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Hyperspectral imaging shows promise for surgical applications to non-invasively provide spatially-resolved, spectral information. For calibration purposes, a white reference image of a highly-reflective Lambertian surface should be obtained under the same imaging conditions. Standard white references are not sterilizable, and so are unsuitable for surgical environments. We demonstrate the necessity for in situ white references and address this by proposing a novel, sterile, synthetic reference construction algorithm. The use of references obtained at different distances and lighting conditions to the subject were examined. Spectral and color reconstructions were compared with standard measurements qualitatively and quantitatively, using $\Delta E$ and normalised RMSE respectively. The algorithm forms a composite image from a video of a standard sterile ruler, whose imperfect reflectivity is compensated for. The reference is modelled as the product of independent spatial and spectral components, and a scalar factor accounting for gain, exposure, and light intensity. Evaluation of synthetic references against ideal but non-sterile references is performed using the same metrics alongside pixel-by-pixel errors. Finally, intraoperative integration is assessed though cadaveric experiments. Improper white balancing leads to increases in all quantitative and qualitative errors. Synthetic references achieve median pixel-by-pixel errors lower than 6.5% and produce similar reconstructions and errors to an ideal reference. The algorithm integrated well into surgical workflow, achieving median pixel-by-pixel errors of 4.77%, while maintaining good spectral and color reconstruction., Comment: 22 pages, 10 figures

Hyperspectral imaging (HSI) captures a greater level of spectral detail than traditional optical imaging, making it a potentially valuable intraoperative tool when precise tissue differentiation is essential. Hardware limitations of current optical systems used for handheld real-time video HSI result in a limited focal depth, thereby posing usability issues for integration of the technology into the operating room. This work integrates a focus-tunable liquid lens into a video HSI exoscope, and proposes novel video autofocusing methods based on deep reinforcement learning. A first-of-its-kind robotic focal-time scan was performed to create a realistic and reproducible testing dataset. We benchmarked our proposed autofocus algorithm against traditional policies, and found our novel approach to perform significantly ($p<0.05$) better than traditional techniques ($0.070\pm.098$ mean absolute focal error compared to $0.146\pm.148$). In addition, we performed a blinded usability trial by having two neurosurgeons compare the system with different autofocus policies, and found our novel approach to be the most favourable, making our system a desirable addition for intraoperative HSI., Comment: To be presented at MICCAI 2023

Metafibers expand the functionalities of conventional optical fibers to unprecedented nanoscale light manipulations by integrating metasurfaces on the fiber tips, becoming an emerging light-coupling platform for both nanoscience and fiber optics communities. Mostly exploring the isolated bare fibers, current metafibers remain as proof-of-concept demonstrations due to a lack of standard interfaces with the universal fiber networks. Here, we develop new methodologies to fabricate well-defined plasmonic metasurfaces directly on the end facets of commercial single mode fiber jumpers using standard planar technologies and provide a first demonstration of their practical applications in the nonlinear optics regime. Featuring plug-play connections with fiber circuitry and arbitrary metasurfaces landscapes, the metafibers with tunable plasmonic resonances are implemented into fiber laser cavities, yielding all-fiber sub-picosecond (minimum 513 fs) soliton mode locked lasers at optical wavelengths of 1.5 micrometer and 2 micrometer, demonstrating their unusual polarimetric nonlinear transfer functions and superior saturation absorption responses. Novel insights into the physical mechanisms behind the saturable absorption of plasmonic metasurfaces are provided. The nanofabrication process flow is compatible with existing cleanroom technologies, offering metafibers an avenue to be a regular member of functionalized fiber components. The work paves the way towards next generation of ultrafast fiber lasers, optical frequency combs, optical neural networks and ultracompact "all-in-fibers" optical systems for sensing, imaging, communications, and many others., Comment: 27 pages, 15 figures

Recently, high-order topological insulators (HOTIs), accompanied by topologically nontrivial boundary states with codimension larger than one, have been extensively explored because of unconventional bulk-boundary correspondences. As a novel type of HOTIs, very recent works have explored the square-root HOTIs, where the topological nontrivial nature of bulk bands stems from the square of the Hamiltonian. In this paper, we experimentally demonstrate 2D square-root HOTIs in photonic waveguide arrays written in glass using femtosecond laser direct-write techniques. Edge and corner states are clearly observed through visible light spectra. The dynamical evolutions of topological boundary states are experimentally demonstrated, which further verify the existence of in-gap edge and corner states. The robustness of these edge and corner states is revealed by introducing defects and disorders into the bulk structures. Our studies provide an extended platform for realizing light manipulation and stable photonic devices.