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Abstract Background The therapeutic role and prognostic relevance of lymphadenectomy in mast cell tumor (MCT) has historically been evaluated on regional rather than sentinel lymph nodes. Hypothesis/Objectives To update information about the association of histological nodal (HN) classes with clinical outcome in dogs with MCT after tumor excision and extirpation of normal‐sized sentinel nodes (SLN) guided by radiopharmaceutical. Animals Ninety‐four dogs with histologically‐confirmed treatment‐naïve MCT (71 cutaneous, 22 subcutaneous and 1 conjunctival MCT) were included if without: distant metastases, lymphadenomegaly, concurrent mixed cutaneous, and subcutaneous MCT. Methods This was a monoistitutional cohort study. Tumors characteristics were retrieved and SLNs were classified according to Weishaar's system. Incidence of MCT‐related events (local, nodal, distant relapse), de novo MCT or other tumors and death (MCT‐related and non‐MCT‐related), were recorded. Incidence curves were compared among the HN classes. Results Twenty‐seven dogs had HN0, 19 HN1, 37 HN2, and 11 HN3 SLN. Thirteen (2 HN0, 4 HN2, and 7 HN3) received adjuvant chemotherapies. Kiupel high grade, increasing number of SLN and lymphocentrums were associated with higher HN classes. Five dogs died for MCT‐related causes: 1 low‐grade (HN0) and 1 subcutaneous (HN3) had a local relapse, 2 high‐grade had distant relapse (HN3‐HN0) and 1 dog developed disease progression from a de novo subcutaneous MCT. No nodal relapse was registered. Fourteen dogs developed de novo MCTs. Conclusion/Discussion Low grade/low‐risk MCT with nonpalpable and normal sized SLN have a favorable outcome independently from the HN. Result should be considered strictly related to the successful SLN detection guided pre‐ and intraoperative by radiopharmaceutical markers.

In 1934, the American writer Roger Shaw stated that “the functioning of the NRA (National Recovery Administration) is clearly an American-style adaptation of the Italian corporate state”. Mussolini himself proudly recognised the mark of fascism in the New Deal overseas. The purpose of this paper, however, is not a historical-ideological comparison. Indeed, recent work has shown that rather than following fascism, the New Deal shows the entry of global tendencies into American politics and that the NRA’s precedent was the War Industries Board of 1917 rather than Alfredo Rocco and Carlo Costamagna’s Labour Charter. It is also now clear that fascist corporatism was one of those national experiments that enjoyed transnational and Atlantic appeal and circulation. Instead, the paper will focus on these main global tendencies, the emergence of plan thinking, and what we see as the red thread that holds together experiments in reforming and restructuring capitalism. Such experiments are varied and and not confined to the history of totalitarianism and the rise of authoritarian regimes. Therefore, the essay analyses how, with what weight and effects, plan thinking played a part in turning the fascist corporate state and the New Deal into alternatives to Soviet planning that threatened to be the only real alternative to capitalism.

The 1960s and 1970s constituted a fundamental turning point in US democracy marked by the apogee of liberalism and its crisis. In this context, one of the best known American economists, John Kenneth Galbraith, observes how technology, its constant advancement, transforms the relationship between state and market and redefines the role of institutions in society. His critique of the technostructure of the corporation, as a form of totalitarian planning that opposes and dominates the market, is aimed at revealing the project of social governance that it conceals. In his trilogy devoted to the new industrial state and what he calls the «affluent society», a new conceptualisation of social power and the possibility of re-establishing public authority over it emerges.

In his novel, Machines Like Me (2019), Ian McEwan offers an interesting example of “alternate history” while dealing with crucial ethical issues connected with the development of Artificial Intelligence. Instead of setting his story in the future, the author chooses to set it in the past, but he radically changes the contours of the latter. Hence, the England of the early 1980s is turned into a technologically advanced society, well ahead of the scientific progress of the early 21st century. Thus, the future casts its light on the past in what appears as a typically postmodernist mélange: besides mingling genres (from speculative fiction to uchronia), McEwan also performs an intriguing hybridization of fact and fiction. The paper intends to explore the rich historical dimension of the novel, which betrays the author’s interest in the reflection on history and on its narrativization – as well as its manipulation and/or contamination – within the literary text.

For bell hooks, the relationship between teaching and learning is historical. What the academy is from the perspective of a concept of knowledge that is historically located within differences of race, class and gender, what hierarchies it reaffirms and what spaces of thought it opens is the focus of hooks' reflection on education. Faced with the corporatization of the US university, the institutionalization of women's and black studies, hooks puts forward a radical vision of education, which considers teaching a transgression of any “bureaucratization of the mind:” learning is about opening up a process of collective transformation.

