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3 results on '"Puthi, Vijith"'

1. Gene expression signature predicts rate of type 1 diabetes progression

Author

Mathieu, Chantal, Gillard, Pieter, Casteels, Kristina, Overbergh, Lutgart, Dunger, David, Wallace, Chris, Evans, Mark, Thankamony, Ajay, Hendriks, Emile, Bruggraber, Sylvaine, Marcoveccchio, Loredana, Peakman, Mark, Tree, Timothy, Morgan, Noel G., Richardson, Sarah, Todd, John A., Wicker, Linda, Mander, Adrian, Dayan, Colin, Alhadj Ali, Mohammad, Pieber, Thomas, Eizirik, Decio L., Cnop, Myriam, Brunak, Søren, Pociot, Flemming, Johannesen, Jesper, Rossing, Peter, Quigley, Cristina Legido, Mallone, Roberto, Scharfmann, Raphael, Boitard, Christian, Knip, Mikael, Otonkoski, Timo, Veijola, Riitta, Lahesmaa, Riitta, Oresic, Matej, Toppari, Jorma, Danne, Thomas, Ziegler, Anette G., Achenbach, Peter, Rodriguez-Calvo, Teresa, Solimena, Michele, Bonifacio, Ezio E., Speier, Stephan, Holl, Reinhard, Dotta, Francesco, Chiarelli, Francesco, Marchetti, Piero, Bosi, Emanuele, Cianfarani, Stefano, Ciampalini, Paolo, De Beaufort, Carine, Dahl-Jørgensen, Knut, Skrivarhaug, Torild, Joner, Geir, Krogvold, Lars, Jarosz-Chobot, Przemka, Battelino, Tadej, Thorens, Bernard, Gotthardt, Martin, Roep, Bart O., Nikolic, Tanja, Zaldumbide, Arnaud, Lernmark, Ake, Lundgren, Marcus, Costacalde, Guillaume, Strube, Thorsten, Schulte, Anke M., Nitsche, Almut, Vela, Jose, Von Herrath, Matthias, Wesley, Johnna, Napolitano-Rosen, Antonella, Thomas, Melissa, Schloot, Nanette, Goldfine, Allison, Waldron-Lynch, Frank, Kompa, Jill, Vedala, Aruna, Hartmann, Nicole, Nicolas, Gwenaelle, van Rampelbergh, Jean, Bovy, Nicolas, Dutta, Sanjoy, Soderberg, Jeannette, Ahmed, Simi, Martin, Frank, Latres, Esther, Agiostratidou, Gina, Koralova, Anne, Willemsen, Ruben, Smith, Anne, Anand, Binu, Datta, Vipan, Puthi, Vijith, Zac-Varghese, Sagen, Dias, Renuka, Sundaram, Premkumar, Vaidya, Bijay, Patterson, Catherine, Owen, Katharine, Piel, Barbara, Heller, Simon, Randell, Tabitha, Gazis, Tasso, Reismen, Elise Bismuth, Carel, Jean-Claude, Riveline, Jean-Pierre, Gautier, Jean-Francoise, Andreelli, Fabrizion, Travert, Florence, Cosson, Emmanuel, Penfornis, Alfred, Petit, Catherine, Feve, Bruno, Lucidarme, Nadine, Beressi, Jean-Paul, Ajzenman, Catherina, Radu, Alina, Greteau-Hamoumou, Stephanie, Bibal, Cecile, Meissner, Thomas, Heidtmann, Bettina, Toni, Sonia, Rami-Merhar, Birgit, Eeckhout, Bart, Peene, Bernard, Vantongerloo, N., Maes, Toon, Gommers, Leen, Suomi, Tomi, Starskaia, Inna, Kalim, Ubaid Ullah, Rasool, Omid, Jaakkola, Maria K., Grönroos, Toni, Välikangas, Tommi, Brorsson, Caroline, Mazzoni, Gianluca, Overbergh, Lut, Chmura, Piotr, and Elo, Laura L.

Published
2023
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2. Gene expression signature predicts rate of type 1 diabetes progression

