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1. RET-MAP: An International Multicenter Study on Clinicobiologic Features and Treatment Response in Patients With Lung Cancer Harboring a RET Fusion

Author

Aldea, Mihaela, Marinello, Arianna, Duruisseaux, Michael, Zrafi, Wael, Conci, Nicole, Massa, Giacomo, Metro, Giulio, Monnet, Isabelle, Gomez Iranzo, Patricia, Tabbo, Fabrizio, Bria, Emilio, Guisier, Florian, Vasseur, Damien, Lindsay, Colin R., Ponce-Aix, Santiago, Cousin, Sophie, Citarella, Fabrizio, Fallet, Vincent, Minatta, Jose Nicolas, Eisert, Anna, de Saint Basile, Hortense, Audigier-Valette, Clarisse, Mezquita, Laura, Calles, Antonio, Mountzios, Giannis, Tagliamento, Marco, Remon Masip, Jordi, Raimbourg, Judith, Terrisse, Safae, Russo, Alessandro, Cortinovis, Diego, Rochigneux, Philippe, Pinato, David James, Cortellini, Alessio, Leonce, Camille, Gazzah, Anas, Ghigna, Maria-Rosa, Ferrara, Roberto, Dall’Olio, Filippo Gustavo, Passiglia, Francesco, Ludovini, Vienna, Barlesi, Fabrice, Felip, Enriqueta, Planchard, David, and Besse, Benjamin

Published
2023
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2. A Transcriptomic-Based Tool to Predict Gemcitabine Sensitivity in Advanced Pancreatic Adenocarcinoma

Author

Bigonnet, Martin, Bongrain, Claire, Lermite, Emilie, Pessaux, Patrick, Giannone, Fabio, Chenard, Marie-Pierre, Michalak, Sophie, Nicolle, Rémy, Rubis, Marion, Poizat, Flora, Giovannini, Marc, Caillol, Fabrice, Rochigneux, Philippe, Fraunhoffer, Nicolas, Chanez, Brice, Teyssedou, Carlos, Iovanna, Juan L., Mitry, Emmanuel, and Dusetti, Nelson J.

Published
2023
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3. Immunotherapy in MSI/dMMR tumors in the perioperative setting: The IMHOTEP trial

Author

Coutzac, Clélia, Bibeau, Frederic, Ben Abdelghani, Meher, Aparicio, Thomas, Cohen, Romain, Coquan, Elodie, Dubreuil, Olivier, Evesque, Ludovic, Ghiringhelli, François, Kim, Stefano, Lesourd, Samuel, Neuzillet, Cindy, Phelip, Jean-Marc, Piessen, Guillaume, Rochigneux, Philippe, Samalin, Emmanuelle, Soularue, Emilie, Touchefeu, Yann, Tougeron, David, Zaanan, Aziz, and de la Fouchardière, Christelle

Published
2022
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5. Table S3 from CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

Author

Fattori, Stéphane, primary, Le Roy, Aude, primary, Houacine, Jemila, primary, Robert, Lucie, primary, Abes, Riad, primary, Gorvel, Laurent, primary, Granjeaud, Samuel, primary, Rouvière, Marie-Sarah, primary, Ben Amara, Amira, primary, Boucherit, Nicolas, primary, Tarpin, Carole, primary, Pakradouni, Jihane, primary, Charafe-Jauffret, Emmanuelle, primary, Houvenaeghel, Gilles, primary, Lambaudie, Eric, primary, Bertucci, François, primary, Rochigneux, Philippe, primary, Gonçalves, Anthony, primary, Foussat, Arnaud, primary, Chrétien, Anne-Sophie, primary, and Olive, Daniel, primary

Published
2023
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6. Supplementary_Materials_and_Methods_Figures_and_Figure_legends from CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

Author

Fattori, Stéphane, primary, Le Roy, Aude, primary, Houacine, Jemila, primary, Robert, Lucie, primary, Abes, Riad, primary, Gorvel, Laurent, primary, Granjeaud, Samuel, primary, Rouvière, Marie-Sarah, primary, Ben Amara, Amira, primary, Boucherit, Nicolas, primary, Tarpin, Carole, primary, Pakradouni, Jihane, primary, Charafe-Jauffret, Emmanuelle, primary, Houvenaeghel, Gilles, primary, Lambaudie, Eric, primary, Bertucci, François, primary, Rochigneux, Philippe, primary, Gonçalves, Anthony, primary, Foussat, Arnaud, primary, Chrétien, Anne-Sophie, primary, and Olive, Daniel, primary

