18 results on '"Qiujing Li"'
Search Results
2. Distribution characteristics of human herpes viruses in the lower respiratory tract and their impact on 30-day mortality in community-acquired pneumonia patients
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Yadi Ding, Guiming Liu, Qiujing Li, Lingqing Zou, Jingyi Dai, and Virasakdi Chongsuvivatwong
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community-acquired pneumonia ,human herpes viruses ,metagenomic next generation sequencing ,human herpes virus 7 ,mortality ,Microbiology ,QR1-502 - Abstract
Human herpes viruses (HHVs) are commonly detected in community-acquired pneumonia (CAP) patients, particularly those with complex complications, attracting increased attention from clinical practitioners. However, the significance of detecting HHVs in bronchoalveolar lavage fluid (BALF) with CAP patients is still unclear. This study retrospectively analyzed BALF samples from 64 CAP patients at the Kunming Third People’s Hospital between August 2021 and December 2023. Metagenomic next generation sequencing (mNGS) was conducted on BALF samples during CAP onset. Multivariate Cox regression models were used to identify independent risk factors for 30-day all-cause mortality in CAP. HHVs were found in 84.4% of CAP patients, which were the most common pathogens (45.1%), followed by bacteria (30.2%) and fungi (11.5%). Bacterial-viral co-infections were most common, occurring in 39 patients. Notably, there was no significant difference in HHV presence between severe and non-severe CAP patients (EBV: P = 0.431, CMV: P = 0.825), except for HHV-7 (P = 0.025). In addition, there was no significant difference in the 30-day mortality between HHV positive and HHV negative groups (P = 0.470), as well as between the HHV-7 positive and HHV-7 negative groups (P = 0.910). However, neither HHVs nor HHV-7 was independent risk factors for 30-day mortality in CAP patients (HHVs: HR 1.171, P = 0.888; HHV-7: HR 1.947, P = 0.382). In summary, among the prevalent presence of multiple HHVs, EBV and CMV were the most prevalent in CAP patients. Patients with sCAP were more susceptible to HHV-7 than those with non-sCAP. These results provide valuable insights for clinicians in guiding appropriate interventions for CAP treatment.
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- 2024
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3. Impact of tonsillectomy on the efficacy of Alt-RAMEC/PFM treatment protocols in children with class III malocclusion and tonsillar hypertrophy: protocol for a cluster randomised controlled trial
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Fang Hua, Tingting Zhao, Xiong Chen, Hong He, Feiyang Guo, Chenxing Lv, Qiujing Li, Peter Ngan, Guoqiang Guan, and Xiuping Yang
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Medicine - Abstract
Introduction Orthodontic treatment using face mask protraction combined with an alternate rapid maxillary expansion and constriction/protraction face mask (Alt-RAMEC/PFM) protocol is effective in the early treatment of patients with class III malocclusion, but the stability of treatment outcomes represents a major concern. Previous studies have suggested that tonsillar hypertrophy can be a risk factor for class III malocclusion and tonsillectomy may prompt the normalisation of dentofacial growth. However, these studies had a low-to-moderate level of evidence. This study was designed to identify the impact of tonsillectomy before orthodontic treatment on the efficacy and stability of Alt-RAMEC/PFM protocols and the sleep quality and oral health in children with anterior crossbite and tonsillar hypertrophy.Methods and analysis This is a two-arm, parallel-group, superiority cluster randomised controlled trial, with four clinics randomly assigned to the surgery-first arm and the orthodontic-first arm in a 1:1 ratio. The Alt-RAMEC protocol involves alternate activation and deactivation of the expander’s jet screw over 6 weeks to stimulate maxillary suture distraction. Patients will be instructed to wear the PFM for a minimum of 14 hours per day. The primary outcomes are changes in Wits appraisal and the degree of maxillary advancement from baseline to the end of orthodontic treatment. Lateral cephalometric radiographs, polysomnography, Obstructive Sleep Apnoea-18 questionnaire and Oral Health Impact Profile-14 questionnaire will be traced, collected and measured. We will recruit 96 patients intofor the study. To assess differences, repeated multilevel linear mixed modelling analyses will be used.Ethics and dissemination This study has been granted ethical approval by the Ethics Committee of the School & Hospital of Stomatology, Wuhan University (approval No. 2023-D10). Written informed consent will be obtained from the participants and their guardians. The results of the trial will be disseminated through academic conferences and journal publications.Trial registration number ChiCTR2300078833.
