32 results on '"SAMe"'
Search Results
2. S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review.
- Author
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Baden, Kyrie Eleyson R., McClain, Halley, Craig, Eliya, Gibson, Nathan, Draime, Juanita A., and Chen, Aleda M. H.
- Abstract
Background/Objectives: S-adenosylmethionine (SAMe) is a natural compound implicated in the treatment of liver dysfunction. In this systematic review, our objective was to determine the efficacy, safety, and optimal dose of SAMe in liver diseases. Methods: Using the PRISMA methodology, we searched PubMed, CINAHL, and Web of Science using key MeSH search terms. For title/abstract screening, full-text review, and data extraction, two independent researchers reviewed articles, and a third researcher resolved conflicts. Data extraction also included a quality assessment of included articles. Results: Of the 1881 non-duplicated studies, 15 articles focusing on SAMe use in the liver were included. All included studies (n = 15) scored a 4 or 5 out of 5 points on the quality assessment, which indicated high study quality. Overall, SAMe was effective in improving liver-related parameters with few adverse events, which were primarily mild, transient gastrointestinal complaints. Conclusions: The most common doses were SAMe 1000 mg or 1200 mg per day with or without another treatment or natural supplement. Future studies are needed to assess long-term efficacy and safety data of SAMe and the optimal route of administration in liver diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Targeting Divergent Pathways in the Nutritional Management of Depression.
- Author
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Tobin, Derek, Vuckovic, Alexander, and Sarris, Jerome
- Abstract
The nutritional management of depression has long been discussed, due to the perceived benefit of a nutritional product having less side effects than pharmaceutical agents. Candidate nutrients for managing depression include vitamin D, B vitamins, tryptophan, branch chain amino acids, probiotics, omega-3 fatty acids, folate/methylfolate (also known as vitamin B9), and s-adenosylmethionine. This paper provides a narrative review of three nutrients which have significant scientific support for the management of depression. A deficiency in each nutrient is associated with depression, and interventional studies indicate that the correction of the nutritional deficiency may provide clinical benefit. We present epidemiological evidence, a mechanistic explanation and a review of interventional studies for these nutrients. Finally, relevant nutritional guidelines are presented with their conclusion for the role of each nutrient in the management of depression. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. The Effects of Nutraceuticals on Hydroxylation and Conjugation of Estrogen Metabolites.
- Author
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Casses, Rochelle L.
- Abstract
The metabolism of estrogen in today's population may be compromised for various reasons, ranging from environmental influences to genetic predispositions. This paper discusses the physiology of liver detoxification of estrogen and ways to optimize both hydroxylation and conjugation of these metabolites using diet and supplementation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
5. Same and different are additive presupposition triggers.
- Author
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Mikkelsen, Line and Hardt, Daniel
- Subjects
PRESUPPOSITION (Logic) ,LANGUAGE & logic ,READING ,PARALLELISM (Linguistics) ,LINGUISTICS - Abstract
We propose an account of interpretive effects involving same and different, relying on two claims: the first is that same and different are able to take scope, and the second is that they are presuppositional. On this account, same and different are decomposed into two parts: an additive operator TOO and a (non-)identity predicate. We argue that this account provides a more parsimonious account of well-known properties of same and different, such as the distinction between internal and external readings, as well as the parallelism effects discovered by Hardt and Mikkelsen (Linguist Philos 38:289–314, 2015). We also present a solution to a previously unexplained puzzle involving comparatives. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Comparing different strategies to reduce hepatocellular damage in obese common marmosets (Callithrix jacchus).
- Author
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Brown, Mallory Gwendolyn, Feller, Laine Elizabeth, Trupkiewicz, John Gregory, Hutchinson, Eric Kenneth, and Izzi, Jessica Marie
- Subjects
- *
CALLITHRIX jacchus , *ASPARTATE aminotransferase , *LIVER enzymes , *LOW-calorie diet , *OBESITY , *MILK thistle - Abstract
Background: Obesity in common marmosets (Callithrix jacchus) can lead to various liver pathologies. In other species, reduced caloric intake and weight loss improve prognosis, and, often, hepatoprotectants are used to halt or reverse hepatocellular damage from fat deposition in the liver. There are no published therapies for reducing hepatocellular damage in obese marmosets. Methods: Fifteen obese marmosets were used to evaluate the ability of caloric restriction and pharmacologic therapy (S-adenosylmethionine + milk thistle extract, or SMT), alone and combined, to reduce elevated liver enzymes. Body weight and serum chemistries were measured every 4 weeks for 6 months. Results: Across treatment groups, there was a significant reduction in liver enzymes ALT and AST over time. SMT alone significantly reduced liver enzymes ALT and AST at 6 months from baseline. Conclusions: Caloric restriction and SMT, alone and combined, are effective at reducing liver enzyme levels in obese marmosets. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. "But I Hate Him Just the Same": On the Rise of Concessive Markers with Same.
- Author
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Traugott, Elizabeth Closs
- Abstract
Concessivity in English is often associated with structures like Although it was hot, she went running. Although introduces a subordinate clause. There are also several markers of concessivity associated with coordinate structures, among them, all the same and nevertheless. The development of coordinate markers of concessivity has received little attention. Here I compare the histories of three markers that arose from expressions of identity: all the same, just the same, and at the same time. All arose at various times in Late Modern English. Rich rhetorical contexts for the development of concessive uses of all the same 'exactly the same' are attested in corpora. Contexts for the later development in the US of just the same are less rich, and analogy to all the same is probable. Both came to be well entrenched in concessive use and are used in clause-final as well as clause-initial and occasionally clause-medial position. By contrast, at the same time functions only marginally as a concessive. It is also used as an elaborator and is not attested in clause-final position. Data are analyzed from the perspective of Diachronic Construction Grammar. Implications for some current debates are discussed, specifically for establishing when a construction has come into being, what kinds of contexts enable this emergence, and what level of abstraction is appropriate for analysis of sets of related constructions. Finally, some modifications of hypotheses about position of connectives relative to the clause are suggested. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. O MESMO NO SOFISTA DE PLATÃO.
- Author
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Araújo, Carolina
- Subjects
- *
ARGUMENT , *INDIVIDUATION (Psychology) - Abstract
This paper aims at determining the contribution of the kind same to the overall purpose of Plato's Sophist by contrasting semantic and syntactic interpretations. Preliminarily, it examines the reasons for the individuation of the kind being in 250a8-c5, pointing out that they depend on two ways of saying being, the collective and the distributive, which are identified by specific syntactic forms. The investigation of the same begins with a reconstruction of the controversial argument in 255a4-b7, which shows not only that it is valid, but also that the collective and distributive modes of saying are central to it. Next, it shows that passage 255b8-c8 bears no proof for the distinction between same and being, which is found only in 256a3-b5, due the introduction of two other modes of saying: according to oneself and in relation to another. A parallel of this result with the being/different distinction found in 255c13-d7 leads to the conclusion that the same differs from being as the kind that only says a being in relation to another. Because this formulation allows for a syntactic distinction between same and being in patterns that grant the equivalence of not-being and different, it is central to the purpose of the dialogue. Therewith, it is also proved that syntactic interpretations are more charitable to the text. [ABSTRACT FROM AUTHOR]
- Published
- 2023
9. قِيَاسُ الشَّبَهِ دراسةٌ في المفهومِ والضّوابطِ والآثارِ.
