136 results on '"Silke, John"'
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2. RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation
3. Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
4. Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity
5. Blocking cell death limits lung damage and inflammation from influenza
6. RIPK1 and necroptosis role in premature ageing
7. A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
8. The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
9. Apoptotic cell death in disease—Current understanding of the NCCD 2023
10. MLKL deficiency protects against low-grade, sterile inflammation in aged mice
11. High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death
12. Deletion of Gpatch2 does not alter Tnf expression in mice
13. OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling
14. Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
15. Dual roles for LUBAC signaling in thymic epithelial cell development and survival
16. Unleashing TNF cytotoxicity to enhance cancer immunotherapy
17. The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
18. Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1−/− mice
19. Telemedical cardiac risk assessment by implantable cardiac monitors in patients after myocardial infarction with autonomic dysfunction (SMART-MI-DZHK9): a prospective investigator-initiated, randomised, multicentre, open-label, diagnostic trial
20. Single-cell spatial proteomics identifies the JAK/STAT pathway as an actionable therapeutic target in lethal cutaneous drug reactions
21. cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation
22. OR05-06 Histone Deacetylase Inhibitor, Panobinostat, In Combination With A Smac-mimetic For The Treatment Of Ovarian Granulosa Cell Tumours
23. Biallelic human SHARPINloss of function induces autoinflammation and immunodeficiency
24. Figure S2 from Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors
25. Movie 1 from Antagonism of IAPs Enhances CAR T-cell Efficacy
26. Data from Antagonism of IAPs Enhances CAR T-cell Efficacy
27. Supplementary Figures 1 and 2 from Antagonism of IAPs Enhances CAR T-cell Efficacy
28. Supplementary Data Legends from Antagonism of IAPs Enhances CAR T-cell Efficacy
29. Table S1 from Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors
30. Movie 2 from Antagonism of IAPs Enhances CAR T-cell Efficacy
31. Data from Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors
32. Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL ‐1β release in X‐linked inhibitor of apoptosis ( XIAP ) deficiency
33. Deletion of Gpatch2 does not alter Tnf expression in mice
34. Human LUBAC deficiency leads to autoinflammation and immunodeficiency by dysregulation in TNF-mediated cell death
35. The unifying catalytic mechanism of the RING-between-RING E3 ligase family
36. A common humanMLKLpolymorphism confers resistance to negative regulation by phosphorylation
37. Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers
38. Langerhans cells are an essential cellular intermediary in chronic dermatitis
39. Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death
40. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
41. Faculty Opinions recommendation of The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling.
42. Necroptosis in chronic obstructive pulmonary disease, a smoking gun?
43. Faculty Opinions recommendation of Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein.
44. Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis
45. Faculty Opinions recommendation of Optimization of a series of RIPK2 protacs.
46. Faculty Opinions recommendation of Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer.
47. NF-κB and Pancreatic Cancer; Chapter and Verse
48. HOIP limits anti‐tumor immunity by protecting against combined TNF and IFN‐gamma‐induced apoptosis
49. OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling.
50. Transplantable programmed death ligand 1 expressing gastroids from gastric cancer prone Nfkb1−/− mice.
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