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Background: Suicide has become a leading cause of death among 15- to 39-year-olds. Recent data suggests that one student commits suicide every 60 seconds in India. One of the suicide preventive strategies adopted is the introduction of a crisis helpline for students but the effectiveness of this support in preventing suicide remains questionable. Our study aims to find out the perspectives of students on suicide and their recommendations for an effective suicide prevention program. Method: A qualitative design with focus group discussions was used to collect data. A universal sampling technique was adopted and the data were analyzed using the framework method. Results: A total of 830 students were divided into 70 groups with each group having 12 to 15 students participating in the focus group discussion. Several themes and subthemes emerged from the discussion. Overall, students had a poor understanding of people who attempt suicide, elaborated the factors instigating a person to make a suicidal attempt, barriers to access help and their views on effective crisis intervention service.Conclusion: The study identified student perspectives on suicide and the challenges perceived by the students for the effective implementation of a crisis intervention program for suicide prevention.

Background: India stands to be the major market of exponential growth for the suppliers of smartphones. With the increasing availability and reduced pricing, both smartphone usage and its dependence are bound to increase. Nomophobia though reported commonly in the young, the behavior seems to span across age which warrants further exploration. This study aimed to determine the relationship between the smartphone use and nomophobia disorder among adults. Methodology: Adults above 18 years responded to our online survey by snowballing method. Information collected included sociodemographic data, smartphone use details, and severity of nomophobia assessed by a 20-item NoMophobia Questionnaires (NMP-Q). Statistical analysis was performed using the SPSS software version 20. Descriptive and inferential statistics were used. Results: A total of 661 participants (female = 309) responded to our survey. Among them 51.1% were in 18–29 years age group. Majority were employed (61.7%) and married (50.4%), coming from an urban background (81.1%), owned a 4G mobile (82.5%), consuming >4 GB per month (58.6%). About 42% of them used smartphones for more than 4 h on activities not related to their jobs. They used smartphones frequently to search information, text and talk to family members. Mostly used when bored, alone or waiting for someone. The median NMP-Q score was 77 (±22.5) and 49.3% of our respondents had scored above the median cutoff score. Nomophobia was positively correlated with duration of phone use per day and inversely with age. Duration of smartphone use predicted nomophobia (80.34 + 4.91; P < 0.001). Conclusion: Nomophobia prevails across age group with increased severity in the young. Intervention need to be planned to decrease the duration of use per day as it emerged as a significant predictor of nomophobia.

Abstract Background In India, for the treatment of cold, fever and inflammation, people consume herbal remedies containing Andrographis paniculata Nees (APE) as main ingredient, along with NSAIDs. So the purpose of this study is to investigate the effect of APE and pure andrographolide (AN) on the pharmacokinetic of with aceclofenac (ACF) and celecoxib (CXB) after oral co-administration in wistar rats. After co-administration of APE (equivalent to 20 mg/kg of AN) and AN (20 mg/kg) with ACF (5 mg/kg) and CXB (5 mg/kg) in rats, orally, drug concentrations in plasma were determined using HPLC method. Non-compartment model was used to calculate pharmacokinetic parameters like Cmax, Tmax, t1/2, MRT, Vd, CL, and AUC. Results Co-administration of ACF and CXB with APE and pure AN altered the systemic exposure level of each compound in vivo. The Cmax, Tmax, MRT of CXB were increased whereas Vd and Cl of CXB were decreased significantly after co-administration of CXB with APE. Whereas co-administration of CXB with AN significantly decreased Vd, CL, and MRT of CXB. The concentration of ACF was increased significantly in co-administered groups with pure AN and APE. The AUC0-∞, AUMC0-∞, MRT, Vd and t1/2 of ACF were also significantly decreased in co-administered groups, hence CL of ACF was increased significantly. Conclusion This study concludes that APE and pure AN have effect on pharmacokinetic of CXB and ACF in rat. Not only patients but medical practitioners using Andrographis paniculata should have awareness regarding probable herb–drug interactions with ACF and CXB.

Background: India stands to be the major market of exponential growth for the suppliers of smartphones. With the increasing availability and reduced pricing, both smartphone usage and its dependence are bound to increase. Nomophobia though reported commonly in the young, the behavior seems to span across age which warrants further exploration. This study aimed to determine the relationship between the smartphone use and nomophobia disorder among adults. Methodology: Adults above 18 years responded to our online survey by snowballing method. Information collected included sociodemographic data, smartphone use details, and severity of nomophobia assessed by a 20-item NoMophobia Questionnaires (NMP-Q). Statistical analysis was performed using the SPSS software version 20. Descriptive and inferential statistics were used. Results: A total of 661 participants (female = 309) responded to our survey. Among them 51.1% were in 18-29 years age group. Majority were employed (61.7%) and married (50.4%), coming from an urban background (81.1%), owned a 4G mobile (82.5%), consuming >4 GB per month (58.6%). About 42% of them used smartphones for more than 4 h on activities not related to their jobs. They used smartphones frequently to search information, text and talk to family members. Mostly used when bored, alone or waiting for someone. The median NMP-Q score was 77 (±22.5) and 49.3% of our respondents had scored above the median cutoff score. Nomophobia was positively correlated with duration of phone use per day and inversely with age. Duration of smartphone use predicted nomophobia (80.34 + 4.91; P < 0.001). Conclusion: Nomophobia prevails across age group with increased severity in the young. Intervention need to be planned to decrease the duration of use per day as it emerged as a significant predictor of nomophobia. [ABSTRACT FROM AUTHOR]