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- 2024
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4. Phylogenetic and mutational analysis of H10N3 avian influenza A virus in China: potential threats to human health
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Jingyi Dai, Jun Zhao, Jiawei Xia, Pei Zhang, Yadi Ding, Qiujing Li, Min Hou, Xianhui Xiong, Qianqi Jian, Yanyan Liu, and Guiming Liu
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H10N3 ,avian influenza A virus ,human infection ,phylogeny analysis ,mutation ,Microbiology ,QR1-502 - Abstract
In recent years, the avian influenza virus has emerged as a significant threat to both human and public health. This study focuses on a patient infected with the H10N3 subtype of avian influenza virus, admitted to the Third People’s Hospital of Kunming City on March 6, 2024. Metagenomic RNA sequencing and polymerase chain reaction (PCR) analysis were conducted on the patient’s sputum, confirming the H10N3 infection. The patient presented severe pneumonia symptoms such as fever, expectoration, chest tightness, shortness of breath, and cough. Phylogenetic analysis of the Haemagglutinin (HA) and neuraminidase (NA) genes of the virus showed that the virus was most closely related to a case of human infection with the H10N3 subtype of avian influenza virus found in Zhejiang Province, China. Analysis of amino acid mutation sites identified four mutations potentially hazardous to human health. Consequently, this underscores the importance of continuous and vigilant monitoring of the dynamics surrounding the H10N3 subtype of avian influenza virus, utilizing advanced genomic surveillance techniques.
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- 2024
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5. Erector spinae muscle-based nomogram for predicting in-hospital mortality among older patients with severe community-acquired pneumonia
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Na Shang, Qiujing Li, Huizhen Liu, Junyu Li, and Shubin Guo
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Severe community-acquired pneumonia ,Aged ,nomogram ,Erector spinae muscle ,Mortality ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background No multivariable model incorporating erector spinae muscle (ESM) has been developed to predict clinical outcomes in older patients with severe community-acquired pneumonia (SCAP). This study aimed to construct a nomogram based on ESM to predict in-hospital mortality in patients with SCAP. Methods Patients aged ≥ 65 years with SCAP were enrolled in this prospective observational study. Least absolute selection and shrinkage operator and multivariable logistic regression analyses were used to identify risk factors for in-hospital mortality. A nomogram prediction model was constructed. The predictive performance was evaluated using the concordance index (C-index), calibration curve, net reclassification improvement (NRI), integrated discrimination improvement (IDI), and decision curve analysis. Results A total of 490 patients were included, and the in-hospital mortality rate was 36.1%. The nomogram included the following independent risk factors: mean arterial pressure, peripheral capillary oxygen saturation, Glasgow Coma Scale score (GCS), lactate, lactate dehydrogenase, blood urea nitrogen levels, and ESM cross-sectional area. Incorporating ESM into the base model with other risk factors significantly improved the C-index from 0.803 (95% confidence interval [CI], 0.761–0.845) to 0.836 (95% CI, 0.798–0.873), and these improvements were confirmed by category-free NRI and IDI. The ESM-based nomogram demonstrated a high level of discrimination, good calibration, and overall net benefits for predicting in-hospital mortality compared with the combination of confusion, urea, respiratory rate, blood pressure, and age ≥ 65 years (CURB-65), Pneumonia Severity Index (PSI), Acute Physiology and Chronic Health Evaluation II (APACHEII), and Sequential Organ Failure Assessment (SOFA). Conclusions The proposed ESM-based nomogram for predicting in-hospital mortality among older patients with SCAP may help physicians to promptly identify patients prone to adverse outcomes. Trial registration This study was registered at www.chictr.org.cn (registration number Chi CTR-2300070377).
