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ObjectiveTo demonstrate measurement precision of cognitive domains in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data set.MethodParticipants with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) were included from all ADNI waves. We used data from each person's last study visit to calibrate scores for memory, executive function, language, and visuospatial functioning. We extracted item information functions for each domain and used these to calculate standard errors of measurement. We derived scores for each domain for each diagnostic group and plotted standard errors of measurement for the observed range of scores.ResultsAcross all waves, there were 961 people with NC, 825 people with MCI, and 694 people with AD at their most recent study visit (data pulled February 25, 2019). Across ADNI's battery there were 34 memory items, 18 executive function items, 20 language items, and seven visuospatial items. Scores for each domain were highest on average for people with NC, intermediate for people with MCI, and lowest for people with AD, with most scores across all groups in the range of -1 to +1. Standard error of measurement in the range from -1 to +1 was highest for memory, intermediate for language and executive functioning, and lowest for visuospatial.ConclusionModern psychometric approaches provide tools to help understand measurement precision of the scales used in studies. In ADNI, there are important differences in measurement precision across cognitive domains. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

We construct an upper ocean (0–1000 m) North Atlantic heat budget (26°–67°N) for the period 1950–2020 using multiple observational datasets and an eddy-permitting global ocean model. On multidecadal time scales, ocean heat transport convergence controls ocean heat content (OHC) tendency in most regions of the North Atlantic with little role for diffusive processes. In the subpolar North Atlantic (45°–67°N), heat transport convergence is explained by geostrophic currents, whereas ageostrophic currents make a significant contribution in the subtropics (26°–45°N). The geostrophic contribution in all regions is dominated by anomalous advection across the time-mean temperature gradient although other processes make a significant contribution, particularly in the subtropics. The time scale and spatial distribution of the anomalous geostrophic currents are consistent with a simple model of basin-scale thermal Rossby waves propagating westward/northwestward in the subpolar gyre, and multidecadal variations in regional OHC are explained by geostrophic currents periodically coming into alignment with the mean temperature gradient as the Rossby wave passes through. The global ocean model simulation shows that multidecadal variations in the Atlantic meridional overturning circulation are synchronized with the ocean heat transport convergence consistent with modulation of the west–east pressure gradient by the propagating Rossby wave. Significance Statement: The purpose of the work is to understand why the North Atlantic Ocean warms up and cools down on time scales of about 40 years. The key finding is that the temperature fluctuations are caused by an oceanic wave pushing the ocean surface up and down and causing ocean currents to change direction, pushing heat into and out of different parts of the ocean, and drawing down or emitting heat to the atmosphere. The findings matter because the warm and cool periods affect the climate of the countries surrounding the North Atlantic. Climate models need to account for this oceanic wave process to correctly predict how it will change in the future and affect the large-scale climate in a warming world. [ABSTRACT FROM AUTHOR]

We present determinations of the gas-phase and stellar metallicities of a sample of 65 star-forming galaxies at |$z \simeq 3.5$| using rest-frame far-ultraviolet (FUV) spectroscopy from the VANDELS survey in combination with follow-up rest-frame optical spectroscopy from VLT /KMOS and Keck/MOSFIRE. We infer gas-phase oxygen abundances (⁠|$Z_{\mathrm{g}}$|⁠ ; tracing O/H) via strong optical nebular lines and stellar iron abundances (⁠|$Z_{\star }$|⁠ ; tracing Fe/H) from full spectral fitting to the FUV continuum. Our sample spans the stellar mass range |$8.5 \lt \mathrm{log}(M_{\star }/\mathrm{M}_{\odot }) \lt 10.5$| and shows clear evidence for both a stellar and gas-phase mass-metallicity relation (MZR). We find that our O and Fe abundance estimates both exhibit a similar mass-dependence, such that |$\mathrm{Fe/H}\propto M_{\star }^{0.30\pm 0.11}$| and |$\mathrm{O/H}\propto M_{\star }^{0.32\pm 0.09}$|⁠. At fixed |$M_{\star }$| we find that, relative to their solar values, O abundances are systematically larger than Fe abundances (i.e. α-enhancement). We estimate an average enhancement of |$\mathrm{(O/Fe)} = 2.65 \pm 0.16 \times \mathrm{(O/Fe)_\odot }$| which appears to be independent of |$M_{\star }$|⁠. We employ analytic chemical evolution models to place a constraint on the strength of galactic-level outflows via the mass-outflow factor (⁠|$\eta$|⁠). We show that outflow efficiencies that scale as |$\eta \propto M_{\star }^{-0.32}$| can simultaneously explain the functional form of of the stellar and gas-phase MZR, as well as the degree of α-enhancement at fixed Fe/H. Our results add further evidence to support a picture in which α-enhanced abundance ratios are ubiquitous in high-redshift star-forming galaxies, as expected for young systems whose interstellar medium is primarily enriched by core-collapse supernovae. [ABSTRACT FROM AUTHOR]

INTRODUCTION: We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging‐defined subgroups. METHODS: We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid‐negative controls. We used voxel‐based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD‐Memory. RESULTS: There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD‐Memory, lower left hemisphere GMV for AD‐Language, anterior lower GMV for AD‐Executive, and posterior lower GMV for AD‐Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD‐Language group than any other group (p = 1.15 × 10−10). For overlap between imaging‐defined and cognitively defined subgroups, AD‐Memory matched up with an imaging‐defined limbic predominant group. DISCUSSION: MRI findings differ across cognitively defined AD subgroups. [ABSTRACT FROM AUTHOR]

