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2. Loss of epidermal Langerhans cells in psoriasiform lesions of de novo induced or worsened pre‐existing psoriasis following uses of immune checkpoint inhibitors

Author

Misaki Kase, Yasuyuki Fujita, Asako Ota, Satoko Shimizu, Saori Itoi‐Ochi, and Shigetoshi Sano

Subjects
Antineoplastic Agents, Immunological, Langerhans Cells, Neoplasms, Humans, Psoriasis, Dermatology, General Medicine, Immune Checkpoint Inhibitors
Abstract

Immune checkpoint inhibitors (ICI), including monoclonal antibodies to programmed death 1, programmed death ligand 1, and cytotoxic T lymphocyte-associated antigen 4, have provided great therapeutic benefits for cancer patients at advanced stages. However, the introduction of ICI frequently results in the development of immune-related adverse events (irAE) through activation of autoreactive T cells. Here, we present three cases of cancer patients with cutaneous irAE, including development of de novo psoriasis and exacerbation of pre-existing psoriasis. Interestingly, these patients shared an altered histological feature characterized by loss of epidermal CD1a

Published
2022
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