- Author
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نور مُحمّد عبد ال and مُحمَّد سماعي
- Subjects
ANALOGY ,AUTHENTICITY (Philosophy) ,EXTRAPOLATION ,SIMILARITY (Psychology) ,SCHOLARS ,JURISPRUDENCE ,ANTIQUITIES - Abstract
Copyright of Journal of Al-Anbar University for Islamic Sciences is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
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10. The Fragmentation Of The Self And Its Relationship With The Other In The Novel: When The Moon Cries By: Suha Jalal Jawdat.
- Author
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Karima, Reggab
- Subjects
PSYCHOLOGICAL factors ,SELF ,ADOLESCENCE ,TEENAGERS ,ENGRAVING - Abstract
The novel Travel to Where the Moon Weeps by the Syrian writer: Suha Jalal Jawdat deals with a distinctive issue in the life of the torn and distressed teen, which is the fragmentation of himself and the relationship of communication and split with the other because of the psychological impacts and scars engraved inside her negatively or positively from her family, school and societal milieu. The writer chose the adolescence stage particularly, because it is the most striking stage in the life of the individual, so how did the external and internal factors impress the formation of a prior self in the novel? How did you deal with the other? What are the types of selves that are fragmented from the overwhelming self because of this ?. To find out this, I used in this study the psychological approach that infiltrates into the midsts of the human psyche to uproot its psychological potentials shrouded in the subconscious area, in addition to the two mechanisms of description and analysis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
11. Tasting/Loving/Writing the Other: The Sensuous Poetics of Li-Young Lee and Walt Whitman.
- Author
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Kajiwara, Teruko
- Subjects
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POETICS , *ETHNICITY , *DIASPORA - Abstract
This essay explores the sensuous poetics of Li-Young Lee and its affinities with Walt Whitman's poetics, and also challenges precedent studies that focus on ethnic identity and Levinasian otherness in Lee's work. Lee and Whitman vividly picture the speaker's reaching out to the Other by tasting — eating, touching and loving — and they associate the ecstatic self-Other encounter which occurs through erotic communication with the ecstasy generated in writing and reading a poem. While most comparative studies of Lee and Whitman have characterised Lee squarely as a diasporic poet of otherness and Whitman as a mainstream poet of sameness, the essay illuminates Lee's ambivalent struggle for sameness along with his consciousness of otherness. The concept of 'foreignness' is key to understanding Lee's ambivalent struggle to reach the Other through acts of loving and writing. The 'foreignness' is what drives the poet to write poetry, which is another way of 'loving' the body of the Other. Lee's diasporic experiences might well have intensified his sense of being exiled, but this feeling has enabled him to explore the 'foreignness' in his relationship with the Other — whether that Other be a lover or a language. Thus, Lee's sensuous poetics exposes our ontological condition. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
12. Impacto de la implementación de un servicio de atención de emergencias sobre las muertes por accidentes de tránsito: el caso del SAME en la provincia de Buenos Aires.
- Author
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Ivana Benzaquén, Nicolás Epele, and Mariana Marchionni
- Subjects
Servicio de emergencias ,SAME ,Defunciones por accidentes de tránsito ,Seguridad vial ,Diferencias en diferencias ,Evaluación de impacto ,Economic history and conditions ,HC10-1085 ,Economic theory. Demography ,HB1-3840 - Abstract
Este trabajo evalúa el impacto de la implementación del Servicio de Atención Médica de Emergencias (SAME) en la provincia de Buenos Aires, Argentina, sobre las muertes por accidentes viales. A partir de información mensual de accidentes de tránsito de los 135 municipios de la provincia para los años 2016, 2017 y 2018, se explota la variabilidad en el momento de implementación entre los municipios y el hecho de que algunos nunca adoptaron el servicio para identificar el efecto promedio de la intervención en los municipios con SAME mediante la metodología de Diferencias en Diferencias. El principal resultado es que la incorporación del SAME produjo una reducción promedio del 19% en la tasa de defunciones cada mil accidentados con respecto a su línea de base.
- Published
- 2022
- Full Text
- View/download PDF
13. Decomposing same.
- Author
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Sun, Yenan
- Subjects
SEMANTICS ,ADJECTIVES (Grammar) ,SYNTAX (Grammar) ,MOTIVATION (Psychology) ,EQUATIONS - Abstract
Motivated by the cross-linguistic connection between same and scalar equatives, this paper proposes an explicit equative-like syntax and semantics of the same-construction by decomposing same into an equation head -eqtv (parameter marker) and an identity predicate ident (parameter). This move not only provides a novel way of unifying the internal and external uses of same under a compositional account, but also further sheds light on why same differs from other relational adjectives in terms of the licensing conditions for the internal use. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Paper wasps form abstract concept of 'same and different'.
- Author
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Weise, Chloe, Ortiz, Christian Cely, and Tibbetts, Elizabeth A.
- Subjects
- *
CONCEPT learning , *WASPS , *LEARNING in animals , *STIMULUS & response (Psychology) - Abstract
Concept formation requires animals to learn and use abstract rules that transcend the characteristics of specific stimuli. Abstract concepts are often associated with high levels of cognitive sophistication, so there has been much interest in which species can form and use concepts. A key abstract concept is that of sameness and difference, where stimuli are classified as either the same as or different than an original stimulus. Here, we used a simultaneous two-item same-different task to test whether paper wasps (Polistes fuscatus) can learn and apply a same-different concept. We trained wasps by simultaneously presenting pairs of same or different stimuli (e.g. colours). Then, we tested whether wasps could apply the concept to new stimuli of the same type (e.g. new colours) and to new stimulus types (e.g. odours). We show that wasps learned a general concept of sameness or difference and applied it to new samples and types of stimuli. Notably, wasps were able to transfer the learned rules to new stimuli in a different sensory modality. Therefore, P. fuscatus can classify stimuli based on their relationships and apply abstract concepts to novel stimulus types. These results indicate that abstract concept learning may be more widespread than previously thought. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
15. Offerrollen i Samisk Representation : En intervjustudie
- Author
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Nutti, Svea and Nutti, Svea
- Abstract
The purpose of this study is to examine the sami identity and self-perception. To understand the self-perception and the construction of sami identity, interviews with members of the sami community in Sweden been concluded. The interview question has been based on the film “Sameblod” released in 2017 by Amanda Kernell. Sameblod is about a teenage girl, Elle-Marja, who struggles with the structural racism the Swedish state caused them during the beginning of the 19th century. The movie is portraying many of the topics considering sami self-perception and identity and was there for a good approach to discuss the matters and produce answers that would be relevant for the researching purpose. The results turned out to be categorized in that the 1. Sami’s identify strongly with their history and therefore the representation of the Swedish history turned out to be valuable for the construction of the sami identity. But the representation of the history could intensify the already undermined sami status caused by the oppression. 2. The sami pride was significantly important for the self-perception. Sameblod dose miss some crucial parts of the sami culture as well as the sami pride. This leads to sami misrepresentation, which damages the self-perception and can lead to undermined cultural heritage, as well as concecuenses of the preception for a non-sami.
