6 results on '"Rivas-Jeremías, Inmaculada"'
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2. Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people
- Author
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Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Consejo Superior de Investigaciones Científicas (España), Vitallé, Joana, Pérez-Gómez, Alberto, Ostos, Francisco José, Gasca-Capote, María del Carmen, Jiménez-León, María Reyes, Bachiller, Sara, Rivas-Jeremías, Inmaculada, Silva-Sánchez, María del Mar, Ruiz-Mateos, Anabel, Martín-Sánchez, María Ángeles, López-Cortés, Luis F., Rafii-El-Idrissi Benhnia, Mohamed, Ruiz-Mateos, Ezequiel, Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Consejo Superior de Investigaciones Científicas (España), Vitallé, Joana, Pérez-Gómez, Alberto, Ostos, Francisco José, Gasca-Capote, María del Carmen, Jiménez-León, María Reyes, Bachiller, Sara, Rivas-Jeremías, Inmaculada, Silva-Sánchez, María del Mar, Ruiz-Mateos, Anabel, Martín-Sánchez, María Ángeles, López-Cortés, Luis F., Rafii-El-Idrissi Benhnia, Mohamed, and Ruiz-Mateos, Ezequiel
- Abstract
The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging was associated with a lower anti–RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2–specific T cell response. The dramatic decrease in thymic function in people > 60 years, which fueled alteration in T cell homeostasis, and their lower CD161+ T cell levels were associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC homing, activation, and TLR-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.
- Published
- 2022
3. Innate and adaptive immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in elderly people
- Author
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Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Consejo Superior de Investigaciones Científicas (España), Vitallé, Joana, Pérez-Gómez, Alberto, Ostos, Francisco José, Gasca-Capote, María del Carmen, Jiménez-León, María Reyes, Bachiller, Sara, Rivas-Jeremías, Inmaculada, Silva-Sánchez, María del Mar, Ruiz-Mateos, Anabel, López-Cortés, Luis F., Rafii-El-Idrissi Benhnia, Mohamed, Ruiz-Mateos, Ezequiel, Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Consejo Superior de Investigaciones Científicas (España), Vitallé, Joana, Pérez-Gómez, Alberto, Ostos, Francisco José, Gasca-Capote, María del Carmen, Jiménez-León, María Reyes, Bachiller, Sara, Rivas-Jeremías, Inmaculada, Silva-Sánchez, María del Mar, Ruiz-Mateos, Anabel, López-Cortés, Luis F., Rafii-El-Idrissi Benhnia, Mohamed, and Ruiz-Mateos, Ezequiel
- Abstract
The immune factors associated with impaired SARS-CoV-2 vaccine response in the elderly are mostly unknown. We studied old and young people vaccinated with SARS-CoV-2 BNT162b2 mRNA before and after the first and second dose. Aging was associated with a lower anti-RBD IgG levels and a decreased magnitude and polyfunctionality of SARS-CoV-2 specific T cell response. The dramatic decrease in thymic function in the elderly, which fueled alteration in T cell homeostasis, and lower CD161+ T cell levels were associated with decreased T cell response two months after vaccination. Additionally, a deficient dendritic cell (DC) homing, activation and Toll like receptor (TLR)-mediated function, along with a proinflammatory functional profile in monocytes, were observed in the elderly, which was also related to lower specific T cell response after vaccination. These findings might be relevant for the improvement of the current vaccination strategies and for the development of new vaccine prototypes.
