjected to 50 KeV N
2 + ion beam irradiation with varying fluence in the range of 1012 to 1016 ions/cm2 . Sensing profile of the irradiated samples for urea suggested enhancement in sensitivity to 2 μA/mM cm2 , when the ion fluence was 5 × 1015 ions/cm2 . This enhancement after irradiation suggests a clear dependence of detection on the fluence of the ion beam. The observed excellent sensitivity of radiation processed nanocomposite material can be used as an enzyme-free platform for urea detection. Additionally, the CDs showed fluorescence quenching on treatment with mere 50 μM urea suggesting the high sensitivity of the platform., Competing Interests: Declaration of competing interest Authors declare no conflict of Interest., (Copyright © 2023. Published by Elsevier Inc.)- Published
- 2023
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25. Exposure, toxicological mechanism of endocrine disrupting compounds and future direction of identification using nano-architectonics.
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Priyadarshini E, Parambil AM, Rajamani P, Ponnusamy VK, and Chen YH
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- Humans, Diethylstilbestrol, Hormones, Signal Transduction, Benzhydryl Compounds, Endocrine Disruptors toxicity, Neoplasms chemically induced
- Abstract
Endocrine-disrupting compounds (EDC) are a group of exogenous chemicals that structurally mimic hormones and interfere with the hormonal signaling cascade. EDC interacts with hormone receptors, transcriptional activators, and co-activators, altering the signaling pathway at both genomic and non-genomic levels. Consequently, these compounds are responsible for adverse health ailments such as cancer, reproductive issues, obesity, and cardiovascular and neurological disorders. The persistent nature and increasing incidence of environmental contamination from anthropogenic and industrial effluents have become a global concern, resulting in a movement in both developed and developing countries to identify and estimate the degree of exposure to EDC. The U.S. Environment Protection Agency (EPA) has outlined a series of in vitro and in vivo assays to screen potential endocrine disruptors. However, the multidisciplinary nature and concerns over the widespread application demand alternative and practical techniques for identifying and estimating EDC. The review chronicles the state-of-art 20 years (1990-2023) of scientific literature regarding EDC's exposure and molecular mechanism, highlighting the toxicological effects on the biological system. Alteration in signaling mechanisms by representative endocrine disruptors such as bisphenol A (BPA), diethylstilbestrol (DES), and genistein has been emphasized. We further discuss the currently available assays and techniques for in vitro detection and propose the prominence of designing nano-architectonic-sensor substrates for on-site detection of EDC in the contaminated aqueous environment., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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26. Gold-carbon dot (Au@Cd) nanoconjugates based electrochemical sensing of cholesterol and effect of nitrogen ion implantation on sensitivity.
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Priyadarshini E, Pandey S, and Rawat K
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- Nanoconjugates, Gelatin, Gold, Cholesterol, Electrodes, Electrochemical Techniques, Carbon, Biosensing Techniques
- Abstract
Serum cholesterol dysregulation is associated with prognosis and diagnosis of many diseases and effective biosensor will improvise their management. A novel electrochemical biosensor was fabricated based on gelatin-Au@CD nanoconjugate films for cholesterol detection. Initially, the surface of indium titanium oxide (ITO) coated glass was modified by drop casting of gelatin-Au@CD nanoconjugates to prepare the electrodes. Electrochemical studies for detection of bioanalytes(such as urea (U), ascorbic acid (AA), oxalic acid (OA), gallic acid (GA), cholesterol (Chox), dextrose (D), l-cysteine (Cys) and citric acid (CA)) were performed using cyclic voltammetry. The presence of nanoconjugates provided an appropriate environment for enhanced electrochemical response for cholesterol. These electrodes exhibited a linear response towards the presence of cholesterol in the linear concentration range of 2-20 mM with a correlation coefficient of 0.95, and the superior sensitivity of 1.36 μA/mM/cm
2 . Additionally, enhanced sensitivity (2.99 μA/mM/cm2 ) of nitrogen ion irradiated films up to a fluence of 1016 ions/cm2 was noticed because of morphological changes in the electrode surface brought about by irradiation. Approximately 54% enhancement was found when the ion fluence was 1016 ions/cm2 . The designed nanoconjugate electrode showed excellent response towards cholesterol sensing and eliminates the requirement of any enzymes making the overall process simpler, cost-effective and allows for room temperature storage., Competing Interests: Declaration of competing interest Authors declare no conflict of Interest., (Copyright © 2023. Published by Elsevier Inc.)- Published
- 2023
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27. Bioaccumulation of CdSe Quantum Dots Show Biochemical and Oxidative Damage in Wistar Rats.