- Published
- 2024
16. “De håller på med renar va?” : En analys av hur urfolket samerna representerats i skolans styrdokument mellan åren 1962 och 2022.
- Author
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Alsén, Peter and Alsén, Peter
- Abstract
Detta är en kvalitativ innehållsanalys av Sveriges styrdokument för svensk grundskola, med fokus på samisk representation. Analysen är avgränsad till tidsperioden 1962-2022 då denna tidsperiod innefattar alla läroplaner för den obligatoriska allmänna grundskolan. Arbetet tar en historiekulturell teoretisk ansats med postkolonial teori som ytterligare en byggsten i analysen. Syftet med detta arbete är att undersöka samernas representation i svensk skolundervisning under tidsperioden 1962-2022 och varför den sett ut som den gjort. Tidigare forskning utförd i Kanada har visat att när elever lär sig om urfolk gynnar det inte bara eleverna i sig, utan även urfolken i landet. Samerna är Sveriges enda urfolk och Europas enda urfolk. Med denna kanadensiska forskning i ryggen går det att hävda att det bör ligga i allmänhetens intresse, och även samernas intresse, att elever lär sig om urfolk. Detta gav ytterligare skäl att utföra denna undersökning med fokus på urfolket samerna i Sverige, då det skulle kunna gynna alla. Resultatet av denna undersökning är att samernas representation i svenska styrdokument har ökat ganska stadigt över tid sedan 1962 fram till 2022, med en minskande representation i 2011 års läroplan, Lgr11. Störst representation fanns i 1994 års läroplan Lpo94 och det var också enda läroplanen som talade om hur samisk historia och kultur hänger ihop med svensk och nordisk historia och identitet. Anledningen till att representationen har ökat är att samernas rättigheter också ökat under samma tidsperiod. Samerna har under tidsperioden blivit erkända som urfolk, blivit grundlagsskyddade som ett eget folk samt bildat en egen statlig myndighet, Sametinget. Även om samernas representation har ökat under tidsperioden är den fortfarande inte stor, samt har samisk kultur och historia blivit förbisedd i den senaste läroplanen Lgr22. Detta verkar bland annat bero på, baserat på det material som undersökts, att Sverige fortfarande bedriver kolonialism.
- Published
- 2024
17. Rätten till den jämtländska marken : en diskursanalys av den jämtländska kritiken mot renbeteslagen i riksdagsdebatten om renbeteslagen 1886
- Author
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Janesköld, Catalina and Janesköld, Catalina
- Abstract
"om den här ifrågasatta lagen skulle blifva antagen, skulle följden blifva oupphörliga rättegångar eller, såsom ordspråket säger, >>hand i hår och knif på strupe>> emellan de bofaste och lapparne." Så avslutar den Jämtländska riksdagsmannen Olof Nikolaus Wagenius sitt tal i andra kammaren 17 april 1886. Tonen är skarp men långt ifrån ett undantag i riksdagsdebatten kring renbeteslagen. Den ”ifrågasatta lagen” som Wagenius syftar på är renbeteslagen och den kontroversiella punkten i renbeteslagen är legaliseringen av samers vinterrenskötsel på privat mark. Om lagen skulle gå igenom skulle det bli möjligt för samer att utföra renskötsel under vinterhalvåret, på privat mark som låg på mark som samer traditionellt sätt används som betesmark. Oroligheterna mellan samer och bofasta i Jämtland hade pågått under en längre tid, men läget hade förvärrats markant efter avvittringen. Avvittringen var en process där staten delade ut norrländsk mark till nybyggare för att utöka jordbruket och befolkningen i Norrland. Lagen ämnade att lösa den största konflikten mellan samer och bofasta i Sverige, men trots det fanns det en grupp riksdagsmän som menade att denna lag skulle ligga till grunden för värre konflikter., "om den här ifrågasatta lagen skulle blifva antagen, skulle följden blifva oupphörliga rättegångar eller, såsom ordspråket säger, >>hand i hår och knif på strupe>> emellan de bofaste och lapparne." This is how the member of parliament from Jämtland Olof Nikolaus Wagenius ends his speech in the second chamber on April 17, 1886. The tone is sharp, but far from an exception in the parliament debate surrounding the Reindeer grazing act (renbeteslagen). The "questioned law" that Wagenius refers to is the Reindeer grazing Act, and the controversial point in the Reindeer Grazing Act is the legalization of the Sami practice of herding reindeer on private land during the winter. If the law was to pass, it would be possible for the Sami to carry out reindeer husbandry during the winter months, on private land that was located on land traditionally used by the Sami as grazing land. The unrest between Sami and settlers in Jämtland had been going on for a long time, but the situation had worsened significantly after avvittringen. Avvittringen was a process in which the state distributed land in Norrland to settlers in order to expand agriculture and the population of Norrland. The law was intended to solve the biggest conflict between Sami and settlers in Sweden, but despite that, there was a group of parliamentarians who believed that this law would lay the foundation for worse conflicts.
- Published
- 2024
18. Combined action of SAMe, Folate, and Vitamin B12 in the treatment of mood disorders: a review.
- Author
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CICERO, A. F. and MINERVINO, A.