Published
2023
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7. Data from CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

Author

Fattori, Stéphane, primary, Le Roy, Aude, primary, Houacine, Jemila, primary, Robert, Lucie, primary, Abes, Riad, primary, Gorvel, Laurent, primary, Granjeaud, Samuel, primary, Rouvière, Marie-Sarah, primary, Ben Amara, Amira, primary, Boucherit, Nicolas, primary, Tarpin, Carole, primary, Pakradouni, Jihane, primary, Charafe-Jauffret, Emmanuelle, primary, Houvenaeghel, Gilles, primary, Lambaudie, Eric, primary, Bertucci, François, primary, Rochigneux, Philippe, primary, Gonçalves, Anthony, primary, Foussat, Arnaud, primary, Chrétien, Anne-Sophie, primary, and Olive, Daniel, primary

Published
2023
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8. File_S1 from CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

Author

Fattori, Stéphane, primary, Le Roy, Aude, primary, Houacine, Jemila, primary, Robert, Lucie, primary, Abes, Riad, primary, Gorvel, Laurent, primary, Granjeaud, Samuel, primary, Rouvière, Marie-Sarah, primary, Ben Amara, Amira, primary, Boucherit, Nicolas, primary, Tarpin, Carole, primary, Pakradouni, Jihane, primary, Charafe-Jauffret, Emmanuelle, primary, Houvenaeghel, Gilles, primary, Lambaudie, Eric, primary, Bertucci, François, primary, Rochigneux, Philippe, primary, Gonçalves, Anthony, primary, Foussat, Arnaud, primary, Chrétien, Anne-Sophie, primary, and Olive, Daniel, primary

Published
2023
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9. Dysthyroidism during immune checkpoint inhibitors is associated with improved overall survival in adult cancers: data mining of 1385 electronic patient records

Author

Beaufils, Mathilde, primary, Amodru, Vincent, additional, Tejeda, Manuel, additional, Boher, Jean Marie, additional, Zemmour, Christophe, additional, Chanez, Brice, additional, Chrétien, Anne Sophie, additional, Gorvel, Laurent, additional, Gravis, Gwenaelle, additional, Bruyat, Damien, additional, Mari, Roxane, additional, Madroszyk, Anne, additional, Cuny, Thomas, additional, Gonçalves, Anthony, additional, Lisberg, Aaron E, additional, Olive, Daniel, additional, Tassy, Louis, additional, Castinetti, Frederic, additional, and Rochigneux, Philippe, additional

Published
2023
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10. Facial palsy after administration of immune checkpoint inhibitors: case report, literature review and clinical care management.

Author

Mezni, Essia, Corazza, Giovanni, Mari, Roxane, Coze, Stephanie, Charrier, Nathalie, Chanez, Brice, Chretien, Anne Sophie, and Rochigneux, Philippe

Subjects
IMMUNE checkpoint inhibitors, LITERATURE reviews, CLINICAL medicine, DRUG side effects, PERIPHERAL nervous system, FACIAL paralysis
Abstract

Neurological immune-related adverse events (irAEs) due to immune checkpoint inhibitors (ICI) are rare complications of immunotherapy, particularly dreadful for patients and clinical teams. Indeed, neurological irAEs are potentially severe and their diagnosis require prompt recognition and treatment. Additionally, the spectrum of neurological irAEs is broad, affecting either neuromuscular junction, peripheral or central nervous system. Here, we described the case of a 55-year man with metastatic melanoma, facing a brutal right peripheral cerebral palsy after his third ipilimumab/nivolumab infusion. After the case presentation, we reviewed the literature about this rare complication of immunotherapy, and described its diagnosis work-up and clinical management. [ABSTRACT FROM AUTHOR]

Published
2024
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11. CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

