5 results on '"Serrano, Oracio"'
Search Results
2. A rollover Ir(III) complex of 2-(6-bromopyridin-2-yl)imidazo[1,2-a]pyridine.
- Author
-
Varela, Yazmin, Ramírez-García, Gonzalo, Jimenez-Halla, J. Oscar C., Segovia-Mendoza, Mariana, Prado-Garcia, Heriberto, Wrobel, Katarzyna, Wrobel, Kazimierz, Gutiérrez-Granados, Silvia, Lemini, Cristina, and Serrano, Oracio
- Subjects
- *
IMIDAZOPYRIDINES , *PYRIDINE , *DENSITY functional theory , *MASS spectrometry , *ABSORPTION spectra - Abstract
Here in, we report a rollover iridacycle complex cis-[Ir(κ2-C–N-L1)(κ2-N–N-L1)Cl2], which can be easily obtained as yellow solid, through the reaction of two equivalents of new 2-(6-bromopyridin-2-yl)imidazo[1,2-a]pyridine (L1) type ligand and IrCl3 in dimethylformamide at 70 °C for a week. Rollover complex have an unusual κ2-C–N-cyclometallated ligand fragment, which involves the C–H bond activation reaction in remote position on bromo-pyridine, with a second one in classic κ2-N–N-donor mode. The structure of both compounds was studied by NMR, IR, and high-resolution mass spectrometry. Rollover complex UV/Vis absorption spectrum showed a dominating π–π* absorption band at 350 nm. Excitation at 385 nm gave a narrow emission band with maximum at 541 nm, which was associated to ligand-centred emission. The ligand shows antiproliferative activities against breast cancer lines. Density Functional Theory (DFT) calculations suggest that the rollover C–H bond activation occurs after a first κ2-N–N coordination during the complexation of the second ligand and is supported by DMF molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. A serendipitous self-assembly synthesis of CNN–Pt pincer complexes.
- Author
-
Sánchez-Pérez, Eva, Santos-Escobar, Fernando, Gutiérrez-Corona, J. Félix, Wrobel, Kazimierz, Wrobel, Katarzyna, and Serrano, Oracio
- Subjects
- *
SCHIFF bases , *ANILINE , *POLYANILINES , *SOLUBILIZATION , *HYDRIDES - Abstract
In this work, we describe a serendipitous self-assembly synthesis of non-symmetrical CNN–platinacycle pincer complexes, with an early formation and detection of hydride species. The synthesis involves a formal C–H bond activation, with an earlier C–N bond formation via C–Br bond excision, instead of the expected rollover cyclometalated complex. According to our experimental results, the nature of the Pt(II)-starting material, having cyclooctene (COE), tetrahydrothiophene (THT) or Cl as co-ligands, does not affect the reaction pathway, and the best yields are achieved using stochiometric amounts of K2PtCl4, and the appropriate Schiff base ligand and aniline, at 70 °C for three days. Structures of platinacycle complexes have been supported by UV/Vis, IR, NMR and ESI-MS experiments, although specific ions formed in the ionization source were affected by the solvent used for compound solubilization/dilution. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
4. Diaryl(fluorinated)-mercury species as potential precursors of triaryl(fluorinated)-gallium to be used in the synthesis of cyclometallated Ga compounds and unexpected formation of aryl-Ga clusters.