- Abstract
Mood disorders affect more than 500 million people around the world. In the last decade, their prevalence has increased, and many people suffer from nervousness, anxiety, and stress at least once in their lives. The incidence of mood disorders and anxiety increases during perimenopause or under stressful conditions. The social restrictions introduced during the COVID-19 pandemic have significantly increased the normal burden of psychological and psychic disorders. In moderate to severe cases, pharmacological treatment is currently recommended, while in mild disorders, especially in the initial phase, psychological therapy is preferable. It is known that several nutrients are crucial for brain function. Among them, folate (vitamin B9), cyanocobalamin (vitamin B12), and S-adenosyl-L-methionine (SAMe) have been shown to influence various neurobiological processes. Overall, the available evidence suggests that dietary supplementation with folic acid, vitamin B12, and SAMe can be beneficial for people with mild mood disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2022
19. A Critique of Studies Discussing the Difference between Do It and Do So Using Such Keywords as ‘Same’, ‘Same Type/Kind’ and ‘Specific’
- Subjects
do it ,same ,same type/kind ,do so ,specific - Abstract
This paper examines what three well-known English grammar books write as to the difference in meaning between do it and do so. Those books attempt to explain the selection conditions of the two pro-forms using keywords such as ‘same’, ‘same type’, ‘same kind’ and ‘specific’. According to the grammarians, do it tends to denote the same action or event as the antecedent, whereas do so tends to denote the same kind/type of action or event. However, such an explanation would possibly confuse non-native speakers of English when they want to tell the difference between the two pro-forms, because the distinction ‘same’ and ‘same type/kind’ is related in a rather complex way to linguistic contexts in which do it and do so are used or to how the speaker views the fact described with the use of the two pro-forms.
- Published
- 2023
20. Impacto de la implementación de un servicio de atención de emergencias sobre las muertes por accidentes de tránsito: el caso del SAME en la provincia de Buenos Aires.
- Author
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Benzaquén, Ivana, Epele, Nicolás, Marchionni, Mariana, Benzaquén, Ivana, Epele, Nicolás, and Marchionni, Mariana
- Abstract
Este trabajo evalúa el impacto de la implementación del Servicio de Atención Médica de Emergencias (SAME) en la provincia de Buenos Aires, Argentina, sobre las muertes por accidentes viales. A partir de información mensual de accidentes de tránsito de los 135 municipios de la provincia para los años 2016, 2017 y 2018, se explota la variabilidad en el momento de implementación entre los municipios y el hecho de que algunos nunca adoptaron el servicio para identificar el efecto promedio de la intervención en los municipios con SAME mediante la metodología de Diferencias en Diferencias. El principal resultado es que la incorporación del SAME produjo una reducción promedio del 19% en la tasa de defunciones cada mil accidentados con respecto a su línea de base.
- Published
- 2023
21. What is it really like? - Mental illness among the Sámi :
- Author
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Digan, Amanda, Edmondson, Aana, Digan, Amanda, and Edmondson, Aana
- Abstract
Background: Mental illness is a problem in today's society. Research shows that indigenous people are more at risk for mental health problems than their non-indigenous peers. Discrimination can affect individuals' self-image and mental health. Research shows that healthcare professionals lack cultural understanding for ethnic minorities. Aim: The aim of this literature review is to examine differences in mental illness between the Sámi and non-Sámi population and to describe factors associated to mental illness among the Sámi population Method: This literature review was based on nine quantitative articles. Searches were made in Cinahl and PubMed. The results of the articles were analysed and sorted responding to the aim. Results: Results show that there are differences in mental illness between Sámi and non-Sámi, but the context of these are crucial. Being Sámi can come with protective- and risk factors. The Sámi are more exposed to discrimination which in turn can lead to more mental illness. Conclusion: The Sámi culture and being Sámi affects mental health in both positive and negative ways. In order to provide equitable care more knowledge and research regarding the Sámi culture and consideration to cultural factors is needed., Bakgrund: Psykisk ohälsa är ett utbrett problem i dagens samhälle. Forskning visar att etniska minoriteter och urfolk har en ökad risk för psykisk ohälsa. Diskriminering kan påverka individers självbild och psykiska ohälsa. Forskning visar att vårdpersonal ofta har otillräcklig kulturell kunskap om etniska minoriteter. Syfte: Syftet med denna litteraturstudie är att undersöka skillnader i psykisk ohälsa mellan samer och icke-samer och beskriva faktorer associerade med psykisk ohälsa hos samer. Metod: Denna litteraturstudie var baserad på nio kvantitativa artiklar. Sökningar gjordes i Cinahl och PubMed. Artiklarna analyserades sedan och sorterades i relation till syftet. Resultat: Resultaten visar att det finns vissa skillnader mellan samer och icke-samer, men kontexten för dessa är viktigt. Att vara same kan komma med både skydds- och riskfaktorer. Forskningen visar även att samer i större utsträckning blir diskriminerade vilket i sin tur kan leda till en försämrad psykisk hälsa. Konklusion: Att vara same påverkar den psykiska hälsan på positiva och negativa plan. För att kunna ge en god personcentrerad vård behövs mer kunskap, forskning samt hänsyn till samernas kultur och de faktorer som påverkar deras psykiska hälsa., Duohke: Sielulasj dávdda l stuor vuorrádis udnásj sebrudagán. Åtsådallam vuoset etnalasj unneplågo ja álggoálmmuga la lasse váhtá sielulasj dávdav oadtjot. Nuppástallam máhttá vájkudit ájnegasj ulmutjij iesjgåvåv ja sielulasj dávdav. Åtsådallam vuoset skihpasujtára dábálattjat e ane nuoges kultuvralasj máhtov etnalasj unneplågoj birra. Ulmme: Ulmme dán låhkusåhpadusájn la guoradallat sieradusájt sielulasj dávdav sámij ja ma älla sáme gaskan ja tjielggit faktåvråjt ma gulluji sámij sielulasj dávddaj. Vuohke: Avtse kvantitatijva artihkkala li vuodon årrom dán låhkusåhpadusán. Åhtsåmusá li dagádum Cinahlan ja PubMedan. Dan maŋŋela artihkkala guoraduvvin ja juogeduvvin gasskasasj ulmmáj. Boados: Boados vuoset gávnnuji muhtem sieradusá sámij ja ma älla sáme gaskan, valla kontäksta dasi la ájnas. Sábmen årrot de båhti goappásj suodje ja váhtáfaktåvrå. Åtsådallam aj vuoset sáme ienep dásen tjuoldeduvvi, vaj dat máhttá sjaddat nievrep psyhkalasj varresvuohtaj. Konklusjåvnnå: Sábmen årrot vájkuda psyhkalasj varresvuodav goappátjin positivalattjat ja negativalattjat. Vaj máhttet vaddet buorre persåvnålasj huvsov de dárbaj ienep máhtov, åtsådallamav ja árvvon adnet sáme kultuvrav ja faktåvråjt majt sijá psyhkalasj varresvuodav vájkut.