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Das K, Meena R, Gaharwar US, Priyadarshini E, Rawat K, Paulraj R, Mohanta YK, Saravanan M, and Bohidar HB
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- Rats, Male, Animals, Rats, Wistar, Bioaccumulation, Oxidative Stress, Sulfides, Zinc Compounds, Cadmium Compounds toxicity, Quantum Dots toxicity, Selenium Compounds toxicity
- Abstract
Cadmium selenium quantum dots (CdSe QDs) with modified surfaces exhibit superior dispersion stability and high fluorescence yield, making them desirable biological probes. The knowledge of cellular and biochemical toxicity has been lacking, and there is little information on the correlation between in vitro and in vivo data. The current study was carried out to assess the toxicity of CdSe QDs after intravenous injection in Wistar male rats (230 g). The rats were given a single dose of QDs of 10, 20, 40, and 80 mg/kg and were kept for 30 days. Following that, various biochemical assays, hematological parameters, and bioaccumulation studies were carried out. Functional as well as clinically significant changes were observed. There was a significant increase in WBC while the RBC decreased. This suggested that CdSe quantum dots had inflammatory effects on the treated rats. The various biochemical assays clearly showed that high dose induced hepatic injury. At a dose of 80 mg/kg, bioaccumulation studies revealed that the spleen (120 g/g), liver (78 g/g), and lungs (38 g/g) accumulated the most. In treated Wistar rats, the bioretention profile of QDs was in the following order: the spleen, liver, kidney, lungs, heart, brain, and testis. The accumulation of these QDs induced the generation of intracellular reactive oxygen species, resulting in an alteration in antioxidant activity. It is concluded that these QDs caused oxidative stress, which harmed cellular functions and, under certain conditions, caused partial brain, kidney, spleen, and liver dysfunction. This is one of the most comprehensive in vivo studies on the nanotoxicity of CdSe quantum dots., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Kishan Das et al.)
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- 2023
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28. Cumulative effects of manganese nanoparticle and radiofrequency radiation in male Wistar rats.
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Pardhiya S, Gaharwar US, Gautam R, Priyadarshini E, Nirala JP, and Rajamani P
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- Animals, Male, Mammals, Manganese toxicity, Radio Waves adverse effects, Rats, Rats, Wistar, Cell Phone, Nanoparticles
- Abstract
Radiofrequency radiation (RFR) is a type of non-ionizing electromagnetic radiation that includes radiowaves and microwaves with a frequency range between 3 KHz and 300 GHz. Mobile phones operate with RFR and are used tremendously resulting in increased and continuous exposure of humans to these radiations. On the other hand, nanoparticles are also being used extensively in various fields. The increasing use of radiofrequency radiations and nanoparticles has become a concern to the general public. Not many studies have reported the cumulative effect of these stressors. Hence, the present investigation was aimed to find out their cumulative effect on the mammalian system. In this study manganese nanoparticles (MNPs) were synthesized and characterized. Adult male Wistar rats were exposed to MNPs and mobile phone radiation for 45 days and their separate, as well as cumulative impact, was investigated. The effect of the MNPs and RFR on liver, kidney, and reproductive parameters were studied. Histopathology as well as liver and kidney parameters were altered when exposed to MNPs and RFR separately. However, their combined treatment did not show a synergistic toxic response in liver and kidney functions which may be due to the fact that the radiation level is low, specific absorption rate (SAR) is subthermal (0.04 W/kg) and liver and kidney are located intra abdominally, hence they would absorb comparatively lesser radiation than the testicles. MNPs and RFR both caused a highly significant decrease in sperm count, which further decreased in the combined treatment (MNPs + RFR). These results indicate that the combined treatment of these stressors can have an additive toxic response to the male reproductive system.
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- 2022
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29. Comparative In Vitro Cytotoxicity Study of Carbon Dot-Based Organometallic Nanoconjugates: Exploration of Their Cell Proliferation, Uptake, and Localization in Cancerous and Normal Cells.
