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Simple Summary: Simple Summary: Due to limited availability, fluctuating prices, and sustainability concerns, the aquaculture sector is increasingly replacing fish oil with vegetable oil in aquafeeds. To comprehensively explore the dependence of growth performance and omega-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA) composition on dietary n-3 LC-PUFA levels in cultured fish with varying feeding habits (herbivorous, omnivorous, and carnivorous) and habitats (marine and freshwater), we employed a Bayesian meta-analysis to quantitatively analyze data from 81 selected studies. This novel approach allowed us to show to what extent the growth performance and n-3 LC-PUFA tissue levels of freshwater and herbivorous fish exhibit higher tolerance than marine and carnivorous fish to reduced amounts of dietary n-3 LC-PUFA levels. The results of this study can help optimize the use of fish oil in aquafeeds and contribute to the development of more sustainable aquaculture practices. Omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) such as eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA) offer protective benefits against various pathological conditions, including atherosclerosis, obesity, inflammation, and autoimmune diseases. Marine fish and seafood are the primary sources of n-3 LC-PUFAs in the human diet. However, the inclusion of fish oil in aquafeeds is declining due to limited availability, fluctuating prices, sustainability concerns, and replacement with vegetable oils. While comprehensive narrative reviews on the impact of substituting fish oil with vegetable oil in aquafeeds exist, quantitative studies are relatively scarce and mainly focused on comparing the source of vegetable oils. Herein, we employed, for the first time, a Bayesian meta-analysis approach, collecting research data from 81 articles to quantitatively analyze the effects of dietary n-3 LC-PUFA levels on the n-3 LC-PUFA composition and growth performance in cultured fish. Our findings indicate that with the exception of herbivorous fish, dietary n-3 LC-PUFA levels significantly affect the EPA and DHA levels in the livers and muscles of carnivorous, omnivorous, freshwater, and marine fish. Additionally, the growths of freshwater and herbivorous fish were less affected by changes in dietary n-3 LC-PUFA levels compared to that of carnivorous and marine fish. [ABSTRACT FROM AUTHOR]