(1) Background: the erythrocyte sedimentation rate (ESR) has been reported to increase in some infectious or inflammatory diseases in dogs, but no information on the frequency of increases in a routine clinical setting exists. The aim of this study was to assess the frequency of an increased ESR in dogs and to investigate its possible association with hematologic changes; (2) Methods: A total of 295 EDTA blood samples were randomly selected from the routine caseload of the Veterinary Teaching Hospital. Samples were grouped in controls and in pathologic groups based on the clinical presentation. A routine hemogram was performed, then the ESR was measured using the instrument MINI-PET; (3) Results: compared with controls, the ESR was significantly higher in all the pathologic groups, except for the hematological disorders group. The highest ESR was found in samples from dogs with chronic kidney disease or inflammation, followed by those from dogs with mild chronic disorders, severe/acute diseases, tumors and urinary disorders. The ESR negatively correlated with hematocrit and positively with neutrophil counts. (4) Conclusions: The ESR increases more frequently in dogs with clinically evident inflammation or CKD, but also in several other conditions, likely as a consequence of anemia and acute phase response.

On 31 August 1886 Eleanor Marx left Liverpool for Chicago for a trip that would be the perfect occasion to sharpen her feminist thought. Inquiring the American workers movement and women condition, Eleanor found the problem of the day. “How should woman organize?” became the crucial question of her socialist activism among women but also among men. The United States were the ground of an essential transformation of socialist politics, where sex, class and race were already political weapons the workers movement had to learn to use for their own freedom.

This essay intends to investigate John A. Hobson’s theory of liberal- ism from a political perspective, starting from his declaration of the death of liberalism, analysing his writings on social problems to ex- plain his so called science of human welfare. In particular, the essay focuses on some crucial knots around which his revision of liberalism moves: 1. the need for an ethical vision of economy; 2. the conception of society, subjectivity and the state in the face of the crisis of individualism and laissez faire; 3. his conception of an a «organic plan of social progress» and its political meaning. The analysis of these aspects of his work shows his importance for the history of political thought also beyond his famous study on imperialism and shows the rise of a new concept of liberal democracy, bringing into light its problems and contradictions.

Small extracellular vesicles (sEV) are a class of extracellular vesicles (30–150 nm), delivering molecules including proteins, metabolites, and microRNAs (miRNAs), involved in physiological intercellular crosstalk and disease pathogenesis. The present pilot study aims are (I) to develop an easy and fast protocol for the isolation of sEV from plasma of mast cell tumor (MCT)-affected dogs; (II) to evaluate if miR-21-5p (sEV-miR-21-5p), a miRNA overexpressed by MCT, is associated with sEV. Seventeen dogs have been enrolled in the study: 4 healthy and 13 (6 with and 7 without nodal metastasis) MCT-affected dogs. sEV were isolated using size exclusion chromatography (SEC) (IZON column 35nm) and were characterized by Western blot, Nanoparticle tracking analysis, and transmission electron microscopy. sEV-miR-21-5p was quantified using digital PCR. sEV expressed the specific markers CD9 and TSG101, and a marker of mast cell tryptase. The sEV mean concentration and size were 2.68E + 10 particles/ml, and 99.6 nm, 2.89E + 10 particles/ml and 101.7 nm, and 3.21E + 10 particles/ml and 124 nm in non-metastatic, nodal metastatic, and healthy samples, respectively. The comparative analysis demonstrated that the level of sEV-miR-21-5p was significantly higher in dogs with nodal metastasis compared to healthy (P = 0.038) and without nodal metastasis samples (P = 0.007). In conclusion, the present work demonstrated that a pure population of sEV can be isolated from the plasma of MCT-affected dogs using the SEC approach and that the level of sEV-miR-21-5p is higher in nodal metastatic MCT-affected dogs compared with healthy and MCT-affected dogs without nodal involvement.

The paper intends to propose a reading of Ian McEwan’s latest novel, Machines Like Me (2019), qua insightful reflection on the topic of Artificial Intelligence and its bearings on different aspects of human life, from interpersonal relationships to moral behaviour. At the same time, the novel also engages in a reflection on the value and the prospects of literature, whose very premises might be called in question in a posthuman context. Set in a 1980s world whose contours radically deviate from historical facts – the atomic bomb was never dropped; Kennedy was not killed in Dallas; the Beatles are still a band; and Alan Turing has survived the conviction for homosexuality and successfully carried on his studies on AI – the novel introduces the simulacrum in the form of an android, Adam, a hyper-sophisticated machine that enters the characters’ life and upsets it thoroughly. The troublesome relationship with Adam forces Charlie, the protagonist-narrator, to ponder on his own system of values, posing questions about the Other which inevitably end up throwing new light – but, above all, casting new doubts – on the Self and on what it ultimately means to be human. By way of his “What if novel” set in an alternative past, McEwan tackles pressing issues of our present, while trying to envisage a future that is not far to come. The paper intends to explore both the ethical and the metaliterary level of the story on the background of the contemporary theoretical debate on transhumanism and posthumanism, pointing to the simulacrum as the uncanny catalyser of the major topics the author intends to tackle.

