91 results on '"Spinelli,G"'
Search Results
2. Is adaptation involved in bilingual language production? A fresh look at the assumptions motivating potential bilingual-monolingual differences in adaptive control
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Spinelli, G, Sulpizio, S, Spinelli, G, and Sulpizio, S
- Abstract
One of the hottest debates in psychology-whether bilingual-monolingual differences exist in cognitive control-is at a stalemate. Here we propose that the stalemate could be broken by shifting the research focus from whether those differences emerge to why they should. We offer an example of this approach by testing the assumption of current theories of language-control associations that adaptive control is involved in bilingualism, specifically language production. Unbalanced Italian-English bilinguals living in the Milan area completed a Stroop task in their L1 and a picture-naming task in their L2. Both tasks involved a manipulation of the proportion of the type of stimuli that are assumed to require control, i.e., incongruent stimuli in the Stroop task (e.g., the word RED written in blue) and pictures with noncognate names in the picture-naming task (e.g., the picture of a horse, whose Italian name, "cavallo," has a very different pronunciation). Both confirmatory and exploratory analyses showed a clear dissociation between the two tasks, with the Stroop task producing an interactive pattern indicative of adaptive-control involvement and the picture-naming task failing to produce a similar one. These results suggest that adaptive control may not be involved in bilingual language production and, therefore, may not produce bilingual-monolingual differences in cognitive control. It is hoped that this research will inspire a change in the study of language-control associations, pushing future research efforts towards grounding the assumptions for those associations in empirical evidence.
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- 2024
3. Fast habituation to semantic interference generated by taboo connotation in reading aloud
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Sulpizio, S, Scaltritti, M, Spinelli, G, Sulpizio, S, Scaltritti, M, and Spinelli, G
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The recognition of taboo words–i.e. socially inappropriate words–has been repeatedly associated to semantic interference phenomena, with detrimental effects on the performance in the ongoing task. In the present study, we investigated taboo interference in the context of reading aloud, a task configuration which prompts the overt violation of conventional sociolinguistic norms by requiring the explicit utterance of taboo items. We assessed whether this form of semantic interference is handled by habituative or cognitive control processes. In addition to the reading aloud task, participants performed a vocal Stroop task featuring different conditions to dissociate semantic, task, and response conflict. Taboo words were read slower than non-taboo words, but this effect was subject to a quick habituation, with a decreasing interference over the course of trials, which allowed participants to selectively attend to goal-relevant information. In the Stroop task, only semantic conflict was significantly reduced by habituation. These findings suggest that semantic properties can be quickly and flexibly weighed on the basis of contextual appropriateness, thus characterising semantic processing as a flexible and goal-directed component of reading aloud.
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- 2024
4. Semantic Stroop interference is modulated by the availability of executive resources: Insights from delta-plot analyses and cognitive load manipulation
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Sulpizio, S, Spinelli, G, Scaltritti, M, Sulpizio, S, Spinelli, G, and Scaltritti, M
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We investigated whether, during visual word recognition, semantic processing is modulated by attentional control mechanisms directed at matching semantic information with task-relevant goals. In previous research, we analyzed the semantic Stroop interference as a function of response latency (delta-plot analyses) and found that this phenomenon mainly occurs in the slowest responses. Here, we investigated whether this pattern is due to reduced ability to proactively maintain the task goal in these slowest trials. In two pairs of experiments, participants completed two semantic Stroop tasks: a classic semantic Stroop task (Experiment 1A and 2A) and a semantic Stroop task combined with an n-back task (Experiment 1B and 2B). The two pairs of experiments only differed in the trial pace, which was slightly faster in Experiments 2A and 2B than in Experiments 1A and 1B. By taxing the executive control system, the n-back task was expected to hinder proactive control. Delta-plot analyses of the semantic Stroop task replicated the enhanced effect in the slowest responses, but only under sufficient time pressure. Combining the semantic Stroop task with the n-back task produced a change in the distributional profile of semantic Stroop interference, which we ascribe to a general difficulty in the use of proactive control. Our findings suggest that semantic Stroop interference is, to some extent, dependent on the available executive resources, while also being sensitive to subtle variations in task conditions.
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- 2024
5. A spatial version of the Stroop task for examining proactive and reactive control independently from non-conflict processes
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Spinelli, G, Lupker, S, Lupker, SJ, Spinelli, G, Lupker, S, and Lupker, SJ
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Conflict-induced control refers to humans' ability to regulate attention in the processing of target information (e.g., the color of a word in the color-word Stroop task) based on experience with conflict created by distracting information (e.g., an incongruent color word), and to do so either in a proactive (preparatory) or a reactive (stimulus-driven) fashion. Interest in conflict-induced control has grown recently, as has the awareness that effects attributed to those processes might be affected by conflict-unrelated processes (e.g., the learning of stimulus-response associations). This awareness has resulted in the recommendation to move away from traditional interference paradigms with small stimulus/response sets and towards paradigms with larger sets (at least four targets, distractors, and responses), paradigms that allow better control of non-conflict processes. Using larger sets, however, is not always feasible. Doing so in the Stroop task, for example, would require either multiple arbitrary responses that are difficult for participants to learn (e.g., manual responses to colors) or non-arbitrary responses that can be difficult for researchers to collect (e.g., vocal responses in online experiments). Here, we present a spatial version of the Stroop task that solves many of those problems. In this task, participants respond to one of six directions indicated by an arrow, each requiring a specific, non-arbitrary manual response, while ignoring the location where the arrow is displayed. We illustrate the usefulness of this task by showing the results of two experiments in which evidence for proactive and reactive control was obtained while controlling for the impact of non-conflict processes.
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- 2024
6. Cues to lexical stress assignment in reading Italian: A megastudy with polysyllabic nonwords
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Spinelli, G, Trettenero, S, Lupker, S, Colombo, L, Lupker, SJ, Spinelli, G, Trettenero, S, Lupker, S, Colombo, L, and Lupker, SJ
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When reading polysyllabic words, assignment of lexical stress is a challenge for readers, especially in languages, such as English or Italian, in which stress position is not strictly determined even though words as well as nonwords typically contain several sublexical cues to stress that readers might use. Here, we attempted to identify such cues using a corpus analysis and to examine their impact on human performance in a megastudy in which participants (N = 45) assigned stress to nonwords (N = 800), stimuli particularly revealing of stress cue use because they have no predefined stress pattern. Hierarchical regression results confirmed an impact of sublexical cues examined in former studies and revealed a role for cues not previously examined, including similarity to real words. These results are informative for computational models of reading as they indicate that readers assign stress to nonwords based on not only sublexical but also lexical information.
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- 2024
7. Cognitive control adjustments are dependent on the level of conflict
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Bognar, M, Szekely, Z, Varga, M, Nagy, K, Spinelli, G, Hartanto, A, Majeed, N, Chen, N, Gyurkovics, M, Aczel, B, Bognar, Miklos, Szekely, Zsuzsa, Varga, Marton A., Nagy, Kinga, Spinelli, Giacomo, Hartanto, Andree, Majeed, Nadyanna M., Chen, Nicole Rui Ying, Gyurkovics, Mate, Aczel, Balazs, Bognar, M, Szekely, Z, Varga, M, Nagy, K, Spinelli, G, Hartanto, A, Majeed, N, Chen, N, Gyurkovics, M, Aczel, B, Bognar, Miklos, Szekely, Zsuzsa, Varga, Marton A., Nagy, Kinga, Spinelli, Giacomo, Hartanto, Andree, Majeed, Nadyanna M., Chen, Nicole Rui Ying, Gyurkovics, Mate, and Aczel, Balazs
- Abstract
The congruency sequence effect (CSE) is one of the most investigated effects in the cognitive control literature. The conflict monitoring theory suggests that the CSE is the result of adjustments in cognitive control based on perceived conflict. A recent paper by Zhang and colleagues, has investigated whether the manipulation of conflict level by changing distractor incompatibility in a flanker task affects the amount of adjustments in cognitive control. Their study produced mixed findings, somewhat supporting the original conflict monitoring theory, but also suggesting other explanations, such as the repetition expectancy account. We replicated the experimental design in a multisite online study (N = 347), with Hungarian, Italian, and Singaporean participants. Our results supported the prediction that changes in the level of conflict trigger conflict adaptation, revealing that increasing conflict levels induced stronger adaptive control. Bayesian hypothesis testing indicated a monotonic reduction in congruency effects as a function of previous conflict strength. This finding is in line with the extension of the traditional conflict monitoring theory, as well as other theories like affective signaling and expected value of control, implying that the relationship between conflict and interference effects is gradual, rather than a binary function.
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- 2024
8. Examining the resource requirements of proactive and reactive control in the Stroop task using a concurrent working-memory load
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Spinelli, G, Sulpizio, S, Spinelli, G., Sulpizio, S., Spinelli, G, Sulpizio, S, Spinelli, G., and Sulpizio, S.
