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Your search keyword '"Sourav Patra"' showing total 33 results
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33 results on '"Sourav Patra"'

1. Electrochemical separation and purification of no-carrier-added 177Lu for radiopharmaceutical preparation: Translation from bench to bed

Author

Sourav Patra, Rubel Chakravarty, Khajan Singh, K.V. Vimalnath, and Sudipta Chakraborty

Subjects
177Lu, Electrochemical separation, No-carrier-added, Purification, Radiopharmaceuticals, DOTA-TATE, Chemical engineering, TP155-156
Abstract

The entry of no-carrier-added (NCA) 177Lu in the arena of clinical nuclear medicine has revolutionized the practice of targeted radionuclide tumor therapy. In this study, we report the development of an electrochemical separation and purification procedure to obtain NCA 177Lu in a clinically usable form. The overall yield of the process developed was > 70% and it was reproducible in multiple batches. The effective specific activity of NCA 177Lu was 3.32 ± 0.04 TBq/mg and the radioisotope was found suitable for formulation of therapeutically relevant doses of [177Lu]Lu-DOTA-TATE with >98% radiolabeling yield. As a proof of concept, [177Lu]Lu-DOTA-TATE synthesized using electrochemically purified NCA 177Lu was administered in patients with proven neuroendocrine tumor (NET) and satisfactory preliminary clinical outcome was obtained. The feasibility of recovery of enriched (in 176Yb) target in chemical form suitable for reuse in the production of a fresh batch of NCA 177Lu was demonstrated, which makes the process economically viable. Overall, this robust and efficient radiochemical separation and purification technology might aid towards introduction of new 177Lu-based radiopharmaceuticals for use in clinical context in the foreseeable future.

Published
2023
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2. Microfluidic solvent extraction of no-carrier-added 64Cu from irradiated Zn target for radiopharmaceutical preparation

Author

Rubel Chakravarty, Nirvik Sen, Sourav Patra, A. Rajeswari, Priyalata Shetty, Krishna Kumar Singh, and Sudipta Chakraborty

Subjects
64Cu, Dithizone, Liquid-liquid extraction, Microfluidics, No-carrier-added, Radiopharmaceuticals, Chemical engineering, TP155-156
Abstract

Microfluidics based liquid-liquid extraction is emerging as an enabling and powerful technology in radiochemical separations of medically important radioisotopes. In this study, we report the production of high specific activity 64Cu via 64Zn (n, p) 64Cu reaction in a research reactor. A microfluidic continuous flow liquid-liquid extraction system based on the use of dithizone as extractant was developed for efficient separation of miniscule quantity of 64Cu (in ng level) from bulk irradiated Zn target (in g level). The extraction process is completely selective for 64Cu, which could subsequently be retrieved in the desired medium for preparation of radiopharmaceuticals. The overall yield of 64Cu after the separation process was > 85 % and it was obtained with adequately high radionuclidic, radiochemical and chemical purities. Additionally, the effective specific activity of radio chemically separated 64Cu was determined to be 12.2 ± 0.8 GBq/µg, which is quite close to that reported for cyclotron produced no-carrier-added (NCA) 64Cu available commercially. The final 64Cu formulation could be effectively used for preparation of a variety of radiopharmaceuticals with high radiolabeling yields. The promising results obtained in this study open the pathway to achieve continuous and efficient recovery of reactor produced NCA 64Cu from the irradiated target using an automated microfluidic setup.