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- 2023
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6. Prognostic and immune infiltration significance of ARID1A in TCGA molecular subtypes of gastric adenocarcinoma
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Zhenkun Zhang, Qiujing Li, Shanshan Sun, Jing Ye, Zhe Li, Zhengguo Cui, Qian Liu, Yujie Zhang, Sili Xiong, and Shukun Zhang
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ARID1A ,gastric adenocarcinoma ,immune infiltration ,prognosis ,TCGA subtype ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background AT‐rich interaction domain 1A (ARID1A) is an essential subunit of the switch/sucrose non‐fermentable chromatin remodeling complex and is considered to be a tumor suppressor. The Cancer Genome Atlas (TCGA) molecular classification has deepened our understanding of gastric cancer at the molecular level. This study explored the significance of ARID1A expression in TCGA subtypes of gastric adenocarcinoma. Methods We collected 1248 postoperative patients with gastric adenocarcinoma, constructed tissue microarrays, performed immunohistochemistry for ARID1A, and obtained correlations between ARID1A and clinicopathological variables. We then carried out the prognostic analysis of ARID1A in TCGA subtypes. Finally, we screened patients by random sampling and propensity score matching method and performed multiplex immunofluorescence to explore the effects of ARID1A on CD4, CD8, and PD‐L1 expression in TCGA subtypes. Results Seven variables independently associated with ARID1A were screened out: mismatch repair proteins, PD‐L1, T stage, differentiation status, p53, E‐cadherin, and EBER. The independent prognostic variables in the genomically stable (GS) subtype were N stage, M stage, T stage, chemotherapy, size, and ARID1A. PD‐L1 expression was higher in the ARID1A negative group than in the ARID1A positive group in all TCGA subgroups. CD4 showed higher expression in the ARID1A negative group in most subtypes, while CD8 did not show the difference in most subtypes. When ARID1A was negative, PD‐L1 expression was positively correlated with CD4/CD8 expression; while when ARID1A was positive, this correlation disappeared. Conclusions The negative expression of ARID1A occurred more frequently in the Epstein–Barr virus and microsatellite instability subtypes and was an independent adverse prognostic factor in the GS subtype. In the TCGA subtypes, ARID1A negative expression caused increased CD4 and PD‐L1 expression, whereas CD8 expression appeared independent of ARID1A. The expression of CD4/CD8 induced by ARID1A negativity was accompanied by an increase in PD‐L1 expression.
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- 2023
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7. Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma
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Zhenkun Zhang, Qiujing Li, Shanshan Sun, Zhe Li, Zheng Guo Cui, Menglan Zhang, Qian Liu, Yujie Zhang, Sili Xiong, and Shukun Zhang
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SWI/SNF ,SMARCA2 ,SMARCA4 ,Undifferentiated ,Gastric carcinoma ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The switch/sucrose nonfermentable (SWI/SNF) complex is an evolutionarily conserved chromatin remodeling complex that displays dysfunction in many tumors, especially undifferentiated carcinoma. Cancer stem cells (CSC), a special type of undifferentiated cancer cells with stem cell-like properties, play an essential role in tumor cell proliferation, invasion, and metastasis. In undifferentiated gastric carcinomas, the association of SWI/SNF complexes with clinicopathological features, CSC phenotype, and the prognosis is not fully understood. Methods We collected a cohort of 21 patients with undifferentiated/dedifferentiated gastric carcinoma. We next performed immunohistochemistry staining for the five subunits of the SWI/SNF complex (ARID1A, ARID1B, SMARCA2, SMARCA4, and SMARCB1), and four mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6), as well as other markers such as p53, PD-L1, and cancer stem cell (CSC) markers (SOX2, SALL4). Then, we investigated the correlation of SWI/SNF complex subunits with clinicopathological characters and performed prognostic analysis. Results We observed SMARCA2 loss in 12 cases (57.14%), followed by ARID1A (5 cases, 23.81%) and SMARCA4 (3 cases, 14.29%). Fourteen cases (66.67%) lost any one of the SWI/SNF complex subunits, including 3 cases with SMARCA2 and ARID1A co-loss, and 3 cases with SMARCA2 and SMARCA4 co-loss. Correlation analysis revealed that the CSC phenotype occurred more frequently in the SWI/SNF complex deficient group (P = 0.0158). Survival analysis revealed that SWI/WNF complex deficiency, undifferentiated status, CSC phenotype, and the loss of SMARCA2 and SMARCA4 resulted in worse survival. Univariate and multivariate Cox regression analyses screened out three independent factors associated with worse prognosis: undifferentiated status, SWI/SNF complex deficiency, and lymph node metastasis. Conclusions The SWI/SNF complex deficiency was more likely to result in a CSC phenotype and worse survival and was an independent prognostic factor in undifferentiated/dedifferentiated gastric carcinoma.