- Published
- 2023
22. Förekomst av arbetsrelaterade skador och sjukdomar hos renskötande samer
- Author
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Kristoffersson, Susanna and Kristoffersson, Susanna
- Abstract
Bakgrund: Arbetsmiljön för renskötande samer klassas som ett av de mest farliga yrken som finns i Sverige, men ändå trots det väldigt lite forskat om. I yrket är det en hög förekomst av problem i rörelseapparaten med smärta i samtliga kroppsdelar, relaterat till arbetsmiljön. Rennäringen har under de senaste årtionden genomgått en mekaniseringsprocess, där stora och nya krav på renskötarens kropp ställs, samtidigt som kravet på den ekonomiska avkastningen ökat, med ökad stress som följd. Syfte: Syftet med denna webbenkätundersökning var att utforska arbetsmiljö och förekomst av arbetsrelaterade skador och sjukdomar hos samiska renskötare i en fjällsameby. Metod: En digital webbenkät skickades till 77 samebymedlemmar inom en fjällsameby. Resultat: Jag fann att renskötarna i (n=20) i fjällsamebyn hade mest besvär i ländrygg/korsrygg 56 % därefter halsrygg/nacke 55 %, handleder/händer 22 %, fotleder/fötter 22 %, knän 17 %, axlar/skuldror 16 %, höfter 6 % och armbågar 0 %. "övriga sjukdomar" förekommer mer sparsamt. Konklusion: Sammanfattningsvis har undersökningen visat att renskötare i Norrbotten har besvär i rörelseapparaten. ser jag att besvären i halsrygg/nacke och ländrygg/korsrygg fortsätter vara höga. Vid en jämförelse med tidigare forskning över en 30-års period ser jag att besvären i halsrygg/nacke och ländrygg/korsrygg fortsätter vara höga. Medan besvären i övriga kroppsdelar minskat. Tidigare studier och renskötarnas förslag till förändring har inte fått genomslag ännu. Ytterligare forskning om samerna och hälsa behövs för att säkerhetsställa patientcentrerad fysioterapi med kulturell kompetens.
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- 2023
23. Han fick tre luođit
- Author
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Stoor, Krister and Stoor, Krister
- Abstract
I åttio år har vi väntat på en svensk version av Die Lappische volksmusik (1942) och nu är den här. Den svenska originaltexten har länge varit bekant för oss som jobbat med Karl Tiéns material. Vi fick vänta åttio år men det var det värt., Ingår även i: Skrifter utgivna av Svenskt visarkiv, 0081-9840 ; 51. Även utgiven av: Umeå: Kungl. Skytteanska Samfundet. Även utgiven av: Stockholm: Svenskt visarkiv, Musikverket.
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- 2023
24. Samen und die Erklärung des Lebendigen: Ein Vergleich von Robert Boyle und Isaac Newton
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Müller, Kim Mara
- Subjects
passive principles ,Seed ,Matter ,Leben ,active priciples ,materia prima ,Alchemie ,spirit ,Materie ,Seele ,Alchemy ,Life ,vegetation ,Same ,ddc:300 ,vis inertiæ ,force ,Soule ,semial principles ,smalles particles - Abstract
Die Arbeit "Samen und die Erklärung des Lebendigen. Ein Vergleich von Robert Boyle und Isaac Newton" betrachtet den Begriff des Samens als Vorstellung eines lebengebenden Elementes aller Dinge und Individuen im wissenschaftlichen Kontext. Dieser Samen stand Synonym für die Vorstellung vieler Wissenschaftler als mögliche erste Entität, aus welcher sich die lebendige Materie der Welt generiere. Dabei fungierte dieser Samen je Vorstellung mal als metaphorisches Erklärungsmodell, als immaterielles Konzept, welches tatsächliche Materie erst erschuf, mal schon im Anfangsstadium als faktische Materie. Durch die Mannigfaltigkeit der Theorien und Vorstellungen, die sich noch im 17. Jahrhundert ausgeprägten, macht diese Arbeit den Versuch, einen möglichen Ursprung dieser Vorstellung zu bestimmen. Dabei entwickelte sich die These zweier Traditionslinien, ausgehend von Aristoteles und Platons Lehren, welche nachfolgende Wissenschaftler aufgriffen und individuell für ihre Wissenschaften nutzbar machten. Es entstand eine rege Rezeption dieses Begriffes und die sich daraus ausprägende Vorstellungen zur Entstehung des Lebens in der Welt. Besonderes Augenmerk liegt diese Arbeit auf der Erklärung des Lebendigen bei Robert Boyle und Isaac Newton. In this paper Seed and the Explanation of the Living. A Comparison of Robert Boyle and Isaac Newton, the concept of the seed is considered as the concept of a life-giving element of all things and individuals in a scientific context.This seed was synonymous with the idea of many scientists as the possible first entity from which the living matter of the world was generated. Depending on the idea, this seed sometimes functioned as a metaphorical explanatory model, as an immaterial concept that first created actual matter, and sometimes as factual matter already in the initial stage. Due to the diversity of theories and ideas that were still developing in the 17th century, this work attempts to determine a possible origin of this idea. In the process, the thesis of two lines of tradition developed, starting from Aristotle and Platon's teachings, which subsequent scientists took up and made individually usable for their sciences. The result was a lively reception of this concept and the resulting ideas about the origin of life in the world. Special attention is paid to Robert Boyle's and Isaac Newton's explanation of the origin of life.
- Published
- 2023
25. Prevalence of work-related injuries and diseases in reindeer herding Sami people
- Author
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Kristoffersson, Susanna
- Subjects
arbetsskador ,besvär i rörelseapparaten ,enkät ,renskötare ,same ,Sjukgymnastik ,arbetsmiljö ,Physiotherapy ,sjukdomar - Abstract
Bakgrund: Arbetsmiljön för renskötande samer klassas som ett av de mest farliga yrken som finns i Sverige, men ändå trots det väldigt lite forskat om. I yrket är det en hög förekomst av problem i rörelseapparaten med smärta i samtliga kroppsdelar, relaterat till arbetsmiljön. Rennäringen har under de senaste årtionden genomgått en mekaniseringsprocess, där stora och nya krav på renskötarens kropp ställs, samtidigt som kravet på den ekonomiska avkastningen ökat, med ökad stress som följd. Syfte: Syftet med denna webbenkätundersökning var att utforska arbetsmiljö och förekomst av arbetsrelaterade skador och sjukdomar hos samiska renskötare i en fjällsameby. Metod: En digital webbenkät skickades till 77 samebymedlemmar inom en fjällsameby. Resultat: Jag fann att renskötarna i (n=20) i fjällsamebyn hade mest besvär i ländrygg/korsrygg 56 % därefter halsrygg/nacke 55 %, handleder/händer 22 %, fotleder/fötter 22 %, knän 17 %, axlar/skuldror 16 %, höfter 6 % och armbågar 0 %. "övriga sjukdomar" förekommer mer sparsamt. Konklusion: Sammanfattningsvis har undersökningen visat att renskötare i Norrbotten har besvär i rörelseapparaten. ser jag att besvären i halsrygg/nacke och ländrygg/korsrygg fortsätter vara höga. Vid en jämförelse med tidigare forskning över en 30-års period ser jag att besvären i halsrygg/nacke och ländrygg/korsrygg fortsätter vara höga. Medan besvären i övriga kroppsdelar minskat. Tidigare studier och renskötarnas förslag till förändring har inte fått genomslag ännu. Ytterligare forskning om samerna och hälsa behövs för att säkerhetsställa patientcentrerad fysioterapi med kulturell kompetens.