Published
2023
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7. Measurement of the B+/B0 production ratio in e+e− collisions at the ϒ(4S) resonance using B→J/ψ(ℓℓ)K decays at Belle

Author

Shubhangi Krishan Maurya, Thomas E Browder, Jyotirmoi Borah, Saurabh Sandilya, Christos Hadjivasiliou, Hiroaki Aihara, Andrzej Bożek, Dmitri Liventsev, Markus Tobias Prim, Ichiro Adachi, Christoph Schwanda, Jan Strube, MIN-ZU WANG, Shohei Nishida, Daniel Ferlewicz, Bruce Yabsley, Longke Li, Paolo Branchini, Leo Piilonen, Stephan Paul, Anselm Vossen, Mario Merola, Jake Bennett, Peter Kodyš, Marcello Campajola, Chunhui Chen, Masako Iwasaki, Isamu Nakamura, Karim Trabelsi, J B Singh, Vipin Gaur, Kevin Varvell, Sourav Patra, Chang-Zheng Yuan, Akimasa Ishikawa, Giacomo De Pietro, Seongbae Yang, Peter Mandeville Lewis, David Asner, Chia-Ling Hsu, PHILLIP URQUIJO, Kiyoshi Tanida, and Elena Solovieva

Published
2023

10. Measurement of branching fractions of Λc+→pKS0KS0 and Λc+→pKS0η at Belle

Author

Shubhangi Krishan Maurya, Swagato Banerjee, Thomas E Browder, Jyotirmoi Borah, Saurabh Sandilya, Gunar Schnell, Christos Hadjivasiliou, Hiroaki Aihara, Andrzej Bożek, Dmitri Liventsev, Markus Tobias Prim, Ichiro Adachi, Christoph Schwanda, Kay Kinoshita, Jan Strube, Armine Rostomyan, MIN-ZU WANG, Shohei Nishida, Daniel Ferlewicz, Bruce Yabsley, Bostjan Golob, Longke Li, Paolo Branchini, Leo Piilonen, Frank Simon, Stephan Paul, Anselm Vossen, Thanh Dong, Mario Merola, Jake Bennett, Peter Kodyš, Marcello Campajola, Masako Iwasaki, Isamu Nakamura, J B Singh, Vipin Gaur, Kevin Varvell, Torben Ferber, Sourav Patra, Chang-Zheng Yuan, Akimasa Ishikawa, Giacomo De Pietro, Seongbae Yang, David Asner, Chia-Ling Hsu, PHILLIP URQUIJO, Kiyoshi Tanida, and Elena Solovieva

Published
2023

12. Measurement of the branching fractions for Cabibbo-suppressed decays D+→K+K−π+π0 and D(s)+→K+π−π+π0 at Belle

Author

Shubhangi Krishan Maurya, Thomas E Browder, Jyotirmoi Borah, Saurabh Sandilya, Gunar Schnell, Christos Hadjivasiliou, Hiroaki Aihara, Andrzej Bożek, Alberto Martini, Dmitri Liventsev, Markus Tobias Prim, Christoph Schwanda, Kay Kinoshita, Lopamudra Nayak, Armine Rostomyan, MIN-ZU WANG, Shohei Nishida, Bruce Yabsley, David Dossett, Longke Li, Paolo Branchini, Leo Piilonen, Frank Simon, Stephan Paul, Sam Cunliffe, Anselm Vossen, Mario Merola, Jake Bennett, Peter Kodyš, Marcello Campajola, Masako Iwasaki, J B Singh, Vipin Gaur, Debashis Sahoo, Kevin Varvell, Sourav Patra, Chang-Zheng Yuan, Akimasa Ishikawa, Giacomo De Pietro, Seongbae Yang, David Asner, Chia-Ling Hsu, Kiyoshi Tanida, Elena Solovieva, and PAO-TI CHANG

Published
2023

15. Leader-Based Consensus in Directed Networks of Homogeneous Positive Agents With Multiple Inputs

Author

Sabyasachi Bhattacharyya and Sourav Patra

Subjects
Control and Systems Engineering, Mechanical Engineering, Instrumentation, Computer Science Applications, Information Systems
Abstract

In this paper, the non-zero finite positive state consensus problem of leader-following multi-agent systems (MASs) connected over a directed network is investigated. The multi-agent network consists of homogeneous linear time-invariant (LTI) positive agents whose minimal positive state-space realization is assumed to be known. In this paper, a state-feedback hierarchical control protocol is proposed where the local controller synthesizes a singular, Lyapunov stable, and Metzler system matrix with a simple dominant eigenvalue at origin. The obtained consensus vector is the positive eigenvector associated with the zero eigenvalue of the synthesized system matrix. The controller gain matrices are obtained by solving a set of necessary and sufficient conditions derived in linear programing framework. A numerical example is given to elucidate the usefulness of the proposed results.