- Author
-
López-Azpeitia, Sergio, Espinoza-Cruz, Tania L., Mejia-Rivera, Fernando, Gómez-Infante, Antonio, Perlata-Hernández, Juan M., Wrobel, Katarzyna, Alvarado-Rodríguez, José Gpe., Wrobel, Kazimierz, and Serrano, Oracio
- Subjects
- *
MERCURY , *LEWIS acids , *MASS spectrometry , *MERCURY compounds , *GAS chromatography , *SPECIES - Abstract
The first goal of this work was to explore the feasibility of diaryl-mercury species as the synthetic precursors of triaryl-gallium species GaAr* 3 (where Ar*= pH, 4; Ar*= 3,5-difluorophenyl, 5; and Ar*= 3,5-trifluoromethylphenyl, 6). Expecting that 4–6 behave as Lewis acids of different strength, the second purpose was to use them for the synthesis of either rollover or classic cyclometallated Ga compounds. Three analogous diaryl-mercury HgAr* 2 species, 1–3, were successfully synthesized. The structures of compounds 2 and 3 were confirmed by gas chromatography - mass spectrometry experiments. Additionally, compound 3 was analyzed through X-ray diffraction; in the crystal structure obtained, π-stacking interactions were observed. The only Ga compound synthesized was GaPh 3 , 4, because the presence of fluorine-containing groups in meta-position caused sublimation of the respective mercury diaryl compounds, impeding their reaction with gallium. The attempts toward the synthesis of the rollover or classic cyclometallated compounds in the reaction of 4 with bipyridine-, pyrazole- or benzo-imidazole- type ligands have failed. On the other hand, under the experimental conditions applied, water traces favored formation of the solid aryl-Ga cluster containing twelve Ga atoms [Ga 12 ], whereas the above-mentioned ligands were quantitatively recovered in the solution. The identity of aryl-gallium cluster was confirmed by electrospray ionization - high resolution mass spectrometry. Although Ga cluster was not expected, it is considered an important finding of this work, owing to the variety of possible applications and still limited data available on the synthesis and structural characterization of such compounds. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. A turn-on fluorescence sensor based on water-soluble amino-pyridyl-benzothiazole-derivatives for measuring cellular Zn2+.
- Author
-
Sevillano-Arredondo, Rosa M., Desirena, Haggeo, Juárez-Moreno, Karla, Serrano, Oracio, and Ramírez-García, Gonzalo
- Subjects
- *
CHEMORECEPTORS , *NUCLEOPHILIC substitution reactions , *FLUORESCENCE , *DETECTORS , *ALIPHATIC amines , *ENERGY transfer - Abstract
[Display omitted] • Novel amino-pyridyl-benzothiazole derivatives were implemented as Zn2+ sensors. • A gradient turn-on luminescence response was observed upon coordination with Zn2+. • Instantaneous and selective determination in the 4.7 to 80 μM range was verified at pH 7.0. • The sensor revealed intracellular Zn2+ levels of some cancer cell lines. • The real-time epifluorescence distribution profiles correlated with the concentration and location of the target within living cells. Novel amino-pyridyl-benzothiazole-derivatives (PBT) were synthesized through cycloaddition/nucleophilic aromatic substitution reactions for the development of a turn-on fluorescence chemosensor that accurately determines Zn2+ in polar media. The selectivity, water-solubility, and overall analytical response were systematically optimized through incorporation of different aliphatic amines as substituents: pyrrolidine (PBT-Pyn), ethylenediamine (PBT-Et) or 1,3-propylenediamine (PBT-Pr). Those ligands presented intense dual radiative emissions in the blue/green region upon activation with a 395 nm LED, which were attributed to the local excitation and internal energy transfer states. Although no variations were observed upon the interaction of Zn2+ with PBT-Pyn, both turn-off and turn-on responses were observed upon its interaction with PBT-Et. These responses depended on the ligand concentration and the associated inner filter effects. Thereby, PBT-Pr was selected for a deeper evaluation towards photoluminescence determination of Zn2+ due to its exclusive turn-on response and major sensibility obtained at pH 7.0, making it very convenient for analysis in physiological media. Under those conditions, the detection limits were 1.9 µM and 4.7 µM for measurements in aqueous or ethanolic solutions, respectively, with linear ranges up to 40 and 80 μM. The selectivity and good biocompatibility of the chemosensor were demonstrated through cell-viability assays with MCF-7, 3T3-L1 and HT-29 cell lines. The probe was then applied for the real-time epifluorescence imaging of Zn2+, observing emission intensities and distribution profiles that correlated with the concentration and location of the target within living cells. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.