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Your search keyword '"Rust, Alistair G."' showing total 18 results
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18 results on '"Rust, Alistair G."'

2. Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

Author

Vaishnavi, Aria, Juan, Joseph, Jacob, Maebh, Stehn, Christopher, Gardner, Eric E, Scherzer, Michael T, Schuman, Sophia, van Veen, J Edward, Murphy, Brandon, Hackett, Christopher S, Dupuy, Adam J, Chmura, Steve A, van der Weyden, Louise, Newberg, Justin Y, Liu, Annie, Mann, Karen, Rust, Alistair G, Weiss, William A, Kinsey, Conan G, Adams, David J, Grossmann, Allie, Mann, Michael B, and McMahon, Martin

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Rare Diseases, Genetics, Lung Cancer, Cancer, Biotechnology, Aetiology, 2.1 Biological and endogenous factors, Animals, Humans, Mice, Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Cell Proliferation, Lung Neoplasms, Mutagenesis, Proto-Oncogene Proteins B-raf, RNA-Binding Proteins, Trans-Activators, Wnt Signaling Pathway, Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Mutationally activated BRAF is detected in approximately 7% of human lung adenocarcinomas, with BRAFT1799A serving as a predictive biomarker for treatment of patients with FDA-approved inhibitors of BRAFV600E oncoprotein signaling. In genetically engineered mouse (GEM) models, expression of BRAFV600E in the lung epithelium initiates growth of benign lung tumors that, without additional genetic alterations, rarely progress to malignant lung adenocarcinoma. To identify genes that cooperate with BRAFV600E for malignant progression, we used Sleeping Beauty-mediated transposon mutagenesis, which dramatically accelerated the emergence of lethal lung cancers. Among the genes identified was Rbms3, which encodes an RNA-binding protein previously implicated as a putative tumor suppressor. Silencing of RBMS3 via CRISPR/Cas9 gene editing promoted growth of BRAFV600E lung organoids and promoted development of malignant lung cancers with a distinct micropapillary architecture in BRAFV600E and EGFRL858R GEM models. BRAFV600E/RBMS3Null lung tumors displayed elevated expression of Ctnnb1, Ccnd1, Axin2, Lgr5, and c-Myc mRNAs, suggesting that RBMS3 silencing elevates signaling through the WNT/β-catenin signaling axis. Although RBMS3 silencing rendered BRAFV600E-driven lung tumors resistant to the effects of dabrafenib plus trametinib, the tumors were sensitive to inhibition of porcupine, an acyltransferase of WNT ligands necessary for their secretion. Analysis of The Cancer Genome Atlas patient samples revealed that chromosome 3p24, which encompasses RBMS3, is frequently lost in non-small cell lung cancer and correlates with poor prognosis. Collectively, these data reveal the role of RBMS3 as a lung cancer suppressor and suggest that RBMS3 silencing may contribute to malignant NSCLC progression.SignificanceLoss of RBMS3 cooperates with BRAFV600E to induce lung tumorigenesis, providing a deeper understanding of the molecular mechanisms underlying mutant BRAF-driven lung cancer and potential strategies to more effectively target this disease.

Published
2022

3. Supplementary Data from Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

Author

Vaishnavi, Aria, primary, Juan, Joseph, primary, Jacob, Maebh, primary, Stehn, Christopher, primary, Gardner, Eric E., primary, Scherzer, Michael T., primary, Schuman, Sophia, primary, Van Veen, J. Edward, primary, Murphy, Brandon, primary, Hackett, Christopher S., primary, Dupuy, Adam J., primary, Chmura, Steven A., primary, van der Weyden, Louise, primary, Newberg, Justin Y., primary, Liu, Annie, primary, Mann, Karen, primary, Rust, Alistair G., primary, Weiss, William A., primary, Kinsey, Conan G., primary, Adams, David J., primary, Grossmann, Allie, primary, Mann, Michael B., primary, and McMahon, Martin, primary

Published
2023
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4. Data from Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis

Author

Vaishnavi, Aria, primary, Juan, Joseph, primary, Jacob, Maebh, primary, Stehn, Christopher, primary, Gardner, Eric E., primary, Scherzer, Michael T., primary, Schuman, Sophia, primary, Van Veen, J. Edward, primary, Murphy, Brandon, primary, Hackett, Christopher S., primary, Dupuy, Adam J., primary, Chmura, Steven A., primary, van der Weyden, Louise, primary, Newberg, Justin Y., primary, Liu, Annie, primary, Mann, Karen, primary, Rust, Alistair G., primary, Weiss, William A., primary, Kinsey, Conan G., primary, Adams, David J., primary, Grossmann, Allie, primary, Mann, Michael B., primary, and McMahon, Martin, primary

Published
2023
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8. Supplementary Tables 1-5 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Author