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- 2023
9. The impact of working memory load on the semantic Stroop effect
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Sulpizio, S, Spinelli, G, Scaltritti, M, Sulpizio, S., Spinelli, G., Scaltritti, M., Sulpizio, S, Spinelli, G, Scaltritti, M, Sulpizio, S., Spinelli, G., and Scaltritti, M.
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- 2023
10. Assessment of the knowledge level and experience of healthcare personnel concerning CPR and early defibrillation: an internal survey
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Spinelli, G., Brogi, E., Sidoti, A., Pagnucci, N., and Forfori, F.
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- 2021
- Full Text
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11. Bilingualism and executive attention: Evidence from studies of proactive and reactive control
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Spinelli, G, Goldsmith, S, Lupker, S, Morton, J, Spinelli G., Goldsmith S. F., Lupker S. J., Morton J. B., Spinelli, G, Goldsmith, S, Lupker, S, Morton, J, Spinelli G., Goldsmith S. F., Lupker S. J., and Morton J. B.
- Abstract
According to some accounts, the bilingual advantage is most pronounced in the domain of executive attention rather than inhibition and should therefore be more easily detected in conflict adaptation paradigms than in simple interference paradigms. We tested this idea using two conflict adaptation paradigms, one that elicits a listwide proportion-congruent effect and one that elicits an item-specific proportion-congruent effect. In both cases, the relevant finding is that congruency effects are reduced when the proportion of congruent to incongruent items is smaller. These effects are validated measures of proactive and reactive control, respectively, and are aspects of executive attention known to be associated with individual differences in working memory capacity. We reasoned that if bilingualism affects executive attention in a similar way as does working memory capacity, indices of proactive and reactive control should be comparably associated with continuous variation in language status and working memory capacity. In two experiments, we replicated previous findings that working memory capacity is associated with variation in congruency effects (suggesting greater reliance on proactive control). In contrast, language status had no consistent association with performance, save for a hint that bilingualism may be associated with greater reliance on reactive control. Thus, the bilingual advantage may exist, but not in proactive control or any other aspects of executive attention that have been proposed thus far.
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- 2022
12. Conflict-Monitoring Theory in Overtime: Is Temporal Learning a Viable Explanation for the Congruency Sequence Effect?
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Spinelli, G, Lupker, S, Spinelli G., Lupker S. J., Spinelli, G, Lupker, S, Spinelli G., and Lupker S. J.
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In interference tasks (e.g., Stroop, 1935), congruency effects are larger following a congruent versus an incongruent trial. This “congruency sequence effect” has been traditionally explained in terms of a conflict-monitoring mechanism that focuses attention toward relevant information when conflict has recently been experienced. More recently, it has been suggested that effects of this sort result from differences in the temporal expectancies formed following congruent trials (fast responding) versus incongruent trials (slow responding). Evidence supporting this “temporal-learning” account was recently reported for a similar effect, the finding that congruency effects are larger in a mostly congruent list than in a mostly incongruent list. That is, consistent with the idea that this “proportion-congruent effect” is based on different temporal expectancies following congruent versus incongruent trials in interference tasks, the proportion-congruent effect was eliminated on normal (i.e., immediate-response) trials when temporal expectancies were equated by requiring a delayed response on the prior trial. In two experiments, we examined whether this delayed-response procedure would have a similar impact on the congruency sequence effect. Consistent with the temporal-learning account (but not inconsistent with conflict-monitoring accounts), the congruency sequence effect on immediate-response trials was eliminated when the previous trial required a delayed response. However, no evidence supporting the temporal-learning account emerged from reanalyses of experiments requiring only immediate responses in which the response latency in the previous trial functioned as the temporal-expectancy index. Overall, the present results and analyses do not provide much evidence favoring the temporal-learning account over conflict-monitoring accounts of the congruency sequence effect.
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- 2022
13. Consonant and vowel transposition effects during reading development: A study on Italian children and adults
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Spinelli, G, Colombo, L, Lupker, S, Spinelli G., Colombo L., Lupker S. J., Spinelli, G, Colombo, L, Lupker, S, Spinelli G., Colombo L., and Lupker S. J.
- Abstract
Recently, Colombo, Spinelli, and Lupker, using a masked transposed letter (TL) priming paradigm, investigated whether consonant/vowel (CV) status is important early in orthographic processing. In four experiments with Italian and English adults, they found equivalent TL priming effects for CC, CV, and VC transpositions. Here, we investigated that question with younger readers (aged 7–10) and adults, as well as whether masked TL priming effects might have a phonological basis. That is, because young children are likely to use phonological recoding in reading, the question was whether they would show TL priming that is affected by CV status. In Experiment 1, target words were preceded by primes in which two letters (either CV, VC, or CC) were transposed versus substituted (SL). We found significant TL priming effects, with an increasing developmental trend but, again, no letter type by priming interaction. In Experiment 2, the transpositions/substitutions involved only pairs of vowels with those vowels having either diphthong or hiatus status. The difference between these two types of vowel clusters is only phonological; thus, the question was, “Would TL priming interact with this factor?” TL priming was again found with an increasing trend with age, but there was no vowel cluster by priming interaction. There was, however, an overall vowel cluster effect (slower responding to words with hiatuses) which decreased with age. The results suggest that TL priming only taps the orthographic level, and that CV status only becomes important at a later phonological level.
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- 2022
14. A systematic examination of the processes Involved in transposed letter effects.
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Lupker, S, Chi, Z, Colombo, L, Jiang, J, Spinelli, G, Lupker, SJ, Lupker, S, Chi, Z, Colombo, L, Jiang, J, Spinelli, G, and Lupker, SJ
- Published
- 2023
15. Ai limiti del controllo adattivo: Nessuna evidenza che l’attenzione venga adattata ad un contesto ininfluente al compito, anche quando la rilevanza del contesto è aumentata
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Spinelli, G, Lupker, S, Lupker, SJ, Spinelli, G, Lupker, S, and Lupker, SJ
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In compiti come lo Stroop, l’effetto di congruenza è ridotto in situazioni in cui gli stimoli usati sono maggiormente incongruenti (una freccia che punta verso l’alto presentata nella parte bassa dello schermo) rispetto a situazioni in cui sono maggiormente congruenti (una freccia che punta verso l’alto presentata in alto). Quando potenziali effetti confondenti sono controllati, questo effetto di Proporzione-Congruenza (PC) dimostra l’abilità di adattare l’attenzione al contesto. Tuttavia, quest’abilità non è stata dimostrata con chiarezza quando il contesto è una componente dello stimolo che non è né il target (per es., la direzione della freccia) né il distrattore (la posizione della freccia) ma una componente irrelevante che non produce interferenza (il colore della freccia). Per affrontare la questione, abbiamo usato una manipolazione PC definita da questo tipo di contesto in uno Stroop spaziale capace di produrre un forte effetto PC in manipolazioni PC più tipiche. Non abbiamo osservato un effetto PC sugli stimoli critici in nessuno dei nostri 4 esperimenti (N minimo 141), nemmeno aumentando la rilevanza del contesto o istruendo i partecipanti a usare il contesto. Questi risultati sembrano indicare dei limiti nella capacità di adattare l’attenzione al contesto quando questo è ininfluente al compito.
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- 2023
16. An examination of models of reading multi-morphemic and pseudo multi-morphemic words using sandwich priming
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Lupker, S, Spinelli, G, Lupker, Stephen J, Spinelli, Giacomo, Lupker, S, Spinelli, G, Lupker, Stephen J, and Spinelli, Giacomo
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Rastle et al. (2004) reported that true (e.g., walker) and pseudo (e.g., corner) multi-morphemic words prime their stem words more than form controls do (e.g., brothel priming BROTH) in a masked priming lexical decision task. This data pattern has led a number of models to propose that both of the former word types are "decomposed" into their stem (e.g., walk, corn) and affix (e.g., -er) early in the reading process. The present experiments were designed to examine the models proposed to explain Rastle et al.'s effect, including models not assuming a decomposition process, using a more sensitive priming technique, sandwich priming (Lupker & Davis, 2009). Experiment 1, using the conventional masked priming procedure, replicated Rastle et al.'s results. Experiments 2 and 3, involving sandwich priming procedures, showed a clear dissociation between priming effects for true versus pseudo multi-morphemic words, results that are not easily explained by any of the current models. Nonetheless, the overall data pattern does appear to be most consistent with there being a decomposition process when reading real and pseudo multi-morphemic words, a process that involves activating (and inhibiting) lexical-level representations including a representation for the affix (e.g., -er), with the ultimate lexical decision being based on the process of resolving the pattern created by the activated representational units.