Summary: Cardiac surgery requiring cardiopulmonary bypass is associated with postoperative acute kidney injury and neurocognitive disorders, including delirium. Intra‐operative inflammation and/or impaired tissue perfusion/oxygenation are thought to be contributors to these outcomes. It has been hypothesised that these problems may be ameliorated by the highly selective α2‐agonist, dexmedetomidine. We tested the effects of dexmedetomidine on renal and cerebral microcirculatory tissue perfusion, oxygenation and histology in a clinically relevant ovine model. Sixteen sheep were studied while conscious, after induction of anaesthesia and during 2 h of cardiopulmonary bypass. Eight sheep were allocated randomly to receive an intravenous infusion of dexmedetomidine (0.4–0.8 μg.kg‐1.h‐1) from induction of anaesthesia to the end of cardiopulmonary bypass, and eight to receive an equivalent volume of matched placebo (0.9% sodium chloride). Commencement of cardiopulmonary bypass decreased renal medullary tissue oxygenation in the placebo group (mean (95%CI) 5.96 (4.24–7.23) to 1.56 (0.84–2.09) kPa, p = 0.001), with similar hypoxic levels observed in the dexmedetomidine group (6.33 (5.33–7.07) to 1.51 (0.33–2.39) kPa, p = 0.002). While no differences in kidney function (i.e. reduced creatinine clearance) were evident, a greater incidence of histological renal tubular injury was observed in sheep receiving dexmedetomidine (7/8 sheep) compared with placebo (2/8 sheep), p = 0.041. Graded on a semi‐quantitative scale (0–3), median (IQR [range]) severity of histological renal tubular injury was higher in the dexmedetomidine group compared with placebo (1.5 (1–2 [0–3]) vs. 0 (0–0.3 [0–1]) respectively, p = 0.013). There was no difference in cerebral tissue microglial activation (neuroinflammation) between the groups. Dexmedetomidine did not reduce renal medullary hypoxia or cerebral neuroinflammation in sheep undergoing cardiopulmonary bypass. [ABSTRACT FROM AUTHOR]

Recent 21 cm line observations of the ultradiffuse galaxy AGC 114905 indicate a rotating disc largely supported against gravity by orbital motion, as usual. Remarkably, this study has revealed that the form and amplitude of the H  i rotation curve are completely accounted for by the observed distribution of baryonic matter, stars, and neutral gas, implying that no dark halo is required. It is surprising to find a dark matter (DM)-free galaxy for a number of reasons, one being that a bare Newtonian disc having low velocity dispersion would be expected to be unstable to both axisymmetric and non-axisymmetric perturbations that would change the structure of the disc on a dynamical time-scale, as has been known for decades. We present N -body simulations of the DM-free model, and one having a low-density DM halo, that confirm this expectation: the disc is chronically unstable to just such instabilities. Since it is unlikely that a galaxy that is observed to have a near-regular velocity pattern would be unstable, our finding calls into question the suggestion that the galaxy may lack, or have little, DM. We also show that if the inclination of this near face-on system has been substantially overestimated, the consequent increased amplitude of the rotation curve would accommodate a halo massive enough for the galaxy to be stable. [ABSTRACT FROM AUTHOR]

The toroid wear tester (TWT) is a lab‐scale device used for the assessment of slurry erosion in pipelines. Historically, its application has been limited to the relative ranking of material performance under different slurry flow conditions; however, recent studies have indicated that TWT tests could be predictive and directly applied to slurry pipeline design—provided that the flow inside a TWT is better characterized. In the present study, air‐liquid multiphase flow inside the TWT was investigated. Torque measurements were taken to characterize friction loss for different air‐liquid combinations. A visualization experiment was also conducted to evaluate flow patterns within the TWT. In the experiment, the displacements of spherical glass beads were used to estimate velocity vector fields for different TWT rotational speeds. A computational fluid dynamics (CFD) analysis was also conducted to complement the experimental measurements. A 3D transient analysis using the volume of fluid (VOF) approach was used to model the system. The simulation results agreed closely with the experimental findings. Furthermore, the simulations revealed that strong secondary flows (back flow, rotation) exist in the TWT. These type of flows do not occur in horizontal pipelines. Therefore, to use the TWT as a tool for slurry pipeline wear assessment, the differences in the flow field between the two systems must be properly quantified. [ABSTRACT FROM AUTHOR]

To report on two rare and one novel TULP1 pathogenic variants in two patients associated with a previously uncharacterized phenotype of retinal degeneration. Case report. A 4 year-old and a 19 year-old female presented with reduced vision and bilateral bull's eye maculopathy. In both patients, a unique pattern of perivascular retinal degeneration was noted. Electroretinography was consistent with a cone-rod dystrophy. Sequence analysis identified pathogenic variants in the TULP1 gene c.1087 G > A, p.(Gly363Arg); c.1568 G > A, p.(Cys523Tyr); and c.821delA, p.(Lys274ArgfsTer36). Patients with TULP1-related retinal dystrophy can have a distinctive retinopathy with a unique pattern of macular degeneration and periarteriolar vascular pigmentation. [ABSTRACT FROM AUTHOR]