- Published
- 2023
26. Hur är det egentligen? - Psykisk ohälsa bland samer
- Author
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Digan, Amanda and Edmondson, Aana
- Subjects
Kultuvrra ,Omvårdnad ,Culture ,Sámi ,sábme ,Nursing ,Mental Illness ,Indigenous ,Kultur ,sielulasj dávdda ,Psykisk ohälsa ,Same ,Urfolk ,álggoálmmuk - Abstract
Background: Mental illness is a problem in today's society. Research shows that indigenous people are more at risk for mental health problems than their non-indigenous peers. Discrimination can affect individuals' self-image and mental health. Research shows that healthcare professionals lack cultural understanding for ethnic minorities. Aim: The aim of this literature review is to examine differences in mental illness between the Sámi and non-Sámi population and to describe factors associated to mental illness among the Sámi population Method: This literature review was based on nine quantitative articles. Searches were made in Cinahl and PubMed. The results of the articles were analysed and sorted responding to the aim. Results: Results show that there are differences in mental illness between Sámi and non-Sámi, but the context of these are crucial. Being Sámi can come with protective- and risk factors. The Sámi are more exposed to discrimination which in turn can lead to more mental illness. Conclusion: The Sámi culture and being Sámi affects mental health in both positive and negative ways. In order to provide equitable care more knowledge and research regarding the Sámi culture and consideration to cultural factors is needed. Bakgrund: Psykisk ohälsa är ett utbrett problem i dagens samhälle. Forskning visar att etniska minoriteter och urfolk har en ökad risk för psykisk ohälsa. Diskriminering kan påverka individers självbild och psykiska ohälsa. Forskning visar att vårdpersonal ofta har otillräcklig kulturell kunskap om etniska minoriteter. Syfte: Syftet med denna litteraturstudie är att undersöka skillnader i psykisk ohälsa mellan samer och icke-samer och beskriva faktorer associerade med psykisk ohälsa hos samer. Metod: Denna litteraturstudie var baserad på nio kvantitativa artiklar. Sökningar gjordes i Cinahl och PubMed. Artiklarna analyserades sedan och sorterades i relation till syftet. Resultat: Resultaten visar att det finns vissa skillnader mellan samer och icke-samer, men kontexten för dessa är viktigt. Att vara same kan komma med både skydds- och riskfaktorer. Forskningen visar även att samer i större utsträckning blir diskriminerade vilket i sin tur kan leda till en försämrad psykisk hälsa. Konklusion: Att vara same påverkar den psykiska hälsan på positiva och negativa plan. För att kunna ge en god personcentrerad vård behövs mer kunskap, forskning samt hänsyn till samernas kultur och de faktorer som påverkar deras psykiska hälsa. Duohke: Sielulasj dávdda l stuor vuorrádis udnásj sebrudagán. Åtsådallam vuoset etnalasj unneplågo ja álggoálmmuga la lasse váhtá sielulasj dávdav oadtjot. Nuppástallam máhttá vájkudit ájnegasj ulmutjij iesjgåvåv ja sielulasj dávdav. Åtsådallam vuoset skihpasujtára dábálattjat e ane nuoges kultuvralasj máhtov etnalasj unneplågoj birra. Ulmme: Ulmme dán låhkusåhpadusájn la guoradallat sieradusájt sielulasj dávdav sámij ja ma älla sáme gaskan ja tjielggit faktåvråjt ma gulluji sámij sielulasj dávddaj. Vuohke: Avtse kvantitatijva artihkkala li vuodon årrom dán låhkusåhpadusán. Åhtsåmusá li dagádum Cinahlan ja PubMedan. Dan maŋŋela artihkkala guoraduvvin ja juogeduvvin gasskasasj ulmmáj. Boados: Boados vuoset gávnnuji muhtem sieradusá sámij ja ma älla sáme gaskan, valla kontäksta dasi la ájnas. Sábmen årrot de båhti goappásj suodje ja váhtáfaktåvrå. Åtsådallam aj vuoset sáme ienep dásen tjuoldeduvvi, vaj dat máhttá sjaddat nievrep psyhkalasj varresvuohtaj. Konklusjåvnnå: Sábmen årrot vájkuda psyhkalasj varresvuodav goappátjin positivalattjat ja negativalattjat. Vaj máhttet vaddet buorre persåvnålasj huvsov de dárbaj ienep máhtov, åtsådallamav ja árvvon adnet sáme kultuvrav ja faktåvråjt majt sijá psyhkalasj varresvuodav vájkut.
- Published
- 2023
27. Same-sex role model effects in education
- Author
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de Gendre, Alexandra, Feld, Jan, Salamanca, Nicolás, Zölitz, Ulf, and University of Zurich
- Subjects
job preferences ,teachers ,gender role models ,analysis ,I24 ,standardized test scores ,J24 ,sex role models ,STEM ,grades ,meta ,330 Economics ,ECON Department of Economics ,country study ,10007 Department of Economics ,math ,reading ,multi ,Same ,external validity ,I21 ,science - Published
- 2023
- Full Text
- View/download PDF
28. Continuity of same/different relational learning in toddlerhood
- Author
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Shivaram, Apoorva and Susan
- Subjects
FOS: Psychology ,relations ,relational learning ,Developmental Psychology ,Psychology ,different ,same ,toddlers ,Social and Behavioral Sciences - Abstract
This project examines whether the same signatures of relational learning that are found in infants (Anderson et al., 2018; Ferry et al., 2015) are also found in toddlers and preschoolers using a similar paradigm across all ages between 1 to 5 years. We ask whether children who receive multiple exemplars during a training phase are more likely to generalize a relation from training to test. We predict that our experimental condition (8 exemplars) will have higher overall accuracy than the control condition (2 exemplars).