Published
2022

16. Search for the decay Bs0→η′KS0

Author

Thomas E Browder, Jyotirmoi Borah, Shawn Dubey, Lopamudra Nayak, Denis Bodrov, Bruce Yabsley, Evgeniy Kovalenko, Sam Cunliffe, Vladimir Savinov, Sourav Patra, Valentina Zhukova, Giacomo De Pietro, Konstantin Belous, Chia-Ling Hsu, and Elena Solovieva

Published
2022

19. Search for the radiative penguin decays B0→KS0KS0γ in the Belle experiment

Author

Shubhangi Krishan Maurya, Thomas E Browder, Jyotirmoi Borah, Alberto Martini, Lopamudra Nayak, Denis Bodrov, Bruce Yabsley, Evgeniy Kovalenko, Andrii Natochii, Sam Cunliffe, Thanh Dong, Jens Sören Lange, Hiroaki Ono, Sourav Patra, Valentina Zhukova, Kookhyun Kang, Konstantin Belous, Felix Metzner, Chia-Ling Hsu, and Elena Solovieva

Published
2022

21. Study of γγ→γψ(2S) at Belle

Author

Andrzej Bożek, Lopamudra Nayak, Evgeniy Kovalenko, Andrii Natochii, Sam Cunliffe, Thanh Dong, Masako Iwasaki, Zbigniew Natkaniec, Jens Sören Lange, Hiroaki Ono, Sourav Patra, BIPUL BHUYAN, Valentina Zhukova, Felix Metzner, Makoto Takizawa, Chia-Ling Hsu, Elena Solovieva, and Olga Werbycka

Published
2022

23. Measurement of Two-Particle Correlations of Hadrons in e+e− Collisions at Belle

Author

Thomas E Browder, Jyotirmoi Borah, Alberto Martini, Lopamudra Nayak, Yu-Chen Chen, Denis Bodrov, Yen-Jie Lee, Evgeniy Kovalenko, Andrii Natochii, Thanh Dong, Marcello Campajola, Masako Iwasaki, Jens Sören Lange, Sourav Patra, Valentina Zhukova, Giacomo De Pietro, Konstantin Belous, Felix Metzner, Chia-Ling Hsu, and Elena Solovieva

Subjects
General Physics and Astronomy
Published
2022

24. Search for a Light Higgs Boson in Single-Photon Decays of ϒ(1S) Using ϒ(2S)→π+π−ϒ(1S) Tagging Method

Author

Shubhangi Krishan Maurya, Thomas E Browder, Kenkichi Miyabayashi, Jyotirmoi Borah, Lopamudra Nayak, Denis Bodrov, Bruce Yabsley, Evgeniy Kovalenko, Andrii Natochii, Sam Cunliffe, Thanh Dong, Marcello Campajola, Chengping Shen, Zbigniew Natkaniec, Hiroaki Ono, Sourav Patra, BIPUL BHUYAN, Valentina Zhukova, Giacomo De Pietro, Konstantin Belous, Felix Metzner, Makoto Takizawa, and Elena Solovieva

Subjects
General Physics and Astronomy
Published
2022

25. Search for tetraquark states Xccs¯s¯ in Ds+Ds+(Ds*+Ds*+) final states at Belle

Author

Shubhangi Krishan Maurya, Thomas E Browder, Kenkichi Miyabayashi, Jyotirmoi Borah, Andrzej Bożek, Alberto Martini, Xuyang Gao, Lopamudra Nayak, Denis Bodrov, Bruce Yabsley, Evgeniy Kovalenko, Andrii Natochii, Sam Cunliffe, Thanh Dong, Marcello Campajola, Chengping Shen, Zbigniew Natkaniec, Jens Sören Lange, Hiroaki Ono, Tianping Gu, Sourav Patra, BIPUL BHUYAN, Valentina Zhukova, Giacomo De Pietro, Yang Li, Konstantin Belous, Felix Metzner, Makoto Takizawa, Chia-Ling Hsu, and Elena Solovieva