Author

Fattori, Stéphane, primary, Le Roy, Aude, additional, Houacine, Jemila, additional, Robert, Lucie, additional, Abes, Riad, additional, Gorvel, Laurent, additional, Granjeaud, Samuel, additional, Rouvière, Marie-Sarah, additional, Ben Amara, Amira, additional, Boucherit, Nicolas, additional, Tarpin, Carole, additional, Pakradouni, Jihane, additional, Charafe-Jauffret, Emmanuelle, additional, Houvenaeghel, Gilles, additional, Lambaudie, Eric, additional, Bertucci, François, additional, Rochigneux, Philippe, additional, Gonçalves, Anthony, additional, Foussat, Arnaud, additional, Chrétien, Anne-Sophie, additional, and Olive, Daniel, additional

Published
2023
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12. Abstract 3239: Selective depletion of regulatory T cells by ALD2510, a novel IL-2-sparing anti-CD25 antibody, synergizes with PD-1 blockade in breast and gynecologic cancers

Author

FATTORI, Stéphane, primary, Roy, Aude Le, additional, Houacine, Jemila, additional, Robert, Lucie, additional, Abes, Riad, additional, Gorvel, Laurent, additional, Granjeaud, Samuel, additional, Rouvière, Marie-Sarah, additional, Amara, Amira Ben, additional, Boucherit, Nicolas, additional, Tarpin, Carole, additional, Pakradouni, Jihane, additional, Charafe-Jauffret, Emmanuelle, additional, Barrou, Julien, additional, Houvenaeghel, Gilles, additional, Lambaudie, Eric, additional, Bertucci, François, additional, Rochigneux, Philippe, additional, Gonçalves, Anthony, additional, Foussat, Arnaud, additional, Chrétien, Anne-Sophie, additional, and Olive, Daniel, additional

Published
2023
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13. A Transcriptomic-Based Tool to Predict Gemcitabine Sensitivity in Advanced Pancreatic Adenocarcinoma

Author

Fraunhoffer, Nicolas, primary, Chanez, Brice, additional, Teyssedou, Carlos, additional, Iovanna, Juan L., additional, Mitry, Emmanuel, additional, Dusetti, Nelson J., additional, Bigonnet, Martin, additional, Bongrain, Claire, additional, Lermite, Emilie, additional, Pessaux, Patrick, additional, Giannone, Fabio, additional, Chenard, Marie-Pierre, additional, Michalak, Sophie, additional, Nicolle, Rémy, additional, Rubis, Marion, additional, Poizat, Flora, additional, Giovannini, Marc, additional, Caillol, Fabrice, additional, and Rochigneux, Philippe, additional

Published
2023
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14. Mass cytometry reveals classical monocytes, NK cells and ICOS(+) CD4(+) T cells associated with pembrolizumab efficacy in lung cancer patients

Author

Rochigneux, Philippe, Lisberg, Aaron, Garcia, Alejandro, Granjeaud, Samuel, Madroszyk, Anne, Fattori, Stephane, Gonçalves, Anthony, Devillier, Raynier, Maby, Pauline, Salem, Nassim, Gorvel, Laurent, Chanez, Brice, Gukasyan, Jaklin, Carroll, James, Goldman, Jonathan, Chretien, Anne Sophie, Olive, Daniel, and Garon, Edward B.

Subjects
CD4-Positive T-Lymphocytes, Killer Cells, Natural, Inducible T-Cell Co-Stimulator Protein, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Humans, Article, Monocytes
Abstract

PURPOSE: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of non-small cell lung cancer (NSCLC), but predictive biomarkers of their efficacy are imperfect. The primary objective is to evaluate circulating immune predictors of pembrolizumab efficacy in advanced NSCLC patients. EXPERIMENTAL DESIGN: We use high-dimensional mass cytometry (CyTOF) in baseline blood samples of advanced NSCLC patients treated with pembrolizumab. CyTOF data are analyzed by machine-learning algorithms (Citrus, tSNE) and confirmed by manual gating followed by principal component analysis (BGA). RESULTS: We analyze 27 patients from the seminal KEYNOTE-001 study (median follow-up of 60.6 months). We demonstrate that blood baseline frequencies of classical monocytes, NK cells and ICOS(+) CD4(+) T cells are significantly associated with improved objective response rates, progression-free survival and overall survival (OS). Additionally, we report that a baseline immune peripheral score combining these three populations strongly predicts pembrolizumab efficacy (OS: HR=0.25 95%CI=0.12–0.51, p