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- 2022
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8. Enhanced Carboxymethylcellulose Sponge for Hemostasis and Wound Repair
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Zhanjian Bi, Haifeng Teng, Qiujing Li, and Shukun Zhang
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carboxymethylcellulose ,dopamine ,carboxymethyl chitosan ,skin ,wound healing ,Technology - Abstract
Skin is the interface between human beings and the outside world. After skin injury, bleeding control and wound protection is urgently needed. In the study, the carboxymethyl cellulose/carboxymethyl chitosan-polydopamine (CMC/CMCS-PDA) sponge is prepared for skin hemostasis and repair. The self-polymerization of dopamine (DA) and cross-linking between DA and CMCS are simultaneously completed by Michael addition reaction to form CMCS-PDA under alkaline conditions. CMCS-PDA is introduced into the CMC sponge by EDC/NHS to improve the hemostasis ability and wound repair. By increasing the dosage of CMCS to get CMC/CMCS-PDA1, CMC/CMCS-PDA2, and CMC/CMCS-PDA3 sponges, and the stability of CMC/CMCS-PDA sponge is improved with the increasing addition of CMCS. Compared with a simple CMC/PDA sponge, CMC/CMCS-PDA sponge has a high hemostatic effect for its dispersion stability and CMC/CMCS-PDA2 exhibits the best hemostatic ability with proper crosslinking. At the same time, the prepared CMC/CMCS-PDA sponge has good antibacterial and antioxidant properties. Rat skin wound model showed that CMC/CMCS-PDA sponge can better promote wound repair. Therefore, CMC/CMCS-PDA sponge could be a potential wound dressing for skin hemostasis and repair.
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- 2022
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9. SMARCA2 deficiency in NSCLC: a clinicopathologic and immunohistochemical analysis of a large series from a single institution
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Shanshan Sun, Qiujing Li, Zhenkun Zhang, Sili Xiong, Yujie Zhang, Qian Liu, Zhe Li, Fujun Yang, and Shukun Zhang
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swi/snf ,smarca2 ,nsclc ,tissue microarray ,pd-l1 ,prognosis ,Public aspects of medicine ,RA1-1270 - Abstract
Background: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2) is an important ATPase catalytic subunit in the switch-sucrose nonfermenting (SWI/SNF) complex. However, its relationship with the pathological features of NSCLC and its prognosis remain unclear. Methods: We retrospectively reviewed 2390 patients with surgically resected NSCLC, constructed tissue microarrays (TMAs) and performed immunohistochemical assays. We analyzed the correlation of SAMRCA2 with clinicopathological features and evaluated its prognostic value. Results: Among 2390 NSCLC cases, the negative expression ratios of SAMRCA2, SMARCA4, ARID1A, ARID1B and INI1 were 9.3%, 1.8%, 1.2%, 0.4% and 0%, respectively. In NSCLC, male sex, T3 and T4 stage, moderate and poor differentiation, tumor ≥ 2 cm, Ki67 ≥ 15%, SOX-2 negative expression, middle lobe lesion and adenocarcinoma were relative risk factors affecting SMARCA2-negative expression. In lung adenocarcinomas, high-grade nuclei, histological morphology of acinar and papillary, solid and micropapillary and TTF-1-negative expression were relative risk factors affecting SMARCA2-negative expression. Kaplan–Meier survival analysis showed that the OS was shorter in the SMARCA2-negative group. Multivariate survival analysis revealed that SMARCA2-negative expression was an independent factor correlated with a poor prognosis in NSCLC. Conclusion: In conclusion, SMARCA2-negative expression is an independent predictor of a poor outcome of NSCLC and is a potential target for NSCLC treatment.