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Priyadarshini E, Meena R, Bohidar HB, Sharma SK, Abdellattif MH, Saravanan M, and Rajamani P
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- Carbon pharmacology, Cell Proliferation, HEK293 Cells, HeLa Cells, Humans, Nanoconjugates, Quantum Dots
- Abstract
Organometallic nanoconjugates have raised great interest due to their bimodal properties and high stability. In the present study, we analyzed the cytotoxicity property of carbon dots (CDs) and a series of organometallic nanoconjugates including gold@carbon dots (Au@CDs) and silver@carbon dots (Ag@CDs) synthesized via an aqueous mode. We aimed to divulge a comparative analysis of cell proliferation, uptake, and localization of the particles in HeLa and HEK293 cell lines. Our results showed dose-dependent cytotoxicity of Au@CDs, Ag@CDs, and CDs. However, Ag@CDs showed the highest inhibition through HeLa cells with an IC
50 value of around 50 ± 1.0 μ g/mL. Confocal imaging signified the uptake of the particles suggested by blue fluorescence in the interior region of HeLa cells. Furthermore, the TEM micrographs depicted that the particles are entrapped by endocytosis assisted through the cell microvilli. The CDs and Au@CDs were thus observed to be relatively safe up to a concentration of 100 μ g/mL and did not induce any morphological changes in the cells. Moreover, the cell proliferation assay of these nanoconjugates against HEK 293 cells signified the nontoxic nature of the nanoconjugates. The results thus revealed two major facts: firstly, the Ag@CDs had potent therapeutic potential, signifying their potential as a promising anticancer drug, and secondly, the CDs and Au@CDs at a defined dose could be used as probes for detection and also bioimaging agents., Competing Interests: The authors declare that they have no conflict of interest., (Copyright © 2022 Eepsita Priyadarshini et al.)- Published
- 2022
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30. Metal accumulation and health risk assessment in wastewater used for irrigation around the Agra Canal in Faridabad, India.
- Author
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Verma A, Gaharwar US, Priyadarshini E, and Rajamani P
- Subjects
- Adult, Child, Environmental Monitoring, Food Contamination analysis, Humans, Risk Assessment, Soil Pollutants analysis, Wastewater analysis
- Abstract
Wastewater application for irrigation is a traditional and economic tool in developing nations. Yet prolonged use of wastewater for agricultural activities contributes to the accumulation of metals in both soil and vegetables. This study investigated the accumulation and contamination of vegetables with heavy metals ensuing from the application of wastewater from the Agra Canal and the associated risks posed to human health. Three sites across the Agra canal were selected for sampling (CW-1, CW-2, and CW-3), where untreated wastewater is being used to irrigate vegetables (spinach, coriander, radish, and garlic crops), for which tube-well water (TW) from a village served as the control site. Water, soil, and vegetable samples were collected from all sites. The presence in them of various metals, such as As, Pb, Cr, Mn, Cu, Zn, and Ni, was detected at all four sites. The greatest content of Mn was found in CW-1's water (7.91 mg/L), soil (633.77 mg/kg), and in spinach 368.12 (mg/kg) grown there. Significantly higher metal concentrations were observed in vegetables irrigated with wastewater than in tube-well-irrigated vegetables, with the metals ranked in accumulation as follows Mn > Zn > Ni > Cu > Cr > Pb > As. Our results also revealed that metal bioaccumulation varied enormously between foliar and non-foliar vegetables, as well as among the four sites. Daily metal intake (DMI) and health risk index (HRI) analyses suggested that children consuming contaminated vegetables are at higher risk than adults. The HRI for Mn, Ni, and Pb was above 1, which indicated significant health hazards to humans consuming the wastewater-irrigated vegetables. Moreover, the control site where tube-well water was used had an HRI below 1, signifying a negligible health risk for its consumption. Therefore, we may conclude that the extensive application of contaminated water for a longer duration would likely further increase metal accumulation in soil and vegetables that may be hazardous to living organisms., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2022
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31. Correction to: Metal accumulation and health risk assessment in wastewater used for irrigation around the Agra Canal in Faridabad, India.
- Author
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Verma A, Gaharwar US, Priyadarshini E, and Rajamani P
- Published
- 2022
- Full Text
- View/download PDF
32. Impact of nonionizing electromagnetic radiation on male infertility: an assessment of the mechanism and consequences.