Published
2022

15. Impact of fiducial markers placement on the delineation of target volumes in radiation therapy for oesophageal cancer: FIDUCOR study

Author

Rochigneux, Philippe, primary, Tyran, Marguerite, additional, Autret, Aurélie, additional, Lopez Almeida, Leonor, additional, Guiramand, Jérôme, additional, Ferre, Marjorie, additional, Chanez, Brice, additional, Mitry, Emmanuel, additional, Ratone, Jean Philippe, additional, Giovannini, Marc, additional, Tallet, Agnès, additional, Moureau-Zabotto, Laurence, additional, and Caillol, Fabrice, additional

Published
2022
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17. Mass Cytometry Reveals Classical Monocytes, NK Cells, and ICOS+ CD4+ T Cells Associated with Pembrolizumab Efficacy in Patients with Lung Cancer

Author

Rochigneux, Philippe, primary, Lisberg, Aaron, additional, Garcia, Alejandro, additional, Granjeaud, Samuel, additional, Madroszyk, Anne, additional, Fattori, Stéphane, additional, Gonçalves, Anthony, additional, Devillier, Raynier, additional, Maby, Pauline, additional, Salem, Nassim, additional, Gorvel, Laurent, additional, Chanez, Brice, additional, Gukasyan, Jaklin, additional, Carroll, James, additional, Goldman, Jonathan, additional, Chretien, Anne Sophie, additional, Olive, Daniel, additional, and Garon, Edward B., additional

Published
2022
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18. Do we need postoperative chemotherapy after preoperative FOLFIRINOX in resected borderline or locally advanced pancreatic cancer? A retrospective analysis.

Author

Mari, Roxane, primary, Garnier, Jonathan, additional, Lapeyre-Prost, Alexandra, additional, Rochigneux, Philippe, additional, Dahel, Yanis, additional, Caillol, Fabrice, additional, Giovannini, Marc, additional, Turrini, Olivier, additional, Mitry, Emmanuel, additional, and Chanez, Brice, additional

Published
2022
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19. Dysthyroidism during immune checkpoint inhibitors is associated with improved overall survival in solid tumors: Data-mining of 1,382 electronic patient records.

Author

Beaufils, Mathilde, primary, Amodru, Vincent, additional, Tejeda, Manuel, additional, Chanez, Brice, additional, Chretien, Anne Sophie, additional, Gravis, Gwenaelle, additional, Madroszyk, Anne, additional, Goncalves, Anthony, additional, Lisberg, Aaron E., additional, Olive, Daniel, additional, Tassy, Louis, additional, Castinetti, Frédéric, additional, and Rochigneux, Philippe, additional

Published
2022
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21. Immunotherapy for localized dMMR/MSI tumors: First interim analysis of the IMHOTEP trial.

Author

De La Fouchardiere, Christelle, Zaanan, Aziz, Cohen, Romain, Le Sourd, Samuel, Tougeron, David, Soularue, Emilie, Dubreuil, Olivier, Willet, Nicolas, Samalin, Emmanuelle, Piessen, Guillaume, Hautefeuille, Vincent, Jary, Marine, Ben Abdelghani, Meher, Evesque, Ludovic, Rochigneux, Philippe, Blanc, Ellen, De Montfort, Aymeric, Bibeau, Frédéric, and Coutzac, Clélia

Published
2023
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22. Impact of fiducial markers placement on the delineation of target volumes in radiation therapy for oesophageal cancer: FIDUCOR study

Author

Philippe Rochigneux, Marguerite Tyran, Aurélie Autret, Leonor Lopez Almeida, Jérôme Guiramand, Marjorie Ferre, Brice Chanez, Emmanuel Mitry, Jean Philippe Ratone, Marc Giovannini, Agnès Tallet, Laurence Moureau-Zabotto, Fabrice Caillol, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), ROCHIGNEUX, Philippe, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
fiducial markers (FMs), [SDV] Life Sciences [q-bio], oesophageal cancer, Cancer Research, radiation therapy (radiotherapy), Oncology, endoscopic ultrasound, [SDV]Life Sciences [q-bio], target volumes
Abstract