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- 2023
17. Target-distractor correlation does not imply causation of the Stroop effect
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Spinelli, G, Lupker, S, Lupker, SJ, Spinelli, G, Lupker, S, and Lupker, SJ
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In the Stroop task, the identities of the targets (e.g., colours) and distractors (e.g., words) used are often correlated. For example, in a list in which 4 words and 4 colours are combined to form 16 stimuli, each of the 4 congruent stimuli is typically repeated 3 times as often as each of the 12 incongruent stimuli. Some accounts of the Stroop effect suggest that in this type of list, often considered as a baseline because of the matching proportion of congruent and incongruent stimuli (50%), the word dimension actually receives more attention than it does in an uncorrelated list in which words and colours are randomly paired. This increased attention would be an important determinant of the Stroop effect in correlated situations, an idea supported by the observation that higher target–distractor correlation lists are associated with larger Stroop effects. However, because target–distractor correlation tends to be confounded with congruency proportion in common designs, the latter may be the crucial factor, consistent with accounts that propose that attention is adapted to the list’s congruency proportion. In four experiments, we examined the idea that target–distractor correlation plays a major role in colour–word Stroop experiments by contrasting an uncorrelated list with a correlated list matched on relevant variables (e.g., congruency proportion). Both null hypothesis significance testing and Bayesian analyses suggested equivalent Stroop effects in the two lists, challenging accounts based on the idea that target–distractor correlations affect how attention is allocated in the colour–word Stroop task.
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- 2023
18. The neglected emotional drawbacks of the prioritization of embryos to transfer
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Spinelli, G., Somigliana, E., Micci, L. G., Vigano, P., Facchin, Federica, Gramegna, M. G., Facchin F. (ORCID:0000-0001-8944-1440), Spinelli, G., Somigliana, E., Micci, L. G., Vigano, P., Facchin, Federica, Gramegna, M. G., and Facchin F. (ORCID:0000-0001-8944-1440)
- Abstract
In recent years, increasing efforts have been made to develop advanced techniques that could predict the potential of implantation of each single embryo and prioritize the transfer of those at higher chance. The most promising include non-invasive preimplantation genetic testing for aneuploidy and artificial intelligence-based algorithms using time lapse images. The psychological effect of these add-ons is neglected. One could speculate that embarking on another transfer after one or more failures with the prospect of receiving an embryo of lower potential may be distressing for the couple. In addition, the symbolic and mental representation of an embryo with ‘lower capacity to implant’ is currently unknown but could affect couples’ choices and wellbeing. These emotional responses may also undermine adherence to the programme and, ultimately, its real effectiveness. Future trials aimed at evaluating the validity of prioritization procedures must also consider the emotional burden on the couples.
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- 2023
19. Erratum to ‘Evaluation of COVID-19 impact on DELAYing diagnostic-therapeutic pathways of lung cancer patients in Italy (COVID-DELAY study): fewer cases and higher stages from a real-world scenario’: [ESMO Open Volume 7, Issue 2, April 2022, 100406](S2059702922000278)(10.1016/j.esmoop.2022.100406)
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Cantini L., Mentrasti G., Lo Russo G., Signorelli D., Pasello G., Rijavec E., Russano M., Antonuzzo L., Rocco D., Giusti R., Adamo V., Genova C., Tuzi A., Morabito A., Gori S., La Verde N., Chiari R., Cortellini A., Cognigni V., Pecci F., Indini A., De Toma A., Zattarin E., Oresti S., Pizzutilo E. G., Frega S., Erbetta E., Galletti A., Citarella F., Fancelli S., Caliman E., Della Gravara L., Malapelle U., Filetti M., Piras M., Toscano G., Zullo L., De Tursi M., Di Marino P., D'Emilio V., Cona M. S., Guida A., Caglio A., Salerno F., Spinelli G. P., Bennati C., Morgillo F., Russo A., Dellepiane C., Vallini I., Sforza V., Inno A., Rastelli F., Tassi V., Nicolardi L., Pensieri M. V., Emili R., Roca E., Migliore A., Galassi T., Rocchi M. B. L., Berardi R., Cantini, L., Mentrasti, G., Lo Russo, G., Signorelli, D., Pasello, G., Rijavec, E., Russano, M., Antonuzzo, L., Rocco, D., Giusti, R., Adamo, V., Genova, C., Tuzi, A., Morabito, A., Gori, S., La Verde, N., Chiari, R., Cortellini, A., Cognigni, V., Pecci, F., Indini, A., De Toma, A., Zattarin, E., Oresti, S., Pizzutilo, E. G., Frega, S., Erbetta, E., Galletti, A., Citarella, F., Fancelli, S., Caliman, E., Della Gravara, L., Malapelle, U., Filetti, M., Piras, M., Toscano, G., Zullo, L., De Tursi, M., Di Marino, P., D'Emilio, V., Cona, M. S., Guida, A., Caglio, A., Salerno, F., Spinelli, G. P., Bennati, C., Morgillo, F., Russo, A., Dellepiane, C., Vallini, I., Sforza, V., Inno, A., Rastelli, F., Tassi, V., Nicolardi, L., Pensieri, M. V., Emili, R., Roca, E., Migliore, A., Galassi, T., Rocchi, M. B. L., and Berardi, R.
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The publisher regrets that at the time the article was published the name of the author N. La Verde was mistakenly abbreviated as N.L. Verde. This has now been corrected. The publisher would like to apologise for any inconvenience caused.
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- 2022
20. Healthcare innovation: whose job is it anyway?
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Spinelli, G
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Leadership and Management ,Health Policy - Published
- 2022
- Full Text
- View/download PDF
21. Codesigning therapeutic and sterilisable soft toys for Paediatric Inpatients
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Spinelli, G and Davies, A
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- 2022
22. Sexual violence in adult women and adolescents
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Barbara, G., Buggio, L., Micci, L., Spinelli, G., Paiocchi, C., Dridi, D., Cetera, G. E., Facchin, Federica, Donati, A., Vercellini, P., Kustermann, A., Facchin F. (ORCID:0000-0001-8944-1440), Barbara, G., Buggio, L., Micci, L., Spinelli, G., Paiocchi, C., Dridi, D., Cetera, G. E., Facchin, Federica, Donati, A., Vercellini, P., Kustermann, A., and Facchin F. (ORCID:0000-0001-8944-1440)
- Abstract
Sexual violence is a widespread phenomenon, as it has been estimated that about 35.6% of women have experienced some forms of sexual abuse, with variable prevalence estimates worldwide. Sexual violence has remarkable negative consequences on women's health and quality of life, with a specific harmful impact on women's psychological well-being and sexuality. In this narrative review, we provide an overview on the phenomenon of sexual violence against adult women and adolescents, discussing its associated multiple negative consequences with a specific focus on clinical and sexological aspects. "Women-centered care" and a multidisciplinary approach appear of pivotal importance when working with sexual violence survivors. Woman should be engaged in all the clinical activities as equal partners in the decision-making process, and should be supported by multiple and different professional figures (i.e. gynecologists, psychologists, sexologists, forensic medical doctors, lawyers) working within the framework of a cooperative integrated model.
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- 2022
23. Speaking a language when another is known: Can bilinguals use contextual information to control influences from the nontarget language?
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Spinelli, G, Moskal, A, Sulpizio, S, Spinelli, G, Moskal, A, and Sulpizio, S
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- 2022
24. When “elefante” helps say “elephant” but “cavallo” does not help say “horse”: Examining the role of contextual information in regulating influences from the non-target language
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Spinelli, G, Moskal, A, Sulpizio, S, Spinelli, G, Moskal, A, and Sulpizio, S
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- 2022
25. Deformata Reformare. Programmi di vita religiosa, di riforma spirituale e amministrativa di canoniche e cenobi nel Quattrocento Veneto
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Andenna G., Veronese F., Tagliabue M., Bartolomei Romagnoli A., Bischof F. X., Cortoni C.U., Trolese F., Dell'Omo M., Spinelli G., Barbeau T., Salvestrini F., Paoli U., Paciolla S., Togni N., Scannerini G., Ceriotti L., Al Kalak M., Lovison F., Vozza V., Rusconi R., Barbieri E., Lovato A., Baroffio Dahnk B. G., Guidarelli G., Leone de Castris P., Toniolo F., Furlan E., Andenna, Giancarlo, Andenna G. (ORCID:0000-0003-0003-7674), Andenna G., Veronese F., Tagliabue M., Bartolomei Romagnoli A., Bischof F. X., Cortoni C.U., Trolese F., Dell'Omo M., Spinelli G., Barbeau T., Salvestrini F., Paoli U., Paciolla S., Togni N., Scannerini G., Ceriotti L., Al Kalak M., Lovison F., Vozza V., Rusconi R., Barbieri E., Lovato A., Baroffio Dahnk B. G., Guidarelli G., Leone de Castris P., Toniolo F., Furlan E., Andenna, Giancarlo, and Andenna G. (ORCID:0000-0003-0003-7674)
- Abstract
L'importanza dell'azione di Ludovico Barbo nella nascita e nello sviluppo della Congregazione "de Unitate". Il suo impegno culturale e organizzativo entro le direttrici della sua forte situazione spirituale e scritturistica. I rapporti con il papato e con i poteri politici di Venezia. Il suo legame con le esperienze venete e con i papi sino alla metà del Quattrocento.
