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It has been shown that associates of cationic glycerolipid (CGL), rac-N-{4-[(2-ethoxy-3-octadecyloxyprop-1-yl)oxycarbonyl]butyl}-N'-methylimidazolium iodide, which has a pronounced antitumor effect, can be used for the solubilization of two hydrophobic biologically active compounds (curcumin and capsaicin) and as templates in the sol–gel synthesis of silica mesoporous container particles (MCPs). The thermodynamic characteristics of solubilization are determined, and it is shown that this process contributes to a significant increase in the solubility of both hydrophobic drugs in water. The hydrolytic condensation of tetraethoxysilane in the presence of CGL associates containing curcumin or capsaicin leads to the formation of MCPs characterized by a narrow size distribution and a high content of encapsulated drugs. This combination of the stages of the synthesis and loading of MCPs is of undoubted interest in relation to the nanoencapsulation of cationic glycerolipids (including in combination with other drugs). [ABSTRACT FROM AUTHOR]

Specific features of the seedless synthesis of gold nanoparticles in micellar solutions of both individual alkyltrimethylammonium bromides with different hydrocarbon chain lengths and their mixtures have been studied. The main attention has been focused on studying the possibility of controlling the shape and, consequently, the position of the localized surface plasmon resonance of the nanoparticles in the presence of octadecyltrimethylammonium bromide (OTAB). It has been found that its use leads to the formation of monodisperse gold nanorods with a larger aspect ratio than that in the case of cetyltrimethylammonium bromide, which is commonly used for this purpose. Moreover, it has been shown that the introduction of OTAB into micellar solutions of its homolog with a noticeably shorter alkyl chain (dodecyltrimethylammonium bromide) promotes a change in the shape of the formed gold nanoparticles from spherical to rodlike one. [ABSTRACT FROM AUTHOR]