Published
2022

27. Measurement of Differential Branching Fractions of Inclusive B→Xuℓ+νℓ Decays

Author

Thomas E Browder, Kenkichi Miyabayashi, Tadeas Bilka, Saurabh Sandilya, Shawn Dubey, Lu Cao, Jan Strube, Lopamudra Nayak, Raynette Van Tonder, Michel Enrique Hernández Villanueva, Bruce Yabsley, Evgeniy Kovalenko, Andrii Natochii, Sam Cunliffe, Thanh Dong, Marcello Campajola, Masako Iwasaki, Florian Bernlochner, Hiroaki Ono, Martin Sevior, Tianping Gu, Sourav Patra, Valentina Zhukova, Giacomo De Pietro, Konstantin Belous, Felix Metzner, Sven Vahsen, Chia-Ling Hsu, Elena Solovieva, and Kirill Chilikin

Subjects
010308 nuclear & particles physics, 0103 physical sciences, General Physics and Astronomy, 010306 general physics, 01 natural sciences
Published
2021

28. Study of e+e−→ϒ(1S,2S)η and e+e−→ϒ(1S)η′ at s=10.866 GeV with the Belle detector

Author

Thomas E Browder, Kenkichi Miyabayashi, Tadeas Bilka, Saurabh Sandilya, Andrzej Bożek, Lopamudra Nayak, Evgeniy Kovalenko, Anna Vinokurova, Andrii Natochii, Sam Cunliffe, Thanh Dong, Marcello Campajola, Masako Iwasaki, Alexander Bondar, Jens Sören Lange, Hiroaki Ono, Martin Sevior, Sourav Patra, Valentina Zhukova, Felix Metzner, Makoto Takizawa, Chia-Ling Hsu, Elena Solovieva, and Kirill Chilikin

Subjects
010308 nuclear & particles physics, 0103 physical sciences, 010306 general physics, 01 natural sciences
Published
2021

32. Electrochemical separation of 132/135La theranostic pair from proton irradiated Ba target

Author

K. C. Jagadeesan, S. V. Thakare, Sudipta Chakraborty, Rubel Chakravarty, and Sourav Patra

Subjects
Materials science, Proton, Radiochemistry, chemistry.chemical_element, Filtration and Separation, Electrolyte, Electrochemistry, Analytical Chemistry, Anode, chemistry, Yield (chemistry), Lanthanum, Irradiation, Platinum
Abstract

Lanthanum-132/135 is an emerging theranostic pair of radiometals that might find widespread application in nuclear medicine. The present study describes the production of 132/135La in a low energy linear accelerator via natBa (p, n) 132/135La reaction. A robust and efficient method has been optimized for separation of no-carrier-added (NCA) 132/135La from the bulk irradiated target by electrodeposition of 132/135La on platinum anode. Near quantitative electrodeposition yield of 132/135La could be obtained when a potential of 6 V was applied for 20 min in an electrolyte solution (containing Ba and La) maintained at pH ∼ 3. After electrochemical separation, 132/135La could be obtained with > 99.99 % radionuclidic purity in a form suitable for radiopharmaceutical preparation. As a proof of concept, 132/135La-complex of a tumor avid peptide conjugate, namely, DOTA-E-[c(RGDfK)]2 was formulated with > 98 % yield and the radiolabeled complex maintained its integrity under physiological conditions over a prolonged period of time. Overall, this study amply demonstrates that electrochemical separation is a viable strategy for obtaining 132/135La for theranostic radiopharmaceutical preparation.

Published
2022

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