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- 2022
26. Robust evidence for proactive conflict adaptation in the proportion-congruent paradigm
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Spinelli, G, Lupker, S, Spinelli, Giacomo, Lupker, Stephen J, Spinelli, G, Lupker, S, Spinelli, Giacomo, and Lupker, Stephen J
- Abstract
In the standard Proportion-Congruent (PC) paradigm, performance is compared between a list containing mostly congruent (MC) stimuli (e.g., the word RED in the color red in the Stroop task; Stroop, 1935) and a list containing mostly incongruent (MI) stimuli (e.g., the word BLUE in red). The PC effect, the finding that the congruency effect (i.e., the latency difference between incongruent and congruent stimuli) is typically larger in an MC list, has been interpreted by the popular conflict-monitoring account (Botvinick et al., 2001) as reflecting a proactive process whereby attention to task-relevant information is adapted based on how frequently conflict from task-irrelevant information arises. Recently, however, alternative accounts of the PC effect have emerged that assume either that the PC effect reflects processes other than proactive conflict adaptation (e.g., stimulus-response contingency learning) or that proactive conflict adaptation is only engaged as a last resort (e.g., when contingency learning cannot be used to minimize interference). We examined these ideas in three experiments in which proactive conflict adaptation could be evaluated independently from processes that are normally confounded with it in the PC paradigm, while still allowing those processes, particularly contingency learning, to be used to minimize interference. Consistent with the conflict-monitoring account of the PC effect, but inconsistent with all the alternative accounts of the PC effect, evidence for proactive conflict adaptation emerged in all experiments. Although multiple processes may be engaged in the PC paradigm, this paradigm remains a valid tool for examining proactive conflict adaptation, its typical use.
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- 2022
27. Both task-irrelevant and task-relevant information trigger reactive conflict adaptation in the item-specific proportion-congruent paradigm
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Spinelli, G, Morton, J, Lupker, S, Spinelli, Giacomo, Morton, J Bruce, Lupker, Stephen J, Spinelli, G, Morton, J, Lupker, S, Spinelli, Giacomo, Morton, J Bruce, and Lupker, Stephen J
- Abstract
Adapting attention flexibly is a fundamental ability of the human control system. In the color-word Stroop task, for example, congruency effects are typically smaller for colors and words that appear mainly in incongruent stimuli (mostly-incongruent items) than for colors and words that appear mainly in congruent stimuli (mostly-congruent items). At least part of this item-specific proportion-congruent (ISPC) effect is due to a process of reactive conflict adaptation that affords higher selectivity (i.e., more efficient selection of task-relevant information) when a specific stimulus is presented that is frequently associated in the experiment with conflicting task-irrelevant information. What is unclear, however, is whether, normally, this stimulus-specific adaptation is triggered by the task-relevant component, the task-irrelevant component, or both components of the stimulus. In two experiments, using modified color-word (Experiment 1) and spatial (Experiment 2) Stroop tasks that allowed task-relevant and task-irrelevant triggering processes to be dissociated, we found that the two processes have approximately equivalent impacts. Because these results were obtained in experiments imposing no limitations on the processes potentially contributing to the ISPC effect, these results challenge claims that the ISPC effect involves conflict-adaptation processes only in special situations. The ISPC effect may involve conflict-adaptation processes in most situations, with both task-relevant and task-irrelevant information triggering such processes.
- Published
- 2022
28. Masked orthographic neighbor priming effects in Chinese two-character words
- Author
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Yang, Huilan, Spinelli, Giacomo, Li, Lingling, Lupker, Stephen J., Yang, H, Spinelli, G, Li, L, and Lupker, S
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Linguistics and Language ,Chinese ,Experimental and Cognitive Psychology ,masked priming lexical decision ,Inhibitory neighbor priming effect ,Language and Linguistics - Abstract
In masked priming lexical decision tasks in alphabetic or syllabic script languages, latencies are longer when a word target is primed by a higher frequency neighbor (e.g., blue–BLUR) than when primed by an unrelated word of equivalent frequency (e.g., care–BLUR) – an “inhibitory neighbor priming effect.” In contrast, Zhou et al. (1999) demonstrated facilitatory orthographic neighbor priming for two-character Chinese words (e.g., 华丽–华贵). However, Zhou et al. did not control for relative prime-target frequency, which has been shown to be important in experiments when examining languages with other scripts. In the present Experiment 1 word neighbor primes (e.g., 容易-容貌) produced an inhibitory neighbor priming effect when the prime was higher frequency than the target, paralleling effects in other script languages. In further experiments, paralleling those in other script languages, two-character targets primed by nonword neighbors (容待-容貌) or single constituent characters matching the target in either position (容-容貌) showed significant facilitation. These results suggest that lexical activation/competition processes for two-character Chinese words are reasonably similar to those for words in alphabetic/syllabic script languages.
- Published
- 2023
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- View/download PDF
29. Robust evidence for proactive conflict adaptation in the proportion-congruent paradigm
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Giacomo Spinelli, Stephen J. Lupker, Spinelli, G, and Lupker, S
- Subjects
Conflict adaptation ,Linguistics and Language ,Proactive control ,Proportion-congruent effect ,Stroop ,Experimental and Cognitive Psychology ,Language and Linguistics ,Conflict monitoring - Abstract
In the standard Proportion-Congruent (PC) paradigm, performance is compared between a list containing mostly congruent (MC) stimuli (e.g., the word RED in the color red in the Stroop task; Stroop, 1935) and a list containing mostly incongruent (MI) stimuli (e.g., the word BLUE in red). The PC effect, the finding that the congruency effect (i.e., the latency difference between incongruent and congruent stimuli) is typically larger in an MC list, has been interpreted by the popular conflict-monitoring account (Botvinick et al., 2001) as reflecting a proactive process whereby attention to task-relevant information is adapted based on how frequently conflict from task-irrelevant information arises. Recently, however, alternative accounts of the PC effect have emerged that assume either that the PC effect reflects processes other than proactive conflict adaptation (e.g., stimulus-response contingency learning) or that proactive conflict adaptation is only engaged as a last resort (e.g., when contingency learning cannot be used to minimize interference). We examined these ideas in three experiments in which proactive conflict adaptation could be evaluated independently from processes that are normally confounded with it in the PC paradigm, while still allowing those processes, particularly contingency learning, to be used to minimize interference. Consistent with the conflict-monitoring account of the PC effect, but inconsistent with all the alternative accounts of the PC effect, evidence for proactive conflict adaptation emerged in all experiments. Although multiple processes may be engaged in the PC paradigm, this paradigm remains a valid tool for examining proactive conflict adaptation, its typical use. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
- Published
- 2023
- Full Text
- View/download PDF
30. Both task-irrelevant and task-relevant information trigger reactive conflict adaptation in the item-specific proportion-congruent paradigm
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Giacomo Spinelli, J. Bruce Morton, Stephen J. Lupker, Spinelli, G, Morton, J, and Lupker, S
- Subjects
Conflict adaptation ,Arts and Humanities (miscellaneous) ,Stroop Test ,Reaction Time ,Reactive control ,Developmental and Educational Psychology ,Humans ,Attention ,Item-specific proportion-congruent effect ,Stroop ,Experimental and Cognitive Psychology - Abstract
Adapting attention flexibly is a fundamental ability of the human control system. In the color-word Stroop task, for example, congruency effects are typically smaller for colors and words that appear mainly in incongruent stimuli (mostly-incongruent items) than for colors and words that appear mainly in congruent stimuli (mostly-congruent items). At least part of this item-specific proportion-congruent (ISPC) effect is due to a process of reactive conflict adaptation that affords higher selectivity (i.e., more efficient selection of task-relevant information) when a specific stimulus is presented that is frequently associated in the experiment with conflicting task-irrelevant information. What is unclear, however, is whether, normally, this stimulus-specific adaptation is triggered by the task-relevant component, the task-irrelevant component, or both components of the stimulus. In two experiments, using modified color-word (Experiment 1) and spatial (Experiment 2) Stroop tasks that allowed task-relevant and task-irrelevant triggering processes to be dissociated, we found that the two processes have approximately equivalent impacts. Because these results were obtained in experiments imposing no limitations on the processes potentially contributing to the ISPC effect, these results challenge claims that the ISPC effect involves conflict-adaptation processes only in special situations. The ISPC effect may involve conflict-adaptation processes in most situations, with both task-relevant and task-irrelevant information triggering such processes.