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- 2022
- Full Text
- View/download PDF
29. «Som lærer må man trå varsomt, det er nesten som å forsøke å gå på tynn is». En kvalitativ intervjustudie av hvordan grunnskolelærere i Sápmi tilrettelegger for elever med internaliserte psykiske vansker
- Author
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Joks, Henriette and Danielsen, Fredrik
- Subjects
psykiske vansker ,Sápmi ,samisk kultur ,VDP::Samfunnsvitenskap: 200::Pedagogiske fag: 280::Spesialpedagogikk: 282 ,samisk samfunn ,internaliserte psykiske vansker ,psykisk helse ,VDP::Social science: 200::Education: 280::Special education: 282 ,same ,PED-3903 ,internaliserte vansker - Abstract
Dette masterprosjektet er en kvalitativ intervjuundersøkelse som omhandler grunnskolelæreres tilrettelegging for samiske elever med internaliserte psykiske vansker. Datainnsamlingen er gjennomført ved semistrukturerte dybdeintervjuer. Prosjektet har videre en fenomenologisk vitenskapsteoretisk tilnærming, der meningsinnholdet i datamaterialet er analysert ved hjelp av systematisk tekstkondensering. Formålet med prosjektet er å bidra med kunnskaper om hvordan tilrettelegging for samiske elever med internaliserte psykiske vansker erfares fra et lærerperspektiv. Problemstillingen for studien er som følger: «Hvordan kan grunnskolelærere i Sápmi tilrettelegge for elever med internaliserte psykiske vansker?». Jeg formulerte tre forskerspørsmål for å avgrense og spisse studien: 1. Hva er lærernes forståelse av begrepet internaliserte psykiske vansker? 2. Hvordan opplever lærerne forståelsen for psykiske vansker i samisk kultur? 3. Hva vektlegger lærerne som forutsetninger for å kunne tilrettelegge for elever med internaliserte psykiske vansker? Resultatene fra denne studien indikerer at lærerne har stor vilje til å tilrettelegge for elever med internaliserte vansker. Informantene i studien trekker fram at kompetanse om internaliserte vansker og hvordan de kommer til synet på skolen er viktig for å kunne oppdage elever med internaliserte psykiske vansker. Et annet funn peket mot at lærere må ha kompetanse om hvordan man i samisk kultur snakker om psykisk helse. Videre erfarer informantene at gode relasjoner, et godt skole-hjem-samarbeid og et godt lærersamarbeid må ligge i grunn for at man skal kunne tilrettelegge for elever med internaliserte psykiske vansker.
- Published
- 2022
30. Foucault and philosophy: from criticism of the same to openness to the other
- Author
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Leal, Guilherme de Freitas, Lopes, Adriana Delbó, Almeida, Fábio Ferreira de, Kraemer, Celso, Marinho, Cristiane Maria, and Aggio, Juliana Ortegosa
- Subjects
Abertura ,Foucault ,Crítica ,Same ,FILOSOFIA [CIENCIAS HUMANAS] ,Other ,Outro ,Mesmo ,Criticism ,Opening - Abstract
A tese visa colaborar na compreensão da relação entre Foucault e a Filosofia. Vislumbrando o campo tripartido da filosofia observado ocorrer pós-Kant, Foucault denomina esse momento de modernidade filosófica justamente porque o infinito como fundamento sai de cena e a finitude passa a se autossustentar. Cruzando o projeto crítico — a Crítica da Razão Pura, a Crítica da Razão Prática e a Faculdade do Juízo — com a Reflexão Antropológica, Foucault absorve a tradição filosófica através de Kant concatenando, ademais, uma resposta radical em Nietzsche, que o permitirá construir sua própria analítica de pensamento. Foucault observa que a fonte, o limite e a extensão do saber, do fazer e do esperar residem entre a verdade e a liberdade, concluindo que o ser humano faz a si próprio no curso da sua história, na interação da sua língua e no uso da sua bíos. As análises de Foucault se constituem em Crítica do Mesmo, que se consolida, obrigatoriamente, em Abertura para o Outro. Em outras palavras, fazendo a Crítica do Mesmo — quer dizer, delimitando as formações de saber, estabelecendo os limites das relações de poder, fixando as possibilidades das práticas de si —, podese promover Abertura para Outros modos de ser; pode-se construir outras formas de saber, outras relações de poder, outras subjetividades. Nesse sentido, a arqueologia, a genealogia e a hermenêutica são lidas como a possibilidade de determinação da Crítica do que é o Mesmo de uma dada época e de um dado lugar para enfim fazer pensar a Abertura para o Outro. A literatura e a linguagem são vistas como saber Outro. A pintura, a gravura, a fotografia, o cinema e o teatro, enquanto o poder Outro. A estética de si junto à política são vistas como o esperar Outro. Experiências que conseguem ir além do Mesmo e estabelecerem, nos âmbitos do Saber, do Poder e do Si, o inédito, o que antes nunca esteve ali — nem como fonte, nem como limite, nem como extensão de conhecimento teórico, prático ou moral no estabelecimento do modo de ser do homem. Dessa forma, possibilitando uma experiência para além do ser humano. The thesis aims to collaborate in understanding the relationship between Foucault and philosophy. Glimpsing the tripartite field of philosophy observed to occur post-Kant, Foucault calls this moment philosophical modernity precisely because the infinite as foundation leaves the scene and finitude starts to sustain itself. Crossing the critical project — the Critique of Pure Reason, the Critique of Practical Reason, and the Faculty of Judgment — with Anthropological Reflection, Foucault absorbs the philosophical tradition through Kant, concatenating, in addition, in Nietzsche a radical answer that will allow him to build his own thought analytics. Foucault observes that the source, the limit, and the extent of knowing, doing, and hoping reside between truth and freedom, concluding that man makes himself in the course of his history, in the interaction of his language, and in the use of his bios. Foucault's analyses constitute a Critique of the Same that necessarily consolidates itself into an Opening to the Other. In other words, by doing the Critique of the Same, that is, by delimiting the formations of knowledge, by establishing the limits of power relations, by fixing the possibilities of the practices of the self, one can promote Openness to Other ways of being, one can construct other discursive forms, other power relations, other subjectivities. In this sense, archeology, genealogy, and hermeneutics are read as methodological tools used by Foucault to perform this Critical determination of what is the Same of a certain time and place in order to finally make us think about the Opening to the Other. Literature and language are seen as knowledge Other, painting, engraving, photography, cinema, and theater as power Other, and the aesthetics of the self together with politics are seen as expecting Other. Experiences that manage to go beyond the Same and establish in the spheres of Knowledge, Power, and Self, the unheard of, what was never there before, neither as a source, nor as a limit, nor as an extension of theoretical, practical, or moral knowledge in the establishment of man's way of being. In this way, making possible an experience beyond man's being Fundação de Amparo à Pesquisa do Estado de Goiás
