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Your search keyword '"Sarah N. Mapelli"' showing total 5 results
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5 results on '"Sarah N. Mapelli"'

1. The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19

Author

Francesco Scavello, Enrico Brunetta, Sarah N. Mapelli, Emanuele Nappi, Ian David García Martín, Marina Sironi, Roberto Leone, Simone Solano, Giovanni Angelotti, Domenico Supino, Silvia Carnevale, Hang Zhong, Elena Magrini, Matteo Stravalaci, Alessandro Protti, Alessandro Santini, Elena Costantini, Victor Savevski, Antonio Voza, Barbara Bottazzi, Michele Bartoletti, Maurizio Cecconi, Alberto Mantovani, Paola Morelli, Federica Tordato, and Cecilia Garlanda

Subjects
Medicine, Medicine (General), R5-920
Published
2024
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2. A cytokine/PTX3 prognostic index as a predictor of mortality in sepsis

Author

Sadaf Davoudian, Daniele Piovani, Antonio Desai, Sarah N. Mapelli, Roberto Leone, Marina Sironi, Sonia Valentino, Rita Silva-Gomes, Matteo Stravalaci, Fatemeh Asgari, Alessandra Madera, Daniele Piccinini, Carlo Fedeli, Denise Comina, Stefanos Bonovas, Antonio Voza, Alberto Mantovani, and Barbara Bottazzi

Subjects
sepsis, biomarkers, cytokines, PTX3, disease severity, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundEarly prognostic stratification of patients with sepsis is a difficult clinical challenge. Aim of this study was to evaluate novel molecules in association with clinical parameters as predictors of 90-days mortality in patients admitted with sepsis at Humanitas Research Hospital.MethodsPlasma samples were collected from 178 patients, diagnosed based on Sepsis-3 criteria, at admission to the Emergency Department and after 5 days of hospitalization. Levels of pentraxin 3 (PTX3), soluble IL-1 type 2 receptor (sIL-1R2), and of a panel of pro- and anti-inflammatory cytokines were measured by ELISA. Cox proportional-hazard models were used to evaluate predictors of 90-days mortality.ResultsCirculating levels of PTX3, sIL-1R2, IL-1β, IL-6, IL-8, IL-10, IL-18, IL-1ra, TNF-α increased significantly in sepsis patients on admission, with the highest levels measured in shock patients, and correlated with SOFA score (PTX3: r=0.44, p

Published
2022
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3. Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

Author

Matteo Stravalaci, Isabel Pagani, Elvezia Maria Paraboschi, Mattia Pedotti, Andrea Doni, Francesco Scavello, Sarah N. Mapelli, Marina Sironi, Chiara Perucchini, Luca Varani, Milos Matkovic, Andrea Cavalli, Daniela Cesana, Pierangela Gallina, Nicoletta Pedemonte, Valeria Capurro, Nicola Clementi, Nicasio Mancini, Pietro Invernizzi, Rafael Bayarri-Olmos, Peter Garred, Rino Rappuoli, Stefano Duga, Barbara Bottazzi, Mariagrazia Uguccioni, Rosanna Asselta, Elisa Vicenzi, Alberto Mantovani, and Cecilia Garlanda

Subjects
Male, Glycosylation, Immunology, Mannose-Binding Lectin, Chlorocebus aethiops, Animals, Coronavirus Nucleocapsid Proteins, Humans, Immunology and Allergy, Complement Activation, Vero Cells, Polymorphism, Genetic, SARS-CoV-2, COVID-19, Phosphoproteins, Immunity, Humoral, Serum Amyloid P-Component, C-Reactive Protein, HEK293 Cells, Case-Control Studies, Receptors, Pattern Recognition, Host-Pathogen Interactions, Spike Glycoprotein, Coronavirus, Female, Protein Binding, Signal Transduction
Abstract