- Published
- 2022
- Full Text
- View/download PDF
31. Consonant and vowel transposition effects during reading development: A study on Italian children and adults
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Giacomo Spinelli, Stephen J. Lupker, Lucia Colombo, Spinelli, G, Colombo, L, and Lupker, S
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Adult ,Consonant ,medicine.medical_specialty ,Physiology ,media_common.quotation_subject ,Diphthong ,reading development ,Experimental and Cognitive Psychology ,Audiology ,Hiatus ,transposition effect ,Physiology (medical) ,Reading (process) ,Vowel ,Reaction Time ,medicine ,Humans ,Child ,General Psychology ,media_common ,consonant–vowel statu ,Linguistics ,General Medicine ,Neuropsychology and Physiological Psychology ,Reading ,Child, Preschool ,Status only ,Masked priming ,Psychology ,Priming (psychology) - Abstract
Recently, Colombo, Spinelli, and Lupker, using a masked transposed letter (TL) priming paradigm, investigated whether consonant/vowel (CV) status is important early in orthographic processing. In four experiments with Italian and English adults, they found equivalent TL priming effects for CC, CV, and VC transpositions. Here, we investigated that question with younger readers (aged 7–10) and adults, as well as whether masked TL priming effects might have a phonological basis. That is, because young children are likely to use phonological recoding in reading, the question was whether they would show TL priming that is affected by CV status. In Experiment 1, target words were preceded by primes in which two letters (either CV, VC, or CC) were transposed versus substituted (SL). We found significant TL priming effects, with an increasing developmental trend but, again, no letter type by priming interaction. In Experiment 2, the transpositions/substitutions involved only pairs of vowels with those vowels having either diphthong or hiatus status. The difference between these two types of vowel clusters is only phonological; thus, the question was, “Would TL priming interact with this factor?” TL priming was again found with an increasing trend with age, but there was no vowel cluster by priming interaction. There was, however, an overall vowel cluster effect (slower responding to words with hiatuses) which decreased with age. The results suggest that TL priming only taps the orthographic level, and that CV status only becomes important at a later phonological level.
- Published
- 2022
32. When 'elefante' helps say 'elephant' but 'cavallo' does not help say 'horse': Examining the role of contextual information in regulating influences from the non-target language
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Spinelli, Giacomo, Auriniya Moskal, Sulpizio, Simone, Spinelli, G, Moskal, A, and Sulpizio, S
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cognitive control ,bilingualism ,cognate effect - Published
- 2022
33. Evaluation of COVID-19 impact on DELAYing diagnostic-therapeutic pathways of lung cancer patients in Italy (COVID-DELAY study): fewer cases and higher stages from a real-world scenario
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L. Cantini, G. Mentrasti, G.L. Russo, D. Signorelli, G. Pasello, E. Rijavec, M. Russano, L. Antonuzzo, D. Rocco, R. Giusti, V. Adamo, C. Genova, A. Tuzi, A. Morabito, S. Gori, N. La Verde, R. Chiari, A. Cortellini, V. Cognigni, F. Pecci, A. Indini, A. De Toma, E. Zattarin, S. Oresti, E.G. Pizzutilo, S. Frega, E. Erbetta, A. Galletti, F. Citarella, S. Fancelli, E. Caliman, L. Della Gravara, U. Malapelle, M. Filetti, M. Piras, G. Toscano, L. Zullo, M. De Tursi, P. Di Marino, V. D’Emilio, M.S. Cona, A. Guida, A. Caglio, F. Salerno, G. Spinelli, C. Bennati, F. Morgillo, A. Russo, C. Dellepiane, I. Vallini, V. Sforza, A. Inno, F. Rastelli, V. Tassi, L. Nicolardi, V. Pensieri, R. Emili, E. Roca, A. Migliore, T. Galassi, M. L. Bruno Rocchi, R. Berardi, Cantini, L., Mentrasti, G., Russo, G. L., Signorelli, D., Pasello, G., Rijavec, E., Russano, M., Antonuzzo, L., Rocco, D., Giusti, R., Adamo, V., Genova, C., Tuzi, A., Morabito, A., Gori, S., Verde, N. L., Chiari, R., Cortellini, A., Cognigni, V., Pecci, F., Indini, A., De Toma, A., Zattarin, E., Oresti, S., Pizzutilo, E. G., Frega, S., Erbetta, E., Galletti, A., Citarella, F., Fancelli, S., Caliman, E., Della Gravara, L., Malapelle, U., Filetti, M., Piras, M., Toscano, G., Zullo, L., De Tursi, M., Di Marino, P., D'Emilio, V., Cona, M. S., Guida, A., Caglio, A., Salerno, F., Spinelli, G., Bennati, C., Morgillo, F., Russo, A., Dellepiane, C., Vallini, I., Sforza, V., Inno, A., Rastelli, F., Tassi, V., Nicolardi, L., Pensieri, V., Emili, R., Roca, E., Migliore, A., Galassi, T., Rocchi, M. L. B., and Berardi, R.
- Subjects
Cancer Research ,ECOG PS, Eastern Cooperative Oncology Group Performance Status ,Lung Neoplasms ,Settore MED/06 - Oncologia Medica ,PD-(L)1, programmed death-(ligand) 1 ,COVID-19 ,diagnostic delay ,lung cancer ,staging ,therapeutic delay ,LC, lung cancer ,SCLC, small cell lung cancer ,NSCLC, non-small cell lung cancer ,Humans ,COVID-19, Coronavirus Disease 19 ,Pandemics ,IQR, interquartile range ,Original Research ,pts, patients ,CI, confidence interval ,Oncology ,Communicable Disease Control ,Italy ,SD, standard deviation - Abstract
Introduction: COVID-19 has disrupted the global health care system since March 2020. Lung cancer (LC) patients (pts) represent a vulnerable population highly affected by the pandemic. This multicenter Italian study aimed to evaluate whether the COVID-19 outbreak had an impact on access to cancer diagnosis and treatment of LC pts compared with pre-pandemic time. Methods: Consecutive newly diagnosed LC pts referred to 25 Italian Oncology Departments between March and December 2020 were included. Access rate and temporal intervals between date of symptoms onset and diagnostic and therapeutic services were compared with the same period in 2019. Differences between the 2 years were analyzed using the chi-square test for categorical variables and the Mann–Whitney U test for continuous variables. Results: A slight reduction (−6.9%) in newly diagnosed LC cases was observed in 2020 compared with 2019 (1523 versus 1637, P = 0.09). Newly diagnosed LC pts in 2020 were more likely to be diagnosed with stage IV disease (P < 0.01) and to be current smokers (someone who has smoked more than 100 cigarettes, including hand-rolled cigarettes, cigars, cigarillos, in their lifetime and has smoked in the last 28 days) (P < 0.01). The drop in terms of new diagnoses was greater in the lockdown period (percentage drop −12% versus −3.2%) compared with the other months included. More LC pts were referred to a low/medium volume hospital in 2020 compared with 2019 (P = 0.01). No differences emerged in terms of interval between symptoms onset and radiological diagnosis (P = 0.94), symptoms onset and cytohistological diagnosis (P = 0.92), symptoms onset and treatment start (P = 0.40), and treatment start and first radiological revaluation (P = 0.36). Conclusions: Our study pointed out a reduction of new diagnoses with a shift towards higher stage at diagnosis for LC pts in 2020. Despite this, the measures adopted by Italian Oncology Departments ensured the maintenance of the diagnostic-therapeutic pathways of LC pts.
- Published
- 2022
34. Enabling by voice: An exploratory study on how Interactive Smart Agents (ISA) can change the design of Environmental Control (EC) equipment and service
- Author
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Shamim, Umber, Spinelli, G, and Manivannan, N
- Subjects
Assistive Technology ,Technology Adoption ,Smart Speakers - Abstract
This thesis was submitted for the award of Master of Philosophy and was awarded by Brunel University London The use of well-designed assistive devices may improve the quality of life of individuals living with severe and permanent impairments and reduce the burden on their caregivers. Interactive Smart Agents (ISA)s use the latest smart home technology to control devices around the house through voice interfaces. This study aims to investigate whether ISAs may be effective to support individuals who are affected by multiple sclerosis, stroke, spinal cord injury (SCI) or other neurological ailments. This study’s approach is user-centred to ensure inclusion. This study includes two main parts: 1. the initial development of a technology adoption model informed by secondary research and exploratory primary data, 2. a second in-depth investigation of the initially identified constructs and relationships through a multipoints qualitative study. After data analysis the initial model was altered to reflect the insights generated by the primary research. By using this modified technology adoption model, designers and manufacturers can make changes in their future ISA devices so that they can be better suited to the needs of users with severe mobility impairments. This research is in collaboration with the North Thames Regional Environmental Control Services (NTRECES), an NHS organisation that provides Environmental Control (EC) devices to manage the patients’ electrical and computing appliances. Clinical staff have indicated an increasing patients’ demand of ISAs instead of traditional EC devices and have suggested that their clients are keen to experiment with more intuitive interfaces. The originality of this work consists of bringing together two established schools of thoughts, the Technology Adoption Model (TAM) and the Theory of Planned Behaviour (TPB) to arrive at a model that specifically considers adoption and usability factors relevant to a niche service user group (people with severe mobility impairments) and a specific technology, ISAs. This research has uncovered that, novelty, and ease of voice interaction as well as its entertainment value played a key role in the decision to adopt an ISA device. Users are willing to overlook the reliability, privacy and security issues if a back-up device is present and as most of the functions the users require are not security and privacy critical. Brunel Partners Academic Centre for Health Sciences (BPACHS)
- Published
- 2022
35. Speaking a language when another is known: Can bilinguals use contextual information to control influences from the nontarget language?
