Search

Your search keyword '"Purser, Lauren"' showing total 6 results
Start Over Author "Purser, Lauren" Publication Year Range Last 3 years
6 results on '"Purser, Lauren"'

1. Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

Author

Wang, Lawrence T., Cooper, Andrew J.R., Farrell, Brendan, Miura, Kazutoyo, Diouf, Ababacar, Müller-Sienerth, Nicole, Crosnier, Cécile, Purser, Lauren, Kirtley, Payton J., Maciuszek, Maciej, Barrett, Jordan R., McHugh, Kirsty, Ogwang, Rodney, Tucker, Courtney, Li, Shanping, Doumbo, Safiatou, Doumtabe, Didier, Pyo, Chul-Woo, Skinner, Jeff, Nielsen, Carolyn M., Silk, Sarah E., Kayentao, Kassoum, Ongoiba, Aissata, Zhao, Ming, Nguyen, Doan C., Lee, F. Eun-Hyung, Minassian, Angela M., Geraghty, Daniel E., Traore, Boubacar, Seder, Robert A., Wilder, Brandon K., Crompton, Peter D., Wright, Gavin J., Long, Carole A., Draper, Simon J., Higgins, Matthew K., and Tan, Joshua

Published
2024
Full Text
View/download PDF

2. Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

Author

Wang, Lawrence T., primary, Cooper, Andrew J.R., additional, Farrell, Brendan, additional, Miura, Kazutoyo, additional, Diouf, Ababacar, additional, Muller-Sienerth, Nicole, additional, Crosnier, Cecile, additional, Purser, Lauren, additional, Maciuszek, Maciej, additional, Barrett, Jordan R., additional, McHugh, Kirsty, additional, Tucker, Courtney, additional, Li, Shanping, additional, Doumbo, Safiatou, additional, Doumtabe, Didier, additional, Pyo, Chul-Woo, additional, Nielsen, Carolyn M., additional, Silk, Sarah E., additional, Kayentao, Kassoum, additional, Ongoiba, Aissata, additional, Zhao, Ming, additional, Nguyen, Doan C., additional, Lee, F. Eun-Hyung, additional, Minassian, Angela M., additional, Geraghty, Daniel E., additional, Traore, Boubacar, additional, Seder, Robert A., additional, Crompton, Peter D., additional, Wright, Gavin J., additional, Long, Carole A., additional, Draper, Simon J., additional, Higgins, Matthew K., additional, and Tan, Joshua, additional

Published
2023
Full Text
View/download PDF

3. Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses

Author

Dacon, Cherrelle, primary, Peng, Linghang, additional, Lin, Ting-Hui, additional, Tucker, Courtney, additional, Lee, Chang-Chun D., additional, Cong, Yu, additional, Wang, Lingshu, additional, Purser, Lauren, additional, Cooper, Andrew J.R., additional, Williams, Jazmean K., additional, Pyo, Chul-Woo, additional, Yuan, Meng, additional, Kosik, Ivan, additional, Hu, Zhe, additional, Zhao, Ming, additional, Mohan, Divya, additional, Peterson, Mary, additional, Skinner, Jeff, additional, Dixit, Saurabh, additional, Kollins, Erin, additional, Huzella, Louis, additional, Perry, Donna, additional, Byrum, Russell, additional, Lembirik, Sanae, additional, Murphy, Michael, additional, Zhang, Yi, additional, Yang, Eun Sung, additional, Chen, Man, additional, Leung, Kwanyee, additional, Weinberg, Rona S., additional, Pegu, Amarendra, additional, Geraghty, Daniel E., additional, Davidson, Edgar, additional, Doranz, Benjamin J., additional, Douagi, Iyadh, additional, Moir, Susan, additional, Yewdell, Jonathan W., additional, Schmaljohn, Connie, additional, Crompton, Peter D., additional, Mascola, John R., additional, Holbrook, Michael R., additional, Nemazee, David, additional, Wilson, Ian A., additional, and Tan, Joshua, additional

Published
2023
Full Text
View/download PDF

5. Broadly neutralizing antibodies target the coronavirus fusion peptide

Author

Dacon, Cherrelle, primary, Tucker, Courtney, additional, Peng, Linghang, additional, Lee, Chang-Chun D., additional, Lin, Ting-Hui, additional, Yuan, Meng, additional, Cong, Yu, additional, Wang, Lingshu, additional, Purser, Lauren, additional, Williams, Jazmean K., additional, Pyo, Chul-Woo, additional, Kosik, Ivan, additional, Hu, Zhe, additional, Zhao, Ming, additional, Mohan, Divya, additional, Cooper, Andrew J. R., additional, Peterson, Mary, additional, Skinner, Jeff, additional, Dixit, Saurabh, additional, Kollins, Erin, additional, Huzella, Louis, additional, Perry, Donna, additional, Byrum, Russell, additional, Lembirik, Sanae, additional, Drawbaugh, David, additional, Eaton, Brett, additional, Zhang, Yi, additional, Yang, Eun Sung, additional, Chen, Man, additional, Leung, Kwanyee, additional, Weinberg, Rona S., additional, Pegu, Amarendra, additional, Geraghty, Daniel E., additional, Davidson, Edgar, additional, Douagi, Iyadh, additional, Moir, Susan, additional, Yewdell, Jonathan W., additional, Schmaljohn, Connie, additional, Crompton, Peter D., additional, Holbrook, Michael R., additional, Nemazee, David, additional, Mascola, John R., additional, Wilson, Ian A., additional, and Tan, Joshua, additional

Published
2022
Full Text
View/download PDF

6. Broadly neutralizing antibodies target the coronavirus fusion peptide.

Author

Dacon C, Tucker C, Peng L, Lee CD, Lin TH, Yuan M, Cong Y, Wang L, Purser L, Williams JK, Pyo CW, Kosik I, Hu Z, Zhao M, Mohan D, Cooper A, Peterson M, Skinner J, Dixit S, Kollins E, Huzella L, Perry D, Byrum R, Lembirik S, Zhang Y, Yang ES, Chen M, Leung K, Weinberg RS, Pegu A, Geraghty DE, Davidson E, Douagi I, Moir S, Yewdell JW, Schmaljohn C, Crompton PD, Holbrook MR, Nemazee D, Mascola JR, Wilson IA, and Tan J

Abstract

The potential for future coronavirus outbreaks highlights the need to develop strategies and tools to broadly target this group of pathogens. Here, using an epitope-agnostic approach, we identified six monoclonal antibodies that bound to spike proteins from all seven human-infecting coronaviruses. Epitope mapping revealed that all six antibodies target the conserved fusion peptide region adjacent to the S2' cleavage site. Two antibodies, COV44-62 and COV44-79, broadly neutralize a range of alpha and beta coronaviruses, including SARS-CoV-2 Omicron subvariants BA.1 and BA.2, albeit with lower potency than RBD-specific antibodies. In crystal structures of Fabs COV44-62 and COV44-79 with the SARS-CoV-2 fusion peptide, the fusion peptide epitope adopts a helical structure and includes the arginine at the S2' cleavage site. Importantly, COV44-79 limited disease caused by SARS-CoV-2 in a Syrian hamster model. These findings identify the fusion peptide as the target of the broadest neutralizing antibodies in an epitope-agnostic screen, highlighting this site as a candidate for next-generation coronavirus vaccine development., One-Sentence Summary: Rare monoclonal antibodies from COVID-19 convalescent individuals broadly neutralize coronaviruses by targeting the fusion peptide.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results