Cytological evaluation of lymph nodes (LN) in canine cutaneous mast cell tumors (MCT) has a key role in MCT staging. However, cytological discrimination between metastatic and reactive LNs is debated and diagnostic criteria inconsistent. The aim of this study was to retrospectively quantify nodal mast cells (MCs) in non-oncological (NOD) and MCT-bearing dogs (MCTBD), using different sample preparation techniques, to evaluate the significance of the MCT number. Cytological specimens from NOD-LNs (10 fine-needle aspirates—FNAs) and MCTBD-LNs (10 FNAs, 10 scrapings, 10 touch imprints) were evaluated. MCTBD-LNs were grouped in: non-metastatic, possibly-metastatic, and metastatic based on current literature criteria. MCs were counted in 4, 8, and 20 high-power-fields, and over 500, 1000, and 2000 total cells. MCs were significantly more numerous in MCTBD-LNs than in NOD-LNs and in “metastatic” samples than in “non-metastatic”. There was no significant difference between “metastatic” and “possibly metastatic” samples. Sample preparation techniques did not influence these results. A negative correlation between MCs number and sample cellularity was observed. Results were confirmed regardless of the counting method applied. MCs counting per se cannot distinguish possibly metastatic and metastatic cytological samples. Sample preparation technique and the counting method applied seem to have no influence on cytological quantification of nodal MCs in MCTBDs.

Methylene Blue (MB) is combined with radiopharmaceutical for intraoperative sentinel lymph node (SLN) mapping, but its role during SLN extirpation has not been investigated yet in veterinary medicine. The aim of this study was to assess whether MB increased surgical detection of SLN beyond the use of intraoperative gamma-probe (IGP) alone in clinically node-negative dogs with mast cell tumors (MCTs) following the detection of sentinel lymphocentrums (SLCs) via preoperative planar lymphoscintigraphy. Dogs enrolled underwent MCT excision and SLC exploration guided by both MB and IGP. Data recorded for each SLN were staining (blue/non-blue), radioactivity (hot/non-hot), and histopathological status (HN0-1 vs. HN2-3). A total of 103 dogs bearing 80 cutaneous, 35 subcutaneous, and 1 mucocutaneous MCTs were included; 140 SLCs were explored, for a total of 196 SLNs removed. Associating MB with IGP raised the SLNs detection rate from 90% to 95%. A total of 44% of SLNs were metastatic: 86% were blue/hot, 7% were only blue, 5% were only hot, and 2% were non-blue/non-hot. All HN3 SLNs were hot. Combining MB with IGP can increase the rate of SLN detection in dogs with MCTs; nonetheless, all lymph nodes identified during dissection should be removed, as they might be unstained but metastatic.

Sentinel lymph node (SLN) biopsy is a well-established staging tool in canine oncology. This study aims to explore the feasibility of SLN biopsy in dogs with scars from prior excised solid malignancies that were referred for further tumor staging and/or adjuvant treatment options. Mapping was either performed using radiopharmaceutical, methylene blue, and/or near-infrared fluorescent (NIRF) imaging. Thirty-three dogs with 34 scars from prior excision of the mast cell tumor (MCT) (n = 29), soft tissue sarcoma (n = 2), oral melanoma (n = 1), subungual melanoma (n = 1), and mammary adenocarcinoma (n = 1) were retrospectively enrolled. Primary treatment consisted of curative intent/wide tumor excisions in 50.0% of dogs and marginal excision in the remaining 50.0%. The median time between tumor excision and SLN biopsy was 50 days (range 17–110 days). The procedure was successful in 31/34 scars, translating to a detection rate of 91.2%. The SLN did not correspond to the regional lymph node in 19/31 scars (61.3%). SLN metastases were histologically identified in 13/31 (41.9%) dogs, all of them affected by MCT. Based on our results, SLN biopsy using lymphoscintigraphy/methylene blue and/or NIRF is feasible in dogs presenting with scars from the prior surgical excision of solid tumors, and should be suggested for accurate nodal staging.