- Author
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Gautam R, Priyadarshini E, Nirala J, and Rajamani P
- Subjects
- Electromagnetic Fields adverse effects, Electromagnetic Radiation, Humans, Male, Radiation, Nonionizing, Radio Waves, Spermatozoa, Cell Phone, Infertility, Male etiology
- Abstract
Purpose: Environment and lifestyle factors are being attributed toward increased instances of male infertility. Rapid technological advancement, results in emission of electromagnetic radiations of different frequency which impacts human both biologically as well as genetically. Devices like cell phone, power line and monitors emit electromagnetic radiation and are a major source of the exposure. Numerous studies describe the detrimental consequence of radiation on physiological parameters of male reproductive system including sperm parameters (morphology, motility, and viability), metabolism and genomic instability. While the thermal and nonthermal interaction of nonionizing radiations with biological tissues can't be ruled out, most studies emphasize the generation of reactive oxygen species. Oxidative stress alters redox equilibrium and disrupts morphology and normal functioning of sperms along with declination of total anti-oxidant capacity., Conclusion: In this paper, we describe a detailed literature review with the intent of analyzing the impact of electromagnetic radiation and understand the consequence on male reproductive system. The underlying mechanism suggesting ROS generation and pathway of action has also been discussed. Additionally, the safety measures while using electronic gadgets and mobile phones has also been presented.
- Published
- 2022
- Full Text
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33. Recent innovations of nanotechnology in water treatment: A comprehensive review.
- Author
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Ajith MP, Aswathi M, Priyadarshini E, and Rajamani P
- Subjects
- Ecosystem, Humans, Nanotechnology, Wastewater, Environmental Pollutants, Environmental Restoration and Remediation, Water Pollutants, Chemical, Water Purification
- Abstract
Environmental pollution from organic and inorganic pollutants poses a threat to the ecosystem. Pollutant's prevalence and persistence have increased significantly in recent years. In order to enhance the quality of naturally accessible water to a level suitable for human consumption, a number of techniques have been employed. In this context, the use of cutting-edge nanotechnology to classical process engineering paves the way for technical encroachments in advanced water and wastewater technology. Nanotechnology has the potential to ameliorate the quality, availability, and viability of water supplies in the long run by facilitating reuse, recycling and remediation of water. The promising role of nanotechnology in wastewater remediation is highlighted in this paper, which also covers current advancements in nanotechnology-mediated remediation systems. Moreover, nano-based materials such as nano-adsorbents, photocatalysts, nano-metals and nanomembranes are discussed in this review of recent breakthroughs in nanotechnologies for water contaminant remediation., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
- Full Text
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34. Modulatory effects of Punica granatum L juice against 2115 MHz (3G) radiation-induced reproductive toxicity in male Wistar rat.
- Author
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Gautam R, Priyadarshini E, Nirala JP, Meena R, and Rajamani P
- Subjects
- Animals, Male, Rats, Rats, Wistar, Testis pathology, Fruit and Vegetable Juices, Pomegranate chemistry, Radiation Injuries, Experimental therapy, Radiation-Protective Agents pharmacology, Testis radiation effects
- Abstract
Advancements in telecommunication sector result in increasing exposure to electromagnetic (EM) radiation, which has been correlated with incidence of male infertility. Therefore, the present study focused on analyzing the consequence of EM radiation (2115 MHz) exposure on the reproductive system of male Wistar rats. Besides, the antioxidant protective effect of Punica granatum juice was also evaluated. For experimental analysis, rats were divided into five groups (control, sham exposed, exposed, herbal plus exposed, and herbal only). Individual group consisted of 6 rats which were exposed to radiation for 45 days (2 h/day). The herbal-treated groups were given 1 ml of Punica granatum extract orally. Various parameters such as organ to body ratio, sperm count, motility, viability, and testis histopathology were studied. Furthermore, oxidative stress parameters and free radical generation were analyzed. The exposed group showed changes in sperm parameters along with decrease in seminiferous tubule diameter. On the contrary, herbal-exposed group showed enhanced sperm count, increased motility, and viability in comparison to exposed group. Histopathology studies also revealed the protective role of herbal juice. Significant alteration in oxidative parameters along with an enhanced free radical generation in exposed group and reduction in herbal groups was observed. The results thus indicate that continuous exposure to EM radiation can lead to oxidative stress which induces biochemical changes in rat sperms. However, Punica granatum extract has a protective role against oxidative damage induced by EM radiation., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2021
- Full Text
- View/download PDF
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