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Many of the urban settlements in Central Italy are placed nearby active faults and, consequently, the ground motion evaluation and seismic site effects under near-fault earthquakes are noteworthy issues to be investigated. This paper presents the results of site investigations, the seismic site characterization, and the local seismic response for assessing the effects induced by the Mw 6.7 2 February 1703, near-fault earthquake at the Madonna delle Fornaci site (Pizzoli, Central Italy) in which notable ground failure phenomena were observed, as witnessed by several coeval sources. Even though recent papers described these phenomena, the geological characteristics of the site and the failure mechanism have never been assessed through in-situ investigations and numerical modeling. Within a project concerning the assessment of soil liquefaction potential and co-seismic ground failure, deep and shallow continuous core drilling, geophysical investigations and in-hole tests have been carried out. Subsequently, the geotechnical model has been defined and the numerical quantification of the different hypotheses of failure mechanisms has been evaluated. Analyses showed that liquefaction did not occur, and the excess pore water pressure induced by the shaking was not the source of the ground failure. Therefore, it was hypothesized that the sinkhole was likely caused by earthquake-induced gas eruption. [ABSTRACT FROM AUTHOR]