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- 2022
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10. Computed tomography-based body composition is associated with adverse clinical outcomes among older patients with sepsis in the emergency department
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Qiujing Li, Na Shang, Qian Gao, Li Yang, and Shubin Guo
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General Medicine - Abstract
Purpose To investigate the association between body composition and adverse clinical outcomes in older patients with sepsis in the emergency department. Methods Body composition, including the skeletal muscle area, skeletal muscle index (SMI), mean skeletal muscle density (SMD), and intramuscular fat area, was measured at the level of the third lumbar vertebra (L3) on abdominal computed tomography scans. Clinical outcomes included 90-day mortality, 90-day readmission, and discharge to long-term care. According to sex-specific cut-off values of L3 SMI and SMD, patients were divided into low SMI, low SMD, both low SMI and low SMD, and neither low SMI nor low SMD groups. Results In total, 443 patients were included, 162 (36.6%) of whom died. Lower SMI and SMD, as continuous variables, were independent risk factors for 90-day mortality (adjusted hazard ratio [HR] = 0.947 and 0.963, respectively, both p < 0.001). Cut-off values of L3 SMI and L3 SMD were 32.24 cm2/m2 and 30.01 HU for men and 28.28 cm2/m2 and 28.20 HU for women, respectively. The both low SMI and low SMD group had an increased risk of 90-day mortality (adjusted HR=3.059, p < 0.001), 90-day readmission (adjusted odds ratio [OR]=2.859, p = 0.006), and discharge to long-term care (adjusted OR = 2.814, p = 0.007). Conclusions Lower muscle mass and muscle quality, as measured by skeletal muscle index and density, were independent risk factors for mortality among older patients with sepsis in the emergency department. Furthermore, patients with both low muscle mass and quality had an increased risk of mortality, readmission, and discharge to long-term care.
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- 2023
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11. Using nafamostat mesilate anticoagulation for continuous renal replacement therapy in high bleeding risk patients: a systematic review and meta-analysis
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Yi Zhang, Xianggping Chen, Yuewen Lao, Qiujing Li, Ping Wang, Li Chen, Yiyu Zhuang, and Xiaoyan Gong
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Objectives: The purpose of this systematic review is to evaluate the safety and efficacy of nafamostat mesilate (NM) for continuous renal replacement therapy in high bleeding risk patients. Methods: We performed a comprehensive search on PubMed, Embase, CINAHL, Web of Science, the Cochrane Library, and CNIK from inception to May 1, 2022. Two reviewers independently screened, selected, and extracted data.A meta-analysis was conducted using RevMan 5.3 software. The systematic review protocol was registered. Results: 7 studies with 639 high bleeding risk patients were included for review including 4RCTs and 3 retrospective cohort studies. The anticoagulant in the control group of all included studies was anticoagulation-free. Compared with the baseline data, the activated partial thromboplastin time of the NM group was shortened at the end of observation (MD -12.16, 95% CI -23.70 to -0.62, p= 0.04). NM for CRRTsignificantly extended filter life (MD 9.65, 95% CI 5.60 to 13.71, p< 0.00001)and reduced mortality compared with anticoagulation-free treatment (RR 0.76, 95% CI 0.64 to 0.90, p= 0.002). No significant difference was observed in the incidence of bleeding complications (RR 1.16, 95% CI 0.59 to 2.26, p= 0.67) and total duration of CRRT (MD 12.65, 95% CI -6.79 to 32.09, p= 0.20) between the groups. Subgroup analysis showed the same results except for the mortality outcome. Conclusions: For patients at high bleeding risk undergoing CRRT, NM is a better anticoagulation option. More multicenter RCTs with large samples are required to validate and compare the effects of NM anticoagulants.