Author

Suomi, Tomi, primary, Starskaia, Inna, additional, Kalim, Ubaid Ullah, additional, Rasool, Omid, additional, Jaakkola, Maria K., additional, Grönroos, Toni, additional, Välikangas, Tommi, additional, Brorsson, Caroline, additional, Mazzoni, Gianluca, additional, Bruggraber, Sylvaine, additional, Overbergh, Lut, additional, Dunger, David, additional, Peakman, Mark, additional, Chmura, Piotr, additional, Brunak, Søren, additional, Schulte, Anke M., additional, Mathieu, Chantal, additional, Knip, Mikael, additional, Lahesmaa, Riitta, additional, Elo, Laura L., additional, Gillard, Pieter, additional, Casteels, Kristina, additional, Overbergh, Lutgart, additional, Wallace, Chris, additional, Evans, Mark, additional, Thankamony, Ajay, additional, Hendriks, Emile, additional, Marcoveccchio, Loredana, additional, Tree, Timothy, additional, Morgan, Noel G., additional, Richardson, Sarah, additional, Todd, John A., additional, Wicker, Linda, additional, Mander, Adrian, additional, Dayan, Colin, additional, Alhadj Ali, Mohammad, additional, Pieber, Thomas, additional, Eizirik, Decio L., additional, Cnop, Myriam, additional, Pociot, Flemming, additional, Johannesen, Jesper, additional, Rossing, Peter, additional, Quigley, Cristina Legido, additional, Mallone, Roberto, additional, Scharfmann, Raphael, additional, Boitard, Christian, additional, Otonkoski, Timo, additional, Veijola, Riitta, additional, Oresic, Matej, additional, Toppari, Jorma, additional, Danne, Thomas, additional, Ziegler, Anette G., additional, Achenbach, Peter, additional, Rodriguez-Calvo, Teresa, additional, Solimena, Michele, additional, Bonifacio, Ezio E., additional, Speier, Stephan, additional, Holl, Reinhard, additional, Dotta, Francesco, additional, Chiarelli, Francesco, additional, Marchetti, Piero, additional, Bosi, Emanuele, additional, Cianfarani, Stefano, additional, Ciampalini, Paolo, additional, De Beaufort, Carine, additional, Dahl-Jørgensen, Knut, additional, Skrivarhaug, Torild, additional, Joner, Geir, additional, Krogvold, Lars, additional, Jarosz-Chobot, Przemka, additional, Battelino, Tadej, additional, Thorens, Bernard, additional, Gotthardt, Martin, additional, Roep, Bart O., additional, Nikolic, Tanja, additional, Zaldumbide, Arnaud, additional, Lernmark, Ake, additional, Lundgren, Marcus, additional, Costacalde, Guillaume, additional, Strube, Thorsten, additional, Nitsche, Almut, additional, Vela, Jose, additional, Von Herrath, Matthias, additional, Wesley, Johnna, additional, Napolitano-Rosen, Antonella, additional, Thomas, Melissa, additional, Schloot, Nanette, additional, Goldfine, Allison, additional, Waldron-Lynch, Frank, additional, Kompa, Jill, additional, Vedala, Aruna, additional, Hartmann, Nicole, additional, Nicolas, Gwenaelle, additional, van Rampelbergh, Jean, additional, Bovy, Nicolas, additional, Dutta, Sanjoy, additional, Soderberg, Jeannette, additional, Ahmed, Simi, additional, Martin, Frank, additional, Latres, Esther, additional, Agiostratidou, Gina, additional, Koralova, Anne, additional, Willemsen, Ruben, additional, Smith, Anne, additional, Anand, Binu, additional, Datta, Vipan, additional, Puthi, Vijith, additional, Zac-Varghese, Sagen, additional, Dias, Renuka, additional, Sundaram, Premkumar, additional, Vaidya, Bijay, additional, Patterson, Catherine, additional, Owen, Katharine, additional, Piel, Barbara, additional, Heller, Simon, additional, Randell, Tabitha, additional, Gazis, Tasso, additional, Reismen, Elise Bismuth, additional, Carel, Jean-Claude, additional, Riveline, Jean-Pierre, additional, Gautier, Jean-Francoise, additional, Andreelli, Fabrizion, additional, Travert, Florence, additional, Cosson, Emmanuel, additional, Penfornis, Alfred, additional, Petit, Catherine, additional, Feve, Bruno, additional, Lucidarme, Nadine, additional, Beressi, Jean-Paul, additional, Ajzenman, Catherina, additional, Radu, Alina, additional, Greteau-Hamoumou, Stephanie, additional, Bibal, Cecile, additional, Meissner, Thomas, additional, Heidtmann, Bettina, additional, Toni, Sonia, additional, Rami-Merhar, Birgit, additional, Eeckhout, Bart, additional, Peene, Bernard, additional, Vantongerloo, N., additional, Maes, Toon, additional, and Gommers, Leen, additional

Published
2023
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3. Presentation and characteristics of children with screen-detected type 1 diabetes: learnings from the ELSA general population pediatric screening study.

Author

Quinn LM, Dias RP, Bidder C, Bhowmik S, Bumke K, Ganapathi J, Gorman S, Hind E, Karandikar S, Kumar K, Lipscomb N, McGovern S, Puthi VR, Randell T, Watts G, and Narendran P

Subjects
Humans, Child, Male, Female, Adolescent, Child, Preschool, Glycated Hemoglobin analysis, Insulin therapeutic use, Insulin administration & dosage, Autoantibodies blood, Follow-Up Studies, Biomarkers analysis, Biomarkers blood, Prognosis, Diabetes Mellitus, Type 1 epidemiology, Diabetes Mellitus, Type 1 diagnosis, Mass Screening methods
Abstract

Introduction: We describe the identification and management of general population screen-detected type 1 diabetes (T1D) and share learnings for best practice., Research Design and Methods: Children diagnosed with T1D through a general population screening initiative, the EarLy Surveillance for Autoimmune diabetes (ELSA) study, were reviewed and described.Parents provided written, informed consent for inclusion in the case series., Results: 14 children with insulin requiring (stage 3) T1D are described. These cases offer unique insights into the features of screen-detected T1D. T1D is identified sooner through screening programs, characterized by absent/short symptom duration, median presenting glycated hemoglobin 6.6% (49 mmol/mol) and insulin requirements<0.5 units/kg/day. ELSA identified four children at stage 3 and another 4 progressed within 4 months of ELSA completion, including two single seropositive children. Six children developed stage 3 T1D prior to ELSA completion, including two children (14%, n=2/14) with diabetic ketoacidosis prior to confirmed antibody status., Conclusions: There are three main learnings from this case series. First, T1D identified through screening is at an earlier stage of its natural history and requires personalized insulin regimens with lower total daily insulin doses. Second, single autoantibody seropositivity can rapidly progress to stage 3. Finally, insulin requirement can manifest at any stage of the T1D screening pathway, and therefore early education around symptom recognition is essential for families participating in screening programs., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2024
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