- Author
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Spinelli, Giacomo, Auriniya Moskal, Sulpizio, Simone, Spinelli, G, Moskal, A, and Sulpizio, S
- Subjects
cognitive control ,bilingualism ,cognate effect - Published
- 2022
36. Conflict-Monitoring Theory in Overtime: Is Temporal Learning a Viable Explanation for the Congruency Sequence Effect?
- Author
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Giacomo Spinelli, Stephen J. Lupker, Spinelli, G, and Lupker, S
- Subjects
Conflict adaptation ,Behavioral Neuroscience ,Arts and Humanities (miscellaneous) ,Stroop Test ,Congruency sequence effect ,Reaction Time ,Humans ,Learning ,Proportion-congruent effect ,Experimental and Cognitive Psychology ,Attention ,Temporal learning ,Conflict monitoring - Abstract
In interference tasks (e.g., Stroop, 1935), congruency effects are larger following a congruent versus an incongruent trial. This "congruency sequence effect" has been traditionally explained in terms of a conflict-monitoring mechanism that focuses attention toward relevant information when conflict has recently been experienced. More recently, it has been suggested that effects of this sort result from differences in the temporal expectancies formed following congruent trials (fast responding) versus incongruent trials (slow responding). Evidence supporting this "temporal-learning" account was recently reported for a similar effect, the finding that congruency effects are larger in a mostly congruent list than in a mostly incongruent list. That is, consistent with the idea that this "proportion-congruent effect" is based on different temporal expectancies following congruent versus incongruent trials in interference tasks, the proportion-congruent effect was eliminated on normal (i.e., immediate-response) trials when temporal expectancies were equated by requiring a delayed response on the prior trial. In two experiments, we examined whether this delayed-response procedure would have a similar impact on the congruency sequence effect. Consistent with the temporal-learning account (but not inconsistent with conflict-monitoring accounts), the congruency sequence effect on immediate-response trials was eliminated when the previous trial required a delayed response. However, no evidence supporting the temporal-learning account emerged from reanalyses of experiments requiring only immediate responses in which the response latency in the previous trial functioned as the temporal-expectancy index. Overall, the present results and analyses do not provide much evidence favoring the temporal-learning account over conflict-monitoring accounts of the congruency sequence effect. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
- Published
- 2022
37. Bilingualism and executive attention: Evidence from studies of proactive and reactive control
- Author
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Giacomo Spinelli, J. Bruce Morton, Stephen J. Lupker, Samantha F. Goldsmith, Spinelli, G, Goldsmith, S, Lupker, S, and Morton, J
- Subjects
Linguistics and Language ,Reactive control ,Short-term memory ,Multilingualism ,Experimental and Cognitive Psychology ,Bilingual advantage ,PsycINFO ,050105 experimental psychology ,Language and Linguistics ,Working-memory capacity ,Executive attention ,Executive Function ,Humans ,Attention ,0501 psychology and cognitive sciences ,Control (linguistics) ,Association (psychology) ,Neuroscience of multilingualism ,Working memory ,05 social sciences ,Inhibition, Psychological ,Memory, Short-Term ,Variation (linguistics) ,Proactive control ,Proactive Inhibition ,Psychology ,Cognitive psychology - Abstract
According to some accounts, the bilingual advantage is most pronounced in the domain of executive attention rather than inhibition and should therefore be more easily detected in conflict adaptation paradigms than in simple interference paradigms. We tested this idea using two conflict adaptation paradigms, one that elicits a list-wide proportion-congruent effect and one that elicits an item-specific proportion-congruent effect. In both cases, the relevant finding is that congruency effects are reduced when the proportion of congruent to incongruent items is smaller. These effects are validated measures of proactive and reactive control, respectively, and are aspects of executive attention known to be associated with individual differences in working memory capacity. We reasoned that if bilingualism affects executive attention in a similar way as does working memory capacity, indices of proactive and reactive control should be comparably associated with continuous variation in language status and working memory capacity. In two experiments, we replicated previous findings that working memory capacity is associated with variation in congruency effects (suggesting greater reliance on proactive control). In contrast, language status had no consistent association with performance, save for a hint that bilingualism may be associated with greater reliance on reactive control. Thus, the bilingual advantage may exist, but not in proactive control or any other aspects of executive attention that have been proposed thus far. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
- Published
- 2022
38. Testing, Experimental Design, and Numerical Analysis of Nanomechanical Properties in Epoxy Hybrid Systems Reinforced with Carbon Nanotubes and Graphene Nanoparticles.
- Author
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Spinelli G, Guarini R, Batakliev T, Guadagno L, and Raimondo M
- Abstract
Hybrid nanocomposites incorporating multiple fillers are gaining significant attention due to their ability to enhance material performance, offering superior properties compared to traditional monophase systems. This study investigates hybrid epoxy-based nanocomposites reinforced with multi-walled carbon nanotubes (MWCNTs) and graphene nanosheets (GNs), introduced at two different weight concentrations of the mixed filler, i.e., 0.1 wt% and 0.5 wt% which are, respectively, below and above the Electrical Percolation Threshold (EPT) for the two binary polymer composites that solely include one of the two nanofillers, with varying MWCNTs:GNs ratios. Mechanical properties, such as contact depth, hardness, and reduced modulus, were experimentally assessed via nanoindentation, while morphological analysis supported the mechanical results. A Design of Experiments (DoE) approach was utilized to evaluate the influence of filler concentrations on the composite's mechanical performance, and Response Surface Methodology (RSM) was applied to derive a mathematical model correlating the filler ratios with key mechanical properties. The best and worst-performing formulations, based on hardness and contact depth results, were further investigated through detailed numerical simulations using a multiphysics software. After validation considering experimental data, the simulations provided additional insights into the mechanical behavior of the hybrid composites. This work aims to contribute to the knowledge base on hybrid composites and promote the use of computational modeling techniques for optimizing the design and mechanical performance of advanced materials.
- Published
- 2024
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- View/download PDF
39. Is adaptation involved in bilingual language production? A fresh look at the assumptions motivating potential bilingual-monolingual differences in adaptive control.
- Author
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Spinelli G and Sulpizio S
- Subjects
- Humans, Adult, Female, Male, Adaptation, Psychological physiology, Young Adult, Psycholinguistics, Executive Function physiology, Multilingualism, Stroop Test
- Abstract
One of the hottest debates in psychology-whether bilingual-monolingual differences exist in cognitive control-is at a stalemate. Here we propose that the stalemate could be broken by shifting the research focus from whether those differences emerge to why they should. We offer an example of this approach by testing the assumption of current theories of language-control associations that adaptive control is involved in bilingualism, specifically language production. Unbalanced Italian-English bilinguals living in the Milan area completed a Stroop task in their L1 and a picture-naming task in their L2. Both tasks involved a manipulation of the proportion of the type of stimuli that are assumed to require control, i.e., incongruent stimuli in the Stroop task (e.g., the word RED written in blue) and pictures with noncognate names in the picture-naming task (e.g., the picture of a horse, whose Italian name, "cavallo," has a very different pronunciation). Both confirmatory and exploratory analyses showed a clear dissociation between the two tasks, with the Stroop task producing an interactive pattern indicative of adaptive-control involvement and the picture-naming task failing to produce a similar one. These results suggest that adaptive control may not be involved in bilingual language production and, therefore, may not produce bilingual-monolingual differences in cognitive control. It is hoped that this research will inspire a change in the study of language-control associations, pushing future research efforts towards grounding the assumptions for those associations in empirical evidence., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
40. Apalutamide in Metastatic Castration-sensitive Prostate Cancer: Results from the Multicenter Real-world ARON-3 Study.
