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To analyze the risk factors affecting prognosis of children with hemophagocytic lymphohistiocytosis (HLH).The clinical manifestations and laboratory data of 143 HLH children who met the HLH-2004 diagnostic criteria in Shenzhen Children's Hospital from January 2009 to May 2017 were retrospectively analyzed, and the independent factors affecting prognosis were also analyzed.The median age of 143 HLH children was 1.9 (0.1-14.3) years old, and the median follow-up time was 6.7 years (1 day - 11.9 years). The overall survival rate of 1 month, 1 year, and 10 years was (87.4±5.5)%, (81.1±6.5)%, and (81.1±6.5)%, respectively. The deaths occurred within 1 year after onset. Multivariate analysis showed that central nervous system (CNS) involvement (P=0.047), low hemoglobin (P=0.002), prolonged activated partial thromboplastin time (APTT) (P0.001), high triglyceride (P=0.005) were all the independent risk factors affecting survival of the children. Receiver operating characteristic curve indicated that APTT (AUC=0.753, P0.001) was more valuable than other risk factors in predicting death of the children. The cut-off value of APTT was 56.6 s, and the sensitivity and specificity of which was 55.6% and 89.7%, respectively.Hypohemoglobinemia, prolonged APTT, hypertriglyceridemia, and CNS involvement the risk factors affecting prognosis of HLH, and prolonged APTT shows a strong predictive value for death.儿童噬血细胞性淋巴组织细胞增生症预后相关因素分析.分析噬血细胞性淋巴组织细胞增生症（HLH）患儿的预后相关危险因素.回顾性分析深圳市儿童医院2009年1月至2017年5月143例符合HLH-2004诊断标准的HLH患儿临床表现及实验室检查，分析影响患儿预后的独立危险因素.患儿的中位年龄为1.9（0.1-14.3）岁，中位随访时间为6.7年（1天-11.9年）；1个月、1年和10年总生存率分别为（87.4±5.5）%、（81.1±6.5）%和（81.1±6.5）%，死亡集中发生在发病后1年内；多因素分析结果显示，中枢神经系统受累（P=0.047）、血红蛋白降低（P=0.002）、活化部分凝血活酶时间延长（P0.001）、高甘油三酯（P=0.005）均是影响患儿生存的独立危险因素；受试者工作特征曲线分析提示，活化部分凝血活酶时间（AUC=0.753，P0.001）较其他危险因素预测死亡的价值更大，其预测死亡的截断值为56.6 s，灵敏度和特异度分别为55.6%和89.7.血红蛋白降低、活化部分凝血活酶时间延长、高甘油三酯及中枢神经系统受累是影响HLH预后的危险因素，其中活化部分凝血活酶时间延长对死亡具有较强的预测价值.

The effects of polymorphic form and particle size of SiO2 fillers on the dielectric, mechanical and thermal properties of SiO2–Polyetheretherketone (SiO2–PEEK) composites were investigated in this paper. Strong low frequency (2 fillers. All the composites obtained in this case demonstrate the dielectric permittivities of [Formula: see text] at high frequencies. The crystalline [Formula: see text]-cristobalite filled composite exhibits lower dielectric loss and mechanical strength, but larger thermal expansion coefficient and thermal conductivity, compared with the similar particle sized amorphous SiO2 filled one. The crystalline [Formula: see text]-quartz filled composite demonstrates the lowest mechanical strength and highest dielectric loss. An increase in particle size of the spherical fused silica fillers decreases the dielectric loss, while increases the thermal conductivity of the composite. The flexural strength of the composite reaches the maximum value of 113 MPa when the particle size of spherical SiO2 filler is [Formula: see text]m. Particle packing by combining optimal amounts of differently sized spherical fused silica fillers leads to a substantial improvement of mechanical strength (153MPa) coupled with reasonable dielectric and thermal properties due to the synergic effect (dielectric permittivity ([Formula: see text] = 3.35, dielectric loss (tan[Formula: see text] @10 GHz, thermal conductivity ([Formula: see text] = 0.74 W/m*k ([Formula: see text]C), coefficient of thermal expansion ([Formula: see text]C and relative density ([Formula: see text]) = 99.72%).