The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID-19). The present study was designed to conduct a systematic investigation of the interaction of human humoral fluid-phase pattern recognition molecules (PRMs) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Of 12 PRMs tested, the long pentraxin 3 (PTX3) and mannose-binding lectin (MBL) bound the viral nucleocapsid and spike proteins, respectively. MBL bound trimeric spike protein, including that of variants of concern (VoC), in a glycan-dependent manner and inhibited SARS-CoV-2 in three in vitro models. Moreover, after binding to spike protein, MBL activated the lectin pathway of complement activation. Based on retention of glycosylation sites and modeling, MBL was predicted to recognize the Omicron VoC. Genetic polymorphisms at the MBL2 locus were associated with disease severity. These results suggest that selected humoral fluid-phase PRMs can play an important role in resistance to, and pathogenesis of, COVID-19, a finding with translational implications.

Published
2022

4. Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Author

Rosanna Asselta, Elvezia Maria Paraboschi, Matteo Stravalaci, Pietro Invernizzi, Paolo Bonfanti, Andrea Biondi, Isabel Pagani, Mattia Pedotti, Andrea Doni, Francesco Scavello, Sarah N. Mapelli, Marina Sironi, Chiara Perucchini, Luca Varani, Milos Matkovic, Andrea Cavalli, Daniela Cesana, Pierangela Gallina, Nicoletta Pedemonte, Valeria Capurro, Nicola Clementi, Nicasio Mancini, Rafael Bayarri-Olmos, Peter Garred, Rino Rappuoli, Stefano Duga, Barbara Bottazzi, Mariagrazia Uguccioni, Elisa Vicenzi, Alberto Mantovani, Cecilia Garlanda, Asselta, R, Paraboschi, E, Stravalaci, M, Invernizzi, P, Bonfanti, P, Biondi, A, Pagani, I, Pedotti, M, Doni, A, Scavello, F, Mapelli, S, Sironi, M, Perucchini, C, Varani, L, Matkovic, M, Cavalli, A, Cesana, D, Gallina, P, Pedemonte, N, Capurro, V, Clementi, N, Mancini, N, Bayarri-Olmos, R, Garred, P, Rappuoli, R, Duga, S, Bottazzi, B, Uguccioni, M, Vicenzi, E, Mantovani, A, and Garlanda, C

Subjects
haplotype, disease resistance, Letter, genetic association, biochemical analysi, Immunology, gene frequency, virus entry, Mannose-Binding Lectin, coronavirus disease 2019, single nucleotide polymorphism, genetic variability, molecular genetic, Humans, Immunology and Allergy, Genetic Predisposition to Disease, human, mannose binding lectin, disease predisposition, allele, COVID-19, gene mapping, thromboembolism, genetic analysi, mannose binding lectin 2, molecular model, genetic, coronavirus spike glycoprotein, hospitalization
Published
2022

5. Pentraxin 3 Inhibits Complement-driven Macrophage Activation to Restrain Granuloma Formation in Sarcoidosis

Author

Relber A. Gonçales, Helder Novais Bastos, Cláudio Duarte-Oliveira, Daniela Antunes, Oksana Sokhatska, Maria Jacob, Rui Rolo, Cláudia F. Campos, Sergio D. Sasaki, Alessia Donato, Sarah N. Mapelli, Sandra Costa, Conceição Souto Moura, Luís Delgado, António Morais, Egídio Torrado, Frank L. van de Veerdonk, Thomas Weichhart, John D. Lambris, Ricardo Silvestre, Cecilia Garlanda, Alberto Mantovani, Cristina Cunha, and Agostinho Carvalho

Subjects
Inflammation, Pulmonary and Respiratory Medicine, Granuloma, Sarcoidosis, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Complement System Proteins, Macrophage Activation, Critical Care and Intensive Care Medicine, Mice, Serum Amyloid P-Component, All institutes and research themes of the Radboud University Medical Center, C-Reactive Protein, Leukocytes, Mononuclear, Animals, Humans
Abstract

Contains fulltext : 285313.pdf (Publisher’s version ) (Open Access)

Published
2022

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