- Author
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Santoni M, Büttner T, Rescigno P, Fiala O, Cavasin N, Basso U, Taha T, Massari F, Myint ZW, Formisano L, Galli L, Scagliarini S, Matrana MR, Facchini G, Bamias A, Messina C, Zacchi F, Manneh RK, Roviello G, Santini D, Poprach A, Navratil J, Uher M, Calabrò F, Pierce E, Berardi R, Aurilio G, Zakopoulou R, Rizzo A, Ansari J, Rizzo M, Bisonni R, Mollica V, Incorvaia L, Spinelli G, Jiang XY, Chandler RA, Grillone F, Morelli F, Buti S, Maluf FC, Marques Monteiro FS, Battelli N, Porta C, Caffo O, and Soares A
- Abstract
Background and Objective: Apalutamide (APA) is a treatment for metastatic castration-sensitive prostate cancer (mCSPC). In the ARON-3 study we investigated real-world experiences with APA treatment for mCSPC., Methods: We retrospectively assessed real-world clinical outcomes for patients with mCSPC treated with APA in the ARON-3 study. Overall survival (OS) was calculated from APA initiation to death from any cause. PSA
90 was defined as a prostate-specific antigen decline of ≥90% from baseline, and PSA0.2 as achievement of a PSA level ≤0.2 ng/ml. Data for adverse events were retrospectively collected from electronic and paper charts and categorized according to Common Terminology Criteria for Adverse Events v5.0., Key Findings and Limitations: We included 531 patients with mCSPC treated with APA. High-volume disease was reported for 214 patients (40%), and 56 (11%) had visceral metastases. Median OS was not reached. PSA90 was experienced by 461 patients (87%) and PSA0.2 by 368 (69%). Median OS was significantly longer for patients with PSA90 or PSA0.2 than for subjects without these responses (p < 0.001). The incidence of grade 3-4 fatigue was higher among elderly patients (≥80 yr) than among younger patients (19% vs 5%), but the incidence of other adverse events was comparable between the age groups., Conclusions and Clinical Implications: APA is an effective and tolerable treatment for mCSPC in the real-world setting., Patient Summary: The ARON-3 project collects data for patients with prostate cancer treated in multiple centers worldwide to assess outcomes in the real-world setting. We analyzed data for patients with metastatic hormone-sensitive prostate cancer receiving apalutamide. Our results show that apalutamide is a safe and effective drug in the real-world setting as well as in clinical trials., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
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41. Improving Resistive Heating, Electrical and Thermal Properties of Graphene-Based Poly(Vinylidene Fluoride) Nanocomposites by Controlled 3D Printing.
- Author
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Kotsilkova R, Georgiev V, Aleksandrova M, Batakliev T, Ivanov E, Spinelli G, Tomov R, and Tsanev T
- Abstract
This study developed a novel 3D-printable poly(vinylidene fluoride) (PVDF)-based nanocomposite incorporating 6 wt% graphene nanoplatelets (GNPs) with programmable characteristics for resistive heating applications. The results highlighted the significant effect of a controlled printing direction (longitudinal, diagonal, and transverse) on the electrical, thermal, Joule heating, and thermo-resistive properties of the printed structures. The 6 wt% GNP/PVDF nanocomposite exhibited a high electrical conductivity of 112 S·m
-1 when printed in a longitudinal direction, which decreased significantly in other directions. The Joule heating tests confirmed the material's efficiency in resistive heating, with the maximum temperature reaching up to 65 °C under an applied low voltage of 2 V at a raster angle of printing of 0°, while the heating Tmax decreased stepwise with 10 °C at the 45° and the 90° printing directions. The repeatability of the Joule heating performance was verified through multiple heating and cooling cycles, demonstrating consistent maximum temperatures across several tests. The effect of sample thickness, controlled by the number of printed layers, was investigated, and the results underscore the advantages of programmable 3D printing orientation in thin layers for enhanced thermal stability, tailored electrical conductivity, and efficient Joule heating capabilities of 6 wt% GNP/PVDF composites, positioning them as promising candidates for next-generation 3D-printed electronic devices and self-heating applications.- Published
- 2024
- Full Text
- View/download PDF
42. Software-assisted bone thickness evaluation in patients with syndromic craniosynostosis undergoing Le Fort III osteotomy: a technical note.
- Author
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Zanchi V, Volpe Y, Genitori L, and Spinelli G
- Abstract
The aim of this study was to assess the value of the use of software for the preoperative evaluation of cranial bone thickness in syndromic patients undergoing Le Fort III osteotomy. Four patients were evaluated preoperatively to determine whether they were eligible for distraction osteogenesis. Data from the computed tomography scans was evaluated using advanced reverse engineering tools to determine the temporal bone thickness. Three patients showed adequate values for the positioning of a rigid external distractor device (average thickness values >3.5 mm), while one patient showed insufficient bone thickness (average value <2.5 mm) and therefore underwent midface advancement according to the traditional technique. Adequate midface advancement was obtained in the three patients who underwent distraction osteogenesis. No complications related to the rigid external distractor were observed. A shorter skeletal advancement was obtained in the patient who underwent Le Fort III osteotomy according to the traditional technique. A cerebrospinal fluid fistula was observed after the removal of the plates, requiring surgical repair. Software evaluation of the cranial bone thickness is a useful tool in the surgical planning of Le Fort III osteotomy in patients affected by syndromic craniosynostosis., Competing Interests: Competing Interests None., (Copyright © 2024 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
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43. Modulations of response activation contribute to block-wide control: Evidence from proportion congruency effects in the prime-probe task.
- Author
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Weissman DH, Schmidt JR, and Spinelli G
- Abstract
Distractor-related congruency effects are smaller in blocks of mostly incongruent (vs. mostly congruent) trials. It remains unclear, though, how control processes produce this proportion congruency effect (PCE). The attentional shift account posits that experiencing conflict more frequently in mostly incongruent (vs. mostly congruent) blocks biases control processes to shift attention away from the distractor. The response modulation account posits that, if participants identify the distractor before the target, control processes use the distractor's identity to prepare a congruent response in mostly congruent blocks and/or an incongruent response in mostly incongruent blocks. We conducted four experiments ( N = 192) to investigate whether a modulation of response activation contributes to the PCE in the prime-probe task. We observed a larger PCE when the prime/distractor appeared 166 ms before (vs. simultaneously with) the probe/target (Experiment 1) and a PCE without an overall congruency effect at a longer, 933-ms stimulus onset asynchrony (SOA; Experiment 2). Critically, the latter PCE was associated with a negative congruency effect in mostly incongruent blocks, consistent with a modulation of response activation but not a shift of attention. Finally, in a modified prime-probe task, wherein participants respond to each stimulus before the next one appears (1,133 ms SOA), we observed analogous PCEs and negative congruency effects (Experiment 3) and a PCE-like effect in response force just before the probe appeared (Experiment 4). These findings indicate an independent contribution of control processes that modulate response activation to the PCE at long prime-probe SOAs, which extends beyond minimizing distraction from irrelevant stimuli. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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- 2024
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44. Semantic Stroop interference is modulated by the availability of executive resources: Insights from delta-plot analyses and cognitive load manipulation.
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Sulpizio S, Spinelli G, and Scaltritti M
- Subjects
- Humans, Young Adult, Adult, Male, Female, Attention physiology, Pattern Recognition, Visual physiology, Memory, Short-Term physiology, Reaction Time physiology, Executive Function physiology, Stroop Test, Semantics
- Abstract
We investigated whether, during visual word recognition, semantic processing is modulated by attentional control mechanisms directed at matching semantic information with task-relevant goals. In previous research, we analyzed the semantic Stroop interference as a function of response latency (delta-plot analyses) and found that this phenomenon mainly occurs in the slowest responses. Here, we investigated whether this pattern is due to reduced ability to proactively maintain the task goal in these slowest trials. In two pairs of experiments, participants completed two semantic Stroop tasks: a classic semantic Stroop task (Experiment 1A and 2A) and a semantic Stroop task combined with an n-back task (Experiment 1B and 2B). The two pairs of experiments only differed in the trial pace, which was slightly faster in Experiments 2A and 2B than in Experiments 1A and 1B. By taxing the executive control system, the n-back task was expected to hinder proactive control. Delta-plot analyses of the semantic Stroop task replicated the enhanced effect in the slowest responses, but only under sufficient time pressure. Combining the semantic Stroop task with the n-back task produced a change in the distributional profile of semantic Stroop interference, which we ascribe to a general difficulty in the use of proactive control. Our findings suggest that semantic Stroop interference is, to some extent, dependent on the available executive resources, while also being sensitive to subtle variations in task conditions., (© 2024. The Author(s).)
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- 2024
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45. Thermo-Mechanical and Thermo-Electric Properties of a Carbon-Based Epoxy Resin: An Experimental, Statistical, and Numerical Investigation.
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Spinelli G, Guarini R, Guadagno L, Vertuccio L, and Romano V
- Abstract
Due to their remarkable intrinsic physical properties, carbon nanotubes (CNTs) can enhance mechanical properties and confer electrical and thermal conductivity to polymers currently being investigated for use in advanced applications based on thermal management. An epoxy resin filled with varying concentrations of CNTs (up to 3 wt%) was produced and experimentally characterized. The electrical percolation curve identified the following two critical filler concentrations: 0.5 wt%, which is near the electrical percolation threshold (EPT) and suitable for exploring mechanical and piezoresistive properties, and 3 wt% for investigating thermo-electric properties due to the Joule effect with applied voltages ranging from 70 V to 200 V. Near the electrical percolation threshold (EPT), the CNT concentration in epoxy composites forms a sparse, sensitive network ideal for deformation sensing due to significant changes in electrical resistance under strain. Above the EPT, a denser CNT network enhances electrical and thermal conductivity, making it suitable for Joule heating applications. Numerical models were developed using multiphysics simulation software. Once the models have been validated with experimental data, as a perfect agreement is found between numerical and experimental results, a simulation study is performed to investigate additional physical properties of the composites. Furthermore, a statistical approach based on the design of experiments (DoE) was employed to examine the influence of certain thermal parameters on the final performance of the materials. The purpose of this research is to promote the use of contemporary statistical and computational techniques alongside experimental methods to enhance understanding of materials science. New materials can be identified through these integrated approaches, or existing ones can be more thoroughly examined.