Mattison, Jenny, primary, Kool, Jaap, primary, Uren, Anthony G., primary, de Ridder, Jeroen, primary, Wessels, Lodewyk, primary, Jonkers, Jos, primary, Bignell, Graham R., primary, Butler, Adam, primary, Rust, Alistair G., primary, Brosch, Markus, primary, Wilson, Catherine H., primary, van der Weyden, Louise, primary, Largaespada, David A., primary, Stratton, Michael R., primary, Futreal, P. Andy, primary, van Lohuizen, Maarten, primary, Berns, Anton, primary, Collier, Lara S., primary, Hubbard, Tim, primary, and Adams, David J., primary

Published
2023
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10. Supplementary Table 7 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Author

Mattison, Jenny, primary, Kool, Jaap, primary, Uren, Anthony G., primary, de Ridder, Jeroen, primary, Wessels, Lodewyk, primary, Jonkers, Jos, primary, Bignell, Graham R., primary, Butler, Adam, primary, Rust, Alistair G., primary, Brosch, Markus, primary, Wilson, Catherine H., primary, van der Weyden, Louise, primary, Largaespada, David A., primary, Stratton, Michael R., primary, Futreal, P. Andy, primary, van Lohuizen, Maarten, primary, Berns, Anton, primary, Collier, Lara S., primary, Hubbard, Tim, primary, and Adams, David J., primary

Published
2023
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13. Supplementary Methods from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Author

Mattison, Jenny, primary, Kool, Jaap, primary, Uren, Anthony G., primary, de Ridder, Jeroen, primary, Wessels, Lodewyk, primary, Jonkers, Jos, primary, Bignell, Graham R., primary, Butler, Adam, primary, Rust, Alistair G., primary, Brosch, Markus, primary, Wilson, Catherine H., primary, van der Weyden, Louise, primary, Largaespada, David A., primary, Stratton, Michael R., primary, Futreal, P. Andy, primary, van Lohuizen, Maarten, primary, Berns, Anton, primary, Collier, Lara S., primary, Hubbard, Tim, primary, and Adams, David J., primary

Published
2023
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15. Data from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Author

Mattison, Jenny, primary, Kool, Jaap, primary, Uren, Anthony G., primary, de Ridder, Jeroen, primary, Wessels, Lodewyk, primary, Jonkers, Jos, primary, Bignell, Graham R., primary, Butler, Adam, primary, Rust, Alistair G., primary, Brosch, Markus, primary, Wilson, Catherine H., primary, van der Weyden, Louise, primary, Largaespada, David A., primary, Stratton, Michael R., primary, Futreal, P. Andy, primary, van Lohuizen, Maarten, primary, Berns, Anton, primary, Collier, Lara S., primary, Hubbard, Tim, primary, and Adams, David J., primary

Published
2023
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16. Supplementary Table 6 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Author

Mattison, Jenny, primary, Kool, Jaap, primary, Uren, Anthony G., primary, de Ridder, Jeroen, primary, Wessels, Lodewyk, primary, Jonkers, Jos, primary, Bignell, Graham R., primary, Butler, Adam, primary, Rust, Alistair G., primary, Brosch, Markus, primary, Wilson, Catherine H., primary, van der Weyden, Louise, primary, Largaespada, David A., primary, Stratton, Michael R., primary, Futreal, P. Andy, primary, van Lohuizen, Maarten, primary, Berns, Anton, primary, Collier, Lara S., primary, Hubbard, Tim, primary, and Adams, David J., primary

Published
2023
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17. "Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis."

Author

Vaishnavi, Aria, primary, Juan, Joseph, additional, Scherzer, Michael T, additional, VanVeen, J Edward, additional, Stehn, Christopher, additional, Hackett, Christopher S., additional, Dupuy, Adam, additional, Chmura, Steven A, additional, van der Weyden, Louise, additional, Newberg, Justin Y., additional, Mann, Karen M, additional, Liu, Annie, additional, Rust, Alistair G., additional, Weiss, William A., additional, Adams, David, additional, Grossman, Allie, additional, Mann, Michael B., additional, and McMahon, Martin, additional

Published
2022
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18. Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-β

Author

Silk, Jonathan D., primary, Abbott, Rachel J. M., additional, Adams, Katherine J., additional, Bennett, Alan D., additional, Brett, Sara, additional, Cornforth, Terri V., additional, Crossland, Katherine L., additional, Figueroa, David J., additional, Jing, Junping, additional, O’Connor, Caitriona, additional, Pachnio, Annette, additional, Patasic, Lea, additional, Peredo, Carlos E., additional, Quattrini, Adriano, additional, Quinn, Laura L., additional, Rust, Alistair G., additional, Saini, Manoj, additional, Sanderson, Joseph P., additional, Steiner, Dylan, additional, Tavano, Barbara, additional, Viswanathan, Preetha, additional, Wiedermann, Guy E., additional, Wong, Ryan, additional, Jakobsen, Bent K., additional, Britten, Cedrik M., additional, Gerry, Andrew B., additional, and Brewer, Joanna E., additional

Published
2022
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