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Abstract Carbapenem-resistant Klebsiella pneumoniae (CRKp) infections continue to be an important cause of mortality. In this retrospective study, the effect of carbapenem or colistin resistance on mortality in Klebsiella pneumoniae bacteremia and combined meropenem + colistin administration in CRKp bacteremia was evaluated. In addition to that, a mathematical model is applied to explore the relationships between the resistance and mortality. A total of 139 adult patients diagnosed with K. pneumoniae bacteremia(73 carbapenem sensitive and 66 carbapenem resistant) between 01/01/2000 and 31/07/2019 were included in the study. The 30-day mortality in entire cohort were 19.4%. 30-day mortality was significantly higher in the carbapenem resistant-colistin sensitive group and in the carbapenem resistant-colistin resistant group compared to the carbapenem susceptible group. Meropenem + colistin combination was administered to 37 (95%) of carbapenem resistant–colistin sensitive (n = 39) and 25 (93%) of carbapenem resistant–colistin resistant patients(n = 27). Notably, mortality was not significantly affected regardless of whether CRKp was colistin sensitive and whether a high dose and prolonged infusion of meropenem was administered. Mortality is higher in carbapenem resistant Klebsiella pneumoniae bacteremia compared to carbapenem susceptible group. In cases of combined meropenem and colistin administration, high dose and prolonged infusion of meropenem is not superior to standard dose and infusion in both carbapenem resistant–colistin sensitive and carbapenem resistant–colistin resistant K. pneumoniae bacteremia.

Objective:Intensive care unit (ICU) readmission is a common and unwanted situation. Mortality rates, length of stay in ICU and treatment expenses are also higher in readmitted patients. This study aimed to examine the hospital/ICU readmission rates and risk factors among patients discharged from the ICU.Materials and Methods:Patients older than 18 years who were hospitalised in the ICU between January 1, 2012 and October 31, 2016 and were re-admitted to the hospital/ICU within 30 days after discharge were retrospectively analysed.Results:A total of 510 patients met the inclusion criteria, of whom 91 (17.84%) patients were readmitted to the ICU. The average age was higher (p=0.002) among the readmitted patients. The acute physiology and chronic health evaluation-II and sequential organ failure assessment scores at admission and discharge, stability and workload index for transfer (SWIFT) scores at discharge and comorbid disease rates were higher among readmitted patients (p