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Your search keyword '"Simas, Rosineide Costa"' showing total 11 results
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11 results on '"Simas, Rosineide Costa"'

3. Antiviral, Cytoprotective, and Anti-Inflammatory Effect of Ampelozizyphus amazonicus Ducke Ethanolic Wood Extract on Chikungunya Virus Infection

Author

Rocha, Daniele C. P., primary, Sisnande, Tháyna, additional, Gavino-Leopoldino, Daniel, additional, Guimarães-Andrade, Iris Paula, additional, Cruz, Fernanda F., additional, Assunção-Miranda, Iranaia, additional, Mendonça, Simony C., additional, Leitão, Gilda Guimarães, additional, Simas, Rosineide Costa, additional, Mohana-Borges, Ronaldo, additional, Leitão, Suzana Guimarães, additional, and Allonso, Diego, additional

Published
2023
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4. Greener molecularly imprinted polymers: Strategies and applications in separation and mass spectrometry methods

Author

Martins, Rafael Oliveira, primary, Bernardo, Ricardo Alves, additional, Machado, Lucas Santos, additional, Batista Junior, Almir Custodio, additional, Maciel, Lanaia Ítala Louzeiro, additional, Aguiar, Deborah Victoria Alves de, additional, Sanches Neto, Flávio Olimpio, additional, Oliveira, João Victor Ataíde, additional, Simas, Rosineide Costa, additional, and Chaves, Andréa Rodrigues, additional

Published
2023
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6. Integrated Metabolic and Inflammatory Signatures Associated with Severity of, Fatality of, and Recovery from COVID-19

Author

Gardinassi, Luiz Gustavo, primary, Servian, Carolina do Prado, additional, Lima, Gesiane da Silva, additional, dos Anjos, Déborah Carolina Carvalho, additional, Gomes Junior, Antonio Roberto, additional, Guilarde, Adriana Oliveira, additional, Borges, Moara Alves Santa Bárbara, additional, dos Santos, Gabriel Franco, additional, Moraes, Brenda Grazielli Nogueira, additional, Silva, João Marcos Maia, additional, Masson, Letícia Carrijo, additional, de Souza, Flávia Pereira, additional, da Silva, Rodolfo Rodrigues, additional, de Araújo, Giovanna Lopes, additional, Rodrigues, Marcella Ferreira, additional, da Silva, Lidya Cardozo, additional, Meira, Sueli, additional, Fiaccadori, Fabiola Souza, additional, Souza, Menira, additional, Romão, Pedro Roosevelt Torres, additional, Spadafora Ferreira, Mônica, additional, Coelho, Verônica, additional, Chaves, Andréa Rodrigues, additional, Simas, Rosineide Costa, additional, Vaz, Boniek Gontijo, additional, and Fonseca, Simone Gonçalves, additional

Published
2023
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8. Laser ablation electrospray ionization mass spectrometry imaging as a new tool for accessing patulin diffusion in mold-infected fruits

Author

da Silva Lima, Gesiane, primary, Franco dos Santos, Gabriel, additional, Ramalho, Ruver Rodrigues Feitosa, additional, de Aguiar, Deborah Victoria Alves, additional, Roque, Jussara Valente, additional, Maciel, Lanaia Itala Louzeiro, additional, Simas, Rosineide Costa, additional, Pereira, Igor, additional, and Vaz, Boniek Gontijo, additional

Published
2022
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9. In vitro α-glucosidase inhibition by Brazilian medicinal plant extracts characterised by ultra-high performance liquid chromatography coupled to mass spectrometry

Author

Lianza, Mariacaterina, primary, Poli, Ferruccio, additional, Nascimento, Alan Menezes do, additional, Soares da Silva, Aline, additional, da Fonseca, Thamirys Silva, additional, Toledo, Marcos Vinicius, additional, Simas, Rosineide Costa, additional, Chaves, Andréa Rodrigues, additional, Leitão, Gilda Guimarães, additional, and Leitão, Suzana Guimarães, additional

Published
2022
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10. Bioassay-Guided Fractionation of Siparuna glycycarpa n-Butanol Extract with Inhibitory Activity against Influenza A(H1N1)pdm09 Virus by Centrifugal Partition Chromatography (CPC)

Author

Leal, Carla Monteiro, primary, Leitão, Suzana Guimarães, additional, de Mello, Leonardo Luiz Oliveira, additional, Rangel, Isabel de Castro, additional, da Silva, Carlos Vinicius Azevedo, additional, Miranda, Milene Dias, additional, Tucci, Amanda Resende, additional, de Assis, Camilla Blanco, additional, Sacramento, Carolina de Queiroz, additional, Fintelman-Rodrigues, Natalia, additional, Koolen, Hector Henrique Ferreira, additional, Vaz, Boniek Gontijo, additional, Simas, Rosineide Costa, additional, and Leitão, Gilda Guimarães, additional

Published
2022
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11. Bioassay-Guided Fractionation of Siparuna glycycarpa   n -Butanol Extract with Inhibitory Activity against Influenza A(H1N1)pdm09 Virus by Centrifugal Partition Chromatography (CPC).

Author

Leal CM, Leitão SG, de Mello LLO, Rangel IC, da Silva CVA, Miranda MD, Tucci AR, de Assis CB, Sacramento CQ, Fintelman-Rodrigues N, Koolen HHF, Vaz BG, Simas RC, and Leitão GG

Subjects
1-Butanol chemistry, Biological Assay, Chemical Fractionation methods, Humans, Chromatography, Liquid methods, Alkaloids pharmacology, Alkaloids chemistry, Alkaloids isolation & purification, Influenza A Virus, H1N1 Subtype drug effects, Plant Extracts chemistry, Plant Extracts pharmacology, Antiviral Agents pharmacology, Antiviral Agents chemistry
Abstract

Siparuna glycycarpa occurs in the Amazon region, and some species of this genus are used in Brazilian folk medicine. A recent study showed the inhibitory effect of this species against influenza A(H1N1)pdm09 virus, and in order to acquire active fractions, a polar solvent system n -butanol-methanol-water (9:1:10, v / v ) was selected and used for bioassay-guided fractionation of n -butanol extract by centrifugal partition chromatography (CPC). The upper phase was used as stationary phase and the lower phase as mobile (descending mode). Among the collected fractions, the ones coded SGA, SGC, SGD, and SGO showed the highest antiviral inhibition levels (above 74%) at 100 µg·mL -1 after 24 h of infection. The bioactive fractions chemical profiles were investigated by LC-HRMS/MS data in positive and negative ionization modes exploring the Global Natural Products Social Molecular Networking (GNPS) platform to build a molecular network. Benzylisoquinoline alkaloids were annotated in the fractions coded SGA, SGC, and SGD collected during elution step. Aporphine alkaloids, O -glycosylated flavonoids, and dihydrochalcones in SGO were acquired with the change of mobile phase from lower aqueous to upper organic. Benzylisoquinolinic and aporphine alkaloids as well as glycosylated flavonoids were annotated in the most bioactive fractions suggesting this group of compounds as responsible for antiviral activity.

Published
2022
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