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- 2022
31. 7. Diabetes mellitus i SAMINOR-kommunene
- Author
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Ann Ragnhild Broderstad, Ali Naseribafrouei, Bjarne K. Jacobsen, and Marita Melhus
- Subjects
Diabetes mellitus ,samer ,sáme ,General Medicine ,SAMINOR - Abstract
Diabetes mellitus (såhkårdávdda) la kronihkalasj ábnasmålssomskihpudahka gå varán la ilá alla såhkårsisadno. Jus rubmaha sella galggi nahkat såhkkårav bajás válldet ja boalldet de dárbahi insulijnav. Gå la diabiehtta sládja 2 de ij rubmaha ietjas insulijnna nuohkás buoragit dåjma. Navti edna såhkår varán báhtsá. Danen diagnåvsåv biedjá navti jut varrasåhkkårav mihtti. Vuorastuvvat, buojddot, ij buorre biebmojt bårråt jali ij heva labudit li ájnas sivá gå nágina oadtju diabiehtav sládja 2, ja duodden li giena ájnnasa. Diabiehtta sládja 2 lassán jåhtelit væráldin, ja skihpudahka la aj viek dábálasj Vuonan. SAMINOR-guoradallama baktu lip gehtjadam makta diabetes mellitus gávnnu sáme bájkijn, sierraláhkáj diabiehtta sládja 2. Såhkårdásse varán le guovte láhkáj mihttidum: plássmáglukåvsså (varrasåhkår) (sihke SAMINOR 1 ja SAMINOR 2) ja HbA1c (guhkesájggásasj varrasåhkår) (dåssju SAMINOR 2) Duodden gatjádalájma oassálasstijs gatjálvissjiemá baktu jus siján lij diabiehtta. Dát kapihtal åvddånbuktá ájnnasamos diabiehtta-gávnnusijt SAMINOR-guoradallamis ja la ienemusát Ali Naseribafrouei dåktårgráda milta jages 2019. Båhtusa vuosedi li baldedahtte alla diabiehttatálla mijá moattetjerdak álmmuga gaskan nuorttan. Muhtem suohkanijn li badjel 10 % viesádijn áldarin 40–79 jage diabiehtta sládja 2. Diabiehtta la dábálasj sihke nissunij ja ålmmåj gaskan, lehkusa sáme jali ælla. Muhtem analijsa vuosedi muhtem mudduj la ienep diabiehtta ja åvddådiabiehtta (åvddål oadtju diabiehtav) sámij gaskan, valla åbbålattjat ælla heva sieradusá sámij ja ietjá viesádij gaskan sáme årrombájkijn., Diabetes mellitus (sukkersyke) er en kronisk stoffskiftesykdom karakterisert ved for høyt sukkerinnhold i blodet. Insulin er nødvendig for at kroppens celler skal kunne ta opp og forbrenne sukker fra blodet. Ved diabetes type 2 virker ikke insulinet som kroppen produserer godt nok. Dermed blir mye av sukkeret værende i blodet. Diagnosen blir derfor stilt ved å måle blodsukkeret. Økende alder, fedme, usunt kosthold og lite fysisk aktivitet er viktige årsaker til at noen får diabetes type 2, i tillegg til at gener spiller en stor rolle. Forekomsten av diabetes type 2 øker raskt i verden, og sykdommen er også veldig vanlig i Norge. Gjennom SAMINOR-undersøkelsen har vi undersøkt utbredelsen av diabetes mellitus i samiske bosettingsområder, spesielt diabetes type 2. Sukkernivået i blodet er målt på to måter: plasma-glukose (blodsukker) (i både SAMINOR 1 og SAMINOR 2) og HbA1c (langtidsblodsukker) (kun i SAMINOR 2). I tillegg ble deltakerne spurt i spørreskjema om de hadde diabetes. Dette kapittelet presenterer de viktigste diabetes-funnene fra SAMINOR og er i hovedsak basert på Ali Naseribafroueis doktorgrad fra 2019. Resultatene viser at det er foruroligende høye diabetestall i vår fleretniske befolkning i nord. I noen kommuner har over 10 % av innbyggerne i alderen 40–79 år diabetes type 2. Diabetes er vanlig både blant kvinner og menn, uansett om de er samer eller ikke. Enkelte analyser viser en litt høyere forekomst av diabetes og prediabetes (forstadiet til diabetes) blant samer, men det er generelt liten forskjell mellom samer og andre innbyggere i samiske bosettingsområder.
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- 2022
- Full Text
- View/download PDF
32. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors.
- Author
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Sales, Amanda J., Maciel, Izaque S., Crestani, Carlos C., Guimarães, Francisco S., and Joca, Sâmia RL.
- Subjects
- *
SEROTONIN receptors , *SEROTONIN antagonists , *LABORATORY mice , *PREFRONTAL cortex , *NORADRENALINE , *SEROTONIN - Abstract
S-adenosyl-l-methionine (SAMe), a methyl donor, induces antidepressant effects in preclinical and clinical studies of depression. However, the mechanisms behind these effects have been poorly investigated. Since SAMe is involved in monoamine metabolism, this work aimed at 1) testing the effects induced by systemic treatment with SAMe in mice submitted to the forced swimming test (FST) and tail suspension test (TST); 2) investigating the involvement of serotonergic neurotransmission in the behavioral effects induced by SAMe. To do that, male Swiss mice received systemic injections (1 injection/day, 1 or 7 days) of imipramine (30 mg/kg), L-methionine (400, 800, 1600, and 3200 mg/kg), SAMe (10, 25, 50, 100, and 200 mg/kg), or vehicle (10 ml/kg) and were submitted to the FST or TST, 30 min after the last injection. The effect of SAMe (50 mg/kg) was further investigated in independent groups of male Swiss mice pretreated with p-chlorophenylalanine (PCPA, serotonin synthesis inhibitor, 150 mg/kg daily, 4 days) or with WAY100635 (5-HT 1A receptor antagonist, 0.1 mg/kg, 1 injection). One independent group was submitted to the FST and euthanized immediately after for collection of brain samples for neurochemical analyses. Serotonin (5-HT) and noradrenaline (NA) levels were measured in the hippocampus (HPC) and prefrontal cortex (PFC). Furthermore, to investigate if the treatments used could induce any significant exploratory/motor effect which would interfere with the FST results, the animals were also submitted to the open field test (OFT). The administration of imipramine (30 mg/kg), L-methionine (400, 800, 1600, and 3200 mg/kg), and SAMe (10 and 50 mg/kg) reduced the immobility time in the FST, an effect blocked by pretreatment with PCPA and WAY100635. None of the treatments increased the locomotion in the OFT. In conclusion, our results suggest that the antidepressant-like effects induced by SAMe treatment are dependent on serotonin synthesis and 5-HT 1A receptor activation. • S-adenosyl-l-methionine (SAMe) shows antidepressant-like properties. • SAMe effects are dependent on serotonin levels. • SAMe effects are blocked by 5-HT 1A receptor antagonist. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
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