PurposeThis prospective monocentric phase II study (FIDUCOR-study, NCT02526134) aimed to assess the impact of fiducial markers (FMs) implantation on conformal chemo-radiation therapy (CRT) planning in oesophageal carcinoma (EC) patients.Methods/materialsFifteen EC patients were enrolled in the study. Each patient underwent two simulation CT-scans before (CT1) and after (CT2) FMs implantation, in the same position. FMs (3 mm length gold markers, preloaded in a 22G needle) were implanted after sedation, under endoscopic ultrasound (EUS) and X-Ray guidance, and were placed at the tumor’s extremities, and in the visible lymph nodes. Target delineation and treatment plan were both performed first on CT1 with the assistance of diagnosis CT, gastroscopy and EUS details, and second on CT2 using FMs and CT-data. The value of FMs implantation was assessed by the difference of growth-tumor-volume (GTV) and clinical-target-volume (CTV) between CT1-based and CT2-based delineation. A significant difference was defined as a ≥5 mm-difference on axial(x) or coronal(y) slices, a ≥10mm-difference on sagittal slices, or a ≥20%-difference in GTV. The impact on dose distribution in organs at risk (OAR) (lung, heart, liver) was also studied.ResultsBetween 09/2014 and 12/2015, 15 patients could achieve fiducial procedures, without any complication. One FM migration occurred. We observed a significant modification of the GTV-dimension in 100% of the cases (15/15, 95%CI: [78.2;100.0]), mainly due to a difference in sagittal dimension with a mean variation of 11.2 mm and a difference> 10 mm for 8/15 patients (53.3%). One patient had a significant isocenter displacement as high as 20 mm. The oesophagus tumor was not seen on the CT-scan in one patient due to its small size. One patient had a distant lymph node metastasis not visible on CT-scan. We observed no significant impact on OAR distribution.ConclusionIn our study, FMs-implantation under EUS had a positive impact on accurate volume definition in EC-patients (modification of GTV in 15/15 patients). Close cooperation between gastroenterologist and radiation oncologist has the potential to improve local treatment of oesophageal carcinoma.

Published
2022
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23. Patients' psychosocial attributes and aggressiveness of cancer treatments near the end of life.

Author

Restivo L, Rochigneux P, Bouhnik AD, Arciszewski T, Bourmaud A, Capodano G, Ducoulombier A, Mancini J, Duffaud F, Gonçalves A, Apostolidis T, and Proux A

Abstract

Background: While the use of chemotherapy near the end of life (EOL) has been identified as a relevant criterion for assessing quality of cancer care and has been estimated as non-beneficial, a trend of aggressiveness in cancer care during the last period of life remains. Both patients' sociodemographic characteristics and physicians' practice setting are associated with this use. The role of patients' psychosocial characteristics has however been understudied. The objectives were to study oncologists' intention to recommend chemotherapy or therapeutic abstention in an EOL patient's case and to examine the factors associated with this decision., Methods: A clinical vignette-based questionnaire survey was conducted. While the case presented to the participating oncologists of a patient with EGFR-mutated lung cancer, progressing after osimertinib, ECOG 3, with leptomeningeal disease (N = 146), was strictly equivalent in terms of medical aspects and age, 4 patients' non-medical characteristics were manipulated: gender, marital status, parenthood, and psychosocial characteristics ("nice" patients, patients "making strong demands," or control patients)., Results: 77.4% of the oncologists surveyed stated that they would recommend chemotherapy in this situation. Only scenarios with nice patients or patients making strong demands were associated with less recommendation of chemotherapy (70.8% for the nice/making strong demands scenarios together vs 87.7%, for the control scenario P = .017). Medical oncologists with previous experience of similar cases were also less keen to recommend chemotherapy (73% vs 100%, P = .007). Of the 76.7% of respondents declaring that they would think of other therapeutic options, 49.1% mentioned "other treatments" without mentioning palliative care., Conclusion: Developing physicians' awareness of the psychosocial aspects at stake in their medical decisions in these sensitive situations may improve EOL care., (© The Author(s) 2024. Published by Oxford University Press.)

Published
2024
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