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- 2023
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12. Preparation of biodegradable carboxymethyl cellulose/dopamine/Ag NPs cryogel for rapid hemostasis and bacteria-infected wound repair
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Shujun Cao, Qiujing Li, Shukun Zhang, Zhuochen Liu, Xiaoyu Lv, and Jingdi Chen
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Staphylococcus aureus ,Hemostasis ,Silver ,Bacteria ,Dopamine ,Metal Nanoparticles ,General Medicine ,Biochemistry ,Hemostatics ,Anti-Bacterial Agents ,Structural Biology ,Carboxymethylcellulose Sodium ,Wound Infection ,Animals ,Molecular Biology ,Cryogels - Abstract
Massive hemorrhage caused by accident or surgery is a major factor in accidental death. In addition, bacterial infection is also an important threat after bleeding. Cryogels with interpenetrating macroporous structures pose great application prospects in rapid hemostasis and infected wound repair. In this study, cryogels with different pore size are prepared by carboxymethyl cellulose (CMC) and dopamine (DA). The CMC grafted with different DA amounts is crosslinked by free DA through oxidative polymerization at low temperatures to form cryogels with different pore sizes. And the CMC/DA-3 cryogel is chosen as the optimal group for its high porosity, suitable mechanical, and good hemostatic ability. CMC/DA-3 cryogel is loaded with silver nanoparticles (Ag NPs) to prepare hemostatic cryogel with antibacterial properties. Antibacterial tests and animal hemostasis experiments confirm that the CMC/DA-3/Ag cryogel has good antibacterial properties and can finish rapid hemostasis. In the S. aureus infection skin defect model, the wound healing is significantly improved compared with commercial gelatin sponge. In summary, the novel cryogel has great potential in rapid hemostasis and infected wound healing.
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- 2022
13. Mycoplasma pneumonia in a patient with X-linked agammaglobulinemia
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Bowen Dai, Shujuan Han, Yuanfang Shen, Zhi Li, Shouhang Chen, Zhuangzhuang Wang, Yan Yuan, Ruyu Zhang, Chenyu Wang, Jiaying Zheng, Qiujing Liang, Qingmei Wang, Yaodong Zhang, Xiaolong Zhang, Fang Wang, and Yuefei Jin
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Primary immunodeficiency ,X-linked agammaglobulinemia ,Mycoplasma pneumonia ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background X-linked agammaglobulinemia (XLA), also referred to as Bruton’s tyrosine kinase deficiency, is a rare genetic disorder that affects the immune system. We conducted genetic analysis on patients suffering from immunodeficiency by utilizing Next-Generation Sequencing techniques, as well as their closest relatives, to facilitate accurate diagnosis, offer genetic counseling services, and enhance our comprehension of XLA.
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- 2024
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14. Shape memory and antibacterial chitosan-based cryogel with hemostasis and skin wound repair
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Shujun Cao, Zhanjian Bi, Qiujing Li, Shukun Zhang, Moganavelli Singh, and Jingdi Chen
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Polymers and Plastics ,Organic Chemistry ,Materials Chemistry - Published
- 2023
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15. Clinical and epidemiological characteristics of 96 pediatric human metapneumovirus infections in Henan, China after COVID-19 pandemic: a retrospective analysis
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Wangquan Ji, Yu Chen, Shujie Han, Bowen Dai, Kang Li, Shuang Li, Zijie Li, Shouhang Chen, Yaodong Zhang, Xiaolong Zhang, Xiaolong Li, Qingmei Wang, Jiaying Zheng, Chenyu Wang, Qiujing Liang, Shujuan Han, Ruyu Zhang, Fang Wang, and Yuefei Jin
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Human metapneumovirus ,Pneumonia ,Epidemiological characteristics ,Clinical characteristics ,Coinfection ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background In the aftermath of the COVID-19 pandemic, there has been a surge in human metapneumovirus (HMPV) transmission, surpassing pre-epidemic levels. We aim to elucidate the clinical and epidemiological characteristics of HMPV infections in the post-COVID-19 pandemic era. Methods In this retrospective single-center study, participants diagnosed with laboratory confirmed HMPV infection through Targeted Next Generation Sequencing were included. The study encompassed individuals admitted to Henan Children's Hospital between April 29 and June 5, 2023. Demographic information, clinical records, and laboratory indicators were analyzed. Results Between April 29 and