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Entrepreneurial education as a scientific field can be regarded as an emerging and growing area of research. In this study we pay particular attention to the community of scholars involved in entrepreneurial education. The aim of the paper is to explore how scholars within the field have integrated into larger scholarly communities. Based on a unique database and Web-based responses from 313 entrepreneurial education scholars, we demonstrate that scholars within the field exhibit great variety in their scientific outlooks and appreciation of communication systems. However, we find that the field consists of four scholarly communities characterized by a specific combination of scholarly inspirations, favorite meeting places, and publication channels, of which three clusters are anchored in the field of entrepreneurship, and only one cluster shows a strong entrepreneurial education research identity. Finally, the results indicate a low consolidation across the scholarly communities, which highlights the need for reflections on how the field can achieve increased integration and cohesion in the future. [ABSTRACT FROM AUTHOR]

Interleukin-22 (IL-22) plays a role in epithelial barrier function and repair, and may provide benefits in conditions like inflammatory bowel disease. However, limited human data are available to assess the clinical effect of IL-22 administration. This study used a human intestinal cell line to identify an IL-22-dependent gene signature that could serve as a pharmacodynamic biomarker for IL-22 therapy. The response to IL-22Fc (UTTR1147A, an Fc-stabilized version of IL-22) was assessed in HT-29 cells by microarray, and the selected responsive genes were confirmed by qPCR. HT-29 cells demonstrated dose-dependent increases in STAT3 phosphorylation and multiple gene expression changes in response to UTTR1147A. Genes were selected that were upregulated by UTTR1147A, but to a lesser extent by IL-6, which also signals via STAT3. IL-1R1 was highly upregulated by UTTR1147A, and differential gene expression patterns were observed in response to IL-22Fc in the presence of IL-1β. An IL-22-dependent gene signature was identified that could serve as a pharmacodynamic biomarker in intestinal biopsies to support the clinical development of an IL-22 therapeutic. The differential gene expression pattern in the presence of IL-1β suggests that an inflammatory cytokine milieu in the disease setting could influence the clinical responses to IL-22. [ABSTRACT FROM AUTHOR]