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Your search keyword '"Redell, Michele S."' showing total 15 results
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15 results on '"Redell, Michele S."'

2. Addressing a Pre-Clinical Pipeline Gap: Development of the Pediatric Acute Myeloid Leukemia Patient-Derived Xenograft Program at Texas Children’s Hospital at Baylor College of Medicine

Author

Stevens, Alexandra M., primary, Terrell, Maci, additional, Rashid, Raushan, additional, Fisher, Kevin E., additional, Marcogliese, Andrea N., additional, Gaikwad, Amos, additional, Rao, Pulivarthi, additional, Vrana, Chelsea, additional, Krueger, Michael, additional, Loken, Michael, additional, Menssen, Andrew J., additional, Cook, Jacqueline A., additional, Keogh, Noah, additional, Alozie, Michelle, additional, Oviedo, Hailey, additional, Gonzalez, Alan K., additional, Ilangovan, Tamilini, additional, Kim, Julia, additional, Sandhu, Sohani, additional, and Redell, Michele S., additional

Published
2024
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5. Repurposing Atovaquone as a Therapeutic against Acute Myeloid Leukemia (AML): Combination with Conventional Chemotherapy Is Feasible and Well Tolerated

Author

Stevens, Alexandra McLean, primary, Schafer, Eric S., additional, Li, Minhua, additional, Terrell, Maci, additional, Rashid, Raushan, additional, Paek, Hana, additional, Bernhardt, Melanie B., additional, Weisnicht, Allison, additional, Smith, Wesley T., additional, Keogh, Noah J., additional, Alozie, Michelle C., additional, Oviedo, Hailey H., additional, Gonzalez, Alan K., additional, Ilangovan, Tamilini, additional, Mangubat-Medina, Alicia, additional, Wang, Haopei, additional, Jo, Eunji, additional, Rabik, Cara A., additional, Bocchini, Claire, additional, Hilsenbeck, Susan, additional, Ball, Zachary T., additional, Cooper, Todd M., additional, and Redell, Michele S., additional

Published
2023
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7. Development of a Pediatric AML Patient Derived Xenograft Program

Author

Stevens, Alexandra McLean, primary, Terrell, Maci, additional, Rashid, Raushan, additional, Munoz, Jaime Omar, additional, Gonzalez, Alan K, additional, Oviedo, Hailey H, additional, Ilangovan, Tamilini, additional, Alozie, Michelle C, additional, Krueger, Michael, additional, Fisher, Kevin E., additional, and Redell, Michele S., additional

Published
2022
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10. Abstract 3479: UBTF tandem duplications (UBTF-TD) in childhood AML: Enrichment in FLT3-ITD and association with clinical outcome

Author

Robinson, Leila, primary, Leonti, Amanda, additional, Alonzo, Todd A., additional, Wang, Yi-Cheng, additional, Redell, Michele S., additional, Ries, Rhonda E., additional, Smith, Jenny L., additional, Hylkema, Tiffany A., additional, Le, Quy, additional, Kolb, E Anders, additional, Aplenc, Richard, additional, Ma, Xiaotu, additional, Klco, Jeffrey, additional, Tarlock, Katherine, additional, and Meshinchi, Soheil, additional

Published
2022
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11. IL-10 and TNFα are associated with decreased survival in low-risk pediatric acute myeloid leukemia; a children's oncology group report.

Author

Stevens, Alexandra M., Horton, Terzah M., Glasser, Chana L., Gerbing, Robert B., Aplenc, Richard, Alonzo, Todd A., and Redell, Michele S.

Subjects
ACUTE myeloid leukemia, INTERLEUKIN-10, PROGNOSIS, BLOOD plasma, ONCOLOGY
Abstract

Pediatric acute myeloid leukemia (AML) is a devastating disease with a high risk of relapse. Current risk classification designates patients as high or low risk (LR) based on molecular features and therapy response. However, 30% of LR patients still suffer relapse, indicating a need for improvement in risk stratification. Cytokine levels, such as IL-6 and IL-10, have been shown to be prognostic in adult AML but have not been well studied in children. Previously, we reported elevated IL-6 levels in pediatric AML bone marrow to be associated with inferior prognosis. Here, we expanded our investigation to assess cytokine levels in diagnostic peripheral blood plasma (PBP) of pediatric AML patients and determined correlation with outcome. Diagnostic PBP was obtained from 80 patients with LR AML enrolled on the Children's Oncology Group AAML1031 study and normal PBP from 11 controls. Cytokine levels were measured and correlation with clinical outcome was assessed. IL-6, TNFα, MIP-3a, and IL-1β were significantly higher in AML patients versus controls when corrected by the Bonferroni method. Furthermore, elevated TNFα and IL-10 were significantly associated with inferior outcomes. Our data demonstrate that in diagnostic PBP of LR pediatric AML patients, certain cytokine levels are elevated as compared to healthy controls and that elevated TNFα and IL-10 are associated with inferior outcomes, supporting the idea that an abnormal inflammatory state may predict poor outcomes. Studies are needed to determine the mechanisms by which these cytokines impact survival, and to further evaluate their use as prognostic biomarkers in pediatric AML. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Author

Youn, Minyoung, primary, Smith, Stephanie M., additional, Lee, Alex Gia, additional, Chae, Hee-Don, additional, Spiteri, Elizabeth, additional, Erdmann, Jason, additional, Galperin, Ilana, additional, Jones, Lara Murphy, additional, Donato, Michele, additional, Abidi, Parveen, additional, Bittencourt, Henrique, additional, Lacayo, Norman, additional, Dahl, Gary, additional, Aftandilian, Catherine, additional, Davis, Kara L., additional, Matthews, Jairo A., additional, Kornblau, Steven M., additional, Huang, Min, additional, Sumarsono, Nathan, additional, Redell, Michele S., additional, Fu, Cecilia H., additional, Chen, I-Ming, additional, Alonzo, Todd A., additional, Eklund, Elizabeth, additional, Gotlib, Jason, additional, Khatri, Purvesh, additional, Sweet-Cordero, E. Alejandro, additional, Hijiya, Nobuko, additional, and Sakamoto, Kathleen M., additional

Published
2021
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14. Europeanpediatric Acute Leukemia (EuPAL) Registry

Author

Majstrowicz, Katarzyna, Waack, Katharina, Antoniou, Evangelia, Niktoreh, Naghmeh, Nichols, Gwen, Di Laurenzio, Laura, Redell, Michele S., Cooper, Todd, Kolb, E. Anders, Tasian, Sarah K., Locatelli, Franco, Zwaan, C. Michel, and Reinhardt, Dirk

Published
2023
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