June 5, 2023, 96 pediatric patients were identified as infected with HMPV with a median age of 33.5 months (interquartile range, 12 ~ 48 months). The majority (87.5%) of infected children were under 5 years old. Notably, severe cases were statistically younger. Predominant symptoms included fever (81.3%) and cough (92.7%), with wheezing more prevalent in the severe group (56% vs 21.1%). Coinfection with other viruses was observed in 43 patients, with Epstein–Barr virus (EBV) (15.6%) or human rhinovirus A (HRV type A) (12.5%) being the most common. Human respiratory syncytial virus (HRSV) coinfection rate was significantly higher in the severe group (20% vs 1.4%). Bacterial coinfection occurred in 74 patients, with Haemophilus influenzae (Hin) and Streptococcus pneumoniae (SNP) being the most prevalent (52.1% and 41.7%, respectively). Severe patients demonstrated evidence of multi-organ damage. Noteworthy alterations included lower concentration of IL-12p70, decreased lymphocytes percentages, and elevated B lymphocyte percentages in severe cases, with statistical significance. Moreover, most laboratory indicators exhibited significant changes approximately 4 to 5 days after onset. Conclusions Our data systemically elucidated the clinical and epidemiological characteristics of pediatric patients with HMPV infection, which might be instructive to policy development for the prevention and control of HMPV infection and might provide important clues for future HMPV research endeavors.
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- 2024
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16. Theoretical Logic and Empirical Facts of Consumption Structure Upgrade and Domestic Value Chain Circulation under the New Development Pattern.
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Bin Liu, Chuanchuan Li, and Qiujing Li
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VALUE chains ,MARKET segmentation ,TECHNOLOGICAL innovations ,INTERNATIONAL economic integration ,ECONOMIC activity - Abstract
Under the new development pattern, this paper explores the characteristic tendencies and intergenerational changes of consumption structure upgrade (CSU) as well as the theoretical logic and empirical paradigm affecting the domestic value chain circulation. This paper constructs a region-industry decomposition framework for domestic value chain circulation based on backward demand to explore the impact of CSU on domestic value chain circulation. The results show that: first, CSU can optimize the structure of domestic value chain circulation and strengthen inter-regional value chain linkage; second, CSU promotes domestic value chain circulation through innovation drive, resource optimization and industrial coupling; finally, the domestic value chain circulation effect caused by CSU may be constrained by market segmentation, and accelerating regional economic integration across a country can help build up the main position of domestic value chain. [ABSTRACT FROM AUTHOR]
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- 2022
17. Double crosslinking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair
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Shujun Cao, Gan Xu, Qiujing Li, Shukun Zhang, Yifan Yang, and Jingdi Chen
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Mechanics of Materials ,Mechanical Engineering ,Ceramics and Composites ,Industrial and Manufacturing Engineering - Published
- 2022
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18. Oxidized bacterial cellulose reinforced nanocomposite scaffolds for bone repair
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Shujun, Cao, Qiujing, Li, Shukun, Zhang, Kaihua, Liu, Yifan, Yang, and Jingdi, Chen
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Chitosan ,Bone Regeneration ,Tissue Engineering ,Tissue Scaffolds ,Surfaces and Interfaces ,General Medicine ,Nanocomposites ,Rats ,Durapatite ,Colloid and Surface Chemistry ,Animals ,Cellulose, Oxidized ,Physical and Theoretical Chemistry ,Biotechnology - Abstract
Bone tissue engineering has been widely used in promoting the repair and regeneration of bone defects. Tissue-engineered bone scaffolds can simulate the extracellular matrix environment and induce the proliferation and differentiation of osteoblasts. The first issues to be considered when constructing bone repair scaffolds include biocompatibility, stress resistance, degradability and stability. Here, a low-cost manufacturing introduces a new bone repair composite scaffold (CS/OBC/nHAP). The scaffolds were composed of only natural derived components, including nano hydroxyapatite (nHAP) formed by in-situ crystallization of Ca
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- 2022
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