- Published
- 2022
4. Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response
- Author
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Pérez-Gómez, Alberto, Gasca-Capote, María del Carmen, Vitallé, Joana, Ostos, Francisco José, Serna, Ana, Trujillo-Rodríguez, María, Muñoz-Muela, Esperanza, Giráldez-Pérez, Teresa, Praena-Segovia, Julia, Navarro-Amuedo, María Dolores, Paniagua-García, María, García-Gutiérrez, Manuel, Aguilar Guisado, Manuela, Rivas-Jeremías, Inmaculada, Jiménez-León, María Reyes, Bachiller, Sara, Fernández-Villar, Alberto, Pérez-González, Alexandre, Gutiérrez-Valencia, Alicia, Rafii-El-Idrissi Benhnia, Mohamed, Weiskopf, Daniela, Sette, Alessandro, López-Cortés, Luis F., Poveda, Eva, Ruiz-Mateos, Ezequiel, Virgen del Rocío Hospital COVID-19 Working Team, COHVID-GS Working Team, National Institutes of Health (US), European Commission, Junta de Andalucía, Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Red Española de Investigación en SIDA, Pérez-Gómez, Alberto [0000-0002-3644-2914], Vitallé, Joana [0000-0002-5292-1851], Ostos, Francisco José [0000-0001-6583-6974], Bachiller, Sara [0000-0002-9000-3787], Pérez-González, Alexandre [0000-0003-4836-6768], Gutiérrez-Valencia, Alicia [0000-0003-3445-1574], Ruiz-Mateos, Ezequiel [0000-0001-6747-7813], Pérez-Gómez, Alberto, Vitallé, Joana, Ostos, Francisco José, Bachiller, Sara, Pérez-González, Alexandre, Gutiérrez-Valencia, Alicia, and Ruiz-Mateos, Ezequiel
- Subjects
SARS-CoV-2 ,Endemic coronaviruses ,IL-2 ,T-Lymphocytes ,endemic coronaviruses ,nucleocapsid ,Medicine (miscellaneous) ,COVID-19 ,Spike ,Severity of Illness Index ,polyfunctionality ,T-cell response ,Immunoglobulin G ,Molecular Medicine ,Humans ,Interleukin-2 ,Nucleocapsid ,Immunologic Memory ,Polyfunctionality - Abstract
SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors’ samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies., NIH (contract to AS, DW), Grant/AwardNumber: 75N9301900065; “Contratación de Personal Investigador Doctor”supported by the European Social Fund and Junta de Andalucía (PAIDIDOCTOR- Convocatoria 2019-2020 toFJO, SB); Instituto de Salud Carlos III,Fondos FEDER. ERM was supported bythe Spanish Research Council (CSIC);Consejería de Transformación Económica, Industria, Conocimiento y Universidades Junta de Andalucía (research project to ERM), Grant/AwardNumber: CV20-85418; Red Temática de Investigación Cooperativa en SIDA, whichis included in the Acción Estratégica en Salud, Plan Nacional de InvestigaciónCientífica, Desarrollo e Innovación Tecnológica, 2008 to 2011 and 2013 to 2016,Grant/Award Numbers: RD16/0025/0020,RD16/0025/0026; Consejeria de Salud Junta de Andalucia (Research contract toJV), Grant/Award Number:RH-0037-2020; Instituto de Salud CarlosIII (PI19/01127 to ERM, CP19/00159 toAGV, FI17/00186 to MRJL, FI19/00083 toCGC, CM20/00243 to APG andCOV20/00698 to support COHVID-GS)
- Published
- 2022
5. Innate and adaptive immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in elderly people
- Author
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Vitallé, Joana, primary, Pérez-Gómez, Alberto, additional, Ostos, Francisco José, additional, Gasca-Capote, Carmen, additional, Jiménez-León, María Reyes, additional, Bachiller, Sara, additional, Rivas-Jeremías, Inmaculada, additional, del Mar Silva-Sánchez, Maria, additional, Ruiz-Mateos, Anabel, additional, López-Cortes, Luis Fernando, additional, Rafii-El-Idrissi Benhnia, Mohammed, additional, and Ruiz-Mateos, Ezequiel, additional
- Published
- 2022
- Full Text
- View/download PDF
6. Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response.
- Author
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Pérez‐Gómez, Alberto, Gasca‐Capote, Carmen, Vitallé, Joana, Ostos, Francisco J., Serna‐Gallego, Ana, Trujillo‐Rodríguez, María, Muñoz‐Muela, Esperanza, Giráldez‐Pérez, Teresa, Praena‐Segovia, Julia, Navarro‐Amuedo, María D., Paniagua‐García, María, García‐Gutiérrez, Manuel, Aguilar‐Guisado, Manuela, Rivas‐Jeremías, Inmaculada, Jiménez‐León, María Reyes, Bachiller, Sara, Fernández‐Villar, Alberto, Pérez‐González, Alexandre, Gutiérrez‐Valencia, Alicia, and Rafii‐El‐Idrissi Benhnia, Mohammed
- Subjects
IMMUNOLOGIC memory ,T cells ,COVID-19 ,SARS-CoV-2 ,POLYHYDRAMNIOS ,ANTIBODY formation ,PERFORINS - Abstract
SARS‐CoV‐2 specific T‐cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS‐CoV‐2 specific T‐cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T‐cell polyfunctionality biased to IL‐2 production and inversely correlated with anti‐S IgG levels, combinations only including IFN‐γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non‐hospitalised and previously hospitalised patients presented robust anti‐S IgG levels and SARS‐CoV‐2 specific T‐cell response. In addition, only previously hospitalised patients showed a T‐cell exhaustion profile. Finally, combinations including IL‐2 in response to S protein of endemic coronaviruses were the ones associated with SARS‐CoV‐2 S‐specific T‐cell response in pre‐COVID‐19 healthy donors' samples. These results could have implications for protective immunity against SARS‐CoV‐2 and recurrent COVID‐19 and may help for the design of new prototypes and boosting vaccine strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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