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- 2024
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46. Nanoindentation Response of Structural Self-Healing Epoxy Resin: A Hybrid Experimental-Simulation Approach.
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Spinelli G, Guarini R, Ivanov E, Calabrese E, Raimondo M, Longo R, Guadagno L, and Vertuccio L
- Abstract
In recent years, self-healing polymers have emerged as a topic of considerable interest owing to their capability to partially restore material properties and thereby extend the product's lifespan. The main purpose of this study is to investigate the nanoindentation response in terms of hardness, reduced modulus, contact depth, and coefficient of friction of a self-healing resin developed for use in aeronautical and aerospace contexts. To achieve this, the bifunctional epoxy precursor underwent tailored functionalization to improve its toughness, facilitating effective compatibilization with a rubber phase dispersed within the host epoxy resin. This approach aimed to highlight the significant impact of the quantity and distribution of rubber domains within the resin on enhancing its mechanical properties. The main results are that pure resin (EP sample) exhibits a higher hardness (about 36.7% more) and reduced modulus (about 7% more), consequently leading to a lower contact depth and coefficient of friction (11.4% less) compared to other formulations that, conversely, are well-suited for preserving damage from mechanical stresses due to their capabilities in absorbing mechanical energy. Furthermore, finite element method (FEM) simulations of the nanoindentation process were conducted. The numerical results were meticulously compared with experimental data, demonstrating good agreement. The simulation study confirms that the EP sample with higher hardness and reduced modulus shows less penetration depth under the same applied load with respect to the other analyzed samples. Values of 877 nm (close to the experimental result of 876.1 nm) and 1010 nm (close to the experimental result of 1008.8 nm) were calculated for EP and the toughened self-healing sample (EP-R-160-T), respectively. The numerical results of the hardness provide a value of 0.42 GPa and 0.32 GPa for EP and EP-R-160-T, respectively, which match the experimental data of 0.41 GPa and 0.30 GPa. This validation of the FEM model underscores its efficacy in predicting the mechanical behavior of nanocomposite materials under nanoindentation. The proposed investigation aims to contribute knowledge and optimization tips about self-healing resins.
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- 2024
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47. Technology innovation to reduce health inequality in skin diagnosis and to improve patient outcomes for people of color: a thematic literature review and future research agenda.
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Khatun N, Spinelli G, and Colecchia F
- Abstract
The health inequalities experienced by ethnic minorities have been a persistent and global phenomenon. The diagnosis of different types of skin conditions, e.g., melanoma, among people of color is one of such health domains where misdiagnosis can take place, potentially leading to life-threatening consequences. Although Caucasians are more likely to be diagnosed with melanoma, African Americans are four times more likely to present stage IV melanoma due to delayed diagnosis. It is essential to recognize that additional factors such as socioeconomic status and limited access to healthcare services can be contributing factors. African Americans are also 1.5 times more likely to die from melanoma than Caucasians, with 5-year survival rates for African Americans significantly lower than for Caucasians (72.2% vs. 89.6%). This is a complex problem compounded by several factors: ill-prepared medical practitioners, lack of awareness of melanoma and other skin conditions among people of colour, lack of information and medical resources for practitioners' continuous development, under-representation of people of colour in research, POC being a notoriously hard to reach group, and 'whitewashed' medical school curricula. Whilst digital technology can bring new hope for the reduction of health inequality, the deployment of artificial intelligence in healthcare carries risks that may amplify the health disparities experienced by people of color, whilst digital technology may provide a false sense of participation. For instance, Derm Assist, a skin diagnosis phone application which is under development, has already been criticized for relying on data from a limited number of people of color. This paper focuses on understanding the problem of misdiagnosing skin conditions in people of color and exploring the progress and innovations that have been experimented with, to pave the way to the possible application of big data analytics, artificial intelligence, and user-centred technology to reduce health inequalities among people of color., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Khatun, Spinelli and Colecchia.)
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- 2024
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48. Masked Translation Priming Effects for Chinese-English-Japanese Triple Cognates in Lexical Decision Tasks.
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Li L, Yang H, Jia G, Spinelli G, and Lupker SJ
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- Adult, Female, Humans, Male, Young Adult, Decision Making, East Asian People, Language, Perceptual Masking physiology, Phonetics, Psycholinguistics, China, Multilingualism
- Abstract
Previous research has demonstrated cognate translation priming effects in masked priming lexical decision tasks (LDTs) even when a bilingual's two languages have different scripts. Because those effect sizes are normally larger than with noncognates, the effects have been partially attributed to the impact of prime-target phonological similarity. The present research extended that work by examining priming effects when using triple different-script cognates, i.e., /ka1 feɪ1/-coffee-コーヒー/KoRhiR/. Specifically, masked cognate priming effects were examined in six different priming directions (i.e., L1↔L2, L1↔L3, and L2↔L3) for Chinese-English-Japanese trilinguals using LDTs. Significant priming effects were observed only when the primes were from the stronger language. This asymmetric pattern suggests that the phonological similarity of cognate primes only facilitates the processing of different-script triple cognates to the extent that the processing of the prime is robust enough to make phonology available before target processing is finished., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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49. Going Beyond Childhood and Gender-Based Violence: Epigenetic Modifications and Inheritance.
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Li Piani L, Somigliana E, Micci LG, Spinelli G, and Barbara G
- Abstract
Being exposed to childhood or gender-based violence is associated with subsequent adverse events in individual lives. Not only can it cause psychological distress but violence survivors suffer from a range of long-term adverse health outcomes, including higher morbidity, higher mortality, and higher risk of chronic diseases. Epigenetics may be involved in the determinisms of these long-term detrimental effects. A large body of evidence supports this biological mechanism to explain violence-related health impairment in the long term. However, studies specifically focusing on violence are scant and nonunivocal. Epigenetic modifications of genes involved in stress response and in the hypothalamus-pituitary-adrenal axis regulation are the most commonly and consistently reported. Promising evidence also emerged for the use of epigenetic clocks. Finally, although very limited, there is evidence supporting the notion that long-term health impairment may be transmitted from one generation to the other. Overall, despite promising, available evidence is yet incomplete. The overlap with pure psychological mechanisms of health impairment exposes the findings to confounders and hampers strong conclusions. Based on a literature search on PubMed/Embase, our narrative review aims to illustrate the evidence concerning the potential bond between epigenetics and violence, including also possible impacts on later generations. The goal is to encourage further research to help the development of a more holistic approach for such a vulnerable and often neglected population. Further research is warranted to precisely disentangle the role of epigenetics in mediating the long-term health impairment associated with childhood or gender-based violence. Advances in this area may open new avenues of treatment. Epigenetic modifications may indeed be reversible and could be an attractive therapeutic target to minimize the long-term consequences of childhood or gender-based violence., (© Letizia Li Piani et al., 2024; Published by Mary Ann Liebert, Inc.)
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- 2024
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50. The association between posterior resting-state EEG alpha rhythms and functional MRI connectivity in older adults with subjective memory complaint.
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Lopez S, Hampel H, Chiesa PA, Del Percio C, Noce G, Lizio R, Teipel SJ, Dyrba M, González-Escamilla G, Bakardjian H, Cavedo E, Lista S, Vergallo A, Lemercier P, Spinelli G, Grothe MJ, Potier MC, Stocchi F, Ferri R, Habert MO, Dubois B, and Babiloni C
- Subjects
- Humans, Aged, Alpha Rhythm, Electroencephalography methods, Magnetic Resonance Imaging, Amyloid, Alzheimer Disease psychology, Amyloidosis, Cognitive Dysfunction
- Abstract
Resting-state eyes-closed electroencephalographic (rsEEG) alpha rhythms are dominant in posterior cortical areas in healthy adults and are abnormal in subjective memory complaint (SMC) persons with Alzheimer's disease amyloidosis. This exploratory study in 161 SMC participants tested the relationships between those rhythms and seed-based resting-state functional magnetic resonance imaging (rs-fMRI) connectivity between thalamus and visual cortical networks as a function of brain amyloid burden, revealed by positron emission tomography and cognitive reserve, measured by educational attainment. The SMC participants were divided into 4 groups according to 2 factors: Education (Edu+ and Edu-) and Amyloid burden (Amy+ and Amy-). There was a statistical interaction (p < 0.05) between the two factors, and the subgroup analysis using estimated marginal means showed a positive association between the mentioned rs-fMRI connectivity and the posterior rsEEG alpha rhythms in the SMC participants with low brain amyloidosis and high CR (Amy-/Edu+). These results suggest that in SMC persons, early Alzheimer's disease amyloidosis may contrast the beneficial effects of cognitive reserve on neurophysiological oscillatory mechanisms at alpha frequencies and connectivity between the thalamus and visual cortical networks., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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